Article
Surgery
Sandra A. N. Walker, Alexandra Cooper, Christine Peragine, Marion Elligsen, Marc G. Jeschke
Summary: A tool was developed and validated for early identification of bloodstream infection in patients with acute burn injury, using common laboratory, clinical, and patient parameters. The tool showed excellent predictive ability in determining which patients should have blood cultures requested.
Article
Nutrition & Dietetics
Sunyoung Ahn, Su Hwan Lee, Kyung Soo Chung, Nam Su Ku, Young-Min Hyun, Sail Chun, Moo Suk Park, Sang-Guk Lee
Summary: The study found significant differences in serum amino acid composition between sepsis patients, healthy individuals, and patients with inflammation only. The newly developed multivariate index based on amino acid profiling showed promising potential in diagnosis and prognosis, expected to be implemented as a sepsis biomarker in clinical practice in the near future.
CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Marie Egebjerg Jensen, Jens Aage Kolsen-Petersen, Hans Kirkegaard, Marie Kristine Jessen
Summary: Patients transported by EMS received more intravenous fluids and less oral fluids in the first 24 hours compared to non-EMS patients. The overall fluid administration was higher in EMS transported patients after adjustment for age, site, and SOFA-score.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Sivasubramanium Bhavani, Matthew Semler, Edward T. Qian, Philip A. Verhoef, Chad Robichaux, Matthew M. Churpek, Craig M. Coopersmith
Summary: Identification of sepsis sub-phenotypes based on vital sign trajectories can provide valuable insights into the heterogeneity of sepsis. These sub-phenotypes exhibit distinct outcomes and responses to treatment.
INTENSIVE CARE MEDICINE
(2022)
Article
Pediatrics
Jennifer F. Anders, Jennifer N. Fishe, Kyle A. Fratta, Jessica H. Katznelson, Matthew J. Levy, Richard Lichenstein, Michael G. Milin, Joelle N. Simpson, Theresa A. Walls, Heather L. Winger
Summary: A novel evidence-based decision tool, PDTree, was developed for pediatric transport destination choice by a multidisciplinary expert panel. Through multiple rounds of review and consensus, the tool was unanimously approved for use in emergency medical services to improve the efficiency and effectiveness of pediatric patient transports.
Article
Public, Environmental & Occupational Health
Mariana Wingood, Elizabeth Peterson, Christopher Neville, Jennifer L. Vincenzo
Summary: This study developed a screening tool for identifying feet- and footwear-related influences on fall risk among community-dwelling older adults. The tool was evaluated and refined in two phases, resulting in a 20-item screening tool with high face and content validity.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Daniela D'angelo, Daniela Coclite, Antonello Napoletano, Silvia Gianola, Greta Castellini, Roberto Latina, Laura Iacorossi, Alice Josephine Fauci, Primiano Iannone
Summary: The study describes the development and validation of the International Guideline Evaluation Screening Tool (IGEST) for screening trustworthy Clinical Practice Guidelines (CPGs) for adoption/adaption. All items obtained a CVI>0.78 through expert opinions, indicating good content validity of the tool.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Wenyuan Zhang, Yuanqiang Lu
Summary: A signature consisting of nine IRRGs can be used to predict the prognosis of sepsis patients, influence their immune status, and may become a therapeutic option in the future.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Multidisciplinary Sciences
Louis Ehwerhemuepha, Theodore Heyming, Rachel Marano, Mary Jane Piroutek, Antonio C. Arrieta, Kent Lee, Jennifer Hayes, James Cappon, Kamila Hoenk, William Feaster
Summary: This study developed and validated an early warning system for sepsis in pediatric Emergency Departments, using predictive models to accurately predict critical conditions related to death, severe sepsis, and bacteremia. Important predictors in the model included age, heart rate, length of stay, temperature, blood pressure, and prior sepsis.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Yoichiro Tohi, Yasukazu Hijikata, Mikio Sugimoto, Hideya Kuroda, Mineo Takei, Takakazu Matsuki, Tsukasa Kamitani, Yoshiyuki Kakehi, Shunichi Fukuhara, Yosuke Yamamoto
