Article
Chemistry, Multidisciplinary
Ming Yuan, Jiangxiu Niu, Fei Li, Huiyuan Ya, Xianghui Liu, Keying Li, Yanli Fan, Qiuyan Zhang
Summary: This study proposes a hydrogel containing CUR-encapsulated nanostructured lipid carriers (CUR-DP-NLCs gel) to enhance topical drug delivery and improve the therapeutic effect. The gel showed increased skin retention of CUR and better anti-inflammatory and analgesic activities after topical administration.
Article
Chemistry, Medicinal
Breno N. Matos, Ana Luiza Lima, Camila O. Cardoso, Marcilio Cunha-Filho, Tais Gratieri, Guilherme M. Gelfuso
Summary: This study prepared polymeric and lipidic nanoparticles (PNPs and NLCs) co-entrapping minoxidil and betamethasone for follicular drug delivery. The nanoparticles showed suitable size and thermal stability, significantly increasing the penetration of minoxidil and betamethasone into the hair follicles and delivering higher concentrations of betamethasone. The nanoparticles are suitable for topical therapy and effectively target the hair follicles.
Article
Pharmacology & Pharmacy
Samet Ozdemir, Burcu Uner, Alptug Karakucuk, Burak Celik, Engin Sumer, Cetin Tas
Summary: This study focuses on the development of innovative topical nanoemulsions for etodolac and optimizes the formulation using a design of experiments approach. The optimized formulation exhibits good hydrophobicity, sustained release profile, and superior anti-inflammatory activity in vivo.
Article
Biochemistry & Molecular Biology
Parinbhai Shah, Benjamin Goodyear, Nirali Dholaria, Vinam Puri, Bozena Michniak-Kohn
Summary: Psoriasis is a chronic autoimmune skin disease that poses challenges in drug delivery due to low bioavailability. This study explores the use of niosomes to improve drug bioavailability of corticosteroids for topical treatment of skin conditions, showing promise for potential use in treating diseases like psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Norhidayu Zainuddin, Ishak Ahmad, Mohd Hanif Zulfakar, Hanieh Kargarzadeh, Suria Ramli
Summary: The study demonstrates that CTAB-NCC-based microemulsions can be used as a controlled-release topical system for delivering curcumin, leading to enhanced penetration rate and accumulation in the skin without cytotoxic effects on cells.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Ahlam Zaid Alkilani, Rania Hamed, Hajer Abdo, Lubna Swellmeen, Haneen A. Basheer, Walaa Wahdan, Amani D. Abu Kwiak
Summary: This study investigates the use of niosomes, a type of nanocarrier, to enhance the transdermal permeability of azithromycin, a BCS class III drug. The results show that niosomal gel can significantly improve the drug release rate compared to conventional gel formulations. These findings suggest that niosomal gel could be a promising alternative route of administration for azithromycin.
Article
Pharmacology & Pharmacy
Nazife Ozge Kocabas, Emine Kahraman, Sevgi Gungor
Summary: This study investigated the relationship between different types of synthetic membranes and drug characteristics in in vitro release and permeation studies. The results showed that mixed cellulose ester or cellulose acetate membranes are suitable for drugs containing abundant, strong acceptor/donor groups, while drug lipophilicity may play a prominent role in these studies. Strat-MTM membrane was found to be more useful for estimating permeability of lipophilic molecules rather than hydrophilic ones. The molecular structure and lipophilicity of the drug should be considered when selecting a synthetic membrane for in vitro release and permeation studies.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Ameeduzzafar Zafar, Syed Sarim Imam, Mohd Yasir, Nabil K. Alruwaili, Omar Awad Alsaidan, Musarrat Husain Warsi, Shehla Nasar Mir Najib Ullah, Sultan Alshehri, Mohammed M. Ghoneim
Summary: In this study, erythromycin-loaded nanostructured lipid carriers (NLCs) were prepared and transformed into an in-situ gel system for the treatment of bacterial conjunctivitis. The optimized formulation showed improved drug release, permeation, and antimicrobial activity compared to conventional erythromycin gel, while also demonstrating good biocompatibility in corneal studies.
Article
Biophysics
Marcel F. Kunrath, Gabriel Rubensam, Felipe V. F. Rodrigues, Daniel R. Marinowic, Patricia Sesterheim, Silvia D. de Oliveira, Eduardo R. Teixeira, Roberto Hubler
Summary: Multifunctional surfaces have great potential in accelerating and promoting the healing process around dental implants, but their cellular biocompatibility, molecular activity, and release of functionalized molecules need further investigation for clinical use.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Yasir Siddique, Muhammad Faizan Nazar, Marryam Mahmood, Muhammad Atif Saleem, Norah Alwadai, Amani Saleh Almuslem, Fwzah H. Alshammari, Sajjad Haider, Muhammad Saeed Akhtar, Syed Zajif Hussain, Muhammad Safdar, Muhammad Akhlaq
Summary: Microemulsified gels (mu EGs) have unique functions and are essential for topical drug delivery systems due to their high stability and flexibility in manufacturing. New formulations using biocompatible ingredients have been developed to encapsulate and control the release of an antimycotic drug, resulting in improved transdermal therapeutic efficacy.
