Journal
CURRENT DIABETES REPORTS
Volume 18, Issue 8, Pages -Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11892-018-1028-y
Keywords
Macroencapsulation; Beta-cell replacement; Islet encapsulation; Oxygenation; Insulin kinetics; Type 1 diabetes
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Funding
- NIDDK NIH HHS [P30 DK036836] Funding Source: Medline
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Purpose of Review There is considerable interest in using macroencapsulation devices as a delivery strategy for transplanting insulin-producing cells. This review aims to summarize recent advances, to highlight remaining challenges, and to provide recommendations for the field. Recent Findings A variety of new device designs have been reported to improve biocompatibility and to provide protection for islet/beta cells from immune destruction while allowing continuous secretion of insulin. Some of these new approaches are in clinical trials, but more research is needed to determine how sufficient beta-cell mass can be transplanted in a clinically applicable device size, and that insulin is secreted with kinetics that will safely provide adequate controls of glucose levels. Summary Macroencapsulation is a potential solution to transplant beta cells without immunosuppression in diabetes patients, but new strategies must be developed to show that this approach is feasible.
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