Article
Chemistry, Physical
Elif Senkuytu, Nadide Akbas, Tuba Yildirim, Gonul Yenilmez Ciftci
Summary: Cancer is a leading cause of death globally, making the search for anti-cancer agents crucial. In this study, novel paraben decorated dispirocyclotriphosphazene compounds were synthesized and evaluated for their cytotoxic activity, showing promising results as potential anti-cancer agents.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Environmental Sciences
Abdulrahman G. Alhamzani, Tarek A. Yousef, Mortaga M. Abou-Krisha, K. Yogesh Kumar, M. K. Prashanth, L. Parashuram, Byong Hun Jeon, M. S. Raghu
Summary: Due to the excessive use of fossil fuels, CO2 emissions into the environment are increasing. An efficient method of converting CO2 to useful carbonaceous products in the presence of light is one way to address the issues associated with energy and environmental remediation. In2S3/WS2 heterostructure has been fabricated using the efficient hydrothermal method, exhibiting enhanced photocatalytic activity compared to pristine In2S3 and WS2. The synthesized InS/WS heterostructure also showed high efficiency in degrading parabens under visible radiation.
Article
Engineering, Environmental
Jing Chen, Kun Chu, Shiquan Sun, Hong Chen, Binghao Song, Jianhui Wang, Zidan Liu, Lei Zhu
Summary: In this research, a novel magnetic Fe3O4-Mn3O4 composite was synthesized and found to have higher catalytic performance for the degradation of sulfadiazine. The composite exhibited outstanding stability and good reusability. The degradation mechanism was confirmed to be the redox reactions between Mn(II)/Mn(III)/Mn(IV), Fe(II)/Fe(III), and the synergistic effect of Mn(III)/Fe(II).
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Environmental Sciences
Heeyeon Chae, Inae Lee, Yunsun Jeong, Sunmi Kim, Gyuyeon Choi, Sungkyoon Kim, Jeongim Park, Hyo-Bang Moon, Kyungho Choi
Summary: Personal care products are a major source of paraben exposure. Fasting status affects the levels of parabens in urine differently among Korean and US women, with fasting Korean women having significantly lower levels of EtP and PrP compared to non-fasting women. In the US population, EtP levels are lower but MeP levels are higher than those in the Korean population.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Physical
Chenyan Hu, Qingdi Chen, Maosheng Tian, Weiwen Wang, Junxia Yu, Lianguo Chen
Summary: In this work, carbon quantum dots (CQDs) were used to modify bismuth vanadate (BiVO4) through a hydrothermal reaction. The as-formed CQDs/BiVO4 composite exhibited improved light harvesting and visible-light activities, leading to the degradation of paraben pollutant BzP. The introduction of CQDs also enhanced photocharge separation and reduced interfacial charge transfer resistance.
Article
Engineering, Environmental
Zhimin Gong, Li Qian, Shuai Shao, Bo Fan, Jianbiao Peng, Kun Lu, Shixiang Gao
Summary: Solvent composition plays a crucial role in the synthesis of metal complex materials. In this study, a unique Schiff base Cu complex catalyst was designed and the effect of adding H2O during the synthesis process on the catalyst's catalytic performance was investigated. The results showed that adding a small amount of H2O significantly enhanced the catalyst's catalytic ability and improved the removal of the pollutant Methyl-paraben.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Sooyeon Hong, Hye Li Jeon, Jueun Lee, Suejin Kim, Chulwoo Lee, Seungho Lee, Yoon Hee Cho, Kyungho Choi, Jiyoung Yoo
Summary: The study investigated exposure profiles and sources of major parabens among Korean children and adolescents. Personal care products and dietary sources were identified as significant factors influencing urinary levels of parabens. The levels of methyl and propyl parabens in Korean children and adolescents were comparable to those in the US, but the high exposure group had much higher levels.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
B. Shalini Reghunath, Deepak Davis, K. R. Sunaja Devi
Summary: MAX phase, with both ceramic and metallic properties, has been of significant interest in materials research. In this study, Cr2AlC MAX phase powder was successfully fabricated and utilized for photocatalytic degradation of organic pollutants, showing high efficiency. The reaction follows pseudo-first-order kinetics with active species identified as O-2 center dot(-) and h(+), and the catalyst can be reused for multiple cycles.
