☆ 4.7 Article

Higher Absolute Lymphocyte Counts Predict Lower Mortality from Early-Stage Triple-Negative Breast Cancer

CLINICAL CANCER RESEARCH (2018)

Get Full Text
Add to Collection

Journal

CLINICAL CANCER RESEARCH
Volume 24, Issue 12, Pages 2851-2858

Publisher

AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-17-1323

Keywords

-

Categories

Oncology

Funding

  1. Susan and Richard Levy Gift Fund
  2. Suzanne Pride Bryan Fund for Breast Cancer Research
  3. Breast Cancer Research Foundation
  4. Susan G. Komen for the Cure Foundation
  5. Jan Weimer Junior Faculty Chair in Breast Oncology
  6. Regents of the University of California's California Breast Cancer Research Program [16OB-0149, 19IB-0124]
  7. Stanford University Developmental Research Fund
  8. BRCA Foundation
  9. NCI's Surveillance, Epidemiology, and End Results Program [HHSN261201000140C, HHSN261201000035C, HHSN261201000034C]
  10. NIH CTSA award [UL1 RR025744]
  11. California Department of Health Services as part of the statewide cancer reporting program [103885]
  12. Centers for Disease Control and Prevention's National Program of Cancer Registries [1U58 DP000807-01]

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Purpose: Tumor-infiltrating lymphocytes (TIL) in pretreatment biopsies are associated with improved survival in triple-negative breast cancer (TNBC). We investigated whether higher peripheral lymphocyte counts are associated with lower breast cancer-specific mortality (BCM) and overall mortality (OM) in TNBC. Experimental Design: Data on treatments and diagnostic tests from electronic medical records of two health care systems were linked with demographic, clinical, pathologic, and mortality data from the California Cancer Registry. Multivariable regression models adjusted for age, race/ethnicity, socioeconomic status, cancer stage, grade, neoadjuvant/adjuvant chemotherapy use, radiotherapy use, and germline BRCA1/2 mutations were used to evaluate associations between absolute lymphocyte count (ALC), BCM, and OM. For a subgroup with TIL data available, we explored the relationship between TILs and peripheral lymphocyte counts. Results: A total of 1,463 stage I-III TNBC patients were diagnosed from 2000 to 2014; 1,113 (76%) received neoadjuvant/adjuvant chemotherapy within 1 year of diagnosis. Of 759 patients with available ALC data, 481 (63.4%) were ever lymphopenic (minimum ALC <1.0 K/mu L). On multivariable analysis, higher minimum ALC, but not absolute neutrophil count, predicted lower OM [HR = 0.23; 95% confidence interval (CI), 0.16-0.35] and BCM (HR = 0.19; CI, 0.11-0.34). Five-year probability of BCM was 15% for patients who were ever lymphopenic versus 4% for those who were not. An exploratory analysis (n = 70) showed a significant association between TILs and higher peripheral lymphocyte counts during neoadjuvant chemotherapy. Conclusions: Higher peripheral lymphocyte counts predicted lower mortality from early-stage, potentially curable TNBC, suggesting that immune function may enhance the effectiveness of early TNBC treatment. (C) 2018 AACR.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Clinical Neurology

International Multicenter Study of Clinical Outcomes of Sinonasal Melanoma Shows Survival Benefit for Patients Treated with Immune Checkpoint Inhibitors and Potential Improvements to the Current TNM Staging System

