Article
Agricultural Engineering
Javier Acosta, Kim Nguyen, Robert C. Spitale, Jesus Fernandez-Lucas
Summary: After characterizing wild-type and mutant uracil phosphoribosyltransferases, the optimal candidate was selected for structure-guided immobilization onto Ni2+ chelate and glutaraldehyde-activated microparticles. The resulting derivatives showed enhanced stability and operability in enzymatic synthesis of different pyrimidine NMPs. Additionally, both derivatives exhibited good reusability in 5-FUMP synthesis at short times.
BIORESOURCE TECHNOLOGY
(2021)
Article
Oncology
Robert B. Scharpf, Archana Balan, Biagio Ricciuti, Jacob Fiksel, Christopher Cherry, Chenguang Wang, Michele L. Lenoue-Newton, Hira A. Rizvi, James R. White, Alexander S. Baras, Jordan Anaya, Blair V. Landon, Marta Majcherska-Agrawal, Paola Ghanem, Jocelyn Lee, Leon Raskin, Andrew S. Park, Huakang Tu, Hil Hsu, Kathryn C. Arbour, Mark M. Awad, Gregory J. Riely, Christine M. Lovly, Valsamo Anagnostou
Summary: The RAS family of small GTPases is commonly activated in human cancers and has been found to have different prevalence and co-occurrence patterns with other genes in a cancer lineage-dependent and context-dependent manner. Multiomic analyses of tumor data revealed distinct gene expression programs and clinical outcomes in RAS-mutant tumors, highlighting the potential for targeted therapies and immunotherapy. The findings provide insights into the genetic architecture and therapeutic vulnerabilities of RAS-mutant tumors.
Article
Medicine, General & Internal
Chen-Chi Wang, Wen-Jiun Lin, Yi-Chun Liu, Chien-Chih Chen, Shang-Heng Wu, Shih-An Liu, Kai-Li Liang
Summary: This study found that neoadjuvant chemotherapy (NACT) may facilitate tumor resection, TORS effectively reduced the dosage of adjuvant irradiation, and it had a satisfactory 5-year survival rate and functional outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Zhiwei Liu, Yingluo Liu, Lili Qian, Shangwen Jiang, Xiameng Gai, Shu Ye, Yuehong Chen, Xiaomin Wang, Linhui Zhai, Jun Xu, Congying Pu, Jing Li, Fuchu He, Min Huang, Minjia Tan
Summary: This study provides a comprehensive profile of the proteome and phosphoproteome of KRAS mutant cancer cell lines, identifying three subsets with distinct characteristics and a set of drug combinations with therapeutic potentials. The integration of phosphoproteome and drug sensitivity information facilitates the identification of effective treatments specific for certain subsets of KRAS mutant cancers.
Review
Oncology
Alicia Gonzalez, Carolina Alonso-Gonzalez, Alicia Gonzalez-Gonzalez, Javier Menendez-Menendez, Samuel Cos, Carlos Martinez-Campa
Summary: Melatonin acts as a promising sensitizer molecule for cancer cells, enhancing the efficacy of chemotherapy and radiotherapy by inhibiting angiogenesis. Its antiangiogenic effects help to overcome the pro-angiogenic factors induced by chemotherapy, making tumors more sensitive to treatment. Melatonin also regulates factors involved in angiogenesis and acts as a radiosensitizer, increasing the effects of radiation on tumor cells.
Article
Oncology
Sivesh K. Kamarajah, Filip Bednar, Clifford S. Cho, Hari Nathan
Summary: Adjuvant radiotherapy after resection of distal cholangiocarcinoma was associated with a survival benefit in patients, even in patients with margin-negative or node-negative resections. Adjuvant radiotherapy should be considered routinely irrespective of margin and nodal status after resection of distal cholangiocarcinoma.
Article
Medicine, Research & Experimental
Ronald S. Wang, Michael S. Chow, Alex J. Gordon, Michele Santacatterina, Alec E. Vaezi, Moses M. Tam, Babak Givi
Summary: This study investigated the impact of adjuvant radiotherapy in isolated locally advanced oral cavity cancers without adverse features. The findings showed that adjuvant radiotherapy was associated with improved survival. However, a significant proportion of patients did not receive adjuvant radiotherapy, highlighting the need for continued efforts to promote guideline-recommended care.
Review
Medicine, General & Internal
Ye Chen, Baoxia Zhang, Chang Liu, Ye Cao, Cheng Lyu, Meng Qiu
Summary: This study conducted a network meta-analysis to determine the benefits of adjuvant therapy in patients with resected biliary tract cancer (BTC). The analysis showed that adjuvant chemoradiotherapy (ACRT) and adjuvant chemotherapy (ACT) provided better overall survival (OS) and disease-free survival (DFS) benefits compared to observation. Adjuvant radiotherapy (ART) only showed improvement in OS. Further studies are needed to confirm these results.
