Article
Medical Laboratory Technology
Timo Kouri, Katariina Alagrund, Maaret Lehtonen, Niina Tohmola, Tero Pihlajamaa, Vesa-Petteri Kouri, Sirpa Friman, Tanja Holma, Vesa Kirjavainen, Anu Patari-Sampo, Anna Lempiainen
Summary: The study validated the UriSed 3 PRO automated microscopes and found high accuracy and consistency in white blood cell, red blood cell, and epithelial cell counts when compared with visual microscopy and urine culture. The instruments also demonstrated high sensitivity in detecting bacteria.
CLINICA CHIMICA ACTA
(2021)
Article
Multidisciplinary Sciences
Dokyun Kim, Seoung Chul Oh, Changseung Liu, Yoonjung Kim, Yongjung Park, Seok Hoon Jeong
Summary: The study constructed a prediction model for urine culture results based on the association between urinalysis results and urine culture results, and validated the diagnostic performance of the UTOPIA value. The UTOPIA value showed good diagnostic performance in predicting urine culture results, which could reduce unnecessary cultures.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Anca Bacarea, Gyula Laszlo Fekete, Bianca Liana Grigorescu, Vladimir Constantin Bacarea
Summary: This study compared results from urine strip examination with microscopic examination of urinary sediment, identifying discrepancies such as false-negative nitrite results and false-positive red blood cell results. The research highlights that despite proper patient instruction, inconsistencies in test results still occur.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medical Laboratory Technology
Eun-Jung Cho, Woochang Lee, Sail Chun, Won-Ki Min
Summary: This study aimed to investigate the differences in cell counting results among a cobas u 701 analyzer, on-screen image review, and manual microscopic examination (MME). The results showed that RBC and WBC counts determined by image analysis tended to be one grade higher than those from MME in the range of 3 to 5/HPF to many/HPF. However, nearly all samples with 0-2/HPF and numerous/HPF for RBC and WBC counts were consistent with the grade found by MME.
CLINICAL LABORATORY
(2021)
Article
Veterinary Sciences
Demitria M. Vasilatis, Larry D. Cowgill, Giosi Farace, Sarah Peterson, Murthy Yerramilli, Sean D. Owens
Summary: The study compared the performance of the IDEXX SediVue Dx Urine Sediment Analyzer with manual microscopy for the detection of urinary casts, finding that SediVue provides moderate agreement with the manual method in detecting casts in urine.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mehmet Erten, Ilknur Tuncer, Prabal D. Barua, Kubra Yildirim, Sengul Dogan, Turker Tuncer, Ru-San Tan, Hamido Fujita, U. Rajendra Acharya
Summary: Microscopic examination of urinary sediments is a common laboratory procedure, and automated image-based classification can improve efficiency. In this study, we developed a classification model that combines an ACM-based mixer algorithm and transfer learning for feature extraction. Our model achieved 98.52% accuracy for seven-class classification, outperforming existing models for urinary cell and sediment analysis.
JOURNAL OF DIGITAL IMAGING
(2023)
Article
Urology & Nephrology
Damin Xu, Jingzi Li, Suxia Wang, Ying Tan, Ying Liu, Minghui Zhao
Summary: The study aims to investigate the association between waxy casts and clinicopathological indices. The results suggest that waxy or pre-waxy casts are closely related to impaired renal function, but they are not sensitive enough.
Article
Multidisciplinary Sciences
Won Seok Yang
Summary: Automated urine sediment analyzers may underestimate the severity of hematuria in glomerular disease, possibly due to dysmorphic red blood cells being susceptible to hemolysis and/or not properly recognized in glomerular disease.
