Review
Oncology
Shaojie Yang, Liwei Pang, Wanlin Dai, Shuodong Wu, Tengqi Ren, Yunlong Duan, Yuting Zheng, Shiyuan Bi, Xiaolin Zhang, Jing Kong
Summary: Hepatocellular carcinoma (HCC) is associated with high morbidity and mortality, with surgical resection being the main treatment. Foxo proteins play crucial roles in HCC and are considered multifunctional targets for cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Qianqian Zhang, Ruby Feng, Omar Chaudhary, Eitezaz Mahmood, Yanick Baribeau, Rayan Rashid, Kamal R. Khabbaz, Louis M. Chu, David C. Liu, Venkatachalam Senthilnathan, Jessica Cassavaugh, Feroze Mahmood, Simon C. Robson, Robina Matyal
Summary: This study found that compared with nondiabetic patients, there was no significant upregulation of FOXO3 alpha in diabetic patients after cardiopulmonary bypass surgery, which may explain the lack of upregulation of the autophagy process. FOXO3 alpha could potentially serve as a therapeutic target to improve cellular homeostasis.
ANNALS OF THORACIC SURGERY
(2021)
Review
Oncology
Peyman Tabnak, Aysa Hasanzade Bashkandi, Mohammad Ebrahimnezhad, Mahdieh Soleimani
Summary: This review discusses the roles of transcription factors FOXOs and FOXM1 in gliomas, including their interactions with other proteins and microRNAs in regulatory networks, as well as their significance in glioma progression.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Kuan-Hung Lin, Jui-Chung Chiang, Wei-Min Chen, Ya-Hsuan Ho, Chao-Ling Yao, Hsinyu Lee
Summary: The balance between LPA receptor subtypes, regulated by GATA factors, plays a critical role in lineage commitment of myeloid progenitors. Manipulation of GATA factors affects the expression levels of LPA(2) and LPA3, indicating a novel mechanism regulating erythropoiesis and megakaryopoiesis. The physical interaction between GATA factors and the promoter region of LPAR genes further supports this regulatory role.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Orthopedics
Chen Zhao, Guantong Sun, Yaxin Li, Keyu Kong, Xiaodong Li, Tianyou Kan, Fei Yang, Lei Wang, Xiaoqing Wang
Summary: This study reveals the role of FOXO3 in regulating ferroptosis of chondrocytes and suggests that inhibiting ferroptosis through activation of FOXO3 may be a new target for the treatment of osteoarthritis.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Review
Hematology
Sarah El Iskandarani, Gary Deng
Summary: Acupuncture is an integrative medicine modality that has been widely used for managing various symptoms and diseases. There is evidence supporting the effectiveness of acupuncture in reducing common symptoms experienced by patients with hematological malignancies.
Article
Peripheral Vascular Disease
Kazuma Nakagawa, Randi Chen, Steven M. Greenberg, G. Webster Ross, Bradley J. Willcox, Timothy A. Donlon, Richard C. Allsopp, D. Craig Willcox, Brian J. Morris, Kamal H. Masaki
Summary: This study aimed to determine the association between the FOXO3 SNP rs2802292 genotype and risk of hypertension-mediated intracerebral haemorrhage (ICH). The results showed that the longevity-associated FOXO3 G allele may attenuate the impact of hypertension on ICH risk.
JOURNAL OF HYPERTENSION
(2022)
Review
Chemistry, Medicinal
Xiaojun Zhang, Lusheng Jiang, Huimin Liu
Summary: Forkhead box protein O1 (FoXO1) is a transcription factor involved in regulating various physiological processes, with dysfunction linked to the pathophysiology of multiple diseases. Different post-translational modifications can dynamically regulate FoXO1 activity and target gene transcription.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Hematology
Hye Sun Kuehn, Julie E. Niemela, Jennifer Stoddard, Sara Ciullini Mannurita, Tala Shahin, Shubham Goel, Mary Hintermeyer, Raul Jimenez Heredia, Mary Garofalo, Laura Lucas, Smriti Singh, Annalisa Tondo, Zachary Jacobs, William A. Gahl, Sylvain Latour, James Verbsky, John Routes, Charlotte Cunningham-Rundles, Kaan Boztug, Eleonora Gambineri, Thomas A. Fleisher, Shanmuganathan Chandrakasan, Sergio D. Rosenzweig
Summary: IKAROS is a transcription factor involved in lymphocyte development and function. Mutations affecting its C-terminal dimerization domain have been linked to hematologic disorders, disrupting dimerization and altering key gene regulation mechanisms. These mutations contribute to a growing spectrum of IKAROS-associated diseases with a genotype-phenotype correlation.
