Journal
CURRENT BIOLOGY
Volume 28, Issue 10, Pages 1661-+Publisher
CELL PRESS
DOI: 10.1016/j.cub.2018.04.019
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Funding
- JSPS KAKENHI [26930008, 24770173/16H01226/16H06161]
- MINECO [BFU2017-89408-R]
- CyLe
- RIKEN intramural grants
- Grants-in-Aid for Scientific Research [16H01226, 26930008, 16H06161] Funding Source: KAKEN
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The production of haploid gametes requires the maintenance of centromeric cohesion between sister chromatids through the transition between two successive meiotic divisions, meiosis I and meiosis II. One mechanism for the cohesion maintenance is shugoshin-dependent protection of centromeric cohesin at anaphase I onset [1-3]. However, how centromeric cohesion is maintained during late anaphase I and telophase I, when centromeric shugoshin is undetectable [1-3], remains largely unexplored. Here we show that the centromeric small ubiquitin-related modifier (SUMO) pathway is critical for the maintenance of centromeric cohesion during post-anaphase-I periods in mouse oocytes. SUMO2/3 and E3 ligase PIAS are enriched near centromeres during late anaphase I and telophase I. Specific perturbation of the centromeric SUMO pathway results in precocious loss of centromeric cohesin at telophase I, although shugoshin-dependent centromeric protection at anaphase I onset remains largely intact. Prevention of the SUMO perturbation during post-anaphase-I periods restores the maintenance of centromeric cohesion through the meiosis I-II transition. Thus, the postanaphase-I centromeric SUMO pathway ensures continuous maintenance of centromeric cohesion through the meiosis I-II transition.
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