Journal
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
Volume 30, Issue 3, Pages 163-170Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/GCO.0000000000000455
Keywords
assisted reproductive technologies; embryo culture; IVF
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Purpose of review To discuss the common aspects of energy generation in the cell, substrate utilization by the oocyte and the preimplantation embryos, metabolic characteristics of the reproductive tract, and how metabolic characteristics of an embryo can be exploited to assess viability. Recent findings Utilization of pyruvate, lactate and glucose by the oocyte and the preimplantation embryo seems to be tightly controlled by the most essential molecular regulatory pathways. Summary Accumulating data on the metabolic needs of the preimplantation embryo and the substrate concentrations in the reproductive tract guide us in improving in-vitro culture conditions, and provide potential biomarkers of embryo viability.
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