Article
Oncology
Xiang Liu, Ge Jin, Qiang Tang, Shumin Huang, Yujie Zhang, Yue Sun, Tianyu Liu, Zixuan Guo, Cheng Yang, Bangmao Wang, Kui Jiang, Weilong Zhong, Hailong Cao
Summary: Early life colonisation with Lactobacillus rhamnosus GG (LGG) can inhibit intestinal tumour formation in offspring by influencing gut microbiota composition and regulating signaling pathways.
BRITISH JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Joshua A. Owens, Bejan J. Saeedi, Crystal R. Naudin, Sarah Hunter-Chang, Maria E. Barbian, Richard U. Eboka, Lauren Askew, Trevor M. Darby, Brian S. Robinson, Rheinallt M. Jones
Summary: The study shows that oral administration of Lactobacillus rhamnosus GG can enhance colonic CD8 T-cell responses in mice and reduce tumor burden. This suggests the potential use of LGG to augment antitumor immune responses in colorectal cancer patients and increase the efficacy of immunotherapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Chemistry, Applied
Cong Xu, Jiage Ma, Zhijing Liu, Wan Wang, Xin Liu, Shanshan Qian, Lijun Chen, Liya Gu, Chuanqiang Sun, Juncai Hou, Zhanmei Jiang
Summary: In this study, shell-core fibers were prepared using coaxial electrospinning technology and were found to have higher thermal stability and higher survival rate of probiotics.
Article
Food Science & Technology
Federico Bueno, Alexander Chouljenko, Subramaniam Sathivel
Summary: The addition of Lactobacilli to coffee kombucha shifted the proportion of microbial families and allowed them to survive in the beverage for 15 days, even after exposure to simulated gastrointestinal conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Naiara Hennig Neuenfeldt, Carla Andressa Almeida Farias, Renius de Oliveira Mello, Silvino Sasso Robalo, Juliano Smanioto Barin, Leila Picolli da Silva, Edson Irineu Muller, Erico Marlon Moraes Flores, Milene Teixeira Barcia, Cristiano Ragagnin de Menezes
Summary: This study demonstrates that the co-microencapsulation of blueberry extract improves the survival rate of Lactobacillus rhamnosus and shows promising application in food.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Bonilla Zavaleta, L. I. Lozano Coavichi, L. C. Velasco Rodriguez, E. Flores Andrade, Hugo S. Garcia, M. P. Rascon Diaz
Summary: Co-microcapsules containing L. rhamnosus and krill oil were prepared using whey protein as wall material through spray drying. Viability of the microcapsules and co-microcapsules at different drying process temperatures was above 1 x 1010 CFU/mL. The main phospholipid detected in the co-microcapsules was phosphatidylethanolamine, and the fatty acids profile revealed a low content of SFA but high levels of MUFA and PUFA. The survivability of L. rhamnosus in the co-microcapsules was influenced by storage temperature, with higher temperatures decreasing the water activity range for stable viability.
Article
Biotechnology & Applied Microbiology
Taiyu Zhai, Wenbo Ren, Pingping Wang, Lei Zheng
Summary: Gut microbiota plays an important role in atherosclerosis, and probiotic Lactobacillus rhamnosus GG can effectively inhibit the generation of AS plaques. It participates in the antiatherosclerotic mechanism by altering the composition of gut microbiota and metabolites.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aldo Stivala, Giuseppe Carota, Virginia Fuochi, Pio Maria Furneri
Summary: This study evaluated the probiotic properties of lactobacilli strains of vaginal origin, finding that the strain L. rhamnosus AD3 showed the best probiotic properties. This suggests that L. rhamnosus AD3 has potential to be a safe and effective prevention and complementary treatment option for urogenital diseases.
Article
Biochemistry & Molecular Biology
Fuli Zheng, Zhi Wang, Catherine Stanton, R. Paul Ross, Jianxin Zhao, Hao Zhang, Bo Yang, Wei Chen
Summary: In this study, it was found that strains of L. reuteri and L. rhamnosus significantly slowed weight gain in mice, alleviated blood glucose and lipid disorders, tissue damage, and gut microbiota disorders, produced SCFAs to induce satiety hormones, inhibit food intake, and increase satiety, ultimately improving metabolic syndrome.
