Article
Medicine, General & Internal
Murad Alturkustani
Summary: GFAP immunostaining can help distinguish pilocytic astrocytoma from other similar tumors. Pilocytic astrocytoma shows strong and diffuse GFAP staining in the tumor cells, while in other tumors only reactive astrocytes display GFAP staining.
Article
Oncology
Weilun Fu, Wenjing Wang, Hao Li, Yuming Jiao, Jiancong Weng, Ran Huo, Zihan Yan, Jie Wang, Hongyuan Xu, Shuo Wang, Jiangfei Wang, Dexi Chen, Yong Cao, Jizong Zhao
Summary: This study used mass cytometry to analyze immune cells in AG patients, demonstrating tumor-driven immune changes and the predominant immune cells in the AG immune microenvironment. The immune milieu in AAmut showed more immunosuppressive characteristics compared to AOD.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yuen Teng, Chaoyue Chen, Yang Zhang, Jianguo Xu
Summary: This study suggests that MRI texture analysis combined with LDA algorithm has the potential to be utilized in distinguishing the subtypes of high-grade gliomas.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Oncology
Elena Katharina Bauer, Jan-Michael Werner, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks
Summary: This study reported neuroimaging findings in a clinically symptomatic 53-year-old woman with a recurrent anaplastic oligodendroglioma, where FET PET imaging indicated treatment-related changes earlier than MRI, highlighting the importance of these unique imaging findings in clinical decision-making.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Marjolein Geurts, Tom J. Snijders, Martin J. van den Bent
Summary: The evolving molecular data of anaplastic glioma have led to a new grading system and the identification of new biomarkers for prognosis. The benefit of adjuvant temozolomide is dependent on the mutational status of isocitrate dehydrogenase, and there is ongoing debate regarding optimal chemotherapy regimens and treatment timing. The trade-off between efficacy and toxicity of treatments for these newly defined entities needs to be re-evaluated in clinical practice.
CURRENT OPINION IN ONCOLOGY
(2021)
Review
Oncology
Michael M. Wollring, Jan-Michael Werner, Garry Ceccon, Philipp Lohmann, Christian P. Filss, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks
Summary: PET imaging using radiolabeled amino acids combined with MRI is a valuable diagnostic tool in managing brain tumor patients. This review provides an overview of PET studies in glioma patients with IDH mutation, which typically do not show contrast enhancement on MRI. The review focuses on the role of amino acid PET in differential diagnosis, treatment planning, and response assessment in patients with IDH-mutant gliomas.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Jacopo Falco, Julius Hoehne, Morgan Broggi, Emanuele Rubiu, Francesco Restelli, Ignazio G. Vetrano, Marco Schiariti, Elio Mazzapicchi, Giulio Bonomo, Paolo Ferroli, Karl-Michael Schebesch, Francesco Acerbi
Summary: The study analyzed the effect of sodium fluorescein (SF) on the visualization and resection of pilocytic astrocytoma. The results showed that SF helped distinguish tumors from viable tissue and improved the intraoperative visualization. This technique may have a positive effect on improving the extent of resection of these lesions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hyun Jeong Kim, Hang-Seok Chang, Young Hoon Ryu
Summary: This study evaluates the prognostic capability of [F-18]FDG PET/CT in patients with anaplastic thyroid cancer (ATC) and finds that glucose metabolism assessed by PET/CT is significantly associated with the overall survival of patients with ATC, making PET-derived parameters useful prognostic biomarkers for ATC.
Article
Clinical Neurology
Christian Ott, Martin Proescholdt, Monika Friedrich, Julius Hoehne, Katharina Rosengarth, Nils-Ole Schmidt, Karl-Michael Schebesch
Summary: This study aimed to verify the feasibility, safety, and benefit of using fluorescein sodium (FL) and a YELLOW 560 nm filter in posterior fossa tumors in children. The results showed that this method has achieved good results in posterior fossa surgery and can safely and reliably remove tumors.
