Article
Endocrinology & Metabolism
Marta Diana Komarowska, Kamil Grubczak, Jan Czerniecki, Adam Hermanowicz, Justyna Magdalena Hermanowicz, Wojciech Debek, Ewa Matuszczak
Summary: The study revealed significantly higher plasma levels of BPA, BPS, and BPF in children with cryptorchidism compared to control subjects, with BPA being the most commonly detected. All three bisphenols were present in plasma samples of both groups, showing a widespread exposure among prepubertal boys.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Food Science & Technology
Iris Reina-Perez, Alicia Olivas-Martinez, Vicente Mustieles, Francisco Javier Ruiz-Ojeda, Jose Manuel Molina-Molina, Nicolas Olea, Mariana F. Fernandez
Summary: BPF and BPS were found to increase intracellular lipid accumulation and affect gene expression related to adipogenesis in human adipose-derived stem cells; their obesogenic effects may involve multiple pathways. This study reveals for the first time the obesogenic potential of BPF in human adipose-derived stem cells.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Shaoxin Zi, Jiale Xu, Yingxin Zhang, Di Wu, Jin Liu
Summary: The behavior of bisphenol A (BPA) and its substitutes in soils was studied, and it was found that bisphenol S (BPS) and bisphenol F (4,4'-BPF) have higher mobility in saturated soils compared to BPA. Additionally, the three isomers of bisphenol F showed variability in mobility in saturated soils with high organic matter content. The results highlight the role of soil organic matter in providing dynamic adsorption sites for the bisphenol analogs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Azim Haziq Zainuddin, Muhammad Qusyairi Jori Roslan, Muhammad Raznisyafiq Razak, Fatimah Md. Yusoff, Didi Erwandi Mohamad Haron, Ahmad Zaharin Aris
Summary: This study utilized solid phase extraction (SPE) and liquid chromatography-tandem quadrupole mass spectrometer (LC-MS/MS) to quantify and qualitatively analyze bisphenol compounds in surface water samples. The concentration of bisphenol analogues in coastal and estuarine surface water of Port Dickson and Lukut ranged from 1.32 ng/L to 1890.51 ng/L. The highest mean concentration was found for BPF at 1143.88 ng/L, followed by BPA and BPS at 59.01 ng/L and 10.96 ng/L, respectively. The RQm values indicated the highest risk for BPF at 2.49 (RQ > 1, high risk), followed by BPS at 0.12 (0.1 < RQ < 1, medium risk) and BPA at 0.09 (0.1 < RQ < 1, medium risk). The presence and current risk of bisphenol analogues should raise concerns about possible water quality degradation soon.
MARINE POLLUTION BULLETIN
(2023)
Article
Environmental Sciences
Iris Reina-Perez, Alicia Olivas-Martinez, Vicente Mustieles, Elena Salamanca-Fernandez, Jose Manuel Molina-Molina, Nicolas Olea, Mariana F. Fernandez
Summary: This study investigated the combined effect of bisphenol A (BPA) and its substitutes, bisphenol F (BPF) and S (BPS), on the adipogenic differentiation of human adipose-derived stem cells (hASCs). The researchers found that the mixture of bisphenols promoted lipid accumulation in the cells in a dose-dependent manner, with a maximal response at 10 μM. The effect was mediated by the estrogen receptor, and the mixture also altered the expression of adipogenic markers in a non-monotonic dose-response pattern.