Article
Oncology
D. Forsse, H. F. Berg, O. Bozickovic, H. Engerud, M. K. Halle, E. A. Hoivik, K. Woie, H. M. J. Werner, I. S. Haldorsen, J. Trovik, C. Krakstad
Summary: The study found that in the treatment of endometrial cancer, an appropriate lymphadenectomy rate is around 50%, and adjuvant chemotherapy may perform equally to adjuvant radiotherapy, potentially being superior for advanced stage patients.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Oncology
Ziwei Zhu, Yunyuan Xiao, Shengye Hu, Ziyuan Wang, Zaisheng Zhu
Summary: For patients with variant histology bladder cancers, neoadjuvant chemotherapy (NAC) or adjuvant chemotherapy (AC) can improve overall survival (OS) and cancer-specific survival (CSS) compared with radical cystectomy alone. NAC benefits the sarcomatoid and neuroendocrine subgroups, while only the neuroendocrine subgroup shows improved CSS with AC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Zhenkun Fu, Zhoujun Lin, Mao Yang, Chenggang Li
Summary: Breast cancer is a common type of cancer, with surgery being the preferred treatment method. Various adjuvant therapies such as radiotherapy, chemotherapy, endocrine therapy, and targeted drug therapy can also be used.
FRONTIERS IN ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Fabiana Gregucci, Alessia Surgo, Ilaria Bonaparte, Letizia Laera, Maria Paola Ciliberti, Roberta Carbonara, Maria Annunziata Gentile, David Giraldi, Roberto Calbi, Morena Caliandro, Nicola Sasso, Salvatore D'Oria, Carlo Somma, Gaetano Martinelli, Giammarco Surico, Giuseppe Lombardi, Alba Fiorentino
Summary: This study aimed to evaluate the efficacy and toxicity of Hypo-RT with SIB in combination with TMZ in poor-prognosis GBM patients. Among 30 patients, 25 were evaluated with a minimum follow-up of 6 months, showing that the treatment was effective and safe, with no severe neurological side effects but some cases of grade 3-4 hematologic toxicity.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ludmila F. de A. Fiuza, Denise G. J. Batista, Roberson D. Girao, Fabian Hulpia, Paula Finamore-Araujo, Mustafa M. Aldfer, Ehab Kotb Elmahallawy, Harry P. De Koning, Otacilio Moreira, Serge Van Calenbergh, Maria de Nazare C. Soeiro
Summary: Chagas disease, caused by Trypanosoma cruzi, is a serious public health problem without effective and safe treatment options. Nucleoside analogues, due to their different substrate specificities, show promise as a therapeutic alternative for Chagas disease. In this study, certain tubercidin derivatives were found to be highly potent and selective against T. cruzi, with their uptake mediated by the nucleoside transporter TcrNT2. These compounds effectively reduced parasitemia in cardiac cultures and showed no noticeable toxicity in mice. Further studies and combination evaluations are needed to identify more effective and safer therapies for Chagas disease.
Article
Multidisciplinary Sciences
James J. Harding, Sarina A. Piha-Paul, Ronak H. H. Shah, Jessica J. Murphy, James M. Cleary, Geoffrey I. Shapiro, David I. Quinn, Irene Brana, Victor Moreno, Mitesh Borad, Sherene Loi, Iben Spanggaard, Haeseong Park, James M. Ford, Monica Arnedos, Salomon M. Stemmer, Christelle de la Fouchardiere, Christos Fountzilas, Jie Zhang, Daniel DiPrimeo, Casey Savin, S. Duygu Selcuklu, Michael F. Berger, Lisa D. Eli, Funda Meric-Bernstam, Komal Jhaveri, David B. Solit, Ghassan K. Abou-Alfa
Summary: In patients with biliary tract cancer, HER2 alterations correlate with poor prognosis. A phase II clinical trial showed that the tyrosine kinase inhibitor neratinib has some efficacy in treating advanced biliary tract cancers with HER2-mutation positive. The objective response rate to neratinib was 16% (95% CI 4.5-36.1%).
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Rui Zou, Jing-Jing Yuan, Qiang Li, Jian-Wu Ding, Bing Liao, Zi-Wei Tu, Rong-Huan Hu, Dan Gong, Jia-Li Hu, Lei Zeng
Summary: The study analyzed the outcomes and toxicities of ICT followed by CCRT plus ACT in LA-NPC patients, and found that this treatment approach did not significantly improve DFS and OS compared to adding ICT to CCRT, with more acute adverse events. Longer-term clinical studies are needed to evaluate treatment outcomes and late toxicities.
