Review
Pharmacology & Pharmacy
Eren Aytekin, Sibel Bozdag Pehlivan
Summary: Current treatment approaches for keratoconus include options such as penetrating keratoplasty, deep anterior lamellar keratoplasty, and corneal collagen cross-linking. Early diagnosis and halting the disease with CXL methods are becoming crucial in clinical practice.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Agata Sommer, Paulina Dederko-Kantowicz, Hanna Staroszczyk, Slawomir Sommer, Marek Michalec
Summary: This study compares the properties of bacterial cellulose/fish collagen composites (BC/Col) after enzymatic and chemical cross-linking, revealing that enzymatic cross-linking can enhance thermal stability and crystallinity of the material, while oxBC/Col resulting from chemical cross-linking shows lower thermal stability and crystallinity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Marcony R. Santhiago, J. Bradley Randleman
Summary: Corneal crosslinking (CXL) surgery halts the progression of keratoconus through a photochemical reaction involving UV light and riboflavin-induced apoptosis of corneal cells. The stiffening effect of CXL primarily occurs in the anterior third of the cornea, and shorter irradiation times may not have the same biological effect.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Yu Zhang, Yueguo Chen
Summary: The study on the outcomes of topography-guided customized excimer laser subepithelial ablation combined with accelerated CXL for progressive keratoconus showed good stability in vision, corneal curvature, and visual quality within 12 months post-surgery. The method resulted in significant improvements in best spectacle-corrected distance visual acuity, corneal regularity, and corneal higher-order aberrations and coma.
Article
Ophthalmology
Jurriaan Brekelmans, Mor M. Dickman, Shwetabh Verma, Samuel Arba-Mosquera, Ruth Goldschmidt, Alexandra Goz, Alexander Brandis, Tos T. J. M. Berendschot, Isabelle E. Y. Saelens, Arie L. Marcovich, Avigdor Scherz, Rudy M. M. A. Nuijts
Summary: The study found that excimer laser-assisted patterned de-epithelialization allows for effective corneal cross-linking treatment. Different chromophores showed similar penetration depths and effects, but full de-epithelialization resulted in significantly lower light transmittance.
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Jia Zhang, Tong Chen, Junjie Wang, Fangjun Bao, Wen Chen, Aleksandar Stojanovic, Qinmei Wang, Shihao Chen
Summary: This study evaluated the outcomes of combining laser in situ keratomileusis (LASIK) with prophylactic corneal collagen cross-linking (CXL) in correcting myopia in cases with increased risk of postoperative corneal ectasia. The results showed that prophylactic CXL seemed to influence corneal regional reshaping after surgery, while not affecting the visual and refractive results at 1 year.
OPHTHALMOLOGY AND THERAPY
(2022)
Review
Ophthalmology
Richa Agarwal, Parul Jain, Ritu Arora
Summary: This article reports and reviews the complications of corneal collagen cross-linking for the treatment of keratoconus and post-LASIK ectasia, aiming to provide better understanding and management of these complications for healthcare professionals and patients.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Pharmacology & Pharmacy
Duoduo Wu, Dawn Ka-Ann Lim, Blanche Xiao Hong Lim, Nathan Wong, Farhad Hafezi, Ray Manotosh, Chris Hong Long Lim
Summary: Corneal cross-linking (CXL) using riboflavin and ultraviolet A (UVA) light is a versatile treatment option for a variety of corneal diseases, including keratoconus. Recent advances include PACK-CXL for infectious keratitis and CurV customized protocols, which have generated increased interest in the field.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Steven Melcher, Cordelia Zimmerer, Roberta Galli, Jonas Golde, Robert Herber, Frederik Raiskup, Edmund Koch, Gerald Steiner
Summary: Corneal cross-linking (CXL) with riboflavin and ultraviolet A light is a therapeutic procedure to restore the mechanical stability of corneal tissue. This study investigated molecular alterations within porcine cornea tissue after treatment with riboflavin and ultraviolet A light using surface enhanced Raman spectroscopy (SERS). The analysis revealed that while there was no general change in collagen secondary structure, modifications on amino acid side chains were the most dominant outcome. The formation of secondary and aromatic amine groups, as well as methylene and carbonyl groups, were observed.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiangjun Wang, Bo Zhang, Zhiwei Li, Mengyao Li, Jia Wang, Guoying Mu
Summary: The study assessed the keratectasia volume (KEV) before and after corneal cross-linking (CXL) in pediatric patients. The support vector machine (SVM) algorithm was used to calculate the KEV from corneal topography. There was a strong positive correlation between KEV and the maximum keratometry (Kmax). KEV showed a more drastic decreasing trend compared to Kmax at the 6th month after surgery.
JOURNAL OF DIGITAL IMAGING
(2023)
Article
Ophthalmology
Farhad Hafezi
Summary: When treating corneal ectasias, traditional epithelium-off corneal cross-linking (CXL) technique has several disadvantages, while epithelium-on CXL technique may become a simple and effective alternative.
Article
Medicine, General & Internal
Francesco D'Oria, Pasquale Puzo, Cosimo Incandela, Alessandra Sborgia, Samuele Gigliola, Francesco Boscia, Giovanni Alessio
Summary: The study aimed to visualize and evaluate the demarcation line after epi-off I-CXL using AS-OCT, finding that it was clearly distinguishable and similar to the one created in standard CXL.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Malwina Kowalska, Elisa Mischi, Szymon Stoma, Simon F. Norrelykke, Sonja Hartnack, Simon A. Pot
Summary: The purpose of this study was to determine the effects of modifications to the PACK-CXL protocol on corneal resistance to enzymatic digestion and treatment depth. The study found that increasing the fluence significantly increased corneal resistance to enzymatic digestion and treatment depth. Other protocol modifications did not significantly affect corneal resistance.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Ophthalmology
Ozlem Barut Selver, Dilek Yesim Metin, Suleyha Hilmioglu Polat, Aylin Dogen, Melis Palamar
Summary: This study aims to report a case of fungal keratitis with perforation after corneal collagen cross-linking (CXL) treatment for keratoconus. The patient had undergone bilateral CXL procedure 4 days prior and presented with redness and discharge in the left eye. The corneal melting with surrounding infiltrates was observed, and microbiological assessment was performed.