Article
Pharmacology & Pharmacy
J. L. Nguyen, E. A. Ricke, T. T. Liu, R. Gerona, L. MacGillivray, Z. Wang, B. G. Timms, W. A. Ricke, D. E. Bjorling, F. S. vom Saal
Summary: This study explores the impact of bisphenol-A (BPA) and its replacements on lower urinary tract dysfunction (LUTD) in adult male mice. The results suggest that mice exposed to these bisphenols exhibit increased bladder and prostate mass, an increased number of prostatic ducts in the prostatic urethra, and a decreased size of the urethra lumen. The bisphenol treatment also induces voiding dysfunction in male mice.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Environmental Sciences
Chenglian Bai, Yi Zheng, Linjie Tian, Jian Lin, Yang Song, Changjiang Huang, Qiaoxiang Dong, Jiangfei Chen
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is increasing in prevalence. The environmental endocrine disruptor bisphenol A (BPA) has been linked to ASD, but little is known about the developmental neurotoxicity (DNT) of BPA analogues (BPs). This study used a zebrafish model and found that many BPA analogues are more toxic than BPA in terms of teratogenic effect and mortality. Additionally, exposure to BPA or BPs in zebrafish embryos resulted in reduced prosocial behavior and ASD-like behavioral deficits. The findings suggest that BPF and BPS may also pose risks for ASD development in humans.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Multidisciplinary
Xiyan Mu, Suzhen Qi, Jia Liu, Lilai Yuan, Ying Huang, Jiaying Xue, Le Qian, Chengju Wang, Yingren Li
Summary: Research found that co-exposure of bisphenol analogues and polystyrene microplastics increased mortality rate among larvae, with little effect on embryos. Microplastics accumulated in the gastrointestinal area of larvae but not in embryos. Combined exposure led to stronger behavioral effects compared to single pollutant exposure.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Article
Engineering, Environmental
Pengyu Chen, Jing Yang, Bowen Xiao, Yanfeng Zhang, Shuai Liu, Lingyan Zhu
Summary: The research demonstrates that graphene oxide (GO) can alleviate the developmental toxicity induced by bisphenol A (BPA) and recover the affected gene pathways, improving the endocrine disruption effects caused by BPA.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Kangyu Hao, Jia Luo, Jing Sun, Honghan Ge, Zhaoguo Wang
Summary: The study found that exposure to BPA and BPS was positively associated with depressive symptoms, especially in men. However, BPS was negatively associated with depressive symptoms in elderly women.
Article
Engineering, Environmental
Kun Qiao, Zhuoying Liang, Aoxue Wang, Qiong Wu, Siyu Yang, Yongfang Ma, Shuying Li, Sabrina Schiwy, Jinhua Jiang, Shengli Zhou, Qingfu Ye, Henner Hollert, Wenjun Gui
Summary: In this study, the effects of tebuconazole on the sex differentiation and hormone levels in zebrafish were investigated. The results showed that long-term exposure to tebuconazole significantly increased the proportion of males and led to an increase in testosterone levels and a decrease in estradiol and aromatase gene expression. However, chemically activated luciferase gene expression assays suggested that the male-biased sex differentiation was not caused by direct binding of tebuconazole to sex hormone receptors. Molecular docking and activity assays further confirmed the interaction between tebuconazole and aromatase. These findings highlight the potential threat of tebuconazole in inducing gender imbalance in fish populations.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Wenhui Qiu, Shuai Liu, Honghong Chen, Shusheng Luo, Ying Xiong, Xuejing Wang, Bentuo Xu, Chunmiao Zheng, Ke-Jian Wang
Summary: The study found that BPA and its analogs stimulate the reproductive neuroendocrine system in zebrafish, increasing the expression levels of related genes and typical hormones. These effects were associated with increased activity of estrogen receptors and aromatase. Additionally, BPAF exhibited similar reproductive neuroendocrine toxicity to BPA in aquatic organisms.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Haiyang Yu, Wenlu Song, Xue Chen, Qiang Zhao, Xinxin Du
Summary: In this study, zebrafish embryo transcriptomic data were used to identify up-regulated genes or pathways in response to different BPA exposures. The systemic lupus erythematosus signaling pathway was found to be significantly enriched in all BPA exposure groups, with most up-regulated genes being histones. This suggests that autoimmunity signaling and histones may play a key role in the zebrafish embryo-larvae response to BPA exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Erico A. Oliveira Pereira, Lisa M. Labine, Sonya Kleywegt, Karl J. Jobst, Andre J. Simpson, Myrna J. Simpson
Summary: This study found that BPA, BPF, and BPS elicited similar non-monotonic concentration responses on the metabolism of Daphnia magna, with pathways related to protein synthesis, amino acid metabolism, and energy metabolism being perturbed. The results suggest a need for metabolomic analyses in exposure assessment for chemicals within the same class that may disrupt biochemistry uniquely at the molecular level.
