Article
Multidisciplinary Sciences
Cristina Vals-Delgado, Juan F. Alcala-Diaz, Helena Molina-Abril, Irene Roncero-Ramos, Martien P. M. Caspers, Frank H. J. Schuren, Tim J. Van den Broek, Raul Luque, Pablo Perez-Martinez, Niki Katsiki, Javier Delgado-Lista, Jose M. Ordovas, Ben van Ommen, Antonio Camargo, Jose Lopez-Miranda
Summary: The study identified a gut microbiome profile associated with the development of type 2 diabetes, and combining microbiome data with clinical parameters improved the prediction accuracy. The results suggest that the microbiome profile is linked to the development of T2DM and could be used for preventive measures.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hezhongrong Nie, Qingquan Xiong, Guanghui Lan, Chunli Song, Xiaohong Yu, Lei Chen, Daming Wang, Tingyu Ren, Zeyan Chen, Xintong Liu, Yiwen Zhou
Summary: Emerging evidence suggests that atherosclerosis is a chronic inflammatory disease and immune cells play critical roles in vascular inflammation and plaque formation. Gastrointestinal disorder is considered a risk factor in mediating the atherosclerotic process. This study demonstrates the pharmacological benefits of sivelestat in protecting against atherosclerosis and the important role of intestinal homeostasis in atherosclerotic development.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jiean Xu, Lina Wang, Qiuhua Yang, Qian Ma, Yaqi Zhou, Yongfeng Cai, Xiaoxiao Mao, Qingen Da, Tammy Lu, Yunchao Su, Zsolt Bagi, Rudolf Lucas, Zhiping Liu, Mei Hong, Kunfu Ouyang, Yuqing Huo
Summary: The study reveals the critical role of Pfkfb3 in LPS-induced sepsis, showing that its knockout protects mice from severe effects and reduces inflammation by regulating the expression of inflammatory factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Renato D. R. Cardoso, Sandmary D. Chambo, Tiago H. Zaninelli, Beatriz H. S. Bianchini, Matheus Deroco Veloso da Silva, Mariana M. Bertozzi, Telma Saraiva-Santos, Anelise Franciosi, Geovana Martelossi-Cebinelli, Pamela E. Garcia-Miguel, Sergio M. Borghi, Rubia Casagrande, Waldiceu A. Verri
Summary: In the study, it was found that RvD5 enhances bacteria phagocytosis, reduces inflammatory mediators, and protects kidneys from tissue injury in gram-negative Escherichia coli infection and LPS endotoxemia. This effect is associated with improved histopathological parameters, reduced leukocyte infiltration, decreased pro-inflammatory cytokine production, and increased antioxidant markers. RvD5 also reduces the activation of NF kappa B and promotes the Nrf2 pathway.
Article
Immunology
Lina S. Hansson, John Axelsson, Predrag Petrovic, Sofie Paues Goranson, Mats J. Olsson, Mats Lekander, Julie Lasselin
Summary: This pilot study found that experimentally induced inflammation affects the cognitive reappraisal of emotions and suggests that disgust stimuli might be more difficult to reappraise than general negative stimuli.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Avtar S. Meena, Pradeep K. Shukla, Rupa Rao, Cherie Canelas, Joseph F. Pierre, RadhaKrishna Rao
Summary: Chronic stress and alcohol use disorder have a reciprocal relationship and hinder recovery from both disorders. This study identified the TRPV6 channel as being involved in stress, corticosterone, and alcohol-induced intestinal permeability, microbiota dysbiosis, systemic inflammation, and liver damage. TRPV6 deficiency also blocked the effects of stress and stress-mediated potentiation of alcohol-induced dysbiosis of gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Evy Goossens, Jianhui Li, Chana Callens, Nathalie Van Rysselberghe, Hannele Kettunen, Juhani Vuorenmaa, Natalia Garcia Gonzalez, Claude Libert, Richard Ducatelle, Filip Van Immerseel
Summary: The acute stage of SIRS induces dysbiosis of the small intestinal and respiratory microbiome, which are associated with systemic inflammation and organ failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Zhuangzhuang Liu, Ximeng Li, Wenjing Li, Min Cai, Jingjing Yan, Chenchen Zang, Runlan Cai, Yuan Gao, Yun Qi
Summary: Osmanthus fragrans flower, a common edible plant in China, has been used as a food ingredient and traditional Chinese medicine for centuries. Research has shown that its extract has anti-inflammatory effects by suppressing the production of pro-inflammatory mediators and inhibiting the activation of NF-kappa B and AP-1 signaling pathways.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Medicine, General & Internal
Marina Mora-Ortiz, Juan F. Alcala-Diaz, Oriol Alberto Rangel-Zuniga, Antonio Pablo Arenas-de Larriva, Fernando Abollo-Jimenez, Diego Luque-Cordoba, Feliciano Priego-Capote, Maria M. Malagon, Javier Delgado-Lista, Jose M. Ordovas, Pablo Perez-Martinez, Antonio Camargo, Jose Lopez-Miranda
Summary: This study identified 12 endogenous metabolites with the potential to predict T2DM remission. These metabolites, combined with clinical variables, can be used to provide more precise therapy.