CHILDS NERVOUS SYSTEM
(2023)
Review
Clinical Neurology
Pedro Miguel Gonzalez-Vargas, Lourdes Calero Felix, Jose Luis Thenier-Villa, Antia Dominguez Nunez, Adolfo de la Lama Zaragoza, Cesareo Conde Alonso
Summary: Anaplastic Pilocytic Astrocytoma (APA) is a rare subtype of Pilocytic Astrocytoma (PA) with aggressive clinical course, especially in patients over 18 years old. This study presented two cases of APA patients who underwent successful surgery without complications and remained asymptomatic during follow-up. Literature review revealed APA to be more aggressive than classical PA, emphasizing the importance of early identification for optimal treatment and prognosis.
INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arnoldo Piccardo, Nathalie L. Albert, Lise Borgwardt, Frederic H. Fahey, Darren Hargrave, Norbert Galldiks, Nina Jehanno, Lars Kurch, Ian Law, Ruth Lim, Egesta Lopci, Lisbeth Marner, Giovanni Morana, Tina Young Poussaint, Victor J. Seghers, Barry L. Shulkin, Katherine E. Warren, Tatjana Traub-Weidinger, Pietro Zucchetta
Summary: This document provides guidelines for the use of [F-18]FDG and radiolabelled amino acid PET imaging in pediatric patients with brain gliomas. The recommendations are consensus opinions of experienced leaders in the field and further research is needed to support evidence-based recommendations.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Huasong Huo, Shurui Shen, Lanyue Zhang, Fuwei Yang, Yunqian Li
Summary: Our systematic review and meta-analysis evaluated the diagnostic performance of [F-18]FDG PET/MRI versus [F-18]FET PET/MRI for recurrent glioma. The analysis of nine studies showed that [F-18]FET PET/MRI had a higher area under the curve compared to [F-18]FDG PET/MRI in detecting tumor recurrence in glioma. However, larger prospective studies are needed to confirm these findings.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Sabine Julia Maria Sag, Karin Menhart, Jirka Grosse, Florian Hitzenbichler, Frank Hanses, Arno Mohr, Bernd Salzberger, Matthaus Zerdzitzki, Michael Hilker, Leopold Rupprecht, Dirk Hellwig, Christof Schmid, Lars Siegfried Maier, Can Martin Sag
Summary: This study assessed the diagnostic value of FDG PET/CT in surgically managed IE patients. Results showed that combining FDG PET/CT with Duke criteria can increase the diagnostic sensitivity in PVE patients, with patients having false-negative scans observed to have higher prosthesis age.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Editorial Material
Clinical Neurology
Ernest J. Barthelemy, Nqobile S. Thango, Julius Hoehne, Laura Lippa, Angelos Kolias, Isabelle M. Germano
WORLD NEUROSURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dominic Kaddu-Mulindwa, Bettina Altmann, Gerhard Held, Stephanie Angel, Stephan Stilgenbauer, Lorenz Thurner, Moritz Bewarder, Maren Schwier, Michael Pfreundschuh, Markus Loffler, Karin Menhart, Jirka Grosse, Marita Ziepert, Ken Herrmann, Ulrich Duhrsen, Andreas Huttmann, Francesco Barbato, Viola Poeschel, Dirk Hellwig
Summary: In patients with aggressive B-cell NHL, routine bone marrow biopsy does not provide critical staging information compared to FDG PET/CT and could therefore be omitted.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Oncology
Martin A. Proescholdt, Petra Schoedel, Christian Doenitz, Tobias Pukrop, Julius Hoehne, Nils Ole Schmidt, Karl-Michael Schebesch
Summary: This comprehensive review focuses on the role of neurosurgical treatment in the challenging management of cerebral metastases, which have been increasing in incidence over recent years. It discusses the benefits of surgical resection in reducing intracranial pressure and symptom burden, as well as the advancements in neurosurgical techniques and the multidisciplinary approach to patient care. The review highlights the importance of maximal resection with minimal morbidity, functional outcomes, and understanding tumor biology in the treatment of brain metastases.
