Article
Medicine, General & Internal
Chao Ren, Yu-xuan Li, De-meng Xia, Peng-yue Zhao, Sheng-yu Zhu, Li-yu Zheng, Li-ping Liang, Ren-qi Yao, Xiao-hui Du
Summary: The presence of sepsis-associated coagulopathy (SAC) was significantly associated with increased risk of in-hospital death and septic shock among postoperative patients with sepsis admitted to the ICU, but there was no statistical difference of hospital length of stay (LOS) between the SAC and no SAC groups.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yolanda Prado, Pablo Tapia, Felipe Eltit, Cristian Reyes-Martinez, Carmen G. Feijoo, Felipe M. Llancalahuen, Claudia A. Riedel, Claudio Cabello-Verrugio, Jimmy Stehberg, Felipe Simon
Summary: Sepsis syndrome is a highly lethal uncontrolled response to infection, characterized by coagulopathy. Oxidized high-density lipoprotein (oxHDL) plays a role in promoting hemostatic dysfunction in septic-shock patients (SSP), leading to a prothrombotic phenotype. A study on 42 patients (26 SSP and 16 non-SSP) and 39 healthy volunteers found that increased plasma oxHDL level in SSP was associated with increased mortality and elevated risk of death, indicating its predictive value. The underlying mechanism involves endothelial protein expression regulation mediated by the LOX-1 receptor.
Article
Critical Care Medicine
Renli Wang, Rongjun Liu, Zhaojun Xu
Summary: Plasma transfusion increases in-hospital mortality in patients with sepsis-induced coagulopathy (SIC), and the mortality rate increases with the amount of plasma transfusion. Patients with SIC who received early plasma infusion had lower in-hospital mortality than those who received no early plasma transfusion.
Article
Multidisciplinary Sciences
Mohammad Esmaeil Barbati, Frank Hildebrand, Hagen Andruszkow, Rolf Lefering, Michael J. Jacobs, Houman Jalaie, Alexander Gombert
Summary: This study examines the etiology, frequency, and impact of abdominal vascular injuries in polytrauma patients, highlighting the potentially underestimated significance of venous injuries. Venous trauma was associated with higher in-hospital mortality compared to arterial injuries, emphasizing the importance of further investigation and assessment in patients with suspected abdominal vascular injuries.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Rozeta Sokou, Andreas G. Tsantes, Maria Lampridou, Konstantina A. Tsante, Dimitra Houhoula, Daniele Piovani, Stefanos Bonovas, Theodora Boutsikou, Zoi Iliodromiti, Nicoletta Iacovidou, Argirios E. Tsantes, Aikaterini Konstantinidi
Summary: This study aimed to evaluate the role of rotational thromboelastometry (ROTEM) assays in predicting in-hospital mortality in neonates with sepsis. The results showed that the INTEM MCF parameter can effectively predict the risk of in-hospital mortality in neonatal sepsis. Therefore, ROTEM can serve as a valuable monitoring tool to identify neonates at risk.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jia-Jia Huang, Zhi-Ye Zou, Zhi-Peng Zhou, Yan Liu, Zhen-Jia Yang, Jing-Jing Zhang, Ying-Yi Luan, Yong-Ming Yao, Ming Wu
Summary: This study aimed to investigate whether early unfractionated heparin (UFH) administration provides a survival advantage for patients with sepsis-induced coagulopathy (SIC). The results showed that early UFH therapy appears to be associated with improved outcomes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pediatrics
Hannah S. S. Dashefsky, Hongyan Liu, Katie Hayes, Heather Griffis, Melissa Vaughan, Marianne Chilutti, Fran Balamuth, Hannah R. R. Stinson, Julie C. C. Fitzgerald, Erin F. F. Carlton, Scott L. L. Weiss
Summary: This study aimed to determine the frequency and cause of readmission within 90 days after discharge for children who survived sepsis, as well as identify patient-level variables associated with readmission. The study found that the readmission rates at 7, 30, and 90 days post-discharge were 7%, 20%, and 33% respectively, with the main cause being infections. Patient-level variables associated with readmission included age <1 year, chronic comorbid conditions, lower hemoglobin and higher blood urea nitrogen at sepsis recognition, and persistently low white blood cell count <2 thous/μL. However, these variables only partially predicted the risk for readmission.