Article
Biochemistry & Molecular Biology
Wentong Hao, Kecheng Li, Xiangyun Ge, Haoyue Yang, Chaojie Xu, Song Liu, Huahua Yu, Pengcheng Li, Ronge Xing
Summary: This study investigates the effect of degree of acetylation (DA) on the anti-inflammatory activity of chitooligosaccharides (COS). It found that COS with a DA of 12% exhibits the highest anti-inflammatory activity and is able to alleviate the damage caused by endotoxemia, providing a foundation for the development of COS as an anti-endotoxemia drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Vincent Millischer, Matthias Heinzl, Anthi Faka, Michael Resl, Ada Trepci, Carmen Klammer, Margot Egger, Benjamin Dieplinger, Martin Clodi, Lilly Schwieler
Summary: The study investigates the effects of acute intravenous LPS administration on tryptophan and kynurenine metabolites in healthy male subjects. It found that LPS led to changes in these metabolites and activated both the neurotoxic and neuroprotective branches of the kynurenine pathway.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cardiac & Cardiovascular Systems
Alejandro Villasanta-Gonzalez, Marina Mora-Ortiz, Juan F. Alcala-Diaz, Lorenzo Rivas-Garcia, Jose D. Torres-Pena, Asuncion Lopez-Bascon, Monica Calderon-Santiago, Antonio P. Arenas-Larriva, Feliciano Priego-Capote, Maria M. Malagon, Fabian Eichelmann, Pablo Perez-Martinez, Javier Delgado-Lista, Matthias B. Schulze, Antonio Camargo, Jose Lopez-Miranda
Summary: This study identified a lipid profile associated with the development of type 2 diabetes mellitus in coronary heart disease patients. A highly sensitive model combining clinical variables and lipid species was established to identify patients at risk of developing type 2 diabetes mellitus.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Food Science & Technology
Magdalena P. Cardelo, Juan F. Alcala-Diaz, Francisco M. Gutierrez-Mariscal, Javier Lopez-Moreno, Alejandro Villasanta-Gonzalez, Antonio P. Arenas-de Larriva, Silvia De la Cruz-Ares, Javier Delgado-Lista, Fernando Rodriguez-Cantalejo, Raul M. Luque, Jose M. Ordovas, Pablo Perez-Martinez, Antonio Camargo, Jose Lopez-Miranda
Summary: This study found that branched chain amino acid (BCAA) plasma levels are associated with type 2 diabetes mellitus (T2DM) remission in patients consuming the Mediterranean diet, but not in those consuming a low-fat diet. Additionally, combining BCAA plasma levels into a score revealed that a high score is associated with a lower risk of T2DM remission in patients following the Mediterranean diet.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xia Wang, Caidie He, Nian Wu, Yingkuan Tian, Songlin An, Wei Chen, Xiang Liu, Haonan Zhang, Shimin Xiong, Yijun Liu, Quan Li, Yuanzhong Zhou, Xubo Shen
Summary: The aim of this study was to develop a visual prediction model for gestational diabetes (GD) in pregnant women and establish an effective and practical tool for clinical application. The study established demographic-lifestyle factor models (DLFM) and demographic-lifestyle-environmental pollution factor models (DLEFM) to predict the occurrence of GD.