FRONTIERS IN ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Linyuan Wang, Anna Piskorz, Tjalling Bosse, Mercedes Jimenez-Linan, Brian Rous, C. Blake Gilks, James D. Brenton, Naveena Singh, Martin Kobel
Summary: PTEN plays a central role in the pathogenesis of endometrial carcinoma. PTEN IHC shows moderate accuracy in predicting loss of function PTEN mutations, and can be used for diagnostic purposes.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Nanda Horeweg, Hagma H. Workel, Dominik Loiero, David N. Church, Lisa Vermij, Alicia Leon-Castillo, Ricki T. Krog, Stephanie M. de Boer, Remi A. Nout, Melanie E. Powell, Linda R. Mileshkin, Helen MacKay, Alexandra Leary, Naveena Singh, Ina M. Juergenliemk-Schulz, Vincent T. H. B. M. Smit, Carien L. Creutzberg, Viktor H. Koelzer, Hans W. Nijman, Tjalling Bosse, Marco de Bruyn
Summary: B-cells and tertiary lymphoid structures (TLS) play critical roles in endometrial cancer (EC). L1CAM is identified as a marker for mature TLS and the presence of TLS is associated with favorable prognosis in EC patients.
NATURE COMMUNICATIONS
(2022)
Review
Obstetrics & Gynecology
Lynn Hoang, Fleur Webster, Tjalling Bosse, Gustavo Focchi, C. Blake Gilks, Brooke E. Howitt, Jessica N. McAlpine, Jaume Ordi, Naveena Singh, Richard Wing-Cheuk Wong, Sigurd F. Lax, W. Glenn McCluggage
Summary: This article introduces the process of the International Collaboration on Cancer Reporting (ICCR) and the development of the vulval carcinoma reporting data set. It provides definitions and commentary for the core and noncore elements of the pathology reports, as well as discusses the updated vulval cancer staging system. The widespread implementation of this data set is expected to improve patient outcomes.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2022)
Article
Oncology
Lisa J. Vermij, Jan J. Jobsen, Alicia Leon-Castillo, Mariel Brinkhuis, Suzan E. Roothaan, Melanie E. M. Powell, Stephanie M. de Boer, Pearly R. Khaw, Linda R. Mileshkin, Anthony Fyles, Alexandra Leary, Catherine M. Genestie, Ina M. J. Jurgenliemk-Schulz, Emma J. J. Crosbie, Helen J. Mackay, Hans. W. A. Nijman, Remi A. Nout, Vincent T. H. B. M. L. Smit, Carien L. Creutzberg, Nanda Horeweg, Tjalling M. Bosse, Stephanie M. de Boer
Summary: This study aimed to investigate whether adding hormone receptor expression, L1CAM expression or CTNNB1 status can improve the accuracy of risk assessment in endometrial cancer (EC). The study found that the expression of ER, PR, L1CAM, and CTNNB1 did not have independent prognostic value in EC, while age, stage, and adjuvant chemotherapy had an independent impact on the risk of recurrence. However, in high-risk EC of non-serous/mixed papillary (NSMP) subgroup, ER positivity was independently associated with a reduced risk of recurrence.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
T. Bosse, C. L. Creutzberg, E. J. Crosbie, K. Han, N. Horeweg, A. Leary, J. R. Kroep, J. N. McAlpine, M. E. Powell, F. Blanc-Durand, M. de Bruyn, D. N. Church, V. H. Koelzer, S. Kommoss, N. Singh, A. Bardet, N. Counsell, H. Putter, D. Tu, R. Edmondson, C. Gordon, J. Ledermann, P. Morice, H. MacKay, H. Nijman, R. A. Nout, V. T. H. B. M. Smit, H. White, J. Alexandre, S. M. de Boer, I Boere, R. Cooper, J. L. Ethier, J. S. Frenel, J. McGrane, A. Taylor, S. Welch, A. M. Westermann, H. Dijcker-van der Linden, L. Farrelly, A. Feeney, M. Kaya, W. Liu, A. Melis, F. Ngadjeua-Tchouatieu, W. Parulekar, K. Verhoeven-Adema, RAINBO Res Consortium
Summary: The RAINBO program aims to investigate molecular class-directed adjuvant treatment strategies for endometrial cancer, with the goal of improving clinical outcomes and reducing toxicity. It consists of four international clinical trials and an overarching research program to advance knowledge of predictive and prognostic markers.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Biochemistry & Molecular Biology
Susanne R. Bruekner, Wietske Pieters, Alexander Fish, A. Manuel Liaci, Serge Scheffers, Emily Rayner, Daphne Kaldenbach, Lisa Drost, Marleen Dekker, Sandrine van Hees-Stuivenberg, Elly Delzenne-Goette, Charlotte de Konink, Hellen Houlleberghs, Hendrikus Jan Dubbink, Abeer AlSaegh, Niels de Wind, Friedrich Forster, Hein te Riele, Titia K. Sixma
