Article
Biochemistry & Molecular Biology
Siyu Wu, Concepcion Garcia-Rama, Lorenzo Romero-Ramirez, Johannes P. J. M. de Munter, Erik Ch Wolters, Boris W. Kramer, Jorg Mey
Summary: The study revealed that TUDCA did not have an additional effect in the treatment of spinal cord injury (SCI) and failed to improve treatment outcomes. Despite showing positive effects in promoting recovery of motor functions and improving autonomic bladder control, the benefits of TUDCA were only temporary.
Article
Biochemistry & Molecular Biology
Ke Wang, Yinshi Ren, Shuxian Lin, Yan Jing, Chi Ma, Jun Wang, X. Baozhi Yuan, Xianglong Han, Hu Zhao, Zheng Wang, Minghao Zheng, Yin Xiao, Lin Chen, Bjorn Reino Olsen, Jian Q. Feng
Summary: This study found that osteocytes, not osteoblasts, directly build mineralized bone structures, and that osteoblasts in Dmp1-null or Hyp mice produce aberrant and poorly mineralized bone. Additionally, the constitutive expression of beta-catenin in osteocytes can recapitulate a similar osteomalacia phenotype as seen in Dmp1 null or Hyp mice. Thus, the conclusion is that osteocytes directly build bone, challenging the existing dogma.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Ecology
Xiangcheng Mi, Zhenhua Sun, Yunfeng Song, Xiaojuan Liu, Jie Yang, Junjie Wu, Xiuqin Ci, Jie Li, Luxiang Lin, Min Cao, Keping Ma
Summary: The study finds that rare species tend to occupy the edges of functional and environmental niche space to avoid competition with common species. However, rare species exhibit similar or larger niche width than common species in functional space, contrasting with their narrower niche width in environmental space. This suggests that rare species may be less constrained in functional space and survive by being able to use a variety of resources.
FUNCTIONAL ECOLOGY
(2021)
Article
Immunology
Trang T. T. Nguyen, Zhi-En Wang, Lin Shen, Andrew Schroeder, Walter Eckalbar, Arthur Weiss
Summary: This research demonstrates that T cell anergy is established in the periphery, rather than in the thymus, and the maintenance of anergy requires antigen presentation via MHC-II. Cbl-b plays a crucial role in the establishment and maintenance of unresponsiveness in T cell anergy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Plant Sciences
Carlos Messina, Dan McDonald, Hanna Poffenbarger, Randy Clark, Andrea Salinas, Yinan Fang, Carla Gho, Tom Tang, Geoff Graham, Graeme L. Hammer, Mark Cooper
Summary: Research has shown that changes in root systems architecture and yield in maize breeding over the past few decades are not the cause of increased water uptake. Single cross hybrids have smaller root systems compared to double cross hybrids, but they exhibit higher yield and yield components, possibly as an adaptation to modern high-density planting conditions.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Oncology
Hanno S. Meyer, Arthur Wagner, Alessandra Raufer, Ann-Kathrin Joerger, Jens Gempt, Bernhard Meyer
Summary: The timing of surgery is significantly correlated with neurological recovery in patients with acute spinal cord injury caused by metastatic compression. Early surgery can substantially increase the chance of neurological improvement without increasing complication rates.
Article
Immunology
Ana Raquel Maceiras, Diogo Silverio, Rute Goncalves, Marcos S. Cardoso, Margarida Saraiva
Summary: During infection, bone marrow hematopoiesis is reprogrammed to produce myeloid cells, a mechanism called emergency myelopoiesis. However, studies using the mouse model of infection and laboratory reference strain M. tuberculosis H37Rv have shown limited emergency myelopoiesis and trained immunity. This study used a hypervirulent M. tuberculosis isolate HN878 to infect mice and found increased frequencies of LSK cells and the GMP population, as well as an increase in monocytes and neutrophils in the blood and lung. However, there was no trained immunity observed in the bone marrow.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Veterinary Sciences
A. Ripplinger, M. R. Wrzesinki, J. S. Rauber, M. L. Schwab, D. A. Ferrarin, R. Baumhardt, G. Aiello, D. V. Beckmann, A. Mazzanti
Summary: This prospective study investigated the functional recovery of surgically treated dogs with thoracolumbar intervertebral disc extrusion (IVDE) without deep pain perception (DPP) for > 96 h. The study found that 61.1% of dogs recovered satisfactory motor function after surgery, with 47.2% having DPP and 13.9% without DPP. The time taken to regain pain perception was associated with the length of recovery time, with a median recovery time of 30 days.
