Article
Pharmacology & Pharmacy
J. David Smeijer, Jeroen Koomen, Donald E. Kohan, John J. McMurray, George L. Bakris, Ricardo Correa-Rotter, Fan-Fan Hou, Dalane W. Kitzman, Hirofumi Makino, Gert Mayer, Michal Nowicki, Vlado Perkovic, Peter Rossing, Sheldon Tobe, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J. L. Heerspink
Summary: The study investigates the influence of genetic polymorphisms on the plasma exposure and pharmacodynamic effects of atrasentan, an endothelin receptor antagonist. The results show that two SNPs in the SLCO1B1 gene have the strongest association with atrasentan plasma exposure. Patients with different SLCO1B1 genotypes exhibit varying efficacy and safety outcomes when treated with atrasentan.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Yukihisa Suzuki, Motohiro Kiyosawa
Summary: This study examined the relationship between diabetic retinopathy (DR) and systemic factors in 261 patients with type 2 diabetes. Logistic regression analyses revealed that the duration of diabetes, average and highest HbA1c levels, and grade of diabetic nephropathy (DN) significantly correlated with the development of DR. Additionally, the severity of DR was significantly correlated with the duration of diabetes, average HbA1c level, and severity of DN. Logistic regression analyses also showed a significant correlation between the development of diabetic macular edema (DME) and the grade of DN. DN grade is associated with the development of DR and DME, and decreased renal function predicts the onset of DR.
Article
Pharmacology & Pharmacy
Mitsugi Ookawara, Yasunori Nio, Midori Yamasaki, Kanako Kuniyeda, Guido Hanauer, Kimio Tohyama, Masatoshi Hazama, Takanori Matsuo
Summary: The study identified compound A as a potent and selective PDE4 inhibitor with therapeutic potential for diabetic nephropathy. The compound showed significant effects on glycosylated hemoglobin and urinary albumin/creatinine ratio in DN mouse models, suggesting it may offer a new treatment option with anti-diabetic, anti-fibrotic, and anti-reactive oxygen species effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, Sarah Abdelaal Mohamed
Summary: This study aimed to evaluate the effects of oral omega-3 supplementation on pediatric patients with type 1 diabetes mellitus (T1DM) and diabetic nephropathy. The results demonstrated that omega-3 fatty acids significantly improved glycemic control, dyslipidemia, delayed disease progression, and subclinical atherosclerosis in these patients.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Jia-Lin Yuan, Le Sun, Bao-Lin Su, Chuang-Xiong Hong
Summary: This case presents a specific adverse drug reaction of corticosteroids that causes diabetes mellitus and subsequently leads to peripheral neuropathy in an acute onset. Mecobalamin and Acupuncture were employed and steroids were discontinued, 8 months later he recovered part of his strength and sensation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Medicinal
Yinbo Pan, Min Zhou, Zhenzhen Liu, Canhua Hao, Jingfang Zhai, Ren Liu, Zezhou Shi, Jie Sun, Xiaojing Wang
Summary: Daidzein analog SJ-6 showed favorable hypoglycemic effects, but its pharmacokinetic limitations led to the synthesis of prodrugs. Compound 10 exhibited superior anti-diabetic nephropathy activity and promising potential for prevention and treatment.
ARCHIV DER PHARMAZIE
(2023)
Article
Endocrinology & Metabolism
Xiajun Zhou, Ying Zhu, Ze Wang, Zhi Lin, Desheng Zhu, Chong Xie, Nigel A. Calcutt, Yangtai Guan
Summary: This study found that gabapentin treatment can restore rate-dependent depression in patients with painful diabetic peripheral neuropathy, and rate-dependent depression may be helpful in predicting the initial efficacy of gabapentin therapy.