Summary: The homozygous V63E mutation in MSH2 disrupts a previously unappreciated interface between mismatch binding domains and leads to reduced DNA binding, which explains the pathogenic phenotype of this mutation and its association with increased cancer risk. Our research provides new insights into the mechanism of the V63E mutation and helps to understand the role of the MBD interface in replication fidelity.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Oncology
I. Suvaal, K. Kirchheiner, R. A. Nout, A. E. Sturdza, E. Van Limbergen, J. C. Lindegaard, H. Putter, I. M. Jurgenliemk-Schulz, C. Chargari, K. Tanderup, R. Poetter, C. L. Creutzberg, M. M. ter Kuile
Summary: The study prospectively evaluated vaginal changes and patient-reported outcomes after image-guided radio(chemo)therapy and brachytherapy for locally advanced cervical cancer. Mild vaginal changes were reported, and a significant proportion of patients experienced vaginal and sexual functioning problems. However, the rate of substantial problems and distress was low, and there was no clear association between vaginal changes and sexual functioning problems.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Medical Informatics
Sarah Fremond, Sonali Andani, Jurriaan Barkey Wolf, Jouke Dijkstra, Sinead Melsbach, Jan J. Jobsen, Mariel Brinkhuis, Suzan Roothaan, Ina Jurgenliemk-Schulz, Ludy C. H. W. Lutgens, Remi A. Nout, Elzbieta M. van der Steen-Banasik, Stephanie M. de Boer, Melanie E. Powell, Naveena Singh, Linda R. Mileshkin, Helen J. Mackay, Alexandra Leary, Hans W. Nijman, Vincent T. H. B. M. Smit, Carien L. Creutzberg, Nanda Horeweg, Viktor H. Koelzer, Tjalling Bosse
Summary: This study developed an interpretable deep learning model for the molecular classification prediction of endometrial cancer based on histopathological slides, identifying morpho-molecular correlates and refining prognostication.
LANCET DIGITAL HEALTH
(2023)
Article
Gastroenterology & Hepatology
Noah c. Helderman, Anne-Sophie van der Werf-'T Lam, Hans Morreau, Arnoud Boot, Tom Van Wezel, Maartje Nielsen
Article
Pathology
Claire J. H. Kramer, Alba Llop-Guevara, Elisa Yaniz-Galende, Benedetta Pellegrino, Natalja T. ter Haar, Andrea Herencia-Ropero, Nicoletta Campanini, Antonino Musolino, Tjalling Bosse, Alexandra Leary, Violeta Serra, Maaike P. G. Vreeswijk
Summary: The RAD51 test shows promise as a biomarker for assessing functional homologous recombination deficiency (HRD). However, the robustness and reproducibility of the immunofluorescence-based RAD51 test in different academic laboratories have not been thoroughly investigated. This study tested the performance of the RAD51 assay in FFPE HGSOC samples and found that subtle differences in staining procedures resulted in low variability of RAD51 and γH2AX scores, but there was substantial variability in RAD51 scoring, likely due to technical and biological factors. Improving technical issues and identifying tissue quality requirements are essential to guide individual treatment for HGSOC patients.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Oncology
Jonathan S. Berek, Xavier Matias-Guiu, Carien Creutzberg, Christina Fotopoulou, David Gaffney, Sean Kehoe, Kristina Lindemann, David Mutch, Endometrial Canc Staging Subcomm, FIGO Womens Canc Comm
Summary: Since the 2009 update of the FIGO staging system, there have been significant advances in understanding the pathologic and molecular features of endometrial cancer. The new staging system aims to better define prognostic groups and create substages to guide more appropriate treatment.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Meeting Abstract
Oncology
Lilian Tran Gien, Brian M. Slomovitz, Mario M. Leitao, Ate Van der Zee, Carien L. Creutzberg, An K. L. Reyners, Petronella Witteveen, Diandra Ayala-Peacock, Jyoti Mayadev, Charles A. Leath, Maaike Oonk
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Pathology
Claire Kramer, Nienke Solleveld, Giacomo Santandrea, Marthe de Jonge, Hans Marten Hazelbag, Marjolein Kagie, Elisabeth Ahsmann, Judith Kroep, Nienke van der Stoep, Cor de Kroon, Katja Gaarenstroom, Tom van Wezel, Vincent Smit, Christi van Asperen, Maaike Vreeswijk, Tjalling Bosse