Journal
CLINICAL IMAGING
Volume 49, Issue -, Pages 37-43Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clinimag.2017.10.017
Keywords
Breast cancer; Supplemental screening; Diffusion-weighted MRI (DWI); Ultrasound; Dynamic contrast-enhanced MRI (DCE-MRI)
Funding
- NIH/NCI [R01CA207290, R01CA151326]
- Earlier.Org - Friends for an Earlier Breast Cancer Test
- Wings of Karen Foundation
- Safeway Foundation
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Purpose: To investigate the visibility of mammographically occult breast cancers on diffusion-weighted MRI (DWI) versus ultrasound. Materials and methods: Mammographically occult breast cancers (n = 60) initially detected on contrast-enhanced MRI that underwent pre-biopsy targeted ultrasound were retrospectively evaluated for visibility on DWI and ultrasound. Results: More cancers were visible on DWI than ultrasound (78% vs. 63%; p = 0.049), with 32 (53%) visible on both and 7 (12%) not visible on either. Visibility differences were more significant in larger lesions (92% vs. 68%, p = 0.006). Conclusion: DWI may detect more mammographically occult cancers than ultrasound, warranting further investigation as an alternative supplemental screening technique.
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