Article
Surgery
Karl-Michael Schebesch, Christian Doenitz, Julius Hoehne, Amer Haj, Nils Ole Schmidt
Summary: The study evaluated the feasibility and efficacy of the innovative micro-inspection tool QEVO (R) in complex intracranial tumor surgeries, finding that it significantly improves intraoperative morphological understanding and can be used for various indications. However, its use is restricted to the specific properties of the respective anatomical area.
FRONTIERS IN SURGERY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Dirk Hellwig
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2021)
Article
Clinical Neurology
Francesco Acerbi, Francesco Restelli, Camilla de Laurentis, Jacopo Falco, Claudio Cavallo, Morgan Broggi, Julius Hoehne, Karl-Michael Schebesch, Marco Schiariti, Paolo Ferroli
Summary: The study evaluated the current practice of fluorescence-guided techniques in neuro-oncological surgery in Europe and found that 5-ALA is still the preferred fluorescent dye for resection of high-grade gliomas, while SF is gaining attention as a cheaper and more ductile alternative.
JOURNAL OF NEUROSURGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas Rinscheid, Tilman Janzen, Babak Alikhani, Ambros J. Beer, Anja Braune, Nina Eberhardt, Diana Fechner, Stefan Foerster, Martin Freesmeyer, Christian Furth, Michael Grunert, Dirk Hellwig, Pedro Fragoso Costa, Christian Kuehnel, Catharina Lange, Rainer Linke, Natalia Razlaw, Tobias Sack, Daniel Schmidt, Christina Schuetze, Alexander Starke, Liane Tondera, Hermann Wengenmair, Klaus Zoephel, Wolfgang Burchert, Constantin Lapa
Summary: New dose reference levels (DRLs) have been defined in Germany for low-dose CT scans in hybrid SPECT/CT and PET/CT examinations. The survey evaluated data from 2020 and compared it with the new DRLs as well as similar studies from other countries. The results show a need for dose optimization for certain examination types to meet the new DRLs in Germany.
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2022)
Article
Oncology
Dennis Christoph Harrer, Florian Lueke, Ingo Einspieler, Karin Menhart, Dirk Hellwig, Kirsten Utpatel, Wolfgang Herr, Albrecht Reichle, Daniel Heudobler
Summary: Acute promyelocytic leukemia (APL) is a serious hematological emergency characterized by thrombocytopenia and coagulopathy. This case report presents a rare extramedullary manifestation of APL that mimics metastasized laryngeal carcinoma but with normal blood counts and absent coagulopathy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Lisa Schindler, Jutta Moosbauer, Daniel Schmidt, Thilo Spruss, Lukas Graetz, Steffen Luedeke, Frank Hofheinz, Sebastian Meister, Bernd Echtenacher, Gunther Bernhardt, Jens Pietzsch, Dirk Hellwig, Max Keller
Summary: This study aimed to develop a peptidic gallium-68 labeled NTS1R PET ligand with high in vivo stability and high NTS1R affinity. A series of potential ligands were prepared by attaching the chelator DOTA to the C-terminal fragment of neurotensin and inserting Ga3+. One of the ligands showed promising results in biodistribution studies and dynamic PET scans, indicating its potential for tumor imaging.
Article
Radiology, Nuclear Medicine & Medical Imaging
Quirin D. Strotzer, Stefanie Heidemanns, Vinzenz Mayr, Roman Stuerzl, Stefanie Meiler, Daniel Schmidt, Stefan Blaas, Jirka Grosse, Dirk Hellwig, Christian Stroszczynski, Okka W. Hamer
Summary: The purpose of this study was to evaluate the use of dual-source and split-beam filter multi-energy chest CT in assessing pulmonary perfusion in patients with lung emphysema, using perfusion SPECT as the reference standard. The results showed that both dual-source and split-beam filter multi-energy CT had significant correlations with SPECT/CT for all lobes, and dual-source CT had a higher overall correlation.