Summary: We developed a simple self-checkable screening tool for chronic prostatitis and internally validated its predictive performance using data from a representative national survey of Japanese men. The tool showed reasonable predictive ability and can be used as a first step in screening patients with chronic prostatitis.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Yoichiro Tohi, Yasukazu Hijikata, Mikio Sugimoto, Hideya Kuroda, Mineo Takei, Takakazu Matsuki, Tsukasa Kamitani, Yoshiyuki Kakehi, Shunichi Fukuhara, Yosuke Yamamoto
Summary: This study developed a simple self-checkable screening tool (S-CP) for chronic prostatitis and evaluated its predictive performance using data from a national survey in Japan. The results showed that S-CP had reasonable predictive performance and could be used as a first step in screening for chronic prostatitis in the general population.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Medicine, General & Internal
Yeongho Choi, Jeong Ho Park, Ki Jeong Hong, Young Sun Ro, Kyoung Jun Song, Sang Do Shin
Summary: The study developed and tested predictive models for traumatic brain injury (TBI) using machine learning algorithms, with the EN model performing the best in predicting TBI. Variables related to loss of consciousness, Glasgow Coma Scale, and light reflex were identified as important predictors for all outcomes.
Article
Medicine, Research & Experimental
Keitaro Makino, Sangyoon Lee, Seongryu Bae, Ippei Chiba, Kenji Harada, Osamu Katayama, Yohei Shinkai, Hiroyuki Shimada
Summary: In this study, a 12-item questionnaire called STAD was developed for predicting dementia risk using telephonic interviews, and its predictive validity was confirmed in a validation study with 4298 community-dwelling older adults. A decision tree model using the CART algorithm showed better performance in dementia prediction accuracy and specificity compared to logistic regression, making STAD a promising screening tool for dementia risk in older adults.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Rico S. C. Lee, Lucy Albertella, Erynn Christensen, Chao Suo, Rebecca A. Segrave, Maja Brydevall, Rebecca Kirkham, Chang Liu, Leonardo F. Fontenelle, Samuel R. Chamberlain, Kristian Rotaru, Murat Yucel
Summary: The purpose of this study was to validate a gamified battery of neurocognitive tasks for assessing addictive behaviors. The findings showed that the gamified tasks were sufficiently valid for assessing key neurocognitive processes related to addiction. This validation has significant implications for risk detection and the successful deployment of next-generation assessment tools for substance use or misuse and other mental disorders characterized by neurocognitive anomalies.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Medicine, General & Internal
Xia Zhu, Jun Lv, Meng Zhu, Caiwang Yan, Bin Deng, Canqing Yu, Yu Guo, Jing Ni, Qiang She, Tianpei Wang, Jiayu Wang, Yue Jiang, Jiaping Chen, Dong Hang, Ci Song, Xuefeng Gao, Jian Wu, Juncheng Dai, Hongxia Ma, Ling Yang, Yiping Chen, Mingyang Song, Qingyi Wei, Zhengming Chen, Zhibin Hu, Hongbing Shen, Yanbing Ding, Liming Li, Guangfu Jin
Summary: We developed a questionnaire-based tool to assess the risk of gastric cancer in the Chinese population and validated its effectiveness. The tool categorized participants into low, intermediate, and high-risk groups and successfully identified 81.6% of gastric cancer cases in the high-risk group.
Article
Endocrinology & Metabolism
Georgia M. Davis, Eileen Faulds, Tara Walker, Debbie Vigliotti, Marina Rabinovich, Joi Hester, Limin Peng, Barbara McLean, Patricia Hannon, Norma Poindexter, Petrena Saunders, Citlalli Perez-Guzman, Seema S. Tekwani, Greg S. Martin, Guillermo Umpierrez, Shivani Agarwal, Kathleen Dungan, Francisco J. Pasquel
Summary: The study shows that a hybrid protocol integrating CGM and POC is helpful for managing critically ill patients with COVID-19 requiring insulin infusion. Sensor accuracy is impacted by mechanical interferences, but the majority of sensor values are within 20% of reference POC glucose levels.
