Journal
CURRENT MEDICINAL CHEMISTRY
Volume 25, Issue 20, Pages 2292-2303Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867324666170502124227
Keywords
Hemocyanin; mollusc; mechanism of action; antiviral activity; immunotherapy; cancer vaccines
Funding
- Australian Research Council (ARC)
- Marine Biotechnology Australia Pty. Ltd.
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Hemocyanins are large and versatile glycoproteins performing various immunological and biological functions in many marine invertebrates including arthropods and molluscs. This review discusses the various pharmacological applications of mollusc hemocyanin such as antiviral activity, immunostimulatory and anticancer properties that have been reported in the literature between the years 2000 and 2016. Emphasis is placed on a better mechanistic understanding of hemocyanin as a therapeutic agent. Elucidation of the mechanism of action is essential to improve the clinical efficacy and for a better understanding of some endogenous immunological functions of this complex glycoprotein.
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