Review
Medicine, General & Internal
Mariana Nassif Kerbauy, Leonardo Javier Arcuri, Sergio Leonardo Favareto, Ana Carolina Pires de Rezende, Nelson Hamerschlak
Summary: Total body irradiation (TBI) is an important part of the conditioning regimen in hematopoietic cell transplantation. However, higher doses of TBI can result in more significant toxicities. To overcome this, total marrow irradiation and total marrow and lymphoid irradiation have been developed to deliver targeted radiotherapy while sparing organs. Studies have shown that these techniques can be safely administered with different chemotherapy conditioning regimens, especially in situations such as multiple myeloma, high-risk hematologic malignancies, relapsed or refractory leukemias, and elderly or frail patients, with low transplant-related mortality rates.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Amirhosein Maharati, Meysam Moghbeli
Summary: Cisplatin (CDDP) is a commonly used chemotherapy drug, but there is a high rate of CDDP resistance among cancer patients. Identifying the molecular mechanisms involved in CDDP resistance, particularly the role of FOX protein family, can help predict CDDP response and introduce prognostic markers. FOX proteins mainly promote CDDP resistance through regulation of DNA repair, autophagy, epithelial-mesenchymal transition (EMT), and signaling pathways. Inhibition of FOX proteins can be considered as a therapeutic strategy in cancer patients undergoing CDDP treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Fisheries
Yuqi Zhao, Ximei Nie, Zhengxiao Han, Peng Liu, Hao Xu, Xin Huang, Qian Ren
Summary: In this study, a FOXO gene (EsFOXO) from E. sinensis was cloned and its involvement in the immune and metabolic regulation of crabs with hepatopancreatic necrosis disease (HPND) was investigated. The expression of EsFOXO was significantly upregulated in the intestine of crabs with HPND compared to normal crabs. RNA interference analysis showed that EsFOXO positively regulates the expression of pancreatic lipases, anti-lipopolysaccharide factors, and crustins. Our study suggests that crabs with HPND adopt strategies of increased antimicrobial peptide synthesis and upregulated expression of enzymes involved in lipid catabolism to survive under starvation.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Oncology
Aneta Sevcikova, Ivana Fridrichova, Nataliia Nikolaieva, Lenka Kalinkova, Radoslav Omelka, Monika Martiniakova, Sona Ciernikova
Summary: Hematologic malignancies can arise at any stage of hematopoiesis and miRNAs play a key role in their development by regulating gene expression. This review summarizes the current knowledge of dysregulated miRNA expression in hematological malignancies and discusses their clinical utility as biomarkers for diagnosis, prognosis, and treatment response. The potential role of miRNAs in hematopoietic stem cell transplantation and post-transplant complications is also explored. The therapeutical potential of miRNA-based approaches, including antagomiRs, mimetics, and circRNAs, is outlined. Overall, miRNAs have the potential to improve the diagnosis and outcomes of hematologic malignancies.
Article
Oncology
Rebecca A. Harrison, Noha Sharafeldin, Jennie L. Rexer, Brennan Streck, Melissa Petersen, Ashley M. Henneghan, Shelli R. Kesler
Summary: Hematopoietic stem cell transplant (HSCT) is crucial in treating hematologic cancers, but can lead to cognitive impairment and other challenges for survivors. Understanding the impact on brain health is essential for clinicians working with HSCT survivors, as it can affect various aspects of their lives. Efforts to identify and manage cognitive dysfunction and related symptoms are important for managing the long-term effects of HSCT.
Article
Environmental Sciences
Tae Hong Kang, Kyung Soo Kang, Sang In Lee
Summary: Research has found that DON can induce apoptosis in intestinal epithelial cells through the FOXO3a-signaling pathway, leading to the translocation of FOXO3a into the nucleus. Inhibiting FOXO3a can alleviate apoptosis and the expression of apoptosis-related genes. Additionally, treatment with an ERK1/2 inhibitor can suppress the translocation of FOXO3a into the nucleus.
Review
Genetics & Heredity
Vijay Menon, Lawrence F. Povirk
Article
Hematology
Elisabetta Beneduce, Alessandro Matte, Luigia De Falco, Serge Mbiandjeu, Deborah Chiabrando, Emanuela Tolosano, Enrica Federti, Sara Petrillo, Narla Mohandas, Angela Siciliano, Wilson Babu, Vijay Menon, Saghi Ghaffari, Achille Iolascon, Lucia De Franceschi
AMERICAN JOURNAL OF HEMATOLOGY
(2019)
Article
Pharmacology & Pharmacy
Vijay R. Menon, Erica J. Peterson, Kristoffer Valerie, Nicholas P. Farrell, Lawrence F. Povirk
BIOCHEMICAL PHARMACOLOGY
(2013)
Article
Genetics & Heredity
Susovan Mohapatra, Steven M. Yannone, Suk-Hee Lee, Robert A. Hromas, Konstantin Akopiants, Vijay Menon, Dale A. Ramsden, Lawrence F. Povirk
Article
Medicine, Research & Experimental
Erica J. Peterson, Vijay R. Menon, Laura Gatti, Ralph Kipping, Dilhara Dewasinghe, Paola Perego, Lawrence F. Povirk, Nicholas P. Farrell
MOLECULAR PHARMACEUTICS
(2015)
Article
Biochemistry & Molecular Biology
Konstantin Akopiants, Susovan Mohapatra, Vijay Menon, Tong Zhou, Kristoffer Valerie, Lawrence F. Povirk
NUCLEIC ACIDS RESEARCH
(2014)
Article
Cell Biology
Vijay R. Menon, Varsha Ananthapadmanabhan, Selene Swanson, Siddharth Saini, Fatmata Sesay, Vasily Yakovlev, Laurence Florens, James A. DeCaprio, Michael P. Washburn, Mikhail Dozmorov, Larisa Litovchick
Article
Cell & Tissue Engineering
Raymond Liang, Tasleem Arif, Svetlana Kalmykova, Artem Kasianov, Miao Lin, Vijay Menon, Jiajing Qiu, Jeffrey M. Bernitz, Kateri Moore, Fangming Lin, Deanna L. Benson, Nikolaos Tzavaras, Milind Mahajan, Dmitri Papatsenko, Saghi Ghaffari
Review
Hematology
Vijay Menon, Saghi Ghaffari
Summary: Erythropoiesis is a complex process involving the daily production of billions of red blood cells, with enucleation being a crucial and intricate step. Factors influencing terminal erythroid maturation and enucleation have been studied extensively in the past two decades.
EXPERIMENTAL HEMATOLOGY
(2021)
Review
Genetics & Heredity
Vijay Menon, Lawrence F. Povirk