Matt Lechner, Yoko Takahashi, Mario Turri-Zanoni, Marco Ferrari, Jacklyn Liu, Nicholas Counsell, Davide Mattavelli, Vittorio Rampinelli, William Vermi, Davide Lombardi, Rami Saade, Ki Wan Park, Volker H. Schartinger, Alessandro Franchi, Carla Facco, Fausto Sessa, Simonetta Battocchio, Tim R. Fenton, Francis M. Vaz, Paul O'Flynn, David Howard, Paul Stimpson, Simon Wang, S. Alam Hannan, Samit Unadkat, Jonathan Hughes, Raghav Dwivedi, Cillian T. Forde, Premjit Randhawa, Simon Gane, Jonathan Joseph, Peter J. Andrews, Manas Dave, Jason C. Fleming, David Thomson, Tianyu Zhu, Andrew Teschendorff, Gary Royle, Christopher Steele, Joaquin E. Jimenez, Jan Laco, Eric W. Wang, Carl Snyderman, Peter D. Lacy, Robbie Woods, James P. O'Neill, Anirudh Saraswathula, Raman Preet Kaur, Tianna Zhao, Murugappan Ramanathan, Gary L. Gallia, Nyall R. London, Quynh-Thu Le, Robert B. West, Zara M. Patel, Jayakar V. Nayak, Peter H. Hwang, Mario Hermsen, Jose Llorente, Fabio Facchetti, Piero Nicolai, Paolo Bossi, Paolo Castelnuovo, Amrita Jay, Dawn Carnell, Martin D. Forster, Diana M. Bell, Valerie J. Lund, Ehab Y. Hanna

Summary: This study retrospectively analyzed clinical data from 505 cases of sinonasal mucosal melanoma (SNMM). It found that further stratifying the T3 stage by sinus involvement has a high predictive value for prognosis. Adjuvant radiotherapy can improve survival rates, and immune checkpoint inhibitors show potential benefits for the treatment of recurrent, persistent, or metastatic disease.

JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE (2023)

Add to Collection
Article Genetics & Heredity

Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

Stefanie H. Mueller, Alvina G. Lai, Maria Valkovskaya, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Zomoruda Abu-Ful, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Thais Baert, Laura E. Beane Freeman, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Hermann Brenner, Sara Y. Brucker, Saundra S. Buys, Jose E. Castelao, Tsun L. Chan, Jenny Chang-Claude, Stephen J. Chanock, Ji-Yeob Choi, Wendy K. Chung, Sarah Colonna, Sten Cornelissen, Fergus J. Couch, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dork, Laure Dossus, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, A. Heather Eliassen, Christoph Engel, D. Gareth Evans, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Manuela Gago-Dominguez, Yu-Tang Gao, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Jeanine Genkinger, Aleksandra Gentry-Maharaj, Felix Grassmann, Pascal Guenel, Melanie Gundert, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Per Hall, Elaine F. Harkness, Patricia A. Harrington, Jaana M. Hartikainen, Mikael Hartman, Alexander Hein, Weang-Kee Ho, Maartje J. Hooning, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Dezheng Huo, Abctb Investigators, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Daehee Kang, Elza K. Khusnutdinova, Sung-Won Kim, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Katerina Kubelka-Sabit, Allison W. Kurian, Ava Kwong, James Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Martha Linet, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Dimitrios Mavroudis, Usha Menon, Kenneth Muir, Rachel A. Murphy, Heli Nevanlinna, William G. Newman, Dieter Niederacher, Katie M. O'Brien, Nadia Obi, Kenneth Offit, Olufunmilayo Olopade, Andrew F. Olshan, Hakan Olsson, Sue K. Park, Alpa Patel, Achal Patel, Charles M. Perou, Julian Peto, Paul D. P. Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Muhammad U. Rashid, Gad Rennert, Atocha Romero, Kathryn J. Ruddy, Matthias Ruebner, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Michael O. Schneider, Christopher Scott, Mitul Shah, Priyanka Sharma, Chen-Yang Shen, Xiao-Ou Shu, Jacques Simard, Harald Surowy, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Soo Hwang Teo, Lauren R. Teras, Amanda E. Toland, Rob A. E. M. Tollenaar, Diana Torres, Gabriela Torres-Mejia, Melissa A. Troester, Therese Truong, Celine M. Vachon, Joseph Vijai, Clarice R. Weinberg, Camilla Wendt, Robert Winqvist, Alicja Wolk, Anna H. Wu, Taiki Yamaji, Xiaohong R. Yang, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, Alison M. Dunning, Douglas F. Easton, Harry Hemingway, Ute Hamann, Karoline B. Kuchenbaecker

Summary: This study identified 14 genes associated with breast cancer using gene-based aggregation analysis, including two newly discovered genes FMNL3 and AC058822.1. Furthermore, associations with established candidate genes like ESR1 were found through the collaboration of multi-ancestral cohorts, highlighting the importance of diversifying study cohorts. These findings provide new insights into the development of breast cancer.