DIABETES OBESITY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Ibukun Elizabeth Osadare, Ling Xiong, Ignacio Rubio, Ute Neugebauer, Adrian T. Press, Anuradha Ramoji, Juergen Popp
Summary: Sepsis is a life-threatening condition caused by an excessive and disproportionate immune response to an infection. This study used Raman spectroscopy to analyze the changes in splenic T-lymphocyte profiles during bacterial sepsis and hyperinflammatory endotoxemia. The results showed significant changes in DNA region of splenocytes during sepsis, indicating notable transcriptomic activity. Additionally, splenocytes exposed to high-dose lipopolysaccharide injection displayed significant protein and lipid profile changes, with variations in inflammation severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Francisco Jose Rodriguez-Cortes, Jorge E. Jimenez-Hornero, Juan Francisco Alcala-Diaz, Francisco Jose Jimenez-Hornero, Juan Luis Romero-Cabrera, Rosaria Cappadona, Roberto Manfredini, Pablo Jesus Lopez-Soto
Summary: The present study investigated the impact of daylight saving time (DST) transitions on the incidence of hospital admissions for major acute cardiovascular events (MACE). Using natural visibility graphs (NVGs) and data from Andalusian public hospitals between 2009 and 2019, the study found a slight increase in the risk of heart attacks after DST transitions, but this increase did not significantly alter the overall pattern of hospital admissions.
Article
Peripheral Vascular Disease
Elena M. Yubero-Serrano, Francisco M. Gutierrez-Mariscal, Purificacion Gomez-Luna, Juan F. Alcala-Diaz, Pablo Perez-Martinez, Jose Lopez-Miranda
Summary: This study analyzed the effects of two healthy diets on the intima-media thickness (IMT-CC) of carotid arteries in patients with type 2 diabetes and coronary heart disease. The results showed that reduction of AGEs levels after consuming the two healthy diets was associated with a decrease in IMT-CC.
CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS
(2023)
Article
Medicine, General & Internal
Juan Luis Romero-Cabrera, Antonio Garcia-Rios, Mercedes Sotos-Prieto, Gracia Quintana-Navarro, Juan Francisco Alcala-Diaz, Laura Martin-Piedra, Jose David Torres-Pena, Raul M. Luque, Elena Maria Yubero-Serrano, Javier Delgado-Lista, Niki Katsiki, Stefanos N. Kales, Jose Lopez-Miranda, Pablo Perez-Martinez
Summary: The study found that among CHD patients, higher adherence to a Mediterranean lifestyle was associated with a lower risk of MetS development and a higher likelihood of reversing preexisting MetS during a 5-year follow-up. Each additional one-point increment in the MEDLIFE index was associated with a 24% lower risk of MetS development and a 21% higher likelihood of reversing preexisting MetS.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Diana Maria Munoz-Perez, Clara Helena Gonzalez-Correa, Elcy Yaned Astudillo Munoz, Maite Sanchez-Giraldo, Juan Carlos Carmona-Hernandez, Jose Lopez-Miranda, Antonio Camargo, Oriol Alberto Rangel-Zuniga
Summary: Overweight and obesity are major global health issues. Healthy diets can induce molecular level changes. A study was conducted to evaluate the effect of a diet based on fruit, avocado, whole grains, and trout on obesity-related gene expression.
Article
Peripheral Vascular Disease
Vicente Pascual, Jose Luis Diaz, Jesus Millan Nunez-Cortes, Pablo Perez-Martinez
Summary: In patients with atherogenic dyslipidemia, a healthy diet, regular exercise, and quitting smoking are the first steps to reduce cardiovascular risk. Improving the nutritional quality of their diet, by replacing foods with atherogenic effects with healthier alternatives, is strongly recommended. Plant-based diets low in saturated fats, cholesterol, and sodium, but high in fiber, potassium, and unsaturated fats, have proven to be beneficial in reducing cardiovascular risk factors. This article emphasizes the role of nutrition in preventing and treating atherogenic dyslipidemia, providing current evidence for healthcare professionals.
CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS
(2023)
Review
Cardiac & Cardiovascular Systems
Francisco Gomez-Delgado, Jose David Torres-Pena, Gema Gutierrez-Lara, Juan Luis Romero-Cabrera, Pablo Perez-Martinez
Summary: The purpose of this review is to analyze the impact of artificial sweeteners on cardiometabolic and cardiovascular disease risk. Recent evidence explores the influence of artificial sweeteners on risk factors such as obesity and type 2 diabetes mellitus. This review aims to provide an updated overview of the impact of artificial sweeteners on cardiovascular health and provide consumption recommendations.
CURRENT OPINION IN CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Francisco M. Gutierrez-Mariscal, Juan F. Alcala-Diaz, Gracia M. Quintana-Navarro, Silvia de la Cruz-ares, Jose D. Torres-Pena, Magdalena P. Cardelo, Antonio P. Arenas-Larriva, Maria M. Malagon, Juan L. Romero-Cabrera, Jose M. Ordovas, Pablo Perez-Martinez, Javier Delgado-Lista, Elena M. Yubero-Serrano, Jose Lopez-Miranda
Summary: Increasing plant protein intake can promote the remission of type 2 diabetes in coronary heart disease patients, especially in the first and second year of follow-up, according to the CORDIOPREV study.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Nutrition & Dietetics
Jose D. Torres-Pena, Antonio P. Arenas-de Larriva, Juan F. Alcala-Diaz, Jose Lopez-Miranda, Javier Delgado-Lista
Summary: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, and it is associated with obesity, metabolic syndrome, dyslipidemia, and diabetes. NAFLD is a global public health concern, affecting individuals of all ages, and its prevalence is expected to increase due to its connection with obesity. Genetic and lifestyle factors may modulate NAFLD and partly explain its relationship with cardiovascular disease (CVD). Currently, there is no specific drug for the treatment of NAFLD, and management relies on lifestyle modifications and a healthy diet.
Review
Endocrinology & Metabolism
Jose Antonio Santos-Marcos, Marina Mora-Ortiz, Manuel Tena-Sempere, Jose Lopez-Miranda, Antonio Camargo
Summary: Metabolic diseases, such as obesity, metabolic syndrome, and type 2 diabetes, show sex differences in their development and prevalence, with sex hormones playing a role in sexual dimorphism. The interaction between steroid hormones and the gut microbiota influences these diseases, leading to a potential new therapeutic approach targeting the gut microbiota. This review focuses on the role of sex hormones in the development of metabolic diseases and their interaction with the gut microbiota, highlighting factors such as gut barrier integrity, inflammatory status, and the gut-brain axis.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Ana Ojeda-Rodriguez, Juan F. Alcala-Diaz, Oriol Alberto Rangel-Zuniga, Antonio Pablo Arenas-de Larriva, Francisco M. Gutierrez-Mariscal, Purificacion Gomez-Luna, Jose D. Torres-Pena, Antonio Garcia-Rios, Juan L. Romero-Cabrera, Maria M. Malagon, Pablo Perez-Martinez, Jose M. Ordovas, Javier Delgado-Lista, Elena M. Yubero-Serrano, Jose Lopez-Miranda
Summary: In this study, the association between telomere length (TL) and the progression of arterial injury in patients with coronary heart disease (CHD) was evaluated. It was found that patients with shorter TL had higher intima-media thickness of common carotid arteries (IMT-CC), while patients who followed a Mediterranean diet showed a significant decrease in IMT-CC, especially those with higher TL risk.
Article
Cardiac & Cardiovascular Systems
Alejandro Villasanta-Gonzalez, Marina Mora-Ortiz, Juan F. Alcala-Diaz, Lorenzo Rivas-Garcia, Jose D. Torres-Pena, Asuncion Lopez-Bascon, Monica Calderon-Santiago, Antonio P. Arenas-Larriva, Feliciano Priego-Capote, Maria M. Malagon, Fabian Eichelmann, Pablo Perez-Martinez, Javier Delgado-Lista, Matthias B. Schulze, Antonio Camargo, Jose Lopez-Miranda
Summary: This study identified a lipid profile associated with the development of type 2 diabetes mellitus in coronary heart disease patients. A highly sensitive model combining clinical variables and lipid species was established to identify patients at risk of developing type 2 diabetes mellitus.
CARDIOVASCULAR DIABETOLOGY
(2023)