Article
Environmental Sciences
Challarapu Venkataramana, Sathish Mohan Botsa, P. Shyamala, R. Muralikrishna
Summary: In recent years, the use and pollution of microplastics have been increasing gradually. Especially, the use of polyethylene bags in food storage has had a significant impact on the environment, highlighting the need to control the degradation of plastics in the environment. This study successfully prepared NiAl2O4 spinels using two different methods and demonstrated their effectiveness in degrading polyethylene bags through various instrumental analyses.
Article
Environmental Sciences
J. Vitku, L. Horackova, L. Kolatorova, M. Duskova, T. Skodova, M. Simkova
Summary: Sensitive and robust LC-MS/MS methods with and without a derivatization step were developed and validated for the simultaneous analysis of EDs and steroids in plasma. These methods allow for the evaluation of the potential impact of EDs on steroid biosynthesis and metabolism.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Polymer Science
Guangwei Hu, Shaohui Lin, Boxin Zhao, Qinmin Pan
Summary: Metathesis degradation and functionalization of natural rubber (NR) were carried out using various chain transfer agents in the presence of Grubbs 2nd generation catalyst to generate NR-based telechelic oligomers, which have been a long-standing challenge due to the structure and impurities of NR. The impact of catalyst concentration on the average molecular weights and polymer dispersity index of the oligomers was studied, leading to the successful synthesis of well-defined telechelic oligomers with potential applications in various fields such as binder and lubricant.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Lucia Rossi, Paula I. Villabrille, Sergio Morales-Torres, Janina A. Rosso
Summary: In this study, palladium-modified titanium dioxide powder photocatalysts were prepared using the sol-gel method. The materials were characterized and their photocatalytic activity for phenol degradation under UV and visible irradiation was tested. The optimal palladium content was determined to be 0.10% atomic Pd, achieving 100% phenol degradation under UV irradiation and 68% under visible irradiation. The immobilization of the material on glass slides using the dip-coating method was also studied, showing promising photocatalytic activity for phenol degradation using solar irradiation.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Environmental Sciences
Weili Mao, Jianli Qu, Songyang Zhong, Xilin Wu, Kaili Mao, Kaizhen Liao, Hangbiao Jin
Summary: Parabens, a family of endocrine-disrupting chemicals, may be associated with the development of lung cancer. The study conducted in Quzhou, China found that urinary concentrations of methyl-paraben and propyl-paraben are positively associated with the risk of lung cancer in adults.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Weili Mao, Jianli Qu, Songyang Zhong, Xilin Wu, Kaili Mao, Kaizhen Liao, Hangbiao Jin
Summary: The association between parabens and lung cancer is unknown. We conducted a study in Quzhou, China, recruiting 189 cases of lung cancer and 198 controls to measure urinary parabens concentrations and examine their association with lung cancer risk. We found that cases had significantly higher concentrations of MeP, EtP, PrP, and BuP compared to controls. In the adjusted model, we identified a significant correlation between urinary PrP concentrations and lung cancer risk. Moreover, higher urinary concentrations of MeP and PrP were also associated with increased lung cancer risk.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Stefanos Dailianis, Dimitris Vlastos, Chloe Zoppou, Argyri Moschopoulou, Maria Antonopoulou
Summary: This study investigated the biological effects of two isoforms of parabens, methyl-(MeP) and propyl-(PrP), on the bacteria Aliivibrio fischeri and the mussel Mytilus galloprovincialis. The results revealed the differences in their toxic potential and their risk to aquatic biota, providing important evidence for assessing their fate and risk to the aquatic environment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Nanoscience & Nanotechnology
Weiqi Liu, Zhiqiang Li, Zixuan Wang, Ziyin Huang, Chenbo Sun, Shiyuan Liu, Yanbin Jiang, Huaiyu Yang
Summary: Developing a drug delivery system (DDS) using a natural supramolecular hydrogel has attracted much attention due to its biocompatibility, efficacy, and adjustable performance. However, designing a functional hydrogel DDS based on the interaction between gelator and model drug is still challenging. In this study, glycyrrhetinic acid (GA) gel was used to encapsulate the model drug pyrazinamide (PZA), achieving polymorph control, stabilization, and pH-responsive release. This work provides a promising option for hydrogel-based DDS design combined with polymorph control and stabilization.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Ge Wang, Wentao Li, Xuan Wang, Xuwen Yuan, Huaiyu Yang