Article
Endocrinology & Metabolism
Aleksandra Mieczkowska, Guillaume Mabilleau
Summary: In this study, a new method for assessing enzymatic cross-link based on FTIR microspectroscopy was proposed, taking into account the secondary structure of type I collagen. The intensities and areas of subbands located at similar to 1660, similar to 1680, and similar to 1690-cm(-1) were found to be positively associated with the concentration of PYD, deoxypyridinoline, or immature dihydroxylysinonorleucine/hydroxylysinonorleucine cross-links. UV exposure and acid treatment significantly reduced the intensity and area of specific subbands. Plod2 and Lox expression were also positively associated with the signal of specific subbands. This method allows for investigation of the tissue distribution of enzymatic cross-links in bone sections.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Ophthalmology
Saurabh Ghosh, Borja Salvador-Culla, Ajay Kotagiri, Sreekumari Pushpoth, Adrian Tey, Zoe K. Johnson, Francisco C. Figueiredo
Article
Ophthalmology
Borja Salvador-Culla, Maddi Alonso-Agesta, Juan Alvarez de Toledo, Rafael I. Barraquer
Article
Ophthalmology
Clara Alvarez de Toledo, Borja Salvador-Culla, Jose Carlos Lopez, Maria Fideliz De la Paz, Rafael Barraquer, Juan Alvarez de Toledo
Article
Ophthalmology
Maria Fideliz de la Paz, Borja Salvador-Culla, Victor Charoenrook, Jose Temprano, Juan Alvarez de Toledo, Guenther Grabner, Ralph Michael, Rafael Barraquer
Article
Ophthalmology
Akash Raj, Borja Salvador-Culla, Hamed Anwar, Evripidis Sykakis, Maria Socorro Figueiredo, Francisco Carlos Figueiredo
Editorial Material
Ophthalmology
Pablo Sanjuan, Borja Salvador-Culla, Maria Isabel Canut, Rafael I. Barraquer
Summary: This case report describes a rare occurrence of a unilateral spontaneous filtering bleb dissecting into the cornea in a patient with high myopia. Surgical resection of the filtering bleb halted the progression of corneal dissection, preserving visual acuity and transparency of the visual axis in this patient.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Engineering, Biomedical
Amy E. Ross, Lokendrakumar C. Bengani, Rehka Tulsan, Daniel E. Maidana, Borja Salvador-Culla, Hidenaga Kobashi, Paraskevi E. Kolovou, Hualei Zhai, Koli Taghizadeh, Liangju Kuang, Manisha Mehta, Demetrios G. Vavvas, Daniel S. Kohane, Joseph B. Ciolino
Editorial Material
Ophthalmology
Marta Jerez-Pena, Borja Salvador-Culla, Maria F. de la Paz, Rafael Barraquer
Summary: Mooren's ulcer is a painful, inflammatory chronic keratitis that requires systemic immunomodulation as the primary treatment. Surgical intervention such as penetrating keratoplasty or Boston keratoprosthesis may be considered in severe cases, but postoperative complications must be addressed promptly to ensure successful outcomes.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Engineering, Biomedical
Lokendrakumar C. Bengani, Hidenaga Kobashi, Amy E. Ross, Hualei Zhai, Borja Salvador-Culla, Rekha Tulsan, Paraskevi E. Kolovou, Sharad K. Mittal, Sunil K. Chauhan, Daniel S. Kohane, Joseph B. Ciolino
ACTA BIOMATERIALIA
(2020)
Article
Ophthalmology
Jose Lamarca Mateu, Borja Salvador-Culla, Cristina Santos, Rafael Barraquer
Summary: This study assessed the correlation of results between both eyes of patients with keratoconus after ICRS implantation. It was found that there was a significant correlation between the results of the right and left eyes, and no significant interaction in the magnitude of change between eye and surgery was observed.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Pablo Sanjuan, Gemma Julio, Jennifer Bolanos, Juan Alvarez de Toledo, Gonzalo Garcia de Oteyza, Jose Temprano, Rafael Ignacio Barraquer
Summary: Autologous contralateral penetrating keratoplasty can be a successful long-term option in patients with one eye with clear cornea and irreversible visual dysfunction, but progression of previous glaucoma is a significant risk factor for long-term cornea decompensation and visual functional failure.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Gonzalo Garcia de Oteyza, Monica Benedetti Sandner, Jorge Velazco Casapia, Carmen Trivino, Borja Salvador-Culla, Ana Mercedes Garcia-Albisua
Summary: In recent years, new therapeutic alternatives have been developed for treating severe keratoconus, showing promising results in improving corneal conditions, visual acuity, and avoiding the need for corneal transplantation. These techniques are not only effective but also relatively safe.
Meeting Abstract
Ophthalmology
Emma Spowart, Sayali Pradhan, Charlotte Bruce, Borja Salvador-Culla, Gustavo Figueiredo, Francisco Figueiredo
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Jose Lamarca-Mateu, Borja Salvador-Culla, Alba Gomez-Benlloch, Rafael Barraquer
INDIAN JOURNAL OF OPHTHALMOLOGY
(2020)