Article
Environmental Sciences
Chenyan Hu, Mengyuan Liu, Lizhu Tang, Baili Sun, Zileng Huang, Lianguo Chen
Summary: The study investigated the interactive effects between probiotic bacteria and the aquatic pollutant PFBS on zebrafish reproduction. It found that probiotic supplementation mitigated the negative impacts of PFBS on egg production by promoting oocyte growth and modulating hormonal signals. Overall, the study provided mechanistic evidence of how probiotics can influence the reproductive outcomes in the presence of environmental pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Food Science & Technology
Jiayan Jiang, Ke Li, Yuanliang Wang, Zhongqin Wu, Huiqin Ma, Shilin Zheng, Zongjun Li
Summary: This study isolated and identified 104 strains of LAB from traditionally fermented vegetables, fresh milk, healthy infant feces, and other environments. The strains were evaluated for their antibacterial properties, acid and bile salts resistance, digestive enzymes resistance, and adhesion ability. Three LAB strains with good comprehensive performance were obtained, which exhibited broad-spectrum antibacterial properties, good acid resistance, and adhesion ability. These strains met the required characteristics and safety evaluation criteria for potential probiotics.
Article
Cell Biology
Agnieszka Magrys, Mateusz Pawlik
Summary: Probiotic bacteria, such as Lactobacillus spp., produce bioactive molecules called postbiotics that play important roles in supporting the immune system in the intestinal mucosa. This study investigated the potential effect of postbiotic fractions from L. rhamonosus and L. plantarum on immune responses induced by inflammation. The results showed that these fractions have a beneficial effect on controlling inflammation and protecting the intestinal barrier. They also found that these fractions can regulate cytotoxic activity in intestinal epithelial cells.
Article
Nutrition & Dietetics
Mo Yang, Jiapeng Zheng, Xinran Zong, Xinyan Yang, Yu Zhang, Chaoxin Man, Yujun Jiang
Summary: The study revealed that L. rhamnosus JL1 isolated from healthy infant feces can prevent obesity and reduce metabolic complications in high-fat diet mice by activating the AMPK pathway and reducing the gene expression of PPAR-γ and LXR-α. Additionally, the intervention with L. rhamnosus JL1 increased the concentration of short-chain fatty acids in the mice, providing a theoretical reference for the development and application of probiotics in health products and functional foods.
Article
Food Science & Technology
Yongzhao Xu, Shiying Nie, Min Wang, Zikuan Zhao, William Kwame Amakye, Erdong Yuan, Jiaoyan Ren
Summary: A peptide derived from walnut-protein (PW5) has been found to counteract the inhibitory effect of polystyrene microplastic (PS-MP) on probiotics by forming new complexes through hydrogen bonding and van der Waals forces. This study reveals the interaction mechanism between food-derived peptides and microplastic, providing a new approach to reduce the health risks posed by microplastic using food-derived bioactive peptides.
Article
Nutrition & Dietetics
Hengxian Qu, Lina Zong, Jian Sang, Yunchao Wa, Dawei Chen, Yujun Huang, Xia Chen, Ruixia Gu
Summary: In this study, transcriptomic and metabolomic analyses were used to explore the mechanism of probiotics in alleviating lipid metabolism disorders. It was found that Lactobacillus rhamnosus hsryfm 1301 fermented milk could directly regulate lipid metabolism through the modulation of metabolic pathways and indirectly regulate it through pathways such as amino acid metabolism, the nervous system, and the endocrine system. This multi-target synergy of the fermented milk helped alleviate lipid metabolism disorders caused by a high-fat diet.