Article
Medicine, General & Internal
Victor Arevalos, Luis Ortega-Paz, Juan Jose Rodriguez-Arias, Margarita Calvo, Leticia Castrillo, Anthony Salazar, Merce Roque, Ana Paula Dantas, Manel Sabate, Salvatore Brugaletta
Summary: The exact mechanisms of myocardial injury in COVID-19 are still unknown. This study found that myocardial injury in COVID-19 patients is associated with inflammation and coagulopathy, leading to a worse in-hospital prognosis. Treatment with anticoagulant agents may help improve in-hospital outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Emergency Medicine
Erin L. Simon, Katarina Truss, Courtney M. Smalley, Kevin Mo, Caroline Mangira, Jessica Krizo, Baruch S. Fertel
Summary: This study evaluated the in-hospital mortality rates of patients diagnosed with sepsis before and after the implementation of emergency department (ED) sepsis teams. The findings indicated that the implementation of ED sepsis teams led to significantly lower inpatient hospital mortality rates, decreased ED length of stay, and reduced hospital length of stay.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Infectious Diseases
Arief Wibowo, Raymond Pranata, Michael Anthonius Lim, Mohammad Rizki Akbara, Januar Wibawa Martha
Summary: This study conducted a systematic review and meta-analysis to compare the levels of von Willebrand Factor (vWF) antigen in COVID-19 patients with poor outcomes compared to those with good outcomes. The analysis found that vWF antigen was significantly higher in patients with poor outcomes, indicating severe endotheliopathy. Meta-regression analysis showed that the differences became larger as the platelet count, d-dimer level, and factor VIII level increased.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Hematology
Keisuke Mori, Yasuyuki Tsujita, Tetsunobu Yamane, Yutaka Eguchi
Summary: Plasma fibrinogen levels may increase or decrease in response to infection, and a decrease in fibrinogen levels is associated with high mortality in septic patients, even those diagnosed with non-overt DIC.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2022)
Article
Medicine, General & Internal
Sandra Ortega-Martorell, Ivan Olier, Brian W. Johnston, Ingeborg D. Welters
Summary: This study investigates the relationship between SIC and atrial fibrillation in patients admitted to the ICU. Age is found to be the strongest predictor, and routine coagulation tests and markers of inflammation are also associated with the occurrence of AF.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Shalom Lebovitz, Guy Rozen, Zahi Abu Ghosh, Maya Korem, Hila Elinav, Hiba Zayyad, Shemy Carasso, David Planer, Offer Amir, Gabby Elbaz-Greener
Summary: This study investigated the relationship between BMI and clinical outcomes in patients hospitalized with bacteremic sepsis. The results showed a reverse-J-shaped relationship, with underweight and normal-weight patients experiencing higher mortality and longer hospital stays compared to higher BMI groups. The protective effect of a higher BMI diminished in the highest BMI group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Emergency Medicine
Gregory Griffin, Courtney M. Smalley, Baruch S. Fertel, Kevin Mo, Jessica Krizo, Caroline Mangira, Erin Simon
Summary: This study found that sepsis patients presenting to FEDs had lower inpatient mortality, shorter treatment times, and faster transfer and admission rates compared to patients seen at a hospital-based emergency department.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Infectious Diseases
Marianne Ask Torvik, Stig Haugset Nymo, Stale Haugset Nymo, Lars Petter Bjornsen, Hanne Winge Kvarenes, Eirik Hugaas Ofstad
Summary: A retrospective chart review of deceased adults in a Norwegian hospital found a high prevalence of advanced frailty, comorbidity, and age among sepsis-related deaths. The findings are significant for understanding sepsis-related mortality in similar populations, applicability of study results to clinical work, and future research designs.