VETERINARY JOURNAL
(2023)
Article
Orthopedics
D. Ian English, William B. Lea, David M. King, Sean M. Tutton, John C. Neilson
Summary: Minimally invasive osteoplasty and screw fixation with or without ablation for periacetabular metastatic bone disease provide pain relief and functional improvement with reduced complications. Outpatient procedures and decreased narcotic usage were observed in the majority of cases, with overall positive outcomes and no surgery-related deaths recorded.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ayisha Al Busaidi, Emma Gangemi, Stephen Wastling, Aaike S. van den Berg, Laura Mancini, Tarek Yousry
Summary: This retrospective study investigates the correlation between functional and structural lateralisation in language pathways. The results indicate that tractography is not suitable for assessing language lateralisation. The discordant results suggest that either the structural lateralisation is less robust than functional lateralisation, or tractography is not sensitive enough.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, Research & Experimental
Saadet Inan, Xiaohong Chen, Eric M. Eisenstein, Joseph J. Meissler, Ellen B. Geller, Christopher Tallarida, Mia Watson, Menahem Doura, James E. Barrett, Alan Cowan, Scott M. Rawls, Martin W. Adler, Toby K. Eisenstein
Summary: The study demonstrated that combining chemokine receptor antagonists with sub-analgesic doses of morphine increased analgesic potency without exacerbating respiratory depression. This drug combination strategy allows for maximal pain relief with reduced opioid doses.
Article
Neurosciences
Hui Ji, Kelly Payette, Anna Speckert, Ruth Tuura, Patrice Grehten, Raimund Kottke, Nicole Ochseinbein-Koelble, Cornelia Hagmann, Luca Mazzone, Martin Meuli, Beth Padden, Annette Hackenberg, David-Alexander Wille, Ueli Moehrlen, Beatrice Latal, Andras Jakab
Summary: The study examined the associations between thalamocortical connectivity topography, neurological function, and developmental outcomes in newborns with open spina bifida who underwent prenatal surgical repair. The findings suggest that altered thalamocortical circuitry development may contribute to impaired lower extremity function in open spina bifida.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ling Wang, Sidong Li, Yandong Liu, Kai Li, Lu Yin, Yongbin Su, Zhe Guo, Li Xu, Pengju Huang, Jian Geng, Wenshuang Zhang, Kangkang Ma, Kebin Cheng, Dong Yan, Glen M. Blake, Bo He, Yajun Liu, Xiaoguang Cheng
Summary: Increased bone marrow fat is associated with lower vBMD in both sexes. However, the relationship between marrow fat and other adipose tissues with vertebral fractures is not significant after adjusting for age.
EUROPEAN RADIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xu Chu, Hongjun Zhuang, Yanyan Liu, Jinjin Li, Ya Wang, Yaqin Jiang, Huilin Zhang, Peiran Zhao, Yang Chen, Xingwu Jiang, Yelin Wu, Wenbo Bu
Summary: The interaction between tumors and neurons can promote the rapid growth of both, offering new therapeutic targets for cancer treatment. The study proposes a strategy for blocking nerve-cancer crosstalk using Mg/Al layered-double-hydroxide nanoshells and alendronate in the treatment of metastatic bone cancer pain.
ADVANCED MATERIALS
(2022)
Article
Cell Biology
Abhishek Chandra, Anthony B. Lagnado, Joshua N. Farr, Madison Doolittle, Tamara Tchkonia, James L. Kirkland, Nathan K. LeBrasseur, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Joao F. Passos, David G. Monroe, Robert J. Pignolo, Sundeep Khosla
Summary: This study demonstrates that cellular senescence-driven radiation-induced osteoporosis is primarily mediated by p21(Cip1) rather than p16(Ink4a), based on the clearance of senescent cells using genetic models. This approach may be used to investigate the contributions of these pathways in other senescence-associated conditions, including aging across tissues.
