Modified Allergens for Immunotherapy

Human CD40 ligand–expressing type 3 innate lymphoid cells induce IL-10–producing immature transitional regulatory B cells

(2018) Zsolt I. Komlósi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Recombinant allergy vaccines based on allergen-derived B cell epitopes

(2017) Rudolf Valenta et al.   IMMUNOLOGY LETTERS

Recombinant Allergens in Structural Biology, Diagnosis, and Immunotherapy

(2017) Angelika Tscheppe et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Comparison of the immunogenicity of BM32, a recombinant hypoallergenic B cell epitope–based grass pollen allergy vaccine with allergen extract–based vaccines

(2017) Milena Weber et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Omalizumab facilitates rapid oral desensitization for peanut allergy

(2017) Andrew J. MacGinnitie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Treatment with grass allergen peptides improves symptoms of grass pollen–induced allergic rhinoconjunctivitis

(2017) Anne K. Ellis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunostimulatory Properties of Lipid Modified CpG Oligonucleotides

(2017) Chunsong Yu et al.   MOLECULAR PHARMACEUTICS

Recombinant allergen and peptide-based approaches for allergy prevention by oral tolerance

(2017) Raffaela Campana et al.   SEMINARS IN IMMUNOLOGY

Epicutaneous allergen application preferentially boosts specific T cell responses in sensitized patients

(2017) Raffaela Campana et al.   Scientific Reports

For t 2 DNA vaccine preventsForcipomyia taiwana(biting midge) allergy in a mouse model

(2016) M.-F. Lee et al.   ALLERGY

A 12-week DBPC dose-finding study with sublingual monomeric allergoid tablets in house dust mite-allergic patients

(2016) C. Hüser et al.   ALLERGY

Three-injection intralymphatic immunotherapy in adolescents and young adults with grass pollen rhinoconjunctivitis

(2016) Amber M. Patterson et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Potential Mechanisms for IgG4 Inhibition of Immediate Hypersensitivity Reactions

(2016) Louisa K. James et al.   CURRENT ALLERGY AND ASTHMA REPORTS

T Cell Epitope Peptide Therapy for Allergic Diseases

(2016) Robyn E. O’Hehir et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Epidemiology of asthma

(2016) Patricia A. Loftus et al.   Current Opinion in Otolaryngology & Head and Neck Surgery

Allergy immunotherapy: the future of allergy treatment

(2016) Jørgen Nedergaard Larsen et al.   DRUG DISCOVERY TODAY

Specific immunotherapy for rhinitis and asthma with a subcutaneous hypoallergenic high-dose house dust mite extract: results of a 9-month therapy

(2016) David El-Qutob et al.   Immunotherapy

A review of allergoid immunotherapy: is cat allergy a suitable target?

(2016) Nhung T Nguyen et al.   Immunotherapy

Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1

(2016) Sofía Sirvent et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy of 2 months of allergen-specific immunotherapy with Bet v 1–derived contiguous overlapping peptides in patients with allergic rhinoconjunctivitis: Results of a phase IIb study

(2016) François Spertini et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intralymphatic immunotherapy induces allergen specific plasmablasts and increases tolerance to skin prick testing in a pilot study

(2016) Johannes Martin Schmid et al.   Clinical and Translational Allergy

Immunotherapy With the PreS-based Grass Pollen Allergy Vaccine BM32 Induces Antibody Responses Protecting Against Hepatitis B Infection

(2016) Carolin Cornelius et al.   EBioMedicine

Mechanisms, safety and efficacy of a B cell epitope-based vaccine for immunotherapy of grass pollen allergy

(2016) Petra Zieglmayer et al.   EBioMedicine

Development and evaluation of a sublingual tablet based on recombinant Bet v 1 in birch pollen-allergic patients

(2015) E. Nony et al.   ALLERGY

Biodegradable pH-Sensitive Poly(ethylene glycol) Nanocarriers for Allergen Encapsulation and Controlled Release

(2015) Hannah Pohlit et al.   BIOMACROMOLECULES

Polymerization of Ethylene Oxide, Propylene Oxide, and Other Alkylene Oxides: Synthesis, Novel Polymer Architectures, and Bioconjugation

(2015) Jana Herzberger et al.   CHEMICAL REVIEWS

What makes an allergen?