Article
Dentistry, Oral Surgery & Medicine
Camila S. Stolf, Catharina M. Sacramento, Helvis E. S. Paz, Renato A. Machado, Lucas P. Ramos, Luciane D. de Oliveira, Karina Cogo-Muller, Mauro P. Santamaria, Karina G. S. Ruiz, Renato C. V. Casarin
Summary: This study demonstrated the association between the IL10 promoter rs6667202 SNP and IL10 expression and production. In patients with periodontal health, the AA and AC genotypes were associated with lower levels of IL10, while in patients with Perio4C, other factors may be affecting the IL-10 response despite the genetic variation.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Amjad Abu Hasna, Ana Luisa Theodoro, Larissa Marques Pereira, Lucas de Paula Ramos, Tiago Moreira Bastos Campos, Maisour Ala Rachi, Talal Al-Nahalwi, Luciane Dias de Oliveira, Claudio Antonio Talge Carvalho
Summary: This study evaluates the antimicrobial, genotoxic, and morphological effects of five mineral oxides and two mineral trioxide aggregates. The results show that 5MO, MTA, and MTA HP have effective antimicrobial action against certain bacteria. Additionally, 5MO and MTA have no genotoxic effects on macrophage and osteoblast cells.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Engineering, Biomedical
Amanda de Oliveira Pinto Ribeiro, Ana Carolina da Silva, Felipe de Camargo Ribeiro, Clarice Ferreira Sabino, Juliana Campos Junqueira, Lucas de Paula Ramos, Luciane Dias de Oliveira, Tiago Moreira Bastos Campos, Renata Marques de Melo Marinho
Summary: This study evaluated the effects of silver-doped soda-lime glass application on the roughness, biofilm formation, cell viability, and flexural strength of zirconia. The results showed that silver-doped soda-lime glass inhibited the growth of Candida albicans, with Ag5 having the strongest antimicrobial effect. However, Ag5 had higher roughness and negatively affected cell viability and flexural strength. Glass infiltration increased the flexural strength of zirconia and improved fracture resistance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Vanessa Marques Meccatti, Larissa de Souza Moura, Juliana Guerra Pinto, Juliana Ferreira-Strixino, Amjad Abu Hasna, Livia Mara Figueiredo-Godoi, Juliana Campos Junqueira, Maria Cristina Marcucci, Lucas de Paula Ramos, Claudio Antonio Talge Carvalho, Cesar Rogerio Pucci, Luciane Dias de Oliveira
Summary: This study evaluated the phototransformation potential of the glycolic extract of Curcuma longa and the antifungal activity of Curcuma longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes (LED) on Candida albicans and Candida tropicalis in vitro. The toxicity of Curcuma longa and curcumin in a Galleria mellonella model was also assessed. The results showed that Curcuma longa, curcumin, and aPDT using blue LED had an antifungal effect on both Candida albicans and Candida tropicalis. Furthermore, the extract of Curcuma longa and curcumin did not exhibit toxicity in the Galleria mellonella model.
INTERNATIONAL JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Nadia Domingues, Lucas de Paula Ramos, Larissa Marques Pereira, Pamela Beatriz do Rosario Estevam dos Santos, Liliana Scorzoni, Thais Cristine Pereira, Amjad Abu Hasna, Claudio Antonio Talge Carvalho, Luciane Dias de Oliveira
Summary: This study evaluated the antimicrobial effect of four herbal plant extracts on mixed-species biofilms composed of Candida albicans and other pathogenic bacteria. The results showed that these extracts had inhibitory effects on the mixed-species biofilms, and some extracts even completely eliminated the biofilms. Therefore, the glycolic extracts of P. paniculata, H. virginiana, S. barbatiman, and G. sylvestre may be considered as potential alternatives for endodontic therapy.
AUSTRALIAN ENDODONTIC JOURNAL
(2023)
Article
Multidisciplinary Sciences
Amjad Abu Hasna, Lucas de Paula Ramos, Tiago Moreira Bastos Campos, Sergio Lucio Pereira de Castro Lopes, Maisour Ala Rachi, Luciane Dias de Oliveira, Claudio Antonio Talge Carvalho
Summary: This study evaluated the properties of Five Mineral Oxides (5MO), Mineral Trioxide Aggregate Repair High Plasticity (MTA Repair HP), and Mineral Trioxide Aggregate (MTA) cements, and found that they exhibited antibacterial effects against certain bacteria, good biocompatibility with cells, and were suitable for clinical use.
SCIENTIFIC REPORTS
(2022)
Review
Microbiology
Paulo Henrique Fonseca do Carmo, Maira Terra Garcia, Livia Mara Alves Figueiredo-Godoi, Anna Carolina Pinheiro Lage, Newton Soares da Silva, Juliana Campos Junqueira
Summary: Candidiasis is a common fungal infection caused by Candida albicans. Current antifungal treatments have limitations such as toxicity and drug resistance, leading to the exploration of nanocarrier systems like metal nanoparticles. This review focuses on the use of silver, gold, and iron nanoparticles as potential antifungal agents against C. albicans, discussing their mechanism of action and potential for reducing drug resistance.
