Article
Cardiac & Cardiovascular Systems
Quanwei He, Hongxiu Guo, Rentang Bi, Shaoli Chen, Jing Shen, Chunnan Long, Man Li, Yuanpeng Xia, Lei Zhang, Zhou Sun, Xiaolu Chen, Zhaowei Wang, Daokai Gong, Jingwen Xu, Dondya Zhu, Yan Wan, Bo Hu
Summary: The study developed a new scoring tool (SIGNALS score) for predicting the risk of in-hospital neurological deterioration in patients with intracerebral hemorrhage.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Critical Care Medicine
David Lin, Michael Minyetty, Magdy Selim, Sarah Marchina, Filipa Carvalho, Elizabeth Heistand, Gogia Bhanu, Saad Hasan, Sandeep Kumar
Summary: The study externally validated the GRAVo score for predicting PEG tube placement after intracerebral hemorrhages (ICH) and found that it was valid but less accurate compared to the derivation cohort. The inclusion of race as a variable did not significantly affect the model's performance.
NEUROCRITICAL CARE
(2022)
Article
Clinical Neurology
Yanan Wang, Junfeng Liu, Qian Wu, Yajun Cheng, Ming Liu
Summary: This study validated and compared different prediction models for symptomatic intracerebral hemorrhage (sICH) after thrombolysis. MSS and GRASPS models showed good discrimination and calibration for predicting sICH and parenchymal hematoma (PH).
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
David Rodriguez-Luna, Olalla Pancorbo, Pilar Coscojuela, Prudencio Lozano, Federica Rizzo, Marta Olive-Gadea, Manuel Requena, Alvaro Garcia-Tornel, Noelia Rodriguez-Villatoro, Jesus M. Juega, Sandra Boned, Marian Muchada, Jorge Pagola, Marta Rubiera, Marc Ribo, Alejandro Tomasello, Carlos A. Molina
Summary: This study aims to derive and validate scores for predicting intracerebral hemorrhage (ICH) expansion using non-contrast CT (NCCT), single-phase CTA, or multiphase CTA markers. The study found that single-phase and multiphase CTA markers have higher discrimination for predicting substantial hematoma expansion compared to NCCT markers. The three scores showed good calibration in both derivation and validation cohorts.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Shen Wang, Xuxu Xu, Qiang Yu, Haicheng Hu, Chao Han, Ruhai Wang
Summary: This study aimed to evaluate the relationship between modified Graeb Score (mGS) at admission and clinical outcomes of spontaneous intracerebral hemorrhage (sICH), and investigate if combining ICH score could improve outcome prediction accuracy. The results showed that mGS was an independent risk factor for poor outcome and combining ICH score with mGS improved the ability to predict postoperative outcome.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Jawed Nawabi, Tobias Orth, Sophia Schulze-Weddige, Georg Lukas Baumgaertner, Anna Tietze, Christian Thaler, Tobias Penzkofer
Summary: Neoplastic intracerebral hemorrhage (ICH) can be distinguished from non-neoplastic ICH using relative perihematomal edema (relPHE) on computed tomography (CT) imaging. This study aims to evaluate the discriminatory power of relPHE in an independent cohort.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Sae-Yeon Won, Johannes Walter, Silvia Hernandez-Duran, Obada T. Alhalabi, Bedjan Behmanesh, Joshua D. Bernstock, Marcus Czabanka, Nazife Dinc, Daniel Dubinski, Charlotte Flueh, Thomas M. Freiman, Anne S. Grosch, Eva Herrmann, Young Sill Kang, Juergen Konczalla, Andreas Kramer, Felix Lehmann, Johannes Lemcke, Ruzanna Melkonian, Dorothee Mielke, Lukas Mueller, Florian Ringel, Veit Rohde, Matthias Schneider, Christian Senft, Patrick Schuss, Merih Oznur Turgut, Michael Synowitz, Joana M. Ullmann, Hartmut Vatter, Klaus Zweckberger, Fatma Kilinc, Florian Gessler
Summary: This study aims to validate the ICH and ICH-GS scores in patients with cerebellar hemorrhage and compare the outcomes of surgical management with conservative treatment. The results showed that both ICH and ICH-GS scores have good prognostic accuracy for overall mortality and functional outcomes. Surgical management was beneficial for patients with severe cerebellar hemorrhages, indicated by high ICH scores, while conservative treatment was reasonable for patients with lower ICH scores. Therefore, ICH and ICH-GS scores are useful tools for predicting survival and outcome in cerebellar ICH patients.
