Journal
CLINICAL INFECTIOUS DISEASES
Volume 67, Issue 1, Pages 50-57Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciy012
Keywords
HIV; cancer; aging; epidemiology
Categories
Funding
- Intramural Research Program of the NCI
- SEER Program of the NCI: Connecticut [HHSN261201300019I]
- SEER Program of the NCI: New Jersey [HHSN261201300021I, N01-PC-2013-00021]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: Colorado [NU58DP006347-01]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: Georgia [5U58DP003875-01]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: Maryland [5NU58DP003919-05-00]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: Michigan [5U58DP003921-03]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: New Jersey [NU58/DP003931-05-00]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: New York [U58/DP003879]
- National Program of Cancer Registries of the Centers for Disease Control and Prevention: Texas [5U58DP000824-04]
- state of New Jersey
- Maryland Cancer Registry by the State of Maryland
- Maryland Cigarette Restitution Fund
- New York State Cancer Registry by the state of New York
- HIV Incidence and Case Surveillance Branch of the Centers for Disease Control and Prevention, National HIV Surveillance Systems: Colorado [NU62PS003960]
- HIV Incidence and Case Surveillance Branch of the Centers for Disease Control and Prevention, National HIV Surveillance Systems: Connecticut [5U62PS001005-05]
- HIV Incidence and Case Surveillance Branch of the Centers for Disease Control and Prevention, National HIV Surveillance Systems: Michigan [U62PS004011-02]
- HIV Incidence and Case Surveillance Branch of the Centers for Disease Control and Prevention, National HIV Surveillance Systems: New Jersey [U62PS004001-2]
Ask authors/readers for more resources
Background. Cancer risk is increased in persons living with human immunodeficiency virus (HIV) (PLWH). Improved survival has led to an aging of PLWH. We evaluated the cancer risk in older PLWH (age >= 50 years). Methods. We included data from the HIV/AIDS Cancer Match Study (1996-2012) and evaluated risks of Kaposi sarcoma (KS), non-Hodgkin lymphoma (NHL), Hodgkin lymphoma, and cervical, anal, lung, liver, oral cavity/pharyngeal, breast, prostate, and colon cancers in older PLWH with risk in the general population by calculating standardized incidence ratios (SIRs) and excess absolute risks (EARs). Cancer risk by time since HIV diagnosis was estimated using Poisson regression. Results. We identified 10 371 cancers among 183 542 older PLWH. Risk was significantly increased for KS (SIR, 103.34), NHL (3.05), Hodgkin lymphoma (7.61), and cervical (2.02), anal (14.00), lung (1.71), liver (2.91), and oral cavity/pharyngeal (1.66) cancers, and reduced for breast (0.61), prostate (0.47), and colon (0.63) cancers. SIRs declined with age for all cancers; however, EARs increased with age for anal, lung, liver, and oral cavity/pharyngeal cancers. Cancer risk was highest for most cancers within 5 years after HIV diagnosis; risk decreased with increasing time since HIV diagnosis for KS, NHL, lung cancer, and Hodgkin lymphoma. Conclusions. Cancer risk is elevated among older PLWH. Although SIRs decrease with age, EARs are higher for some cancers, reflecting a greater absolute excess in cancer incidence among older PLWH. High risk in the first 5 years after HIV diagnosis for some cancers highlights the need for early HIV diagnosis and rapid treatment initiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available