Article
Multidisciplinary Sciences
Akihiro Shiroshita, Keisuke Anan, Masafumi Takeshita, Yuki Kataoka
Summary: This study evaluated the impact of systemic steroid therapy on 30-day mortality in patients with pneumonic chronic obstructive pulmonary disease (COPD) exacerbation. The results showed that systemic steroid therapy initiated within two days of admission was associated with higher 30-day mortality rates.
Article
Medicine, General & Internal
Kulothungan Gunasekaran, Swetha Murthi, Kalaimani Elango, Mandeep Singh Rahi, Bright Thilagar, Sathishkumar Ramalingam, Dinesh Voruganti, Vijaya Kumar Paramasivam, Krishna Prasad Kolandaivel, Ashish Arora, Arul Chandran
Summary: Investigating the impact of diabetes on COPD patient outcomes during inpatient hospitalization revealed that patients with COPD and diabetes had longer hospital stays and higher risks of complications, but lower odds of mortality during hospitalization compared to COPD patients without diabetes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Emergency Medicine
Man -Ju Ting, Ya -Hui Tsai, Shih-Ping Chuang, Ping-Huai Wang, Shih-Lung Cheng
Summary: This study investigates the short-term association between PM2.5 concentration and emergency department visits among patients with acute exacerbation of COPD requiring mechanical ventilation. Results show that PM2.5 concentration has a significant impact on EDVs for AECOPD patients with acute respiratory failure, especially in the spring season.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Medicine, General & Internal
Kai Zhu, Jagdeep Gill, Ashley Kirkham, Joel Chen, Amy Ellis, Stephanie Crosbie, Holly Denson-Camp, Hannah Peters, Pat Camp
Summary: This study aims to assess the safety and efficacy of in-hospital pulmonary rehabilitation for patients with AECOPD during the acute phase through a systematic review with meta-analysis. Data will be recorded using the Population, Intervention, Comparator, Outcomes and Study characteristics framework, and the quality of evidence will be evaluated using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework. The results will be disseminated through peer-reviewed publications and research conferences.
Article
Medicine, General & Internal
Rohan Karkra, Chaya Sindaghatta Krishnarao, Jayaraj Biligere Siddaiah, Mahesh Padukudru Anand
Summary: COPD is a common and serious condition with significant global impact. Quick and affordable investigations are needed to predict mortality in patients with acute exacerbations, especially in low resource settings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Fu-Shun Yen, James Cheng-Chung Wei, Yu-Cih Yang, Chih-Cheng Hsu, Chii-Min Hwu
Summary: This study found that in patients with both T2DM and COPD, the use of TZD is associated with increased risks of cardiovascular events, ventilation use, pneumonia, and lung cancer. The study suggests that monitoring for cardiovascular and respiratory complications should be implemented when using TZD in these patients.
FRONTIERS IN MEDICINE
(2021)
Article
Physiology
Xiaoyan Gai, Chenglin Guo, Linlin Zhang, Lijiao Zhang, Mairipaiti Abulikemu, Juan Wang, Qingtao Zhou, Yahong Chen, Yongchang Sun, Chun Chang
Summary: The study found that during acute exacerbation of chronic obstructive pulmonary disease (AECOPD), specific glycerophospholipids were significantly reduced in expression. These glycerophospholipids were able to predict the acute exacerbation and recovery stages, particularly in the non-eosinophilic subtype. Abnormalities in glycerophospholipid metabolism may be associated with the onset of AECOPD.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Kuang-Ming Liao, Chung-Feng Liu, Chia-Jung Chen, Yu-Ting Shen
Summary: The study constructed prediction models for acute respiratory failure, ventilator dependence, and mortality in COPD patients after hospitalization using machine learning algorithms. The best models were built by XGBoost, random forest, and LightGBM algorithms, showcasing excellent predictive quality.
Article
Critical Care Medicine
Cedric Daubin, Francois Fournel, Fabrice Thiolliere, Fabrice Daviaud, Michel Ramakers, Andrea Polito, Bernard Flocard, Xavier Valette, Damien Du Cheyron, Nicolas Terzi, Muriel Fartoukh, Stephane Allouche, Jean-Jacques Parienti
Summary: Procalcitonin levels showed limited accuracy in predicting bacterial infection in severe AECOPD patients, despite higher levels in those with bacterial infection. PCT may not be reliable as a standalone marker for initiating antibiotic treatment in this population.