Article
Chemistry, Physical
Soledad Stagnoli, Cintia Garro, Ozlem Ertekin, Susanne Heid, Stefan Seyferth, Gaston Soria, N. Mariano Correa, Aldo Leal-Egana, Aldo R. Boccaccini
Summary: This study developed a system for delivering water-insoluble drugs, which can efficiently load drugs and increase the likelihood of drug uptake by cancer cells instead of healthy cells. The system also demonstrates high efficiency and stability during topical application, and it is less invasive compared to alternative methods.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Medicine, General & Internal
Tory R. Spindle, Dennis J. Sholler, Edward J. Cone, Timothy P. Murphy, Mahmoud ElSohly, Ruth E. Winecker, Ronald R. Flegel, Marcel O. Bonn-Miller, Ryan Vandrey
Summary: This study evaluated the accuracy of CBD and THC labeling in topical cannabinoid products and found that they are often inaccurately labeled and many contain THC. These findings suggest the need for clinical studies to determine whether topical cannabinoid products with THC can produce psychoactive effects or positive drug tests for cannabis.
Article
Pharmacology & Pharmacy
Takato Masada, Toshihide Takagi, Keiko Minami, Makoto Kataoka, Shoko Takeyama, Yoshimine Fujii, Masayuki Takahashi, Shinji Yamashita
Summary: This study developed a new in vitro system called BiDP system to evaluate the oral absorbability of solid drugs, utilizing side-by-side chambers with octanol as the receiver fluid and a hydrophilic filter to separate the donor and receiver fluids. The predictability of the system was shown to be equal to or better than existing in vitro systems, making it a promising tool for high throughput screening of oral absorbability of drugs or drug candidates at an early stage of development.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Greta Frei, Adam Haimhoffer, Eniko Csapo, Krisztina Bodnar, Gabor Vasvari, Daniel Nemes, Istvan Lekli, Alexandra Gyongyosi, Ildiko Bacskay, Palma Feher, Liza Jozsa
Summary: The aim of this study was to formulate topical dosage forms containing curcumin for the treatment of certain inflammatory diseases. Self emulsifying drug delivery systems were used to increase the solubility and bioavailability of curcumin. Creams and gels were formulated using penetration-enhancing surfactants and gelling agents. The results showed that the curcumin-containing preparations were safe for skin application and had antioxidant effects. Animal experiments confirmed the effectiveness of the curcumin-containing topical preparations.
Article
Pharmacology & Pharmacy
Khaled H. Elfakhri, Mengmeng Niu, Priyanka Ghosh, Tannaz Ramezanli, Sam G. Raney, Snober Ahmed, Daniel R. Willett, Huzeyfe Yilmaz, Muhammad Ashraf, Ahmed S. Zidan
Summary: This study investigated the spatial distribution of drugs within microparticle matrices and its impact on the critical performance attributes of topical gels. The results showed that factors such as particle size, drug loading efficiency, and solid-state interaction affect the release of drugs. Further characterization of the drug products is necessary to understand their impact on the bioavailability and efficacy of tretinoin gels.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Dermatology
Silas Arandas e Silva, Joel Goncalves de Souza, Priscilla Siqueira Melo, Ivani Aparecida Marchetto Moreno, Severino Matias Alencar, Renata Fonseca Vianna Lopez, Gislaine Ricci Leonardi
Summary: The use of antioxidants in topical applications shows promise, but further studies are needed to ensure effectiveness in combating free radicals in the skin. This study found that gallic acid had the strongest antioxidant activity and retention in deeper skin layers was promoted by iontophoresis, demonstrating the importance of polymeric gelling agents for optimizing antioxidant activity.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Beatriz Ewert de Oliveira, Otavio Henrique Junqueira Amorim, Loneta Lauro Lima, Rodrigo Alvarenga Rezende, Natalia Cammarosano Mestnik, Edileia Bagatin, Gislaine Ricci Leonardi
Summary: 5-Fluorouracil (5-FU) is a chemotherapy drug used for over 70 years, with potential in treating precancerous and cancerous lesions when used topically. Microemulsions and nanocarriers significantly impact the bioavailability of 5-FU, increasing drug effects on deeper skin layers and showing promising results in lesion treatment. Delivery systems like occlusive dressing, chemowrap, and transdermal 5-FU, along with their combination, are more effective than cream formulations in treating widespread precancerous lesions in the skin.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Dermatology
Roberta B. Rigon, Andrea C. P. de Freitas, Juliano L. Bicas, Karina Cogo-Muller, Alberto K. Kurebayashi, Renata F. Magalhaes, Gislaine R. Leonardi
Summary: Psoriasis is a chronic disease that significantly impacts quality of life, with skin microbiota potentially playing a crucial role in its immune and inflammatory response. The use of probiotic therapy may contribute to skin homeostasis, but more clinical studies are needed to fully explore its benefits.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Dermatology
Silas Arandas Monteiro e Silva, Gislaine Ricci Leonardi
Summary: Combining iontophoresis technique with microencapsulated retinoic acid can enhance the penetration of the active ingredient to deeper layers of the skin, leading to improved therapeutic effectiveness.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Dermatology
Juliana Rodrigues Pinto, Silas Arandas Monteiro E Silva, Valeria de Souza Santos Holsback, Gislaine Ricci Leonardi
