Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 24, Issue 21, Pages 2432-2437Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612824666180516111939
Keywords
Magnetic nanoparticle; MRI; hepatocellular carcinoma; molecular imaging; cancer; diagnosis
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Funding
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201511]
- National Natural Science Foundation of China [81571746]
- Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology [CE140100036]
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Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, leading to the second most likely cause of cancer-related deaths. Medical imaging is crucial in clinic for HCC screening and diagnosis. Due to the relatively high special resolution and excellent sensitivity, magnetic resonance imaging (MRI) by using magnetic nanoparticle-based contrast agents has been used so far in HCC imaging and staging, demonstrating great potential and promising in vivo applications. This review focuses on the use of different magnetic nanoparticles for construction of HCC nanoprobes for MR imaging and theranostic purpose.
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