ANNALS OF INTENSIVE CARE
(2021)
Article
Medicine, General & Internal
Jun-Jun Wang, Zhong Zhou, Li-Ying Zhang
Summary: This study compared the effects and side effects of volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) in patients with acute COPD exacerbation. The results showed that PCV can lower peak airway pressures (PAPs) and reduce the incidence of barotrauma compared to VCV, without compromising clinical outcomes and oxygenation parameters.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Article
Multidisciplinary Sciences
Kentaro Hyodo, Hironori Masuko, Hisayuki Oshima, Rie Shigemasa, Haruna Kitazawa, Jun Kanazawa, Hiroaki Iijima, Hiroichi Ishikawa, Takahide Kodama, Akihiro Nomura, Katsunori Kagohashi, Hiroaki Satoh, Takefumi Saito, Tohru Sakamoto, Nobuyuki Hizawa
Summary: This study aimed to investigate the exacerbation-prone phenotypes beyond disease labels in asthma and COPD using shared risk factors and to examine the role of the IL4RA gene polymorphism related to type 2 inflammation. The results showed common exacerbation-prone endotypes in chronic inflammatory airway diseases, supporting the use of a treatable traits approach for prevention.
Article
Cell Biology
Haroon Arshad, Anastasios Siokis, Raimo Franke, Aamna Habib, Juan Carlos Lopez Alfonso, Yuliya Poliakova, Eva Luecke, Katina Michaelis, Mark Broenstrup, Michael Meyer-Hermann, Ursula Bilitewski, Jordi Vila, Laurent Abel, Thomas Illig, Jens Schreiber, Frank Pessler
Summary: Amino acid metabolism is dysregulated in both community-acquired pneumonia (CAP) and infection-triggered chronic obstructive pulmonary disease (COPD) exacerbation. Total amino acid concentrations, asparagine, and threonine show promise as plasma biomarkers for differentiating CAP from COPD exacerbation, while reduced tryptophan and histidine levels are accurate biomarkers for distinguishing acute CAP from healthy controls. The kynurenine/tryptophan ratio correlates with clinical recovery and resolution of inflammation.
Review
Respiratory System
Debora Petry Moecke, Kai Zhu, Jagdeep Gill, Shanjot Brar, Polina Petlitsyna, Ashley Kirkham, Mirha Girt, Joel Chen, Hannah Peters, Holly Denson-Camp, Stephanie Crosbie, Pat G. Camp
Summary: This review suggests that it is safe and effective to provide pulmonary rehabilitation (PR) during hospitalization for individuals with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In-hospital PR improves functional exercise capacity, quality of life, and lower limb strength without prolonging the hospital length of stay.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Review
Medicine, General & Internal
Shuo Xu, Zi Ye, Jianyong Ma, Taiwen Yuan
Summary: This meta-analysis study found that the presence of COPD in HF patients may increase the risk of all-cause mortality, but not cardiovascular mortality. Additionally, COPD was associated with increased risks of all-cause hospitalization and HF hospitalization in chronic HF patients. Further research is needed to confirm the findings related to hospitalization due to the limited studies included in this analysis.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Respiratory System
Sunmin Park, Sang Jun Lee, Beomsu Shin, Seok Jeong Lee, Sang-Ha Kim, Woo Cheol Kwon, Jihye Kim, Myoung Kyu Lee
BMC PULMONARY MEDICINE
(2020)
Article
Emergency Medicine
Jung Mo Ahn, Sung Oh Hwang, Jin Sil Moon, Seok Jeong Lee, Yong Sung Cha
JOURNAL OF EMERGENCY MEDICINE
(2020)
Article
Respiratory System
Sunmin Park, Beomsu Shin, Ji-Ho Lee, Seok Jeong Lee, Myoung Kyu Lee, Won-Yeon Lee, Suk Joong Yong, Sang-Ha Kim
JOURNAL OF THORACIC DISEASE
(2020)
Article
Critical Care Medicine
Sun Ju Kim, Stephen R. Thom, Hyun Kim, Sung Oh Hwang, Yoonsuk Lee, Eung Joo Park, Seok Jeong Lee, Yong Sung Cha
CRITICAL CARE MEDICINE
(2020)
Article
Multidisciplinary Sciences
Sae Byol Kim, Won-Yeon Lee, Ji-Ho Lee, Seok Jeong Lee, Myoung Kyu Lee, Sang-Ha Kim, Young Uh, Soon-Hee Jung, Beomsu Shin
Article
Respiratory System
Ji-Ho Lee, You Hyun Park, Dae Ryong Kang, Seok Jeong Lee, Myoung Kyu Lee, Sang-Ha Kim, Suk Joong Yong, Won-Yeon Lee
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2020)
Article
Respiratory System
Jae-Hwa Choi, Keun-Bae Jeong, You Hyun Park, Iseul Yu, Seok Jeong Lee, Myoung Kyu Lee, Sang-Ha Kim, Won-Yeon Lee, Suk Joong Yong, Ji-Ho Lee
