Journal
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Volume 45, Issue 8, Pages 747-754Publisher
WILEY
DOI: 10.1111/1440-1681.12946
Keywords
inflammation; interleukin-4; rheumatic diseases
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Funding
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX17-1940]
- National Natural Science Foundation of China [81671616, 81471603]
- Science and Technology Project of Nantong City [MS32015021]
- project of 333 Natural Science Foundation of Jiangsu [BRA2016527]
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Rheumatism is a group of diseases, most of which are autoimmune diseases, that violate joints, bones, muscles, blood vessels and related soft tissue. As is well known, cytokines play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, and systemic lupus erythematosus. Recently, the role of interleukin-4 (IL-4), which may participate in the mechanism of rheumatism, have been discovered. It is reported that IL-4 takes part in the regulation of T cell activation, differentiation, proliferation, and survival of different T cell types. IL-4 also has an immunomodulatory effect on B cells, mast cells, macrophages, and many cell types. A review of the literature on functions of IL-4 in rheumatic diseases is presented.
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