RADIOLOGY-CARDIOTHORACIC IMAGING
(2023)
Article
Clinical Neurology
Karl -Michael Schebesch, Julius Hoehne, Katharina Rosengarth, Ekaterina Noeva, Nils Ole Schmidt, Martin Proescholdt
Summary: FL-guided resection of newly diagnosed HGG significantly improves extent of resection and prolongs overall survival in patients.
Article
Cardiac & Cardiovascular Systems
Jing Li, Tamara Ruegamer, Christoph Brochhausen, Karin Menhart, Andreas Hiergeist, Lukas Kraemer, Dirk Hellwig, Lars S. Maier, Christof Schmid, Jonathan Jantsch, Christian Schach
Summary: This study investigated diagnostic tools for infective endocarditis and their correlation with mortality outcomes. Positive blood cultures and transesophageal echocardiography were found to be the most sensitive for diagnosing IE, while vegetation size showed high predictive power. Systemic embolism and NT-proBNP levels were associated with mortality.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Letter
Hematology
Roch Houot, Viola Poeschel, Bettina Altmann, Stephanie Angel, Lorenz Thurner, Thomas Illmer, Marc Andre, Martin Dreyling, Herve Maisonneuve, Herve Tilly, Stephanie Mayer, Olivier Casasnovas, Steven Le Gouill, Fritz Offner, Guillaume Cartron, Andrea Kerkhoff, Thomas Weber, Joerg Hoffmann, Marita Ziepert, Wolfram Klapper, Emmanuel Itti, Dirk Hellwig, Giorgi Natchkebia, Laurence de Leval, Andreas Rosenwald, Corinne Haioun, Laurent Dercle, Philippe Gaulard, Gerhard Held
Meeting Abstract
Oncology
M. Heidenreich, W. Herr, M. Vogelhuber, J. Hahn, D. Hellwig, K. Menhart, J. Rennert, M. Beutl, F. Weber, K. Koelble, B. Gad
ONCOLOGY RESEARCH AND TREATMENT
(2021)
Article
Clinical Neurology
Hyunjung Kim, Jhii-Hyun Ahn, Sung Min Ko, Jin Woo Kim
Summary: The pre-navigation balloon technique significantly reduces the occurrence of distal embolism and increases the first-pass effect (FPE) during stent retriever thrombectomy. This technique is particularly effective for patients with ICA occlusion, improving clinical outcomes.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Review
Clinical Neurology
Mehdi Khaleghi, Joshua Vignolles-Jeong, Bradley Otto, Ricardo Carrau, Daniel Prevedello
Summary: This study presented a rare case of symptomatic ectopic Rathke's cleft cyst (RCC), which was located posterior to the pituitary gland and caused extensive clival erosion. The surgical technique of wide marsupialization of the cyst using intraoperative ultrasound-assisted endoscopic endonasal transclival approach was described, and a systematic literature review of intracranial ectopic RCCs was conducted.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Oscar H. Del Brutto, Denisse A. Rumbea, Aldo F. Costa, Maitri Patel, Mark J. Sedler, Robertino M. Mera
Summary: This study found an association between cognitive impairment and mortality risk in adults of Amerindian ancestry living in rural Ecuador.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Yangjingyi Xia, Li Li, Yunze Li, Manyan Hu, Tianrui Zhang, Qinghua Feng, Wenlei Li, Yuan Zhu, Minghua Wu
Summary: This study shows that fasting blood glucose (FBG) level is significantly associated with unfavorable outcome after acute ischemic stroke (AIS) in patients. The risk of unfavorable outcome increases significantly when FBG is above 5.5 mmol/L.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)