Article
Environmental Sciences
Mengxi Cao, Jinbo Wei, Yu Pan, Ling Wang, Zhunjie Li, Yeli Hu, Yong Liang, Huiming Cao
Summary: Bisphenol A (BPA) and its analogues can disrupt the endocrine system and reproductive function. Recent studies have shown that some BPA analogues have strong anti-estrogenic effects, but conflicting results were observed in different in vitro assays, and it is still unclear whether these BPA analogues have in vivo effects at environmentally relevant concentrations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Deling Fan, Jining Liu, Lei Wang, Xianhai Yang, Shenghu Zhang, Yan Zhang, Lili Shi
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2016)
Article
Chemistry, Medicinal
Xianhai Yang, Huihui Liu, Jining Liu, Fei Li, Xuehua Li, Lili Shi, Jingwen Chen
CHEMICAL RESEARCH IN TOXICOLOGY
(2016)
Article
Environmental Sciences
Cen Yin, Xianhai Yang, Mengbi Wei, Huihui Liu
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2017)
Article
Environmental Sciences
Qian Yang, Xianhai Yang, Jining Liu, Wenjuan Ren, Yingwen Chen, Shubao Shen
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2017)
Article
Environmental Sciences
Ying Wang, Guangshui Na, Humin Zong, Xindong Ma, Xianhai Yang, Jingli Mu, Lijun Wang, Zhongsheng Lin, Zhifeng Zhang, Juying Wang, Jinsong Zhao
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2018)
Article
Environmental Sciences
Huihui Liu, Mengbi Wei, Xianhai Yang, Cen Yin, Xiao He
SCIENCE OF THE TOTAL ENVIRONMENT
(2017)
Article
Environmental Sciences
Qian Yang, Xianhai Yang, Jining Liu, Wenjuan Ren, Yingwen Chen, Shubao Shen
WATER AIR AND SOIL POLLUTION
(2017)
Article
Chemistry, Analytical
Xiang Luo, Xianhai Yang, Xianliang Qiao, Ya Wang, Jingwen Chen, Xiaoxuan Wei, Willie J. G. M. Peijnenburg
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2017)
Article
Environmental Sciences
Wang Ou, Huihui Liu, Junyi He, Xianhai Yang
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2018)
Article
Environmental Sciences
Junyi He, Tao Peng, Xianhai Yang, Huihui Liu
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2018)
Review
Toxicology
Shuxin Sui, Huihui Liu, Xianhai Yang
Summary: Since 1974, over 800 disinfection byproducts (DBPs) have been identified in various types of water sources. Some DBPs are considered environmental contaminants due to their potential to cause health and ecological effects. This study focuses on summarizing the potential endocrine-disrupting effects of DBPs and highlights gaps in knowledge for future research. The evidence suggests that certain DBPs can perturb the endocrine system of organisms through various molecular initiating events.
JOURNAL OF XENOBIOTICS
(2022)
Article
Environmental Sciences
Feng Ding, Xianhai Yang, Guosong Chen, Jining Liu, Lili Shi, Jingwen Chen
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2017)
Article
Environmental Sciences
Xianhai Yang, Felichesmi Lyakurwa, Hongbin Xie, Jingwen Chen, Xuehua Li, Xianliang Qiao, Xiyun Cai
Article
Environmental Sciences
Huihui Liu, Xianhai Yang, Cen Yin, Mengbi Wei, Xiao He
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2017)
Article
Biochemistry & Molecular Biology
Gabriela Maressa Machado Baesso, Amanda Vitoria Venancio, Livia Costa Varela Barca, Pepita Fernanda Peppi, Caique Aparecido Faria, Joao Pedro Cosmo Machado, Luiz David Solis Murgas, Alvaro Jose de Almeida Bicudo, Eduardo Mauricio Mendes de Lima, Andre Rodrigues da Cunha Barreto-Vianna
Summary: This study evaluated the effects of eugenol, menthol, and lidocaine as anesthetics on glucose levels and recovery times in zebrafish. The results showed that eugenol and menthol did not affect glucose levels, while lidocaine caused non-concentration-dependent hyperglycemia. Recovery times were similar for eugenol and menthol, but concentration-dependent for lidocaine. Eugenol and menthol were deemed safe and satisfactory for glucose analysis in zebrafish research, while lidocaine could introduce biases and safety concerns. Researchers should carefully consider the selection of anesthetics for reliable results in zebrafish assessments.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaoxue Li, Tangsong Feng, Weiqun Lu
Summary: This study reveals that exposure to VPA induces ASD-like phenotypes and behaviors, including gene transcription changes, social interaction deficit, decreased aggression, increased anxiety behavior, and elevated cortisol levels. The aggression behavior assay is a better predictor of neurotoxicology behavior of VPA.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: In this study, we investigated the hepatotoxicity and mechanism of action of pyridaben using zebrafish and ZFL cells. Pyridaben caused liver size reduction and apoptosis, and these effects were associated with uncontrolled intracellular calcium flow and downregulation of the PI3K/Akt signaling cascade.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Md Alamgir Kabir, Md. Golam Rabbane, Marco R. Hernandez, Md Aftab Ali Shaikh, Mohammad Moniruzzaman, Xuexiu Chang