SCIENTIFIC REPORTS
(2021)
Article
Medical Laboratory Technology
Giovanni B. Fogazzi, Giuseppe Garigali, Federico Pieruzzi, Alessandro Corbelli, Fabio Fiordaliso, Dario Consonni, Piergiorgio Messa
Summary: This study demonstrates a wide and complex morphology of fat particles in the urinary sediment of Fabry disease patients, with significant differences in morphology between Fabry disease patients and the control group.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Veterinary Sciences
Sandra Seigner, Kirsten Bogedale, Roswitha Dorsch, Yury Zablotski, Karin Weber
Summary: The Vet Fluidlab 1 (Anvajo) is a new urine sediment analyzer that uses holographic microscopy to detect urine sediment particles in uncentrifuged urine. Compared to manual microscopy and Idexx SediVue analysis, the Fluidlab showed acceptable performance in detecting white blood cells and bacteria, but improvement is needed in the sensitivity for detecting crystals and casts, and the specificity for detecting red blood cells and epithelial cells.
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2022)
Article
Anatomy & Morphology
Abdourahamane Yacouba, Sara Bellali, Gabriel Haddad, Noelle Mavros, Anthony Fontanini, Gregory Dubourg, Jean-Christophe Lagier, Didier Raoult, Jacques Bou Khalil
Summary: SEM and EDX were used to detect and identify microorganisms and crystals in urine samples, showing promising results for their application in urine sediment analysis.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Biochemical Research Methods
Damian Garbicz, Tomas Pilzys, Iga Wisniowski, Malgorzata Grzesiuk, Radoslaw Cylke, Maciej Kosieradzki, Elzbieta Grzesiuk, Jan Piwowarski, Michal Marcinkowski, Wojciech Lisik
Summary: Centrifuging urine samples removes proteins and enriches them with important proteins, increasing the possibility of finding new biomarkers and improving diagnostic accuracy for diseases undiagnosable with classic urine analysis.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Shao-Hsuan Kuo, Alberto Peraro, Hsiu-Pen Lin, Chun-Hao Chang, Bor -Ran Li
Summary: Urinalysis is a simple and common medical test in modern cities, but it remains a challenge for residents in healthcare-poor areas. Therefore, developing a smart and affordable widget to address this challenge is crucial. The proposed mu CUREX platform successfully provides an ultra-low-cost solution for urinalysis in resource-poor settings.
Article
Chemistry, Multidisciplinary
Eric Schwenker, Venkata Surya Chaitanya Kolluru, Jinglong Guo, Rui Zhang, Xiaobing Hu, Qiucheng Li, Joshua T. Paul, Mark C. Hersam, Vinayak P. Dravid, Robert Klie, Jeffrey R. Guest, Maria K. Y. Chan
Summary: This paper introduces an open-source automation framework called ingrained, which solves the correspondence between simulation and experimental images and fuses atomic resolution image simulations into the corresponding experimental images.
Review
Medical Laboratory Technology
Allison B. Chambliss, Tam T. Van
Summary: This review summarizes studies that evaluated reflexive urine microscopy and reflexive urine culture performance, particularly in the context of urinary tract infections. It also examines the reported clinical outcomes from reflexive urinalysis interventions and their impact on antibiotic stewardship efforts.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Article
Medical Laboratory Technology
Eun-Jung Cho, Dae-Hyun Ko, Woochang Lee, Sail Chun, Hae-Kyung Lee, Won-Ki Min
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2018)
Article
Medical Laboratory Technology
Eun-Jung Cho, Chang Kwon Bang, Hyunjung Kim, Hae Kyung Lee
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2020)
Article
Medical Laboratory Technology
Jinyoung Hong, Eun-Jung Cho, Hyun-Ki Kim, Woochang Lee, Sail Chun, Won-Ki Min
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2020)
Article
Medical Laboratory Technology
Su-Kyung Lee, Su Jin Oh, Seoheui Choi, Soo Han Choi, Seon-Hee Shin, Eun Jin Lee, Eun-Jung Cho, Jungwon Hyun, Hyun Soo Kim
Summary: The study investigated the relationship between rotavirus genotype and HBGA-Lewis blood type in Korean children, revealing the predominance of the rotavirus P[6] strain in Korean neonates. The unique VP8* sequence of Korean P[6] strains and amino acid substitutions may be contributing factors to this predominance. This information may be beneficial for future neonatal vaccine development.