Editorial Material
Pathology
Steven C. Schachter, Denise R. Dunlap, Wilbur A. Lam, Yukari C. Manabe, Greg S. Martin, Sally M. McFall
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2021)
Review
Critical Care Medicine
Yaseen M. Arabi, Elie Azoulay, Hasan M. Al-Dorzi, Jason Phua, Jorge Salluh, Alexandra Binnie, Carol Hodgson, Derek C. Angus, Maurizio Cecconi, Bin Du, Rob Fowler, Charles D. Gomersall, Peter Horby, Nicole P. Juffermans, Jozef Kesecioglu, Ruth M. Kleinpell, Flavia R. Machado, Greg S. Martin, Geert Meyfroidt, Andrew Rhodes, Kathryn Rowan, Jean-Francois Timsit, Jean-Louis Vincent, Giuseppe Citerio
Summary: The COVID-19 pandemic has highlighted the importance of critical care response and emergency preparedness in healthcare systems, as well as the value of digital transformation and data collection.
INTENSIVE CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Jonathan E. Sevransky, Richard E. Rothman, David N. Hager, Gordon R. Bernard, Samuel M. Brown, Timothy G. Buchman, Laurence W. Busse, Craig M. Coopersmith, Christine DeWilde, Wesley Ely, Lindsay M. Eyzaguirre, Alpha A. Fowler, David F. Gaieski, Michelle N. Gong, Alex Hall, Jeremiah S. Hinson, Michael H. Hooper, Gabor D. Kelen, Akram Khan, Mark A. Levine, Roger J. Lewis, Chris J. Lindsell, Jessica S. Marlin, Anna McGlothlin, Brooks L. Moore, Katherine L. Nugent, Samuel Nwosu, Carmen C. Polito, Todd W. Rice, Erin P. Ricketts, Caroline C. Rudolph, Fred Sanfilippo, Kert Viele, Greg S. Martin, David W. Wright
Summary: A trial on the effects of a combination treatment of vitamin C, thiamine, and hydrocortisone on ventilator- and vasopressor-free days in patients with sepsis did not show a significant increase within 30 days. However, the trial was terminated early and may have been underpowered to detect a clinically important difference.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Editorial Material
Critical Care Medicine
Greg S. Martin
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Sara C. Auld, Kristin R. Harrington, Max W. Adelman, Chad J. Robichaux, Elizabeth C. Overton, Mark Caridi-Scheible, Craig M. Coopersmith, David J. Murphy
Summary: This study aims to explore the association between time period of hospitalization and hospital mortality among critically ill adults with coronavirus disease 2019. The study found that the risk of death was highest for patients admitted during the fall and winter of 2020. Hospital mortality was associated with preexisting risk factors, clinical status at ICU admission, and ICU interventions.
CRITICAL CARE MEDICINE
(2022)
Review
Critical Care Medicine
Mark E. Nunnally, Ricard Ferrer, Greg S. Martin, Ignacio Martin-Loeches, Flavia R. Machado, Daniel De Backer, Craig M. Coopersmith, Clifford S. Deutschman
Summary: The document outlines priorities for administrative, epidemiologic and diagnostic research in sepsis, addressing questions regarding care delivery, epidemiology, organ dysfunction, screening, identification of septic shock, and information predicting outcomes.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2021)
Article
Medical Informatics
Abeed Sarker, Mohammed Ali Al-Garadi, Yuan-Chi Yang, Jinho Choi, Arshed A. Quyyumi, Greg S. Martin
Summary: The capabilities of natural language processing methods have significantly grown, but they are still underutilized in patient-oriented clinical research and care. Clinical NLP methods are often optimized for specific data sets and tasks, leading to a gap in meeting the needs of patient-facing medical experts. To increase practical use, future research and development efforts should incorporate characteristics crucial for patient-oriented clinical research and care.
