Journal
CORTEX
Volume 98, Issue -, Pages 8-27Publisher
ELSEVIER MASSON, CORPORATION OFFICE
DOI: 10.1016/j.cortex.2016.10.020
Keywords
Action; fMRI; Functional connectivity; Perception; Resting-state; Sensorimotor
Funding
- Canadian Institutes of Health Research (CIHR) [MOP84293, MOP126158]
- Natural Sciences and Engineering Research Council (NSERC)
- CIHR
- Canadian Institute of Health Research (CIHR)
- Brain and Behavior Research Foundation NARSAD/Evelyn Toll Family Young Investigator Grant
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Several lines of evidence point to areas in the occipitotemporal pathway as being critical in the processes of visual perception and object recognition. Much less appreciated, however, is the role that this pathway plays in object-related processing for the purposes of visually guided action. Here, using functional MRI (fMRI) and functional connectivity (FC) measures, we examined interactions between areas in frontoparietal cortex (FPC) involved in grasping, reaching, eye movements, and tool use and areas in occipitotemporal cortex (OTC) involved in object-, face-, scene-, body-, tool-, and motion-related processing, both during the performance of sensorimotor and visual-perceptual tasks, as well as during passive fixation (resting-state). Cluster analysis of regional time course data identified correspondence in the patterns of FPC and OTC connectivity during the visual-perceptual tasks and rest that both tended to segregate regions along traditional dorsal/ventral pathway boundaries. During the sensorimotor tasks, however, we observed a notable separation in functional coupling between ventral-medial and ventral-lateral regions of OTC, with several of the latter areas often being clustered together with sensorimotor-defined areas in parietal cortex. These findings indicate that the functional coupling of ventral-lateral OTC areas to dorsal parietal and ventral-medial structures is flexible and task-dependent, and suggests that regions in lateral occipital cortex, in particular, may play an important role in mediating interactions between the dorsal and ventral pathways during tasks involving sensorimotor control. (C) 2016 Elsevier Ltd. All rights reserved.
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