Summary: The inhibition performance of a novel Mannich base-type imidazoline quaternary salt, PPLC, for mild steel in 0.5 M HCl was investigated. The experimental and theoretical results showed that PPLC exhibited excellent corrosion inhibition ability through strong chemisorption on the metal surface.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Engineering, Chemical
Yuehua Deng, Wei Luo, Zhiyong Zheng, Guixuan Wei, Shiyuan Liu, Yanbin Jiang, Huaiyu Yang
Summary: Co-amorphous (CA) formulation is a promising strategy to improve the solubility of poorly water-soluble drugs. This study developed a modified non-bonded interaction energy (AEnon-bonded) model to predict CA formation based on solvent-based methods. The model successfully predicted CA formation for several drugs and revealed a quadratic relationship between co-former proportion and AEnon-bonded.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Zhiyong Zheng, Yuehua Deng, Weining Xie, Sirui Chen, Xiaoxiao Liang, Shiyuan Liu, Yanbin Jiang, Huaiyu Yang
Summary: A prediction method based on partial least squares regression was developed to screen for multicomponent crystal systems. Through experimental preparation, seven successful multicomponent crystal systems were obtained, exhibiting higher solubility and different dissolution behaviors in pH 6.8 phosphate buffer solution. The hygroscopic stability of all multicomponent crystals was substantially improved compared to the raw drug.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Wenqing Tian, Wei Li, Huaiyu Yang
Summary: Protein crystallization is a promising alternative to traditional downstream processing for protein-based pharmaceuticals, offering improved stability, storage, and delivery. In order to better understand the crystallization process, real-time tracking is crucial. A batch crystallizer with in situ monitoring capabilities using a focused beam reflectance measurement (FBRM) probe and a thermocouple was designed. Three stages were identified: slow nucleation, rapid crystallization, and slow growth and breakage. The induction time was estimated by FBRM and found to decrease with increasing supersaturation under the same salt concentration. The interfacial energy for nucleation was analyzed and found to decrease with increasing salt concentration. Protein and salt concentrations significantly influenced the yield of the experiments, with up to 99% yield and a median crystal size of 26.5 μm achieved. Three stages with different nucleation and concentration changes were identified, and the occurrence of secondary nucleation was delayed. Needle-shaped crystals appeared after tetragonal crystals but had higher bioavailability, suggesting that crystallization can be a better method for maintaining bioavailability compared to lyophilization.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Fangfang Wang, Yang Wang, Weicheng Qiu, Qiansen Zhang, Huaiyu Yang, Gaojie Song
Summary: Adhesion G protein-coupled receptors (aGPCRs) are important in human immune responses and other biological processes. GPR110, a member of aGPCR subfamily VI, is involved in lung and prostate cancers. The crystal structure of GPR110 reveals the connection between different domains and the importance of glycosylation for folding and expression.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yuan Wang, Wei Zhang, Torsten Mueller, Prakash Lakshmanan, Yu Liu, Tao Liang, Lin Wang, Huaiyu Yang, Xinping Chen
Summary: Using agricultural wastes as an alternative phosphorus source can greatly improve soil phosphorus status. Cattle manure outperforms other phosphorus sources in improving soil phosphorus availability. pH has a direct positive effect on labile phosphorus fractions in the acidic red soil amended with different phosphorus sources.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Ke Zhang, Yuan Li, Xiangyi Kong, Chuqi Lei, Huaiyu Yang, Nianchang Wang, Zhongzhao Wang, Hu Chang, Lixue Xuan
Summary: AGR2 is a secreted protein widely found in breast tissue. Its increased expression in precancerous lesions, primary tumors, and metastatic tumors raises interest. This review discusses the gene and protein structure of AGR2, highlighting its various functions within and outside breast cancer cells due to its endoplasmic reticulum retention sequence, protein disulfide isomerase active site, and multiple protein binding sequences. The review also explores the role of AGR2 in breast cancer progression and prognosis, emphasizing its potential as a biomarker and target for immunotherapy, providing new insights for early diagnosis and treatment of breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pediatrics
Lidong Gao, Yan Li, Peng He, Zhen Chen, Huaiyu Yang, Fangjun Li, Siyuan Zhang, Danni Wang, Guangyan Wang, Shilong Yang, Lihui Gong, Fan Ding, Mengyu Ling, Xilu Wang, Leilei Ci, Lianpan Dai, George Fu Gao, Tao Huang, Zhongyu Hu, Zhifang Ying, Jiufeng Sun, Xiaohu Zuo
Summary: The study aimed to evaluate the safety and immunogenicity of the ZF2001 vaccine in children and adolescents aged 3-17 years in China. The results showed that ZF2001 is safe, well tolerated, and immunogenic in children and adolescents. These findings support further studies of the ZF2001 vaccine in this population.