JMIR MEDICAL INFORMATICS
(2021)
Article
Nutrition & Dietetics
Xian Qiao, Markos G. Kashiouris, Michael L'Heureux, Bernard J. Fisher, Stefan W. Leichtle, Jonathon D. Truwit, Rahul Nanchal, Robert Duncan Hite, Peter E. Morris, Greg S. Martin, Jonathan Sevransky, Alpha A. Fowler
Summary: In this study, the disease-modifying effects of high-dose intravenous vitamin C (HDIVC) on sepsis-induced acute respiratory distress syndrome (ARDS) were investigated. It was found that HDIVC infusion could attenuate cell-free DNA and syndecan-1 levels, which are biomarkers associated with sepsis-induced ARDS.
Article
Environmental Sciences
Maryam Ehteshami, Carlos Leon Edgar, Lucia Yunuen Delgado Ayala, Michael Hagan, Greg S. Martin, Wilbur Lam, Raymond F. Schinazi
Summary: Scientific societies and conference secretariats have resumed in-person meetings with COVID-19 safety measures in place. The MEX-DART case study conducted at the Hep-DART 2021 conference highlighted the successful implementation of safety measures, including vaccination requirements, social distancing, mask wearing, and daily rapid testing. None of the 166 delegates tested positive during the conference, but two delegates tested positive after the conference, suggesting they contracted the virus during their travels or postconference vacation. This case study serves as a helpful template for organizing future in-person meetings, but caution is still necessary due to seasonal surges in respiratory virus infections.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Fahad Marmarchi, Michael Liu, Srikant Rangaraju, Sara C. Auld, Maria Christina Creel-Bulos, Christine L. Kempton, Milad Sharifpour, Manila Gaddh, Roman Sniecinski, Cheryl L. Maier, Fadi Nahab
Summary: The study found that African Americans admitted to the ICU with COVID-19 had higher rates of comorbidities, such as hypertension and diabetes, but showed no significant difference in mortality compared to other races.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2022)
Letter
Respiratory System
Max W. Adelman, Divya R. Bhamidipati, Alfonso C. Hernandez-Romieu, Ahmed Babiker, Michael H. Woodworth, Chad Robichaux, David J. Murphy, Sara C. Auld, Colleen S. Kraft, Jesse T. Jacob
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Correction
Critical Care Medicine
Juan Pablo Domecq, Amos Lal, Christopher R. Sheldrick, Vishakha K. Kumar, Karen Boman, Scott Bolesta, Vikas Bansal, Michael O. Harhay, Michael A. Garcia, Margit Kaufman, Valerie Danesh, Sreekanth Cheruku, Valerie M. Banner-Goodspeed, Harry L. Anderson, Patrick S. Milligan, Joshua L. Denson, Catherine A. St Hill, Kenneth W. Dodd, Greg S. Martin, Ognjen Gajic, Allan J. Walkey, Rahul Kashyap
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Jean-Louis Vincent, Julia Wendon, Greg S. Martin, Nicole P. Juffermans, Jacques Creteur, Maurizio Cecconi
Summary: The current coronavirus pandemic has heavily impacted ICUs worldwide, putting immense pressure on healthcare systems and staff. It is important to learn from both the positive and negative aspects of the response to improve organization and patient care in the future.
Review
Critical Care Medicine
Max W. Adelman, Michael H. Woodworth, Virginia O. Shaffer, Greg S. Martin, Colleen S. Kraft
Summary: Clostridioides difficile infection is the most common healthcare-associated infection in the United States with antibiotics being the most significant risk factor. Age, diabetes, and other conditions increase the risk of infection. Treatment for fulminant cases involves oral vancomycin and IV metronidazole.
