Article
Surgery
Samuel Frey, Bastien Perrot, Cecile Caillard, Maelle Le Bras, Maxime Gerard, Claire Blanchard, Bertrand Cariou, Matthieu Wargny, Eric Mirallie
Summary: This study evaluated the long-term impact of parathyroidectomy (PTX) on quality of life (QoL) in patients with primary hyperparathyroidism (PHPT). The results showed that QoL significantly improved at 1 year and was sustained for at least 3 years after PTX. Additionally, while the physical component score normalized after 3 years, the mental component score remained lower than the reference population.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Endocrinology & Metabolism
Milan Jovanovic, Vladan Zivaljevic, Sandra Sipetic Grujicic, Katarina Tausanovic, Nikola Slijepcevic, Branislav Rovcanin, Ksenija Jovanovic, Bozidar Odalovic, Matija Buzejic, Zoran Bukumiric, Ivan Paunovic
Summary: This study aimed to evaluate the quality of life and cognitive impairment in patients with primary hyperparathyroidism (pHPT) before and after parathyroidectomy. The results showed that 6 months after surgery, patients' quality of life improved, levels of depression, anxiety, and stress decreased, and cognitive status improved. Patients with more impaired quality of life and pronounced neurocognitive symptoms may benefit more from the surgery.
Article
Endocrinology & Metabolism
Georgios Tzikos, Angeliki Chorti, Sykaras Evangelos, Evangelia Boura, Christina Manani, Fotini Adamidou, Ioannis Tziatzios, Anna Zisi, Fotios Economou, Konstantinos Toulis, Ioannis Pliakos, Antonios Michalopoulos, Theodosios Papavramidisos
Summary: This study found that the QoL of patients with PHPT significantly improved 3 months and 3 years after successful parathyroidectomy, while the QoL of the conservative treatment group continued to deteriorate over 3 years. Parathyroidectomy had a significant positive impact on improving QoL.
ENDOCRINE PRACTICE
(2021)
Review
Psychiatry
Daniel Pankowski, Kinga Wytrychiewicz-Pankowska, Konrad Janowski, Ewa Pisula
Summary: This review assessed the relationship between cognitive appraisals, illness beliefs, and indicators of adaptation to rheumatoid arthritis. The findings showed that both cognitive appraisals and illness beliefs were associated with indicators such as depressive symptom severity, anxiety, and acceptance levels. Future longitudinal research is needed to further understand the impact of cognitive factors on adaptation level and its trajectories over time.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Julie Wulf Christensen, Karin Folmer Thogersen, Lars Thorbjorn Jensen, Martin Krakauer, Bent Kristensen, Finn Noe Bennedbaek, Bo Zerahn
Summary: This study aimed to assess the changes in quality of life (QoL) in patients with primary hyperparathyroidism (PHPT) after successful parathyroidectomy. The results showed significant improvements in QoL in six out of eight SF-36 subcategories. These improvements appeared within a month after surgery and did not show further significant changes at later time points.
ENDOCRINE CONNECTIONS
(2022)
Review
Biochemistry & Molecular Biology
Mara Carsote, Claudiu Nistor, Mihaela Stanciu, Florina Ligia Popa, Remus Calin Cipaian, Ovidiu Popa-Velea
Summary: Tumors of the parathyroid glands can cause various complications and symptoms, including cognitive impairment, fatigue, muscle dysfunction, depressive mood, bone pain, and sleep problems. Parathyroidectomy can improve these symptoms, but there is insufficient evidence to consider them as independent indications for surgery.
Article
Gastroenterology & Hepatology
Surain B. Roberts, Gideon M. Hirschfield, Lawrence J. Worobetz, Catherine Vincent, Jennifer A. Flemming, Angela Cheung, Karim Qumosani, Mark Swain, Dusanka Grbic, Hin Hin Ko, Kevork Peltekian, Nazia Selzner, Lusine Abrahamyan, Bishoi Aziz, Ellina Lytvyak, Kattleya Tirona, Aliya F. Gulamhusein, Harry L. A. Janssen, Aldo J. Montano-Loza, Andrew L. Mason, Bettina E. Hansen
Summary: In a diverse Canadian cohort of PBC patients, Indigenous Canadians have poorer liver transplant-free and event-free survival compared to White patients. They are more likely to have a clinical event before diagnosis and present with higher liver function test indicators, which persist during follow-up.
Article
Medicine, General & Internal
Hye Ryeon Choi, Sun Hyung Choi, Namki Hong, Yumie Rhee, Jin Kyong Kim, Cho Rok Lee, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung
Summary: Normocalcemic primary hyperparathyroidism (NPHPT) is a heterogeneous disease entity of primary hyperparathyroidism, characterized by high rates of multi-gland disease and mild biochemical abnormalities but symptomatic presentation. Intraoperative PTH monitoring may improve surgical outcomes, and short-term outcomes after surgery are similar to those of typical primary hyperparathyroidism (TPHPT).
