Genetics of immune-mediated inflammatory diseases

The Autoimmune Risk VariantPTPN22C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire

(2017) Genita Metzler et al.   JOURNAL OF IMMUNOLOGY

Interleukin 23 inhibitors for psoriasis: not just another number

(2017) Hervé Bachelez   LANCET

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types

(2017) Sung Chun et al.   NATURE GENETICS

The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping

(2017) Stephen Eyre et al.   Nature Reviews Rheumatology

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn’s Disease

(2016) Stephan R Targan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Environmental exposures and the development of systemic lupus erythematosus

(2016) Medha Barbhaiya et al.   CURRENT OPINION IN RHEUMATOLOGY

Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice

(2016) Shatakshi Sood et al.   JOURNAL OF IMMUNOLOGY

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

(2016) David Ellinghaus et al.   NATURE GENETICS

Immune checkpoints and rheumatic diseases: what can cancer immunotherapy teach us?

(2016) Michiel van der Vlist et al.   Nature Reviews Rheumatology

The Autoimmune Ecology

(2016) Juan-Manuel Anaya et al.   Frontiers in Immunology

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

(2015) Suna Onengut-Gumuscu et al.   NATURE GENETICS

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

(2015) Mary D Fortune et al.   NATURE GENETICS

Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis

(2015) Dominique Baeten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic Arthritis

(2015) Philip J. Mease et al.   NEW ENGLAND JOURNAL OF MEDICINE

Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci

(2015) Paul Martin et al.   Nature Communications

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

(2015) John Bowes et al.   Nature Communications

Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families

(2015) Chang-Fu Kuo et al.   JAMA Internal Medicine

The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization

(2014) G. Fousteri et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cigarette smoking, alcohol consumption and risk of systemic lupus erythematosus

(2014) SU Takvorian et al.   LUPUS

How do autoimmune diseases cluster in families? A systematic review and meta-analysis

(2013) Jorge Cárdenas-Roldán et al.   BMC Medicine

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

(2013) Anne Hinks et al.   NATURE GENETICS

Genetic insights into common pathways and complex relationships among immune-mediated diseases

(2013) Miles Parkes et al.   NATURE REVIEWS GENETICS

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

(2013) Ricardo C. Ferreira et al.   PLoS Genetics

Seventeen in Crohn's disease: less prime than we thought?

(2012) Tim Raine et al.   GUT

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

(2012) Adam P. Gregory et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Chromatin marks identify critical cell types for fine mapping complex trait variants

(2012) Gosia Trynka et al.   NATURE GENETICS

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

(2012) Lam C Tsoi et al.   NATURE GENETICS

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

(2012) Kim A. Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of Tumor Necrosis Factor-alpha (TNF-α) in the pathogenesis of systemic lupus erythematosus

(2011) Mariana Postal et al.   CYTOKINE

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

(2011) Tihamer Orban et al.   LANCET

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

(2011) Indra Adrianto et al.   NATURE GENETICS

Promise and pitfalls of the Immunochip

(2011) Adrian Cortes et al.   ARTHRITIS RESEARCH & THERAPY

Pervasive Sharing of Genetic Effects in Autoimmune Disease

(2011) Chris Cotsapas et al.   PLoS Genetics

Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus

(2010) G. Orozco et al.   ANNALS OF THE RHEUMATIC DISEASES

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

(2010) Edoardo Fiorillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23

(2009) Gisela Orozco et al.   HUMAN MOLECULAR GENETICS

Role of B cells in systemic lupus erythematosus and rheumatoid arthritis

(2008) Laura Mandik-Nayak et al.   CURRENT OPINION IN IMMUNOLOGY

Efficacy and safety of TNF-blocker therapy in systemic lupus erythematosus

(2008) Martin Aringer et al.   Expert Opinion On Drug Safety

Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity

(2008) Diana Chessman et al.   IMMUNITY

Abatacept in children with juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled withdrawal trial

(2008) Nicolino Ruperto et al.   LANCET