Summary: This study evaluated the occlusive performance of different vegetable oils used as emollients in skincare cosmetics. Compared to petrolatum, the vegetable oils did not provide a high immediate skin occlusion effect but showed a comparable occlusion performance throughout the 6-hour time period.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Dermatology
Mariane Massufero Vergilio, Guilherme Gomes, Laura Moretti Aiello, Monique Fontana, Alexandre Aldred, Joao Alberto de Souza Ribeiro, Tatiana Villas Boas Gabbi, Gislaine Ricci Leonardi
Summary: Thermography in the medical field has seen a resurgence due to advancements in infrared thermographic imaging technology. In dermatology and aesthetic applications, this noninvasive tool can be used for diagnosis, clinical management of skin conditions, and monitoring of aesthetic procedures.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Medicine, General & Internal
Barbarah Helena Nabarretti, Roberta Balansin Rigon, Jonny Burga-Sanchez, Gislaine Ricci Leonardi
Summary: Alternative methods to animal testing have become a global trend, especially after the introduction of the 3R's principle. In the cosmetic industry, using animals for safety and efficacy assessments has sparked controversy, leading to the widespread use of in vitro research techniques. However, the evaluation of cosmetic ingredients and products remains an expanding field that requires global collaboration.
EINSTEIN-SAO PAULO
(2022)
Article
Dermatology
Mariane Massufero Vergilio, Laura Moretti Aiello, Andreza Sonego Furlan, Amanda Costa Carita, Jaqueline Rezende Azevedo, Marie-Alexandrine Bolzinger, Yves Chevalier, Gislaine Ricci Leonardi
Summary: The performance of a topical emulsion containing ascorbic acid was evaluated using high-frequency ultrasound (HFUS) skin image analysis method. The results showed a significant increase in dermal echogenicity and collagen synthesis after topical application of ascorbic acid. The study demonstrated that topical use of ascorbic acid promoted dermal redensification.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Editorial Material
Dermatology
Valeria S. S. Holsback, Loneta L. Lima, Marcos A. d'Avila, Gislaine R. Leonardi
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Louise Idalgo Vasques, Cristina Wohlke Vendruscolo, Gislaine Ricci Leonardi
Summary: The topical application of vitamin C and its derivatives in skincare is essential, but there is still a lack of scientific data regarding their efficacy, especially in vivo. Studies on the stability, safety, adverse reactions, and efficacy with standardized parameters and a relevant number of subjects are necessary for better understanding their effects.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Dermatology
Andrea Carolina Pinheiro de Freitas, Roberta Balansin Rigon, Edileia Bagatin, Gislaine Ricci Leonardi
Summary: Melasma is a facial hyperpigmentation mainly affecting women, causing negative impact on self-esteem. It is difficult to treat and various drugs can be used in mono or combination therapy. Topical therapies including sunscreens, pharmacological agents, and plant extracts are commonly used, but adverse reactions should be considered.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Lilia R. S. Guadanhim, Helio A. Miot, Juliana L. M. Soares, Silas A. M. Silva, Gislaine R. Leonardi, Renato D. Lopes, Edileia Bagatin
Summary: This study investigated the effects of oral and/or topical hydrolyzed collagen on the forearm skin of postmenopausal women with stage I dermatoporosis. The results showed that after 6 months of intervention, there were no significant benefits observed in any of the efficacy parameters, indicating that collagen peptides should not be routinely used in this population.
DERMATOLOGY AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Louise Idalgo Vasques, Gislaine Ricci Leonardi
Summary: One of the most important characteristics of aging skin is dehydration, which is why moisturizing products are crucial. Companies are interested in the user experience to develop specific cosmetics based on physiological needs and preferences. A moisturizer was developed containing an antioxidant active, ascorbyl tetraisopalmitate, and was well accepted by 33 Brazilian women aged 30-60. Perception of sensory characteristics was more influenced by the nature and proportion of compounds than the age of the subjects.
Article
Chemistry, Applied
Juliana Rodrigues Pinto, Silas Arandas Monteiro e Silva, Gislaine Ricci Leonardi
Summary: This study demonstrates that the increase in 1,3-propanediol concentration, as well as its combination with glycerol, provides a greater benefit to the skin, improving both hydration and the skin barrier function.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Lucas Portilho, Laura Moretti Aiello, Louise Idalgo Vasques, Edileia Bagatin, Gislaine Ricci Leonardi
Summary: The effectiveness of sun protection depends on the type of sunscreen used, its application method, and the amount applied. However, many studies have found that sunscreens are often applied incorrectly and in inadequate amounts. Factors such as sun exposure conditions, level of protection, product type, and application technique influence the effectiveness of sunscreens. There is a lack of research comparing the effectiveness of different sunscreen forms and the amount applied by consumers. This study aims to review the available literature on this topic and discuss the factors influencing sun protection.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