Article
Biochemistry & Molecular Biology
Vanessa Marques Meccatti, Lana Ferreira Santos, Lara Steffany de Carvalho, Clara Bulhoes Souza, Claudio Antonio Talge Carvalho, Maria Cristina Marcucci, Amjad Abu Hasna, Luciane Dias de Oliveira
Summary: This study evaluated the isolated and synergistic antifungal effect of glycolic extracts from Rosa centifolia L., Curcuma longa L., Rosmarinus officinalis L., and Punica granatum L. against Candida spp. The findings showed that these plant extracts have antifungal and antibiofilm action against Candida spp. at different concentrations and times of action.
Article
Pharmacology & Pharmacy
Thais S. Veriato, Inglid Fontoura, Luciane D. D. Oliveira, Leandro J. J. Raniero, Maiara L. L. Castilho
Summary: Researchers have successfully synthesized and characterized a new nano-antibiotic based on silver nanoparticles functionalized with vancomycin-cysteamine, which demonstrates excellent bacteriostatic and bactericidal potential against Gram-positive strains.
PHARMACOLOGICAL REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sheila Mondragon Contreras, Juliana Benace Fernandes, Manuela da Silva Spinola, Maira Terra Garcia, Juliana Campos Junqueira, Eduardo Bresciani, Taciana Marco Ferraz Caneppele
Summary: This study investigated the ability of bioactive materials to prevent caries in enamel and dentine specimens. The results showed that bioactive restorative materials provided greater protection against surface caries development than resin composite.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2023)
Article
Microbiology
Maira Terra Garcia, Jessica Diane dos Santos, Paulo Henrique Fonseca do Carmo, Gabriela Vieira Mendes, Jonatas Rafael de Oliveira, Luciane Dias de Oliveira, Juliana Campos Junqueira
Summary: This study demonstrates that the supernatant of Streptococcus mutans can inhibit virulence factors and infectivity of Candida albicans, potentially providing new therapeutic strategies for candidiasis.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Thais C. Pereira, Paulo H. F. do Carmo, Raquel T. de Menezes, Haroldo C. de Oliveira, Luciane D. de Oliveira, Juliana C. Junqueira, Liliana Scorzoni
Summary: This study evaluated the antifungal activity of verapamil alone and in combination with amphotericin B against Cryptococcus neoformans. Verapamil showed antifungal activity against C. neoformans and when combined with amphotericin B, exhibited synergistic effect and reduced the drugs' concentrations. The combination therapy also reduced the size and glucuronoxylomannnan content of C. neoformans capsule.
FOLIA MICROBIOLOGICA
(2023)
Article
Multidisciplinary Sciences
Leonardo A. Da Silva, Lucas P. Ramos, Tatiane A. Silva, Simone A. B. De Lapena, Carlos Eduardo R. Santos, Amjad A. Hasna, Adriano Bressane, Luciane D. De Oliveira
Summary: This study evaluated the therapeutic effect and cytotoxicity of Juglans regia (J) and Zingiber officinale (Z) extracts, alone or in combination, on various bacteria and biofilms. The results showed that these extracts exhibited antimicrobial activity and effectively reduced biofilms. However, their cytotoxic effects on mouse macrophages were relatively low.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Biochemistry & Molecular Biology
Juliana de C. Fenley, Patricia P. de Barros, Paulo H. F. do Carmo, Maira T. Garcia, Rodnei D. Rossoni, Juliana C. Junqueira
Summary: This study evaluated the effects of two HIV-PIs, ATV and DRV, on C. albicans and experimental candidiasis. The results showed that ATV and DRV exhibited antifungal activity, reduced biofilm formation and filamentation, and downregulated the expression of virulence genes. They also decreased the occurrence of candidiasis.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Raquel T. Menezes, Thais C. Pereira, Juliana C. Junqueira, Luciane D. Oliveira, Liliana Scorzoni
Summary: This study evaluated the effect of duloxetine hydrochloride on Cryptococcus neoformans and found that duloxetine hydrochloride is active against this yeast alone and in combination with fluconazole, resulting in a reduction in the capsule size.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)