Article
Neurosciences
Jianyu Zou, Huihuang Chen, Cuiqing Liu, Zhenbin Cai, Jie Yang, Yunlong Zhang, Shaojin Li, Hongsheng Lin, Minghui Tan
Summary: This study identified independent risk factors for 30-day mortality of ICH patients and constructed a predictive nomogram model, which may help to improve the prognosis of ICH patients. The nomogram exhibited good discrimination in predicting the 30-day mortality risk, outperforming other scoring systems such as SAPSII and OASIS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Wenlin Chen, Chuxiang Lei, Yuekun Wang, Dan Guo, Sumei Zhang, Xiaoxi Wang, Zixin Zhang, Yu Wang, Wenbin Ma
Summary: In this study, ferroptosis-related genes associated with glioblastoma (GBM) were identified and a risk score model was constructed based on these genes. The model showed a significant difference in overall survival between high- and low-risk groups, suggesting its potential as a prognostic tool for GBM patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Craig I. Coleman, Mauricio Concha, Bruce Koch, Belinda Lovelace, Mary J. Christoph, Alexander T. Cohen
Summary: The aim of this study was to develop a composite score for predicting functional outcome post-intracerebral hemorrhage (ICeH) using proxy measures that can be assessed retrospectively. Data from the ERICH study were analyzed to derive the SAVED(2) score and its discriminative ability was measured using the area under the curve (AUC). External validation was performed in the ATACH-2 trial. The SAVED(2) score showed good predictive ability for unfavorable 90-day modified Rankin scale (mRS) score in ICeH patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Steven D. Shapiro, Miryam Alkayyali, Alexandra Reynolds, Kaitlin Reilly, Magdy Selim, Neha Dangayach, J. Mocco, Christopher P. Kellner, John W. Liang
Summary: This study suggests that minimally invasive hematoma evacuation with the SCUBA technique for ICH may reduce predicted 30-day mortality, with a number needed to treat of 4 to prevent 1 mortality.
WORLD NEUROSURGERY
(2022)
Review
Medicine, General & Internal
Xin-Ni Lv, Zuo-Qiao Li, Qi Li
Summary: Intracerebral hemorrhage is a dangerous subtype of stroke with high rates of morbidity and mortality. Targeting prevention of hematoma growth and perihematomal edema expansion shows promise as a therapeutic approach. Blood-based biomarkers are being studied as potential diagnostic, predictive, and prognostic markers due to their accessibility and acceptance in clinical practice. Validation studies are needed to determine the usefulness of these biomarkers in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Jiawen Li, Dong Luo, Feifei Peng, Qi Kong, Huawei Liu, Meiyuan Chen, Lusha Tong, Feng Gao
Summary: The novel ANAID-ICH nomogram, incorporating age, NIHSS score, anemia, infratentorial location, presence of DWILs, and prior ICH, may facilitate the identification of patients at higher risk for an unfavorable outcome.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
William A. Bird, Philipp Hendrix, Christian Bohan, Oded Goren, Clemens M. Schirmer, Christoph J. Griessenauer
Summary: The study conducted the first external validation of the R2eD AVM scoring system, demonstrating acceptable external validity in predicting the risk of hemorrhagic presentation in brain AVMs.
Article
Clinical Neurology
Edward R. Bader, Tiberiu A. Pana, Raphae S. Barlas, Anthony K. Metcalf, John F. Potter, Phyo K. Myint
Summary: This study investigates the association between admission inflammatory biomarkers and adverse outcomes in spontaneous intracerebral hemorrhage (ICH) using a stroke register in the United Kingdom. The results show that elevated inflammatory biomarkers are associated with poor outcomes in ICH, highlighting the importance of inflammation in this condition.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Xiaochuan Huo, Gaoting Ma, Xuelei Zhang, Yuesong Pan, Xu Tong, Dapeng Sun, Liping Liu, Yilong Wang, David S. Liebeskind, Yongjun Wang, Vitor Mendes Pereira, Zeguang Ren, Zhongrong Miao
Summary: This article presents the design of a clinical trial investigating the effect of endovascular therapy on neurological functional outcomes in patients with large infarct core.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Clinical Neurology
Yueyang Wu, Xiaomeng Yang, Jing Jing, Xia Meng, Zixiao Li, Yuesong Pan, Yong Jiang, Hongyi Yan, Xinying Huang, Liping Liu, Xingquan Zhao, Yilong Wang, Hao Li, Yongjun Wang
Summary: This study found that atrial cardiopathy markers, especially PTFV1 and aIAB, are significantly associated with a higher risk of poor prognosis in patients with ischemic stroke.