Article
Health Care Sciences & Services
Gina M. Piscitello, Rene S. Bermea, John W. Stokes, Whitney D. Gannon, Anthony J. Kanelidis, Megan Konopka, Claire Shappell, Laura K. Frye, Patrick G. Lyons, Mark Siegler, William F. Parker
Summary: Informed consent for ECMO presents a major ethical challenge, with variations in the content of discussions. Clinician viewpoints on the ethical complexities related to ECMO in practice differ among departments. Significant differences exist among departments and institutions in terms of the use of categorical exclusion criteria and the option to withdraw ECMO for patients who cannot be liberated from it and are ineligible for heart or lung transplant.
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
(2022)
Article
Critical Care Medicine
Utpal S. Bhalala, Katja M. Gist, Sandeep Tripathi, Karen Boman, Vishakha K. Kumar, Lynn Retford, Kathleen Chiotos, Allison M. Blatz, Heda Dapul, Sourabh Verma, Imran A. Sayed, Varsha P. Gharpure, Erica Bjornstad, Nancy Tofil, Katherine Irby, Ronald C. Sanders, Julia A. Heneghan, Melissa Thomas, Manoj K. Gupta, Franscene E. Oulds, Grace M. Arteaga, Emily R. Levy, Neha Gupta, Margit Kaufman, Amr Abdelaty, Mark Shlomovich, Shivanand S. Medar, A. M. Iqbal O'Meara, Joshua Kuehne, Shina Menon, Paras B. Khandhar, Aaron S. Miller, Suzanne M. Barry, Valerie C. Danesh, Ashish K. Khanna, Kimberly Zammit, Casey Stulce, Patrick W. McGonagill, Asher Bercow, Ioana G. Amzuta, Sandeep Gupta, Mohammed A. Almazyad, Louisdon Pierre, Prithvi Sendi, Sidra Ishaque, Harry L. Anderson, Pooja Nawathe, Murtaza Akhter, Patrick G. Lyons, Catherine Chen, Allan J. Walkey, Azra Bihorac, Imam Wada Bello, Judith Ben Ari, Tanja Kovacevic, Vikas Bansal, John T. Brinton, Jerry J. Zimmerman, Rahul Kashyap
Summary: This retrospective study analyzed the characteristics, ICU admissions, and outcomes of 874 children hospitalized with coronavirus disease 2019 in 51 hospitals from February 2020 to January 2021. The study found that ICU admission was common among children with coronavirus disease 2019, and older age, fever, multisystem inflammatory syndrome in children, and seizure disorder were independently associated with ICU admission. Mortality among children was lower than that reported in adults.
CRITICAL CARE MEDICINE
(2022)
Article
Urology & Nephrology
Erica C. Bjornstad, Gary Cutter, Pramod Guru, Shina Menon, Isabella Aldana, Scott House, Nancy M. Tofil, Catherine A. St Hill, Yasir Tarabichi, Valerie M. Banner-Goodspeed, Amy B. Christie, Surapaneni Krishna Mohan, Devang Sanghavi, Jarrod M. Mosier, Girish Vadgaonkar, Allan J. Walkey, Rahul Kashyap, Vishakha K. Kumar, Vikas Bansal, Karen Boman, Mayank Sharma, Marija Bogojevic, Neha Deo, Lynn Retford, Ognjen Gajic, Katja M. Gist
Summary: SARS-CoV2-related AKI is common among hospitalized patients and shows a bimodal age distribution that cannot be fully explained by known risk factors.
Article
Pharmacology & Pharmacy
Aileen Scheibner, Kevin D. Betthauser, Alice F. Bewley, Paul Juang, Bryan Lizza, Scott Micek, Patrick G. Lyons
Summary: This study aimed to develop and validate a model for predicting the response to vasopressin in patients with septic shock. The study found that nonresponsiveness to vasopressin is common and associated with increased mortality. The machine learning models showed moderate discrimination in predicting vasopressin responsiveness.
Article
Critical Care Medicine
Neha Gupta, Lisa Settle, Brent R. Brown, Donna L. Armaignac, Michael Baram, Nicholas E. Perkins, Margit Kaufman, Roman R. Melamed, Amy B. Christie, Valerie C. Danesh, Joshua L. Denson, Sreekanth R. Cheruku, Karen Boman, Vikas Bansal, Vishakha K. Kumar, Allan J. Walkey, Juan P. Domecq, Rahul Kashyap, Christopher E. Aston
Summary: In hospitalized COVID-19 patients, prior use of a combination of renin-angiotensin-aldosterone system inhibitors (RAASIs) was associated with higher in-hospital mortality compared to the use of RAASIs alone. Compared to ARBs, ACEIs were associated with significantly higher mortality in hospitalized COVID-19 patients.
CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
Patrick G. Lyons, Ashraf Rjob, Scott C. Stockholm, Alice Bewley, M. Cristina Vazquez Guilamet, Marin H. Kollef, Matthew M. Churpek, Juan C. Rojas, Colleen A. McEvoy
Article
Medicine, General & Internal
Patrick G. Lyons, Sivasubramanium V. Bhavani, Aaloke Mody, Alice Bewley, Katherine Dittman, Aisling Doyle, Samuel L. Windham, Tej M. Patel, Bharat Neelam Raju, Matthew Keller, Matthew M. Churpek, Carolyn S. Calfee, Andrew P. Michelson, Thomas Kannampallil, Elvin H. Geng, Pratik Sinha
Summary: This study found differences in clinical presentation, hospital course, and outcome predictors between SARS-CoV-2 and influenza pneumonia, suggesting the need for distinct management approaches.
Article
Critical Care Medicine
Nicole S. Benzoni, Kyle A. Carey, Alice F. Bewley, Jeff Klaus, Brian M. Fuller, Dana P. Edelson, Matthew M. Churpek, Sivasubramanium V. Bhavani, Patrick G. Lyons
Summary: In this study, temperature trajectory modeling identified distinct clinical subphenotypes among oncology patients with neutropenia and suspected infection, and these subphenotypes were independently associated with important outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Patrick G. Lyons, Colleen A. McEvoy
Article
Health Care Sciences & Services
Elle Mizuki Fukui, Patrick G. Lyons, Emily Harris, Emma K. McCune, Juan C. Rojas, Lekshmi Santhosh
Summary: This study evaluates the implementation process of the ICU-PAUSE handoff tool in 10 academic medical centers, including adoption rate and acceptability. The study uses a mixed methods approach, including chart review, quantitative surveys, and qualitative interviews. The study anticipates that ICU-PAUSE will serve as an effective handoff tool for ICU-ward transitions.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Public, Environmental & Occupational Health
J. H. Kwon, K. B. Nickel, K. A. Reske, D. Stwalley, E. R. Dubberke, P. G. Lyons, A. Michelson, K. McMullen, J. M. Sahrmann, S. Gandra, M. A. Olsen, J. P. Burnham
Summary: This study aimed to evaluate the risk factors for hospital-acquired infections (HAI) during the SARS-CoV-2 pandemic. The results showed that SARS-CoV-2 infection was one of the strongest risk factors for HAI.
JOURNAL OF HOSPITAL INFECTION
(2023)
Letter
Medicine, General & Internal
Patrick G. Lyons, Mackenzie R. Hofford, Sean C. Yu, Andrew P. Michelson, Philip R. O. Payne, Catherine L. Hough, Karandeep Singh
Summary: This cohort study examines the variation in a sepsis prediction model across 9 hospitals using electronic health records.
JAMA INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ella G. Cornell, Emily Harris, Emma McCune, Elle Fukui, Patrick G. Lyons, Juan C. Rojas, Lekshmi Santhosh
Summary: The study explores barriers and facilitators to implementing a diagnostic pause at the ICU-to-ward transition. The use of the ICU-PAUSE tool, which includes a diagnostic pause, is recognized as a key benefit to reduce medical errors. However, implementing this new tool faces challenges in workflow, institutional culture, people, and assessment.
Letter
Infectious Diseases
Nicole Benzoni, Alice F. Bewley, M. Cristina Vazquez-Guillamet, Patrick G. Lyons
LANCET INFECTIOUS DISEASES
(2022)
Meeting Abstract
Health Care Sciences & Services
Gina Piscitello, Rene Bermea, Anthony Kanelidis, Claire Shappell, Laura Frye, Patrick Lyons, Mark Siegler
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)