ANNALS OF LABORATORY MEDICINE
(2021)
Article
Microbiology
Seri Jeong, Nuri Lee, Su Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Eun Ju Jung, Heungjeong Woo, Yu Bin Seo, Jin Ju Park, Hyun Soo Kim
Summary: This study assessed the positivity rates and associated factors of SARS-CoV-2 antibodies after AstraZeneca vaccination, showing increasing positivity rates over time. More severe and longer lasting adverse reactions were correlated with higher antibody levels, and there was significant agreement and correlation among different detection methods.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Medical Laboratory Technology
Tae-Dong Jeong, Eun-Jung Cho, Kyunghoon Lee, Woochang Lee, Yeo-Min Yun, Sail Chun, Junghan Song, Won-Ki Min
Summary: This study analyzed long-term data of serum creatinine (Cr) assays in Korea between 2011 and 2019, showing a decreasing trend in average bias over time. The study emphasizes the need for continuous efforts to improve the accuracy of Cr assays, especially at low concentrations.
ANNALS OF LABORATORY MEDICINE
(2021)
Article
Medical Laboratory Technology
Eun Ju Jung, Su Kyung Lee, Seon Hee Shin, Jin Soo Kim, Heungjeong Woo, Eun-Jung Cho, Jungwon Hyun, Jae-Seok Kim, Hyun Soo Kim
Summary: This study compared the utility of nasal swabs, naso-pharyngeal swabs (NPSs), and saliva samples for detecting SARS-CoV-2 and other respiratory virus infections. The results showed that NPSs were the most effective sample type, but nasal swabs and saliva samples could be used as alternatives to NPSs. Vigorously rubbed nasal swabs can provide similar SARS-CoV-2 concentrations to NPSs.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Eun-Jung Cho, Tae-Dong Jeong, Sollip Kim, Hyung-Doo Park, Yeo-Min Yun, Sail Chun, Won-Ki Min
Summary: In order to ensure valid results in medical big data research, it is important to have high-quality laboratory input. This study aimed to establish a strategy for evaluating the quality of laboratory results suitable for big data research using KEQAS data. The acceptance rate and bias of different test items were analyzed, showing significant differences based on the quality grade for each criterion.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Eun-Jung Cho, Jinyoung Hong, Jungwon Hyun, Woochang Lee, Hyun Soo Kim, Sail Chun, Won-Ki Min
Summary: This study evaluated the levels of KL-6 and SP-A in healthy individuals and their usefulness in diagnosing ILAs. The results showed a positive association between increased SP-A levels and abnormal CT scans, as well as higher levels of both biomarkers in the mixed pulmonary function test pattern.
CLINICAL BIOCHEMISTRY
(2023)
Article
Medical Laboratory Technology
Seunghoo Lee, Joonsang Yu, Chan-Ik Cho, Eun-Jung Cho, Tae-Dong Jeong, Sollip Kim, Woochang Lee, Sail Chun, Won-Ki Min
Summary: This study evaluates the performance of a collaboration between academia and the government in standardizing laboratory medicine in Korea, specifically in the field of creatinine testing. The results show improvements in acceptance rates and bias levels over the eight-year period, indicating the positive impact of the collaboration.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Letter
Medical Laboratory Technology
Sollip Kim, Eun-Jung Cho, Tae-Dong Jeong, Hyung-Doo Park, Yeo-Min Yun, Kyunghoon Lee, Yong-Wha Lee, Sail Chun, Won-Ki Min
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Eun-Jung Cho, Younggil Cha, Su Kyung Lee, Han-Sung Kim, Jae-Seok Kim, Eun Jin Lee, Nuri Lee, Ki Ho Hong, Hee Jin Huh, Young Joo Cha, Hyun Soo Kim
Summary: In this study, synthetic norovirus GI and GII RNA reference materials were developed and characterized. The results showed that the synthetic RNAs could be accurately detected using commercial detection kits and exhibited homogeneity and stability. These synthetic RNAs can serve as reference materials for norovirus molecular detection methods.
ANNALS OF LABORATORY MEDICINE
(2023)