Journal
CURRENT OPINION IN ANESTHESIOLOGY
Volume 31, Issue 5, Pages 593-600Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ACO.0000000000000636
Keywords
cancer recurrence; regional anesthesia; survival
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Purpose of reviewTo summarize the current evidence on the impact of regional anesthesia or analgesia on cancer recurrence.Recent findingsPreclinical investigations suggest that regional anesthesia could have a positive impact on reducing cancer growth and progression. Regional anesthesia is also associated with better immunological and stress-related outcomes in patients undergoing major oncological surgery. Most recent retrospective studies do not show any benefit of regional anesthesia or analgesia on cancer recurrence or recurrence-free survival.SummaryThe available clinical evidence does not support the use of any anesthesia technique to improve the cancer-related survival after major oncological surgery. The results from four randomized controlled trials will shed light on this critical topic in perioperative medicine.
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