LANCET CHILD & ADOLESCENT HEALTH
(2023)
Article
Medicine, General & Internal
Haosheng Tan, Huaiyu Yang, Jiaxin Qian, Shaoyan Liu, Dangui Yan, Liyuan Wei, Wensheng Liu
Summary: This study explored the role of KLRK1 in immune infiltration and prognosis of HNSCC. It was found that KLRK1 was highly expressed in HNSCC and correlated with better prognosis and immune cell infiltration. High expression of KLRK1 ligands was associated with worse prognoses.
Article
Engineering, Chemical
Zhichun Lin, Wenqing Tian, Yang Su, Vikash Kumar Yadav, Huaiyu Yang
Summary: Heterogeneous template-induced nucleation is a promising method for controlling protein crystallization events. This study investigated the protein crystallization process using graphite and graphene oxide as heterogeneous templates. The presence of graphite flakes resulted in faster nucleation of lysozyme crystals, particularly around the edges of the flakes. Monolayer graphene oxide also influenced nucleation, with more crystals appearing around the graphene oxide particles. The use of templates affected crystal morphology and crystallization kinetics, with more crystals observed in the solution with graphite templates compared to graphene oxide templates or no templates.
Article
Materials Science, Multidisciplinary
Lei Guo, Zhuping Li, Xiubang Wu, Kai Wang, Faheem Abbas, Yundong Wu, Fan Zhang
Summary: In this work, a simple photocuring method was used to create a series of zwitterionic coatings containing polyhedral oligomeric silsesquioxane (POSS) without the need to prepare copolymer. The coating thickness was typically about 6 μm, and the surface POSS content showed a tendency of increasing with POSS. The zwitterionic coating with high POSS content exhibited better water absorbing capability and transmittance, leading to excellent antifogging properties.
Article
Chemistry, Physical
Wenqing Tian, Oladayo Ogunyinka, Charlie Oretti, H. C. Hemaka Bandulasena, Chris Rielly, Huaiyu Yang
Summary: Lysozyme crystallisation was successfully carried out in a microfluidic device with the presence of different gases, demonstrating the influence of protein adsorption on the stability of gas bubbles. The nucleation on the gas-liquid interface was found to be more preferable than on the capillary glass wall, reducing fouling inside the capillary. The resulting crystals exhibited curved surfaces and floated in the solution with gas bubbles. The population density of lysozyme crystals increased with the solubility of the gases, and three stages of protein crystallisation on different interfaces were discussed.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Polymer Science
Xuan Wang, Xu-wen Yuan, Ge Wang, Huai-yu Yang
Summary: In this study, liquid polysulfide rubber was used as the core material and polystyrene as the shell material to prepare microcapsules with uniform size and smooth surface by solvent evaporation method. The experimental results showed that using a mixed solution of PVA and NaOA as the emulsion system can obtain microcapsules with better uniformity. This research laid a good foundation for the engineering application of the new generation microcapsule-based sealant, which was of great significance and application value to the assembly automation of sealants.
ACTA POLYMERICA SINICA
(2023)
Article
Chemistry, Physical
Lizhou Fan, Yuxiang Song, Fan Zhang, Brian J. J. Timmer, Alexander Kravberg, Biaobiao Zhang, Licheng Sun
Summary: Water oxidation is a key reaction in natural and artificial photosynthesis. Designing efficient water-oxidation catalysts for solar fuel production is a long-term challenge. Mimicking the structures of the oxygen-evolving complex (OEC) is a direct strategy, but the high efficiency of the OEC relies on its holistic system for well-organized electron transfer and proton transport.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
