Journal
CLINICAL INFECTIOUS DISEASES
Volume 68, Issue 1, Pages 139-142Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciy486
Keywords
virus discovery; orthobunyavirus; CNS infection; Uganda; encephalitis
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Funding
- Academic Medical Center
- Platform for European Preparedness Against (Re-)emerging Epidemics project
- European Union Seventh Framework Programme [602525]
- Host Switching Pathogens, Infectious Outbreaks and Zoonosis
- European Union Horizon 2020 Innovative Training Networks [721367]
- Netherlands-African Partnership for Capacity Development and Clinical Interventions against Poverty-Related Diseases-Africa Research Initiative and Support program - Dutch Government
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A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient.
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