GENOME MEDICINE (2023)

Add to Collection
Article Oncology

Breast Cancer Diagnosis, Treatment, and Outcomes of Patients From Sex and Gender Minority Groups

Erik Eckhert, Olivia Lansinger, Victor Ritter, Mina Liu, Summer Han, Lidia Schapira, Esther M. M. John, Scarlett Gomez, George Sledge, Allison W. W. Kurian

Summary: Most hospitals and cancer registries do not collect data on sexual orientation and gender identity, leading to a lack of knowledge about the quality of breast cancer treatment for patients from sex and gender minority (SGM) groups. A retrospective study found that SGM patients with breast cancer experienced delayed diagnosis, higher recurrence rates, and a higher likelihood of refusing recommended treatment compared to cisgender heterosexual patients.

JAMA ONCOLOGY (2023)

Add to Collection
Editorial Material Oncology

Artificial intelligence in breast pathology - dawn of a new era

Sunil S. Badve

Summary: This article discusses the use of artificial intelligence methods for analyzing pathology slides. The authors describe a reliable second reader system that can differentiate in situ and advanced invasive carcinomas from non-neoplastic lesions of the breast.

NPJ BREAST CANCER (2023)

Add to Collection
Review Obstetrics & Gynecology

Care after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations

Denise R. Nebgen, Susan M. Domchek, Joanne Kotsopoulos, Joanne A. de Hullu, Emma J. Crosbie, Vincent Singh Paramanandam, Monique Brood van Zanten, Barbara M. Norquist, Theresa Guise, Serge Rozenberg, Allison W. Kurian, Holly J. Pederson, Nese Yuksel, Rachel Michaelson-Cohen, Sharon L. Bober, Agnaldo Lopes da Silva, Nora Johansen, F. Guidozzi, D. Gareth Evans, Usha Menon, Sheryl A. Kingsberg, C. Bethan Powell, Giovanni Grandi, Claudia Marchetti, Michelle Jacobson, Donal J. Brennan, Martha Hickey

Summary: Women with high inherited risk of ovarian cancer can undergo risk-reducing salpingo-oophorectomy (RRSO) between the ages of 35 and 45. While RRSO can save lives, it can also cause symptoms that negatively impact quality of life and long-term health. This scoping review explores the effects of RRSO on short- and long-term health and provides evidence-based international consensus recommendations for comprehensive care.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2023)

Add to Collection
Article Oncology

The association between age at breast cancer diagnosis and prevalence of pathogenic variants

Mary B. Daly, Eric Rosenthal, Shelly Cummings, Ryan Bernhisel, John Kidd, Elisha Hughes, Alexander Gutin, Stephanie Meek, Thomas P. Slavin, Allison W. Kurian

Summary: Young age at breast cancer diagnosis and family history of breast cancer are strongly associated with pathogenic variants in BRCA1 and BRCA2 genes, but limited evidence exists for associations with ATM, CHEK2, and PALB2 genes.

BREAST CANCER RESEARCH AND TREATMENT (2023)

Add to Collection
Article Oncology

Changes in Breast Cancer Risk and Risk Factor Profiles among US-Born and Immigrant Asian American Women Residing in the San Francisco Bay Area

Esther M. John, Jocelyn Koo, Sue A. Ingles, Allison W. Kurian, Lisa M. Hines

Summary: A case-control study in the San Francisco Bay Area found that migration and birthplace are associated with breast cancer risk in Asian American women. Among the younger birth cohort, foreign-born Chinese women had a two-fold increased risk of breast cancer. Other migration characteristics, such as age of migration and length of U.S. residence, were also associated with increased risk. However, the education level did not fully explain these associations.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2023)

Add to Collection
Article Genetics & Heredity

Clinical implications of conflicting variant interpretations in the cancer genetics clinic

Elyssa Zukin, Julie O. Culver, Yuxi Liu, Yunqi Yang, Charite N. Ricker, Rachel Hodan, Duveen Sturgeon, Kerry Kingham, Nicolette M. Chun, Courtney Rowe-Teeter, Kathryn Singh, Jason A. Zell, Uri Ladabaum, Kevin J. McDonnell, James M. Ford, Giovanni Parmigiani, Danielle Braun, Allison W. Kurian, Stephen B. Gruber, Gregory E. Idos

Summary: The clinical impact of conflicting classifications of genetic variants issued by commercial laboratories was studied. Results from 2000 patients undergoing genetic testing were analyzed, and discrepancies between laboratory-provided classifications and other laboratories were identified. Only 36% of patients with conflicting classifications had a documented discussion by a provider. The study highlights the frequency of interpretation discrepancies and the importance of clinician awareness.