Summary: This study investigated the toxicity of high concentrations of cadmium (Cd) on intestinal immunity and microbial diversity in common carp. The results showed that high Cd concentration caused intestinal inflammation, immunosuppression, and changes in the gut microbiome, leading to detrimental effects on the intestinal homeostasis and health status of the fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Anuradha Batabyal, Veronica Rivi, Cristina Benatti, Johanna M. C. Blom, Fabio Tascedda, Ken Lukowiak
Summary: This study found that exposure to heat shock stressors and bacterial lipopolysaccharide can induce the Garcia effect in pond snails. Additionally, aspirin can prevent the formation of the Garcia effect. However, unexpectedly, exposure to crushed aspirin and heat shock stressors together leads to long-lasting feeding suppression and molecular changes in the snails' serotoninergic system and neuroplasticity genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Li-Yih Lin, Chieh-An Cheng, Sian-Tai Liu, Jiun-Lin Horng
Summary: This study reveals that ammonia exposure impairs ion regulation in zebrafish embryos by inducing oxidative stress, mitochondrial dysfunction, and cell death. The findings suggest that ammonia is toxic to aquatic animals and can lead to the death of embryos.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Antonio Durate Pagano, Natieli Machado Goncalves, William Borges Domingues, Tony Leandro Rezende da Silveira, Mateus Tavares Kutter, Antonio Sergio Varela Jr, Carine Dahl Corcini, Mariana Cavalcanti Nascimento, Luana Ferreira Viana dos Reis, Patricia Gomes Costa, Adalto Bianchini, Matheus Vieira Volcan, Mariana Harter Remia, Vinicius Farias Campos
Summary: This study analyzed the toxic effects of Roundup Transorb (R) on the endangered Neotropical annual killifish Austrolebias charrua by evaluating molecular and biochemical biomarkers. The findings showed that exposure to Roundup significantly increased the production of reactive oxygen species, lipid peroxidation, and DNA damage in the fish's blood cells. It also decreased membrane fluidity. Gene expression analysis revealed alterations in genes associated with oxidative stress and antioxidant defense. This study provides new insights into adaptive mechanisms of A. charrua in response to Roundup, and it has important implications for environmental monitoring and aquatic toxicology assessment.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaochan Gao, Hongtao Ren, Yong Huang, Yimin Li, Jiaqi Shen
Summary: The influence of multi-walled carbon nanotubes (MWCNTs) on the toxicity of zinc oxide nanoparticles (ZnONPs) in the intestine of common carp was investigated. The study found that the concentration and concentration ratio of the mixture played a role in the toxicity of ZnONPs. The presence of MWCNTs significantly decreased intercellular zinc accumulation and altered the microbial community diversity and composition of the gut microbiota.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Guangchao Yang, Qian Yang, Trust Beta, Qin Liu, Zhenzhu Zhu, Fei Shen
Summary: The study found that black garlic MLDs have alleviative effects on ZEN-induced toxicity, and exert their effects through antioxidative, anti-apoptotic, and inhibitory mechanisms on ZEN absorption.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tuul Sepp, Ciara Baines, Randel Kreitsberg, Joern Peter Scharsack, Pedro Nogueira, Thomas Lang, Jerome Fort, Elin Sild, John T. Clarke, Arvo Tuvikene, Richard Meitern
Summary: Environmental factors can cause cancer in both wild animals and humans. The use of polluted habitats provides opportunities to study cancer defense mechanisms, which can be influenced by genetic variation and natural selection. Flatfish species, specifically flounders, show higher resistance to pollution-induced cancer compared to dabs, with elevated pollutant metabolism and stronger tumor suppression mechanisms in their liver tissue. This suggests a potential hormetic upregulation of tumor suppression or stronger natural selection pressure for cancer resistance in flounders. Wild species offer valuable insights into understanding the nature and evolution of natural cancer defense mechanisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Regan A. Moss, Kaitlyn M. Murphy, Steven T. Gardner, Madison M. Watkins, John W. Finger Finger Jr, Meghan D. Kelley, Ruth M. Elsey, Daniel A. Warner, Mary T. Mendonca
Summary: The study explored the impact of environmentally relevant concentrations of E2 on the immune system and hormone levels of hatchling American alligators. Results showed that exposure to environmental estrogen can alter plasma hormone concentrations but have little to no impact on morphology and immune responses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ye Liang, Zihao Li, Jing Yuan, Yiwen Zhou, Meng Li, Haifeng Gu
Summary: This study investigated the toxicity mechanism of homo-YTX and NH3-N on the survival of abalone. The results showed that homo-YTX and NH3-N enhanced oxidative stress and lipid peroxidation reactions, inhibited energy supply, disrupted metabolic and immune physiological functions, and activated apoptosis in the gills of abalone.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)