(2015) S. Scheurer et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Immunoregulatory T cell epitope peptides: the new frontier in allergy therapy

(2015) S. R. Prickett et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Fel d 1-derived synthetic peptide immuno-regulatory epitopes show a long-term treatment effect in cat allergic subjects

(2015) P. Couroux et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Recombinant Fusion Allergens, Cry j 1 and Cry j 2 from Japanese Cedar Pollen, Conjugated with Polyethylene Glycol Potentiate the Attenuation of Cry j 1-Specific IgE Production in Cry j 1-Sensitized Mice and Japanese Cedar Pollen Allergen-Sensitized Monkeys

(2015) Takashi Fujimura et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Development of a Hypoallergenic Recombinant Parvalbumin for First-in-Man Subcutaneous Immunotherapy of Fish Allergy

(2015) Laurian Zuidmeer-Jongejan et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

A Randomized Dbpc Dose-Finding Trial of Slit Allergoids Tablets in House Dust Mites (HDM) Allergic Patients

(2015) Silke Allekotte et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The allergy epidemics: 1870-2010

(2015) Thomas A.E. Platts-Mills   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An accelerated dose escalation with a grass pollen allergoid is safe and well-tolerated: a randomized open label phase II trial

(2015) A. M. Chaker et al.   Clinical and Translational Allergy

Allergy immunotherapy with a hypoallergenic recombinant birch pollen allergen rBet v 1-FV in a randomized controlled trial

(2015) Ludger Klimek et al.   Clinical and Translational Allergy

Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens

(2015) Cezmi A Akdis et al.   World Allergy Organization Journal

Immune regulation by intralymphatic immunotherapy with modular allergen translocation MAT vaccine

(2014) A. Zaleska et al.   ALLERGY

Hypoallergenic derivatives of Fel d 1 obtained by rational reassembly for allergy vaccination and tolerance induction

(2014) M. Curin et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Safety and immunogenicity of immunotherapy with Bet v 1–derived contiguous overlapping peptides

(2014) François Spertini et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Persistent Treatment Effect Achieved At One Year After Four Doses Of Der p Derived Synthetic Peptide Immuno-Regulatory Epitopes In An Exposure Chamber Model Of House Dust Mite Allergy

(2014) Rod Hafner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of allergen-specific immunotherapy: Multiple suppressor factors at work in immune tolerance to allergens

(2014) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergic diseases and asthma: a global public health concern and a call to action

(2014) Ruby Pawankar   World Allergy Organization Journal

Safety and Tolerability of Escalating Doses of House Dust Mite- Peptide Antigen Desensitization (HDM-PAD)

(2013) Mark Larche et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses

(2013) Willem van de Veen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Recombinant allergen-based provocation testing

(2013) Verena Niederberger et al.   METHODS

Pollinex Quattro: An innovative four injections immunotherapy In allergic rhinitis

(2013) Martin Rosewich et al.   Human Vaccines & Immunotherapeutics

Novel birch pollen specific immunotherapy formulation based on contiguous overlapping peptides

(2013) Céline Pellaton et al.   Clinical and Translational Allergy

Immune Regulatory Function of B Cells

(2012) Claudia Mauri et al.   Annual Review of Immunology

Specific subcutaneous immunotherapy with recombinant grass pollen allergens: first randomized dose-ranging safety study

(2012) L. Klimek et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Hypoallergenic Der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergy

(2012) Kuan-Wei Chen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections

(2012) Gabriela Senti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2

(2012) Natalija Novak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of allergen-specific immunotherapy

(2012) Hiroyuki Fujita et al.   Clinical and Translational Allergy

Peptide and Recombinant Immunotherapy

(2011) Mark Larché   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

A hypoallergenic cat vaccine based on Fel d 1–derived peptides fused to hepatitis B PreS

(2011) Katarzyna Niespodziana et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy

(2011) Margitta Worm et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epicutaneous allergen-specific immunotherapy ameliorates grass pollen–induced rhinoconjunctivitis: A double-blind, placebo-controlled dose escalation study

(2011) Gabriela Senti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genetic engineering of trimers of hypoallergenic fragments of the major birch pollen allergen, Bet v 1, for allergy vaccination

(2011) Susanne Vrtala et al.   VACCINE

From Allergen Genes to Allergy Vaccines

(2010) Rudolf Valenta et al.   Annual Review of Immunology

Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly

(2010) Raffaela Campana et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effect of pretreatment with omalizumab on the tolerability of specific immunotherapy in allergic asthma

(2010) Marc Massanari et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Altered IgE epitope presentation: A model for hypoallergenic activity revealed for Bet v 1 trimer

(2010) Raffaela Campana et al.   MOLECULAR IMMUNOLOGY

Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trial

(2009) G. Senti et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Engineering of major house dust mite allergens Der p 1 and Der p 2 for allergen-specific immunotherapy

(2009) J. A. Asturias et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Contribution of histamine metabolism to tachyphylaxis during the buildup phase of rush immunotherapy

(2009) Laura Maintz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Peptide immunotherapy in allergic asthma generates IL-10–dependent immunological tolerance associated with linked epitope suppression

(2009) John D. Campbell et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors

(2008) F. Meiler et al.   ALLERGY

Allergen structures and biologic functions: The cutting edge of allergy research

(2008) Anna Pomés   CURRENT ALLERGY AND ASTHMA REPORTS

Alum adjuvanticity: Unraveling a century old mystery

(2008) Ennio De Gregorio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis

(2008) Gabrielle Pauli et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure

(2008) Flurina Meiler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reduction of the in vivo allergenicity of Der p 2, the major house-dust mite allergen, by genetic engineering

(2008) Kuan-Wei Chen et al.   MOLECULAR IMMUNOLOGY