GENETICS IN MEDICINE (2023)

Add to Collection
Article Endocrinology & Metabolism

The Frequency of Undiagnosed Celiac Disease in Youth with Type 1 Diabetes and Its Association with Diabetic Retinopathy: The SEARCH for Diabetes in Youth Study

Ryan P. Brady, Elizabeth T. Jensen, Joseph Rigdon, Nancy A. Crimmins, Daniel Mallon, Lawrence M. Dolan, Giuseppina Imperatore, Anna R. Kahkoska, Amy K. Mottl, Ann Honor, David J. Pettitt, Lina Merjaneh, Dana Dabelea, Amy S. Shah

Summary: Undiagnosed celiac disease is likely present in youth with type 1 diabetes, and potentially undiagnosed CD is associated with a higher risk of diabetic retinopathy. These findings indicate the importance of routine screening for CD in type 1 diabetes in youth.

PEDIATRIC DIABETES (2023)

Add to Collection
Article Oncology

Cascade Genetic Risk Education and Testing in Families With Hereditary Cancer Syndromes: A Pilot Study

Steven J. Katz, Paul Abrahamse, Rachel Hodan, Allison W. Kurian, Aaron Rankin, Rachel S. Tocco, Sonia Rios-Ventura, Kevin C. Ward, Lawrence C. An

Summary: Cascade genetic testing in families with hereditary cancer syndromes can be achieved through an online platform that offers genetic risk education and low-cost testing to relatives.

JCO ONCOLOGY PRACTICE (2023)

Add to Collection
Article Health Policy & Services

Automated generation of comparator patients in the electronic medical record

Joseph Rigdon, Brian Ostasiewski, Kamah Woelfel, Kimberly D. Wiseman, Tim Hetherington, Stephen Downs, Marc Kowalkowski

Summary: This study proposes a multi-step process for selecting comparators in the electronic medical record (EMR), providing a reproducible and efficient source of comparator data for observational studies.

LEARNING HEALTH SYSTEMS (2023)

Add to Collection
Article Genetics & Heredity

Recurrent BRCA2 exon 3 deletion in Assyrian families

Rachel Hodan, Kerry Kingham, Allison W. Kurian

Summary: We identified a recurrent mutation in six patients from five Assyrian families, characterized by NM_000059.3 (BRCA2) exon 3 deletion. This mutation is associated with a classic BRCA2-associated cancer, occurring in individuals with early-onset breast cancer, ovarian cancer, male breast cancer, and/or high-grade prostate cancer. The mutation, classified as pathogenic, has not been previously identified as a founder mutation in a specific population, making our findings significant.

JOURNAL OF MEDICAL GENETICS (2023)