Article
Pharmacology & Pharmacy
Sjoukje van der Hoek, Douwe J. Mulder, Antoon T. M. Willemsen, Ton Visser, Andre Heeres, Riemer H. J. A. Slart, Philip H. Elsinga, Hiddo J. L. Heerspink, Jasper Stevens
Summary: This study reveals a relationship among interindividual differences in plasma exposure, kidney tissue distribution, angiotensin-1 receptor occupancy, and urinary-albumin-to-creatinine ratio (UACR) response after telmisartan administration.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Jian-Bo Zhong, Yu-Feng Yao, Guo-Qiang Zeng, Yi Zhang, Bai-Kang Ye, Xiao-Yan Dou, Li Cai
Summary: Blood urea nitrogen (BUN) is positively associated with the probability of diabetic retinopathy (DR) in patients with type 2 diabetes, and this association is influenced by the duration of diabetes mellitus (DM). This study included 426 participants and found a significant positive relationship between BUN and the probability of DR (OR = 1.12; 95% CI 1.03-1.21; P = 0.0107). A test for interaction between DM duration and BUN on the probability of DR was also significant (P = 0.0295).
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Shalki Choudhary, Manoj Kumar, Om Silakari
Summary: This study evaluated the potential neuroprotective and nephroprotective effects of a series of mutual-prodrugs of epalrestat through computational simulations and in vivo experiments, with EP-G-MFA and EP-MFA exhibiting the most significant protective abilities against diabetic complications.
BIOORGANIC CHEMISTRY
(2021)
Article
Clinical Neurology
Charles S. Venuto, Luoying Yang, Monica Javidnia, David Oakes, D. James Surmeier, Tanya Simuni
Summary: Higher plasma exposure of isradipine did not affect clinical assessment measures of PD severity in this trial, but modestly decreased cumulative levodopa equivalent dose and shortened the time needed for initiation of antiparkinson treatment.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Genetics & Heredity
Samira Asadollahi, Morteza Hadizadeh, Nasim Namiranian, Seyed Mehdi Kalantar, Ali Dehghani Firoozabadi, Nastaran Injinari
Summary: This study found that the dysregulation of LINC01410, MAFB, and FOSL1 is associated with diabetic nephropathy (DN) and may serve as potential biomarkers. These findings provide new insights into the pathogenesis and diagnosis of DN.
Article
Endocrinology & Metabolism
Hongying Liu, Sheng Tan, Zhenyu Ma, Qingchun Gao, Weihong Yang
Summary: This study evaluated nerve conduction studies, sympathetic skin response, and microalbuminuria (MAU) as an indicator of diabetic nephropathy in patients with type 2 diabetes mellitus (T2DM). The results showed that sympathetic skin response was more sensitive than nerve conduction studies for the early diagnosis of diabetic peripheral neuropathy. Abnormal sympathetic skin response may serve as an indicator for early diabetic nephropathy. Additionally, diabetic peripheral neuropathy may occur earlier than diabetic nephropathy in the development of T2DM.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Veterinary Sciences
Carl Ekstrand, Helena Pettersson, Ronette Gehring, Mikael Hedeland, Sara Adolfsson, Inger Lilliehook
Summary: This study quantitatively characterized the concentration-effect relationship for prednisolone in dogs, showing pharmacokinetic parameters such as clearance rate, volume of distribution, and half-life, as well as pharmacodynamic parameters for neutrophil and lymphocyte trafficking, and cortisol suppression in this species. The effective concentrations of prednisolone on neutrophil, lymphocyte, and cortisol responses in dogs were determined to be 10, 22.5, and 0.04 ng/mL, respectively.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Ophthalmology
Chewang U. Bhutia, Prempal Kaur, Karamjit Singh, Sukhraj Kaur
Summary: This study investigated the correlation between serum inflammatory and metabolic biomarkers in patients with diabetic retinopathy (DR) and diabetic macular edema (DME). The results showed significant differences in the levels of IL-6 and CRP between patients with and without DR, with a positive correlation between IL-6 and CRP and the severity of DR. Only IL-6 was found to be significantly elevated in DR patients with DME compared to those without DME. None of the metabolic markers correlated significantly with DR and DME.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)