PR-957 mediates neuroprotection by inhibiting Th17 differentiation and modulating cytokine production in a mouse model of ischaemic stroke

PR-957, a selective inhibitor of immunoproteasome subunit low-MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing Th17-cell differentiation and regulating cytokine production

(2017) Haijie Liu et al.   FASEB JOURNAL

Genetic Variants and Multiple Sclerosis Risk Gene SLC9A9 Expression in Distinct Human Brain Regions

(2016) Guiyou Liu et al.   MOLECULAR NEUROBIOLOGY

Inhibition of immunoproteasome reduces infarction volume and attenuates inflammatory reaction in a rat model of ischemic stroke

(2015) X Chen et al.   Cell Death & Disease

Applying the ARRIVE Guidelines to an In Vivo Database

(2015) Natasha A. Karp et al.   PLOS BIOLOGY

Chrysin Protects against Focal Cerebral Ischemia/Reperfusion Injury in Mice through Attenuation of Oxidative Stress and Inflammation

(2014) Yang Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reactive glia show increased immunoproteasome activity in Alzheimer’s disease

(2013) Marie Orre et al.   BRAIN

Interleukin-17 in post-stroke neurodegeneration

(2013) Walter Swardfager et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Temporal and Geographic Trends in the Global Stroke Epidemic

(2013) A. S. Kim et al.   STROKE

Transient Focal Cerebral Ischemia Upregulates Immunoproteasomal Subunits

(2012) Lanhai Lü et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Importance of T Lymphocytes in Brain Injury, Immunodeficiency, and Recovery after Cerebral Ischemia

(2012) Vanessa H Brait et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Immunoproteasome Subunit LMP7 Deficiency and Inhibition Suppresses Th1 and Th17 but Enhances Regulatory T Cell Differentiation

(2012) K. W. Kalim et al.   JOURNAL OF IMMUNOLOGY

How does adaptation sweep through the genome? Insights from long-term selection experiments

(2012) M. K. Burke   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Distinctive Effects of T Cell Subsets in Neuronal Injury Induced by Cocultured Splenocytes In Vitro and by In Vivo Stroke in Mice

(2012) Lijuan Gu et al.   STROKE

The Antiviral Immune Response in Mice Devoid of Immunoproteasome Activity

(2011) M. Basler et al.   JOURNAL OF IMMUNOLOGY

Stroke and the immune system: from pathophysiology to new therapeutic strategies

(2011) Richard Macrez et al.   LANCET NEUROLOGY

The Temporal Profile of Inflammatory Markers and Mediators in Blood after Acute Ischemic Stroke Differs Depending on Stroke Outcome

(2010) H. Worthmann et al.   CEREBROVASCULAR DISEASES

Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice

(2010) Jacqueline Moebius et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Reduction of β-Amyloid Deposits by γ-Secretase Inhibitor is Associated with the Attenuation of Secondary Damage in the Ipsilateral Thalamus and Sensory Functional Improvement after Focal Cortical Infarction in Hypertensive Rats

(2010) Yusheng Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Prevention of Experimental Colitis by a Selective Inhibitor of the Immunoproteasome

(2010) M. Basler et al.   JOURNAL OF IMMUNOLOGY

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A combined scoring method to assess behavioral recovery after mouse spinal cord injury

(2010) Ahdeah Pajoohesh-Ganji et al.   NEUROSCIENCE RESEARCH

Isoflurane Posttreatment Reduces Neonatal Hypoxic–Ischemic Brain Injury in Rats by the Sphingosine-1-Phosphate/Phosphatidylinositol-3-Kinase/Akt Pathway

(2010) Yilin Zhou et al.   STROKE

Behavioral deficits after distal focal cerebral ischemia in mice: Usefulness of adhesive removal test.

(2009) Thomas Freret et al.   BEHAVIORAL NEUROSCIENCE

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice

(2009) Valentine Bouet et al.   Nature Protocols