Review
Dentistry, Oral Surgery & Medicine
Jonathan Meza-Mauricio, Camila Pinheiro Furquim, Antonella Geldres, Gerardo Mendoza-Azpur, Belen Retamal-Valdes, Vittorio Moraschini, Marcelo Faveri
Summary: The systematic review found that PRF membrane can improve wound healing, reduce postoperative pain, and enhance control of postoperative bleeding in the palatal area. However, due to the limited number of included RCTs and high heterogeneity among PRF protocols, the results should be interpreted with caution.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Medicine, Research & Experimental
Mohammed Albahrawy, Marwa Abass, Esam Mosbah, Gamal Karrouf, Walaa Awadin, Adel Zaghloul
Summary: This study investigated the regenerative efficacy of leukocyte platelet-rich fibrin (L-PRF) on colon anastomotic healing in rabbits. The results showed that L-PRF can enhance collagen deposition, promote re-epithelialization of the mucosa, stimulate angiogenesis, reduce adhesions, and diminish the degree of stenosis. Therefore, it has potential as a promising aid in healing bowel anastomoses.
Article
Veterinary Sciences
Anamika Changrani-Rastogi, Krutika Swadi, Mitali Barve, Niyati Bajekal
Summary: This study evaluated the effect of autologous platelet-rich fibrin (PRF) in the management of feline cutaneous wounds. The results showed that PRF could serve as a low-risk and convenient adjunctive therapy to promote wound healing in cats.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Dermatology
Tian Long, Changkai Li, Fan Xu, Junwen Xiao
Summary: This meta-analysis aimed to evaluate the role of platelet-rich fibrin (PRF) in promoting surgical site wound healing and reducing scar formation following oral carcinoma resection. The findings showed that PRF significantly improves wound healing and reduces scar formation, suggesting its potential therapeutic value in post oral carcinoma resection.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Bianca Nausica Petrescu, Ioana Codruta Mirica, Richard Miron, Radu Septimiu Campian, Ondine Lucaciu
Summary: PRF is a low-cost regenerative modality that can potentially improve wound healing, reduce post-operative pain, and minimize the risk of infection, making it a promising option in soft tissue regeneration.
JOURNAL OF DENTAL SCIENCES
(2021)
Article
Engineering, Biomedical
Sadaf Mukhtar, Vivek Kumar Bains, Chetan Chandra, Ruchi Srivastava
Summary: This study evaluated the effectiveness of platelet-rich fibrin (PRF) and low-level laser therapy (LLLT) on donor site healing after vascularized interpositional periosteal connective tissue (VIP-CT) flap. The results showed that both LLLT and PRF can effectively improve tissue thickness, consistency, color, and contour, reduce pain and burning sensation, and improve patient comfort.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Dermatology
Fatma Bilgen, Alper Ural, Mehmet Bekerecioglu
Summary: Platelet-rich fibrin (PRF) shows beneficial effects on chronic ulcers, offering a safe, practical, and cost-effective treatment option for wound closure.
JOURNAL OF TISSUE VIABILITY
(2021)
Article
Critical Care Medicine
Jose Maria Garcia-Sanchez, Vicente Mirabet Lis, Alejandro Ruiz-Valls, Aranzazu Perez-Plaza, Pilar Sepulveda Sanchis, Maria Dolores Perez-del-Caz
Summary: This study compared the therapeutic effects of hydrocolloid dressing, platelet rich plasma (PRP), and plasma rich in growth factors (PRGF) in the management of donor site morbidity in split thickness skin graft (STSG). The results showed that PRP and PRGF decreased the time to epithelialization and improved pain control and scar quality.
Article
Dermatology
Tahereh Haghparast-Kenarsari, Majid Abdouss, Saeed Heidari Keshel, Zoheir Heshmatipour, Azam Rahimi, Esmaeil Biazar
Summary: Tannic acid was used as a green cross-linker to improve the properties of platelet-rich fibrin (PRF). The results showed that increasing the cross-linker concentration led to changes in scaffold structure, decreased degradation rate, and increased mechanical strength. The cross-linked scaffolds exhibited good biocompatibility and antibacterial effect.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Cell Biology
Ivo van der Bijl, Dirk de Korte, Esther Middelkoop
Summary: The role of platelet-rich plasma (PRP) in burn and wound management is currently unclear due to high variation in product composition, mode, and timing of application. Further research and efforts are needed to address these issues and define the position of PRP in wound healing.
WOUND REPAIR AND REGENERATION
(2021)
Article
Medicine, General & Internal
Nida Riaz, Muhammad Ajmal, Muhammad Sheharyar Khan
Summary: The use of PRF during myringoplasty results in improved graft uptake, enhanced hearing, reduced infection rates, and decreased perforation sizes.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Orthopedics
Andre Luis Lugnani de Andrade, Amanda Veiga Sardeli, Thiago Alves Garcia, Bruno Livani, William Dias Belangero
Summary: In a meta-analysis of four studies involving 157 patients, it was found that applying PRP to the bone-patellar tendon-bone donor site can reduce knee pain within a year, but this effect diminishes over time and does not lead to improved functional knee scores.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Budhan Manasa, K. V. Baiju, R. Ambili
Summary: The study aimed to evaluate the efficacy of injectable platelet-rich fibrin (i-PRF) for gingival phenotype modification. Significant increase in gingival thickness was observed after injecting i-PRF into the attached gingiva, but no significant difference was found in the width of keratinized gingiva. Further well-controlled studies with long-term follow-up are needed to provide more evidence.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mohamadreza Tavakoli, Marjan Mirhaj, Sheyda Labbaf, Jaleh Varshosaz, Somayeh Taymori, Franoosh Jafarpour, Saeedeh Salehi, Shaghayegh Amini Mosleh Abadi, Azadeh Sepyani
Summary: The study developed a freeze-dried chitosan/polyvinylpyrrolidone sponge with the addition of platelet-rich fibrin (PRF) as a wound dressing. The addition of 1% PRF significantly improved the mechanical properties of the sponge and showed effective antibacterial activity. The release of growth factors from PRF and the increased proliferation and angiogenic potential of cells were observed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Iwona Niedzielska, Daniel Ciapinski, Michal Bak, Damian Niedzielski
Summary: The main objective of this study was to explore the application of PRF in dental surgery to prevent changes in alveolar height and width after tooth extraction. The research involved 50 patients who underwent extraction of two corresponding teeth, with one alveolus filled with PRF while the other one left empty. Results showed that the PRF group displayed better healing of soft tissues and higher quality of newly formed bone after six months.