Sickle cell dehydration: Pathophysiology and therapeutic applications

Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore

(2017) Hai M. Nguyen et al.   MOLECULAR PHARMACOLOGY

Dense red blood cell and oxygen desaturation in sickle-cell disease

(2016) Gaetana Di Liberto et al.   AMERICAN JOURNAL OF HEMATOLOGY

Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease

(2016) J. O. Nwankwo et al.   HAEMATOLOGICA

Senicapoc: a potent candidate for the treatment of a subset of hereditary xerocytosis caused by mutations in the Gardos channel

(2016) Raphael Rapetti-Mauss et al.   HAEMATOLOGICA

Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter

(2016) Kristopher T. Kahle et al.   Science Signaling

Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease

(2016) J. O. Nwankwo et al.   HAEMATOLOGICA

Senicapoc: a potent candidate for the treatment of a subset of hereditary xerocytosis caused by mutations in the Gardos channel

(2016) Raphael Rapetti-Mauss et al.   HAEMATOLOGICA

Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter

(2016) Kristopher T. Kahle et al.   Science Signaling

Iron restriction in sickle cell anemia: Time for controlled clinical studies

(2015) Oswaldo Castro et al.   AMERICAN JOURNAL OF HEMATOLOGY

Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis)

(2015) Immacolata Andolfo et al.   AMERICAN JOURNAL OF HEMATOLOGY

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

(2015) Fiona C. Brown et al.   BLOOD

A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children

(2015) D. C. Brousseau et al.   BLOOD

Mutations in the Gardos channel (KCNN4) are associated with hereditary xerocytosis

(2015) E. Glogowska et al.   BLOOD

A mutation in the Gardos channel is associated with hereditary xerocytosis

(2015) R. Rapetti-Mauss et al.   BLOOD

Hydroxyurea treatment does not increase blood viscosity and improves red blood cell rheology in sickle cell anemia

(2015) N. Lemonne et al.   HAEMATOLOGICA

Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia

(2015) B. E. Shmukler et al.   HAEMATOLOGICA

Dietary  -3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease

(2015) B. T. Kalish et al.   HAEMATOLOGICA

The clinical significance of K-Cl cotransport activity in red cells of patients with HbSC disease

(2015) D. C. Rees et al.   HAEMATOLOGICA

Six Months of Hydroxyurea Reduces Albuminuria in Patients with Sickle Cell Disease

(2015) P. Bartolucci et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea

(2015) Marie Georgine Rakotoson et al.   Orphanet Journal of Rare Diseases

Piezo1 regulates mechanotransductive release of ATP from human RBCs

(2015) Eyup Cinar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydroxyurea treatment does not increase blood viscosity and improves red blood cell rheology in sickle cell anemia

(2015) N. Lemonne et al.   HAEMATOLOGICA

Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia

(2015) B. E. Shmukler et al.   HAEMATOLOGICA

Dietary  -3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease

(2015) B. T. Kalish et al.   HAEMATOLOGICA

The clinical significance of K-Cl cotransport activity in red cells of patients with HbSC disease

(2015) D. C. Rees et al.   HAEMATOLOGICA

Cation Homeostasis in Red Cells From Patients With Sickle Cell Disease Heterologous for HbS and HbC (HbSC Genotype)

(2015) A. Hannemann et al.   EBioMedicine

Hereditary xerocytosis revisited

(2014) Natasha M. Archer et al.   AMERICAN JOURNAL OF HEMATOLOGY

Haemolysis and abnormal haemorheology in sickle cell anaemia

(2014) Philippe Connes et al.   BRITISH JOURNAL OF HAEMATOLOGY

Malaria parasites and red cell variants

(2014) Steve M. Taylor et al.   CURRENT OPINION IN HEMATOLOGY

Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α

(2013) Caryn S. Gonsalves et al.   AMERICAN JOURNAL OF HEMATOLOGY

Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1

(2013) I. Andolfo et al.   BLOOD

Endothelin-1 receptor antagonists regulate cell surface-associated protein disulfide isomerase in sickle cell disease

(2013) Gregory N. Prado et al.   FASEB JOURNAL

A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes

(2013) C. R. Morris et al.   HAEMATOLOGICA

The SLC12 family of electroneutral cation-coupled chloride cotransporters

(2013) Juan Pablo Arroyo et al.   MOLECULAR ASPECTS OF MEDICINE

Intravenous Magnesium Sulfate for Vaso-occlusive Episodes in Sickle Cell Disease

(2013) R. D. Goldman et al.   PEDIATRICS

Physiology and pathophysiology of SLC12A1/2 transporters

(2013) Nicolas Markadieu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Identification of the Ca2+ entry pathway involved in deoxygenation-induced phosphatidylserine exposure in red blood cells from patients with sickle cell disease

(2013) U. M. Cytlak et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The terminal density reversal phenomenon of aging human red blood cells

(2013) Virgilio L. Lew et al.   Frontiers in Physiology

Erythrocyte density in sickle cell syndromes is associated with specific clinical manifestations and hemolysis

(2012) P. Bartolucci et al.   BLOOD

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease

(2012) Lucia De Franceschi et al.   FASEB JOURNAL

The conductance of red blood cells from sickle cell patients: ion selectivity and inhibitors

(2012) Y.-L. Ma et al.   JOURNAL OF PHYSIOLOGY-LONDON

Anti-haemolytic effect of senicapoc and decrease in NT-proBNP in adults with sickle cell anaemia

(2011) Caterina P. Minniti et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mild haemorheological changes induced by a moderate endurance exercise in patients with sickle cell anaemia

(2011) Edwige Balayssac-Siransy et al.   BRITISH JOURNAL OF HAEMATOLOGY

The effects of hydroxycarbamide and magnesium on haemoglobin SC disease: results of the multi-centre CHAMPS trial

(2011) Winfred Wang et al.   BRITISH JOURNAL OF HAEMATOLOGY

Senicapoc trial results support the existence of different sub-phenotypes of sickle cell disease with possible drug-induced phenotypic shifts

(2011) Oswaldo L. Castro et al.   BRITISH JOURNAL OF HAEMATOLOGY

Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapo

(2011) Kenneth I. Ataga et al.   BRITISH JOURNAL OF HAEMATOLOGY

K-Cl Cotransporter Gene Expression during Human and Murine Erythroid Differentiation

(2011) Dao Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of interleukin-8 and RANTES on the Gardos channel activity in sickle human red blood cells: Role of the Duffy antigen receptor for chemokines

(2010) Marie-Claude Durpès et al.   BLOOD CELLS MOLECULES AND DISEASES

Novel permeability characteristics of red blood cells from sickle cell patients heterozygous for HbS and HbC (HbSC genotype)

(2010) S. Dalibalta et al.   BLOOD CELLS MOLECULES AND DISEASES

Activation State of α4β1 Integrin on Sickle Red Blood Cells Is Linked to the Duffy Antigen Receptor for Chemokines (DARC) Expression

(2010) Marie-Claude Durpès et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Activates a Ca2+-Permeable Cation Conductance Sensitive to Carbon Monoxide and to GsMTx-4 in Human and Mouse Sickle Erythrocytes

(2010) David H. Vandorpe et al.   PLoS One

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

Hematologic, biochemical, and cardiopulmonary effects of l-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy

(2009) Jane A. Little et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia

(2008) K. I. Ataga et al.   BLOOD