Summary: This study investigated the risk of pneumonia in a population-based cohort according to the type of ICS. The results showed that fluticasone propionate users were more likely to develop pneumonia compared to budesonide users, and the risk of pneumonia increased with higher cumulative doses of ICS.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Multidisciplinary Sciences
Yoonki Hong, Sunmin Park, Myoung Kyu Lee
Summary: The presence of endobronchial metastatic lesion (EML) is associated with a poorer prognosis in patients with non-small cell lung cancer (NSCLC), particularly in those without detectable lesions on PET or CT scans. This study evaluated the progression-free survival (PFS) and overall survival (OS) in NSCLC patients with or without EML. The results showed that patients with EML had shorter median PFS and OS compared to those without EML. Additionally, EGFR mutation status, performance status, and pleural effusion were also significant factors affecting PFS in NSCLC patients.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Aishwarya Raja, Rishi K. Wadhera, Eunhee Choi, Siyan Chen, Changyu Shen, Jose F. F. Figueroa, Robert W. W. Yeh, Eric A. A. Secemsky
Summary: After reimbursement rates for outpatient peripheral vascular intervention were modified in 2008, providers increasingly performed these procedures in privately owned office-based clinics. This study compared the characteristics and outcomes of patients treated in office-based clinics and hospital-based centers and found that the two groups were similar in long-term outcomes.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Article
Peripheral Vascular Disease
Tali Elfassy, Charles A. German, Paul Muntner, Eunhee Choi, Gabriel Contreras, Daichi Shimbo, Eugene Yang
Summary: This study found that the association between blood pressure and cardiovascular disease mortality is sex-specific, with women having a higher risk of cardiovascular disease mortality at lower levels of systolic blood pressure compared to men.
Article
Peripheral Vascular Disease
Corey K. Bradley, Eunhee Choi, Marwah Abdalla, Hiroyuki Mizuno, Michael Lam, Maria Cepeda, Dona Sangapalaarachchi, Justin Liu, Paul Muntner, Kazuomi Kario, Anthony J. Viera, Joseph E. Schwartz, Daichi Shimbo
Summary: For most people, high home blood pressure can be identified or ruled out with a high degree of confidence within 3 days or less of monitoring.
Review
Cardiac & Cardiovascular Systems
Tariq Jamal Siddiqi, Muhammad Shariq Usman, Ahmed Mustafa Rashid, Syed Sarmad Javaid, Aymen Ahmed, Donald Clark III, John M. Flack, Daichi Shimbo, Eunhee Choi, Daniel W. Jones, Michael E. Hall
Summary: This study investigates the prevalence and types of hypertension-mediated organ damage in patients with hypertensive emergencies presenting to the emergency department. The findings reveal that the prevalence of hypertensive emergencies in the ED is 0.5%, with ischemic stroke and pulmonary edema/acute heart failure being the most common. The in-hospital mortality rate among patients with hypertensive emergency is 9.9%.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Respiratory System
Anica C. Law, Jennifer P. Stevens, Eunhee Choi, Changyu Shen, Anuj B. Mehta, Robert W. Yeh, Allan J. Walkey
Summary: This retrospective cohort study investigated the number of days alive and out of institution (DAOIs) and mortality after tracheostomy and gastrostomy placement in critically ill patients. The study found that patients who received these procedures had short DAOIs and high short- and long-term mortality. Pre-existing health states were associated with outcomes, with non-robust health states having worse outcomes compared to the robust state.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Medicine, General & Internal
Ji-Ho Lee, Jae-Hwa Choi, Keun-Bae Jeong, Seok Jeong Lee, Myoung Kyu Lee, Won-Yeon Lee, Suk Joong Yong, Sang-Ha Kim
Summary: This study aimed to investigate the safety and utility of rush immunotherapy (RIT) with aqueous allergens. The results showed that RIT with aqueous allergens reduced the build-up phase duration and frequency of hospital visits, while maintaining acceptable safety levels. Therefore, RIT with aqueous allergens may be suitable for a broad application to patients with respiratory allergies.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)