Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 169, Issue -, Pages 289-297Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2018.05.024
Keywords
PLGA-PEG/LA nanoparticles; As2O3; Surface modification; Drug delivery; Liver cancer
Funding
- National Natural Science Foundation of China [21201149]
- Natural Science Foundation of Jiangsu Province [BK2012259]
- Project of the Testing Center of Yangzhou University (China)
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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As2O3-loaded nanoparticles (NPs) based on poly (lactic-co-glycolic acid) (PLGA) were prepared by double emulsion-solvent evaporation method. Then Lactose acid (LA) and/or PEG were modified onto the NPs by chemical covalent coupling through -NH2 and -COOH. The FTIR results showed that LA and PEG could be successfully modified onto the surface of the NPs. All the As2O3-loaded PLGA NPs (As2O3@PLGA NPs) presented suitable physical stability, favorable size, and spherical shape. The in vitro release rate of As2O3 from the NPs depended on the surface of the NPs. As expected, the As2O3@PLGA-PEG/LA NPs showed a moderate release rate, the highest anticancer effects and cellular internalization against SMMC-7721 cell line. The PLGA-PEG/LA NPs could represent an effective nano-size delivery system of As2O3 for treatment of liver cancer.
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