Add to Collection
Article Genetics & Heredity

Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel

Hagai Levi, Shai Carmi, Saharon Rosset, Rinat Yerushalmi, Aviad Zick, Tamar Yablonski-Peretz, Qin Wang, Manjeet K. Bolla, Joe Dennis, Kyriaki Michailidou, Michael Lush, Thomas Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Antonis C. Antoniou, Volker Arndt, Annelie Augustinsson, Paivi Auvinen, Laura Beane Freeman, Matthias Beckmann, Sabine Behrens, Marina Bermisheva, Clara Bodelon, Natalia Bogdanova, Stig E. Bojesen, Hermann Brenner, Helen Byers, Nicola Camp, Jose Castelao, Jenny Chang-Claude, Maria-Dolores Chirlaque, Wendy Chung, Christine Clarke, Margriet J. Collee, Sarah Colonna, Fergus Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary Daly, Peter Devilee, Thilo Dork, Laure Dossus, Diana M. Eccles, A. Heather Eliassen, Mikael Eriksson, Gareth Evans, Peter Fasching, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Jose Angel Garcia-Saenz, Jeanine Genkinger, Graham G. Giles, Mark Goldberg, Pascal Guenel, Per Hall, Ute Hamann, Wei He, Peter Hillemanns, Antoinette Hollestelle, Reiner Hoppe, John Hopper, Simona Jakovchevska, Anna Jakubowska, Helena Jernstrom, Esther John, Nichola Johnson, Michael Jones, Joseph Vijai, Rudolf Kaaks, Elza Khusnutdinova, Cari Kitahara, Stella Koutros, Vessela Kristensen, Allison W. Kurian, James Lacey, Diether Lambrechts, Loic Le Marchand, Flavio Lejbkowicz, Annika Lindblom, Sibylle Loibl, Adriana Lori, Jan Lubinski, Arto Mannermaa, Mehdi Manoochehri, Dimitrios Mavroudis, Usha Menon, AnnaMarie Mulligan, Rachel Murphy, Ines Nevelsteen, William G. Newman, Nadia Obi, Katie O'Brien, Ken Offit, Andrew Olshan, Dijana Plaseska-Karanfilska, Janet Olson, Salvatore Panico, Tjoung-Won Park-Simon, Alpa Patel, Paolo Peterlongo, Brigitte Rack, Paolo Radice, Gad Rennert, Valerie Rhenius, Atocha Romero, Emmanouil Saloustros, Dale Sandler, Marjanka K. Schmidt, Lukas Schwentner, Mitul Shah, Priyanka Sharma, Jacques Simard, Melissa Southey, Jennifer Stone, William J. Tapper, Jack Taylor, Lauren Teras, Amanda E. Toland, Melissa Troester, Therese Truong, Lizet E. van der Kolk, Clarice Weinberg, Camilla Wendt, Xiaohong Rose Yang, Wei Zheng, Argyrios Ziogas, Alison M. Dunning, Paul Pharoah, Douglas F. Easton, Shay Ben-Sachar, Naama Elefant, Ron Shamir, Ran Elkon

Summary: This study examined the performance of European-based breast cancer (BC) polygenic risk score (PRS) models in Ashkenazi Jewish (AJ) women. The results showed that the European-based PRS models can identify AJ women with significantly increased BC risk, offering potential improvement in BC risk assessment for this population.

JOURNAL OF MEDICAL GENETICS (2023)

Add to Collection
Article Oncology

Cascade testing for hereditary cancer: comprehensive multigene panels identify unexpected actionable findings in relatives

Brandie Heald, Sara Pirzadeh-Miller, Rachel E. Ellsworth, Sarah M. Nielsen, Emily M. Russell, Peter Beitsch, Edward D. Esplin, Robert L. Nussbaum, Daniel E. Pineda-Alvarez, Allison W. Kurian, Heather Hampel

Summary: Current guidelines recommend single variant testing in relatives of cancer patients with known pathogenic or likely pathogenic germline variants. However, this approach may result in missed risk-reducing strategies in family members with pathogenic or likely pathogenic variants in other cancer predisposition genes. Cascade testing using multigene panels identified unexpected pathogenic or likely pathogenic germline variants in 6.2% of relatives, including those who were negative for the familial variant but positive for a variant in a different gene, as well as those who tested positive for the familial variant and had an additional variant in a different gene.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2023)

Add to Collection
Article Medicine, General & Internal

Overall Survival Among Patients With De Novo Stage IV Metastatic and Distant Metastatic Recurrent Non-Small Cell Lung Cancer

Chloe C. Su, Julie T. Wu, Eunji Choi, Nathaniel J. Myall, Joel W. Neal, Allison W. Kurian, Henning Stehr, Douglas Wood, Solomon M. Henry, Leah M. Backhus, Ann N. Leung, Heather A. Wakelee, Summer S. Han

Summary: This study aimed to evaluate the impact of metastatic disease type on overall survival (OS) among patients with non-small cell lung cancer (NSCLC) and identify potential mechanisms underlying any survival difference.

JAMA NETWORK OPEN (2023)

Add to Collection
No Data Available
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.