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Georgios Tzikos, Christina Manani, Fotini Adamidou, Alexandra Menni, Moysis Moysidis, Despoina Tsalkatidou, Angeliki Chorti, Kalliopi Kotsa, Konstantinos Toulis, Panagiotis Anagnostis, Antonios Michalopoulos, Theodosios Papavramidis
Summary: This study translated and validated the Greek version of the Pasieka Questionnaire, which can be used to evaluate the health-related quality of life of patients with primary hyperparathyroidism in Greek-speaking populations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Nardeen B. Dawood, Chi-Hong Tseng, Dalena T. Nguyen, Kimberly L. Yan, Masha J. Livhits, Angela M. Leung, Michael W. Yeh
Summary: PHPT, a common cause of hypercalcemia and secondary osteoporosis, is often underdiagnosed. A retrospective cohort study revealed that more than half of patients with confirmed hypercalcemia were not assessed for PHPT, leading to missed opportunities to avoid skeletal and other complications. Care gaps in BMD assessment and therapy represent areas for improvement in PHPT management.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Tian-jiao Yuan, Yu-ying Yang, Min-ting Zhu, Yang He, Lin Zhao, Wen-zhong Zhou, Ting-wei Su, Hong-yan Zhao, Li-hao Sun, Bei Tao, Jian-min Liu
Summary: Exposure to the Chinese Great Famine is associated with changes in the phenotype of PHPT, with milder clinical presentations in recent years. Less famine exposure may be responsible for the milder form of PHPT in recent years.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Sarah Vincze, Nicholas Peters, Chia-Ling Kuo, Taylor C. Brown, Reju Korah, Timothy D. Murtha, Justin Bellizzi, Aaliyah Riccardi, Kourosh Parham, Tobias Carling, Jessica Costa-Guda, Andrew Arnold
Summary: GCM2 variants are found in a significant number of patients with primary hyperparathyroidism, but their penetrance is very low, indicating a low risk of developing the disease for individuals carrying these variants. Further research is needed to assess the clinical importance of detecting these GCM2 variants.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
T. S. Papavramidis, P. Anagnostis, I Pliakos, G. Tzikos, A. Chorti, K. Kotsa, A. Michalopoulos
Summary: Objective parathyroidectomy (PTx) improves quality of life (QoL) in patients with primary hyperparathyroidism (PHPT), with differential effects on QoL items observed in older and younger patients. Frailty only improves in the older group after PTx.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Erkan Somuncu, Yasin Kara
Summary: The study demonstrated that parathyroidectomy (PTx) for primary hyperparathyroidism (PHPT) significantly improved the quality of life (QoL) of patients, particularly in terms of physical functioning and mental health.
Review
Endocrinology & Metabolism
Manju Chandran, Lydia Tan Li Yeh, Mechteld C. de Jong, John P. Bilezikian, Rajeev Parameswaran
Summary: Classic symptoms of primary hyperparathyroidism (PHPT) are seen in approximately 20% of patients, with cognitive dysfunction and reduced quality of life being common complaints. While some animal studies suggest potential roles of PTH and PTH receptors in brain function, the evidence on whether parathyroidectomy improves cognition in PHPT patients remains inconclusive.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Endocrinology & Metabolism
Marcella D. Walker, Elaine Cong, James A. Lee, Anna Kepley, Chiyuan Zhang, Donald J. McMahon, Shonni J. Silverberg
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2015)
Article
Endocrinology & Metabolism
Elaine Cong, Marcella D. Walker, Anna Kepley, Chiyuan Zhang, Donald J. McMahon, Shonni J. Silverberg
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2015)
Article
Endocrinology & Metabolism
Marcella D. Walker, Kyle K. Nishiyama, Bin Zhou, Elaine Cong, Ji Wang, James A. Lee, Anna Kepley, Chengchen Zhang, X. Edward Guo, Shonni J. Silverberg
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2016)
Article
Endocrinology & Metabolism
M. D. Walker, I. Saeed, J. A. Lee, C. Zhang, D. Hans, T. Lang, S. J. Silverberg
OSTEOPOROSIS INTERNATIONAL
(2016)
Article
Endocrinology & Metabolism
A. L. Kepley, K. K. Nishiyama, B. Zhou, J. Wang, C. Zhang, D. J. McMahon, K. F. Foley, M. D. Walker, X. Edward Guo, E. Shane, T. L. Nickolas
OSTEOPOROSIS INTERNATIONAL
(2017)
Review
Endocrinology & Metabolism
Marcella D. Walker, Shonni J. Silverberg
NATURE REVIEWS ENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
M. D. Walker, A. Kepley, K. Nishiyama, B. Zhou, E. Guo, T. L. Nickolas
OSTEOPOROSIS INTERNATIONAL
(2017)
Article
Endocrinology & Metabolism
I. Chiodini, E. Cairoli, S. Palmieri, J. Pepe, M. D. Walker
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2018)
Article
Endocrinology & Metabolism
Daniele Massera, Mary L. Biggs, Marcella D. Walker, Kenneth J. Mukamal, Joachim H. Ix, Luc Djousse, Rodrigo J. Valderrabano, David S. Siscovick, Russell P. Tracy, Xiaonan Xue, Jorge R. Kizer
Article
Endocrinology & Metabolism
Yu-Kwang Donovan Tay, Minghao Liu, Leonardo Bandeira, Mariana Bucovsky, James A. Lee, Shonni J. Silverberg, Marcella D. Walker
ENDOCRINE RESEARCH
(2018)
Correction
Endocrinology & Metabolism
A. L. Kepley, K. K. Nishiyama, B. Zhou, J. Wang, C. Zhang, D. J. McMahon, K. F. Foley, M. D. Walker, X. E. Guo, E. Shane, T. L. Nickolas
OSTEOPOROSIS INTERNATIONAL
(2018)
Article
Surgery
Denise Lee, Marcella D. Walker, Hsin Yi Chen, John A. Chabot, James A. Lee, Jennifer H. Kuo
Article
Cardiac & Cardiovascular Systems
Nicholas O. Palmeri, Karina W. Davidson, William Whang, Ian M. Kronish, Donald Edmondson, Marcella D. Walker
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2018)
Article
Endocrinology & Metabolism
Haley M. Zylberberg, Benjamin Lebwohl, Arindam RoyChoudhury, Marcella D. Walker, Peter H. R. Green