Review
Biochemistry & Molecular Biology
Jie Wang, Feng Yun, Jiahui Sui, Wenpeng Liang, Dingding Shen, Qi Zhang
Summary: Epilepsy, a common and severe chronic neurological disorder, has been the subject of extensive research on post-translational modification (PTM) mechanisms, particularly protein acetylation modifications. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate acetylation, with HATs transferring acetyl groups to lysine residues and HDACs removing acetyl groups. Epilepsy is associated with the regulation of gene expression through histone acetylation and deacetylation, as well as the acetylation modification of non-histone substrates. HDAC inhibitors (HDACi) have been developed as potential antiepileptic drugs. This review summarizes the changes in acetylation modification during epileptogenesis, the application of HDACi in epilepsy treatment, and the underlying mechanisms. Further understanding of acetylation regulation will provide insights into the pathological mechanism of epilepsy and novel therapeutic ideas.
Review
Cardiac & Cardiovascular Systems
Qiu Jun, Li Youhong, Zhong Yuan, Yang Xi, Bingyu Wang, Sun Xinyi, Yin Fu, Cen Kedan, Jiangfang Lian, Zhou Jianqing
Summary: This review discusses the role and driving mechanisms of histone modifications in EndMT and proposes the possibility of guiding cardiovascular disease therapy by targeting histone-modifying enzymes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yi Luan, Hui Liu, Ying Luan, Yang Yang, Jing Yang, Kai-Di Ren
Summary: Atherosclerosis (AS) is a disease characterized by progressive hardening and reduced elasticity of arteries, leading to increased morbidity and mortality. Recent studies have shown that epigenetic modifications on genes, especially histone deacetylases (HDACs), play a significant role in the development of AS and other diseases. HDACs promote chromatin compaction and inhibit the transcription of downstream genes, affecting various physiological and pathological processes. This review discusses the role of HDACs in vascular systems, their diverse roles in AS, and the potential of HDAC inhibitors as drugs for AS treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jacob King, Maya Patel, Sriram Chandrasekaran
Summary: Histone deacetylases (HDACs) are epigenetic enzymes that regulate gene expression and are influenced by cellular metabolism. The crosstalk between metabolism and histone acetylation impacts various biological processes. The use of systems biology methods can help uncover the interactions between metabolism, HDACs, and HDAC inhibitors, leading to the identification of potential biomarkers and therapeutic targets.
Review
Cell Biology
Saikat Dewanjee, Jayalakshmi Vallamkondu, Rajkumar Singh Kalra, Pratik Chakraborty, Moumita Gangopadhyay, Ranabir Sahu, Vijaykrishna Medala, Albin John, P. Hemachandra Reddy, Vincenzo De Feo, Ramesh Kandimalla
Summary: Diabetes mellitus is a major manifestation of metabolic syndrome with increasing prevalence. Chronic hyperglycemia can lead to various vascular complications, being the major cause of morbidity and mortality in diabetic patients. Histone deacetylase (HDAC) plays a crucial role in regulating molecular activities in diabetes and could serve as a potential therapeutic target for developing novel intervention strategies.
Review
Genetics & Heredity
Shuang Li, Xu He, Yuan Gao, Chenguang Zhou, Vincent L. Chiang, Wei Li
Summary: The article summarizes the changes in histone acetylation in plant response to drought stress, and reviews the functions of histone acetyltransferases and histone deacetylases in drought response and resistance.
Article
Cell Biology
Irati Hervas-Corpion, Jorge Navarro-Calvo, Paula Martin-Climent, Marianela Iriarte-Gahete, Noelia Geribaldi-Doldan, Carmen Castro, Luis M. Valor
Summary: By exploring the TCGA database, we identified alterations in histone/DNA modifications and chromatin remodeling factors at transcriptional and genetic levels in glioblastoma (GB) compared to lower-grade gliomas. We also found a significant reduction in the levels of acetylated lysines 9 and 14 of histone H3 in high-grade compared to low-grade tumors. The transcriptional changes associated with histone deacetylase (HDAC) inhibition in GB-derived cultures were consistent with our RNA-seq analysis, suggesting the potential use of HDAC inhibitors in therapy.
Review
Pharmacology & Pharmacy
Chaithanya Ganji, Batoul Farran
Summary: This review focuses on dysregulated genes associated with epigenetic mechanisms in pancreatic cancer progression and resistance, as well as current clinical trials for epigenetic drugs. Combining epigenetic drugs with targeted therapies might represent a promising approach for treating pancreatic cancer.
DRUG DISCOVERY TODAY
(2022)
Review
Oncology
Chongyang Chen, Jingfang Liu
Summary: Thyroid cancer, particularly papillary thyroid cancer (PTC), is a common malignancy of the endocrine system. The incidence of PTC is increasing annually. Histone acetylation modification, an important epigenetic mechanism, plays a role in PTC cell proliferation, differentiation, and the treatment and prognosis of PTC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Miao Yan, Heng Cao, Kangjia Tao, Bing Xiao, Yifan Chu, Ding Ma, Xiaoyuan Huang, Yingyan Han, Teng Ji
Summary: This study explored the role of histone deacetylases (HDACs) in the tumor immune microenvironment of gynecologic tumors. Elevated HDAC expression was associated with poor prognosis and highly malignant cancer subtypes. Increased HDAC expression was linked to reduced infiltration of immune cells and negative associations with certain gene expression, while treatment with HDAC inhibitor and PD-1 antibody inhibited tumor growth and promoted immune microenvironment activation in a breast cancer model.
Article
Neurosciences
Heena Khan, Palak Tiwari, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Sirtuins, as a class III of histone deacetylases dependent on nicotinamide adenine dinucleotide, play a significant role in influencing the progression of neurodegenerative disorders by switching between deacetylation and acetylation processes. Pharmacological modulation of sirtuin activity has shown promising effects on various neurodegenerative disorders, and sirtuins may serve as a potential therapeutic target for the treatment of these diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Microbiology
Yiman Li, Zhihui Song, Ente Wang, Liming Dong, Jie Bai, Dong Wang, Jinyan Zhu, Chao Zhang
Summary: Invasive aspergillosis is a significant cause of death in patients with hematological malignancies and transplant recipients. Antifungal drug resistance has become a concern in managing infections, and understanding histone posttranslational modifications may provide insights for developing new antifungal drugs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dora Romhanyi, Kornelia Szabo, Lajos Kemeny, Gergely Groma
Summary: Psoriasis is a chronic immune-mediated skin disease characterized by gene expression changes in symptom-free, uninvolved skin. Histones and histone acetylation-related processes regulate gene expression and immune responses, and their dysregulation likely contributes to the development of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Milad Shirvaliloo
Summary: The article summarizes the importance of histones and their role in gene expression regulation. It highlights the significance of recent research on histone modifications published in Epigenomics since 2020.
Article
Biochemistry & Molecular Biology
Xishi Zhou, Junna He, Christos N. Velanis, Yiwang Zhu, Yuhan He, Kai Tang, Mingku Zhu, Lisa Graser, Erica de Leau, Xingang Wang, Lingrui Zhang, W. Andy Tao, Justin Goodrich, Jian-Kang Zhu, Cui-Jun Zhang
Summary: Research has shown that Harbinger transposon-derived SANT domain-containing proteins play a crucial role in histone deacetylation and flowering time control in plants.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2021)