CRITICAL CARE MEDICINE
(2021)
Letter
Emergency Medicine
Zhao-Yu Hsieh, Chen-Xiong Hsu
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Laura E. Walker, Jessica A. Stanich, Fernanda Bellolio
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
E. Tekin
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amanda S. Dupont, Patrick S. Walsh
Summary: Recent research indicates that children who unintentionally ingest cannabis often undergo extensive additional testing, such as head imaging or lumbar puncture. However, the yield of these tests is limited. While head imaging and lumbar puncture are frequently performed, diagnoses such as skull fracture, intracranial hemorrhage, intracranial neoplasm, meningitis, or intracranial abscess are rare. Additionally, discharge diagnoses related to other drugs are infrequent. The most common co-diagnoses are cocaine and opioids. Therefore, prompt consideration of cannabis ingestion and quick identification through testing may result in more effective neuroimaging outcomes.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
Mio Nagata, Shunsuke Kudo, Motoyasu Nakamura
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Andy Hung-Yi Lee, Katherine Dickerson Mayes, Regan Marsh, Christina Toledo-Cornell, Eric Goralnick, Michael Wilson, Leon D. Sanchez, Alice Bukhman, Damarcus Baymon, Dana Im, Paul C. Chen
Summary: This study assessed the disparities in transferring patients from an academic medical center emergency department to a community hospital general medical service, revealing healthcare disparities among different patient populations.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Annabelle Croskey, William Trautman, David Barton, Mary Kathleen Ratay, Joshua Shulman
Summary: This case report describes a successful management of ocular palytoxin exposure in a young male, highlighting the importance of prompt recognition and treatment of ocular PTX toxicity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Matthew K. Kolbeck, Rachel F. Schult, Nicholas Nacca
Summary: This article presents four cases of adolescents who experienced seizures after acute fluoxetine overdose. Although seizures are an uncommon complication after fluoxetine overdose, they occurred in some patients at doses lower than those reported in the literature.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Daven Patel, John Bailitz, Simone Ymson, Jonas Neichin, Gary D. Peksa, Michael Gottlieb
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amichai Gutgold, Shaden Salameh, Jeries Nashashibi, Yonatan Gershinsky
Summary: This study aimed to test the prognosis of patients with a pH lower than 6.9 on emergency department admission. The findings showed that a small but significant portion of these patients survived at least 24 hours and until hospital discharge.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Na-Yeon Emily Song, Ki Hong Kim, Ki Jeong Hong
Summary: This study aimed to evaluate the effect of the duration of no-flow (NF) interval on the vaso-pressor effect of initial epinephrine administration in a porcine model of cardiac arrest. The results showed that a shorter NF interval can enhance the vasopressor effect of epinephrine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Kenneth A. Scheppke, Paul E. Pepe, Jonathan Jui, Remle P. Crowe, Eric K. Scheppke, Nancy G. Klimas, Aileen M. Marty
Summary: This study reported cases of rapid and complete remission of severe long COVID after receiving monoclonal antibody treatment. The findings suggest that monoclonal antibody infusions may be effective in treating severe debilitation caused by long COVID.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Suhrith Bhattaram, Varsha S. Shinde
Summary: Nerve blocks have emerged as promising options for targeted pain relief in the Emergency Department, providing effective analgesia without compromising motor function. The successful use of ultrasound-guided genicular nerve blocks (GNBs) in this case series demonstrates their potential as an alternative to traditional nerve blocks and opioid-based pain control strategies in the ED.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Rick Kye Gan, Jude Chukwuebuka Ogbodo, Yong Zheng Wee, Ann Zee Gan, Pedro Arcos Gonzalez
Summary: The aim of this study was to evaluate and compare the performance of ChatGPT, Google Bard, and medical students in performing START triage during mass casualty situations. The results showed that Google Bard had significantly higher accuracy compared to ChatGPT, while there was no significant difference between Google Bard and medical students.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Nancy Clemens, Paria M. Wilson, Matthew J. Lipshaw, Holly Depinet, Yin Zhang, Michelle Eckerle
Summary: This study compared clinical features and outcomes between pediatric sepsis patients with blood cultures positive versus negative for bacterial pathogens. The results showed that children with blood culture positive sepsis had higher rates of organ dysfunction, a larger base deficit, and higher procalcitonin levels.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)