EUROPEAN STROKE JOURNAL
(2023)
Article
Clinical Neurology
Jing Jing, Xuewei Xie, S. Claiborne Johnston, Philip M. Bath, Zixiao Li, Xingquan Zhao, Liping Liu, Yilong Wang, Qin Xu, Anxin Wang, Yong Jiang, Hao Li, Xia Meng, Yongjun Wang
Summary: This study investigates whether ticagrelor/aspirin can further reduce the risk of stroke recurrence in patients with positive diffusion-weighted imaging (DWI) compared to clopidogrel/aspirin. The results show that ticagrelor/aspirin is associated with a lower risk of stroke in patients with positive DWI compared to clopidogrel/aspirin. Therefore, imaging evaluation should be emphasized in future clinical research and practice to target the best candidates for genotype-guided dual antiplatelet therapy.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Yue Suo, Yuesong Pan, Weiqi Chen, Jing Jing, Hongyi Yan, Hao Li, Liping Liu, Xingquan Zhao, Yilong Wang, Xia Meng, Yongjun Wang
Summary: This study aimed to evaluate the impact of aminotransferase levels on the safety and efficacy of dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack. The results showed that mild elevation of aminotransferase levels did not undermine the protective efficacy of dual antiplatelet treatment in reducing recurrent stroke or TIA, indicating its safety and effectiveness in these patients.
CEREBROVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Jing Jing, Chang Liu, Wanlin Zhu, Yuesong Pan, Jiyang Jiang, Xueli Cai, Zhe Zhang, Zixiao Li, Yijun Zhou, Xia Meng, Jian Cheng, Yilong Wang, Hao Li, Yong Jiang, Huaguang Zheng, Suying Wang, Haijun Niu, Wei Wen, Perminder S. Sachdev, Tiemin Wei, Tao Liu, Yongjun Wang
Summary: This study investigated the impact of brain structure and function on cognitive function in individuals with diabetes, especially type 2 diabetes. The results showed that compared to individuals with normal glucose metabolism, those with type 2 diabetes had smaller brain volume in various regions and stronger functional connectivity between the bilateral thalamus and brain networks. Additionally, individuals with prediabetes had smaller brain volume in specific regions and stronger functional connectivity between the right thalamus and visual network. Cognitive function was associated with larger thalamus volume and lower functional connectivity with the visual network.
Article
Clinical Neurology
Hong-Qiu Gu, Chun-Juan Wang, Xin-Miao Zhang, Yong Jiang, Hao Li, Xia Meng, Xin Yang, Li-Ping Liu, Xing-Quan Zhao, Yi-Long Wang, Yong-Jun Wang, Zi-Xiao Li
Summary: This study conducted a nationwide survey in China from 2005 to 2015, aiming to assess the 10-year trends in sex differences in cardiovascular risk factors, in-hospital management, and outcomes among ischemic stroke patients. The results showed that women with ischemic stroke had different risk factors and treatment outcomes compared to men.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Yongjun Wang, Jiejie Li, S. Claiborne Johnston, Graeme J. Hankey, J. Donald Easton, Xia Meng, Fu-Dong Shi, Yilong Wang, Xingquan Zhao, Zixiao Li, Liping Liu, Hongqiu Gu, Yong Jiang, Anxin Wang, Yuesong Pan, Jing Jing, Siying Niu, Hao Li
Summary: The CHANCE-3 study is a randomized, double-blind, placebo-controlled multicenter trial that aims to investigate the efficacy of colchicine therapy in patients with acute minor-to-moderate ischemic stroke or transient ischemic attack. The study will randomly assign 8,238 patients with high-sensitivity CRP level of >= 2 mg/L to receive colchicine or placebo, in addition to optimal medical therapy. The primary outcome is the occurrence of any stroke within 3 months of randomization, with a goal of detecting a 25% reduction in the colchicine group.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Endocrinology & Metabolism
Yu Tian, Dongxiao Yao, Aoming Jin, Mengxing Wang, Yuesong Pan, Yongjun Wang, Yilong Wang
Summary: This study used 2-sample Mendelian randomization analysis to investigate the causal relationship between thyroid function and the risk of cerebral small vessel disease (CSVD). The results showed that genetically predicted increase in thyrotropin (TSH) was associated with increased white matter microstructural injury, while genetically predicted increase in free thyroxine (FT4) was associated with increased white matter integrity. There were no significant causal relationships of hypothyroidism or hyperthyroidism with CSVD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Neuroimaging
Yuesong Pan, Xiaochuan Huo, Aoming Jin, Thanh N. Nguyen, Gaoting Ma, Xu Tong, Xuelei Zhang, Feng Gao, Ning Ma, Dapeng Mo, Zeguang Ren, Yongjun Wang, Zhongrong Miao
Summary: Endovascular therapy for acute ischemic stroke with large infarction may be cost-effective in China. The study evaluated the cost-effectiveness of endovascular therapy for this condition and found that it was cost-effective compared to medical management alone, starting from the fourth year and throughout the lifetime.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Yuesong Pan, Xia Meng, Baoshi Yuan, S. Claiborne Johnston, Hao Li, Philip M. Bath, Qiang Dong, Anding Xu, Jing Jing, Jinxi Lin, Yong Jiang, Xuewei Xie, Aoming Jin, Yue Suo, Hongqin Yang, Yefang Feng, Yanhua Zhou, Qing Liu, Xueli Li, Bin Liu, Hui Zhu, Jinguo Zhao, Xuerong Huang, Haitao Li, Yunyun Xiong, Zixiao Li, Yilong Wang, Xingquan Zhao, Liping Liu, Yongjun Wang
Summary: This study compared indobufen with aspirin in reducing the risk of recurrent stroke in patients with moderate-to-severe ischemic stroke. The results showed that indobufen was not non-inferior to aspirin in reducing the risk of recurrent stroke at 90 days. Additionally, there was no significant difference in the risk of moderate or severe bleeding between the two drugs. Therefore, the findings do not support the use of indobufen for secondary stroke prevention in patients with moderate-to-severe ischemic stroke.
Article
Clinical Neurology
Yu Tian, Mengxing Wang, Yuesong Pan, Xia Meng, Xingquan Zhao, Liping Liu, Yongjun Wang, Yilong Wang
Summary: This study examined whether enlarged perivascular spaces (EPVS) can predict adverse clinical outcomes in patients with acute ischaemic stroke (AIS) or transient ischaemic attack (TIA). The results showed that BG-EPVS was associated with a decreased risk of recurrent ischaemic stroke but an increased risk of haemorrhagic stroke, while CSO-EPVS was associated with a decreased risk of disability and all-cause death. Both BG-EPVS and CSO-EPVS were also associated with a decreased risk of subsequent ischaemic stroke in patients with small arterial occlusion (SAO). These findings suggest that EPVS may have important clinical implications in the diagnosis and treatment of stroke patients.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Clinical Neurology
Yaning Xu, Chengchun Liu, Wei Li, Ximing Nie, Shuhan Huang, Xiaoshu Li, Ya Wu, Wang-Sheng Jin, Jiaojin Jiang, Jun Dong, Yi Yang, Zhiqiang Sun, Wenjun Han, Yanjiang Wang, Liping Liu, Meng Zhang
Summary: This study aimed to evaluate the effect of early anticoagulation after successful recanalisation in acute ischaemic stroke (AIS) patients with atrial fibrillation. The results showed that early anticoagulation can improve functional outcomes without increasing the risk of intracranial haemorrhages.
STROKE AND VASCULAR NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
David Wang, Christopher Leo, Liping Liu, Li Huang, Lisa Huang, Yun Lu
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Clinical Neurology
Xuan Sun, Ming Yang, Dapeng Sun, Guangge Peng, Yiming Deng, Xingquan Zhao, Liping Liu, Ning Ma, Feng Gao, Dapeng Mo, Wengui Yu, Yongjun Wang, Yilong Wang, Zhongrong Miao
Summary: This study is a randomised controlled trial comparing the efficacy and safety of balloon angioplasty plus aggressive medical management (AMM) to AMM alone for symptomatic intracranial artery stenosis (sICAS). The study design is a multicentre, prospective, open-label, blinded end-point trial named BASIS, aiming to investigate whether balloon angioplasty plus AMM can improve clinical outcome compared with AMM alone in sICAS patients.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Clinical Neurology
Xiaoling Liao, Shuo Feng, Yicong Wang, Yuesong Pan, Weiqi Chen, Hui Qu, Xingquan Zhao, Liping Liu, Yongjun Wang, Yilong Wang
Summary: The ongoing STRATEGY trial in China aims to compare the effectiveness and safety of tirofiban combined with aspirin versus placebo combined with aspirin in reducing the risk of recurrence and early neurological deterioration in patients with perforating artery territorial infarction caused by branch atheromatous disease.
STROKE AND VASCULAR NEUROLOGY
(2023)