Review
Medicine, General & Internal
Aleksandra Kaluzna, Pawel Olczyk, Katarzyna Komosinska-Vassev
Summary: This review paper summarizes the current understanding of the involvement of the innate and adaptive immune systems in the pathogenesis of ulcerative colitis (UC). It discusses the role of various immune cells, such as neutrophils, dendritic cells, macrophages, innate lymphoid cells, cytotoxic lymphocytes, regulatory T cells, and helper T cells in the development of UC. The review also highlights the influence of B lymphocytes and cytokines on the disease. The paper concludes by mentioning the advancement in immune-targeted treatments for UC, known as biologic agents.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jonasz Jeremiasz Weber, Stefanie Cari Anger, Priscila Pereira Sena, Rana Dilara Incebacak Eltemur, Chrisovalantou Huridou, Florian Fath, Caspar Gross, Nicolas Casadei, Olaf Riess, Huu Phuc Nguyen
Summary: This study demonstrates that calpains cleave TBP and cause mislocalization of its fragments, leading to the development of SCA17. SCA17 cell and rat models show excessive activation of calpains, resulting in fragmentation and depletion of neuronal proteins. Additionally, pharmacological or genetic inhibition of calpains improves cell viability.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Immunology
Tianmeng Yan, Zhenying Zhang
Summary: Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting elderly individuals. It presents with heterogeneous manifestations, typically characterized by microscopically subepidermal separation and mixed inflammatory infiltrate. The development mechanism of BP remains unclear. B cells are involved in pathogenic autoantibody production, and other immune cells such as T cells, type II inflammatory cytokines, eosinophils, mast cells, neutrophils, and keratinocytes also contribute to the pathogenesis of BP. This review focuses on the roles and crosstalk between innate and adaptive immune cells in BP.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Wolfgang Poller, Bettina Heidecker, Enrico Ammirati, Andreas W. Kuss, Ana Tzvetkova, Wolfram C. Poller, Carsten Skurk, Arash Haghikia
Summary: In the field of clinical immunology, the outbreak of COVID-19 has driven studies on the role of inflammation in cardiovascular diseases. Advanced molecular genetic methods have been used to explore the diagnostic significance of these diseases and to identify immunological interactions at organ and system levels. Additionally, research has shown the influence of emotional stress on viral and cardiovascular disorders through brain-immune system interactions. However, there are challenges that need to be addressed before these findings can be fully applied in the clinical arena.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Anne-Charlotte Heba, Simon Toupance, Djesia Arnone, Laurent Peyrin-Biroulet, Anthanase Benetos, Ndeye Coumba Ndiaye
Summary: Telomeres are repetitive DNA sequences located at the ends of linear chromosomes that play a crucial role in maintaining the integrity and stability of the genome. Research has shown a close connection between telomere length dynamics and immune-mediated inflammatory diseases, although the causality between these diseases and telomere attrition remains controversial.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Cell Biology
Aicha Kriaa, Vincent Mariaule, Amin Jablaoui, Soufien Rhimi, Hela Mkaouar, Juan Hernandez, Brice Korkmaz, Adam Lesner, Emmanuelle Maguin, Ali Aghdassi, Moez Rhimi
Summary: Inflammatory bowel diseases (IBDs) are a global public health problem with limited effective therapeutic options. Changes in gut microbiota composition and alterations in bile acids (BAs) have been identified as important factors in dysregulated intestinal immunity and the pathogenesis of IBDs. This review explores the interactions between BAs and gut microbiota in IBDs and discusses how the gut microbiota-BA-host axis may influence digestive inflammation.
Article
Immunology
Ming-Wei Jan, Hong-Lin Su, Tsung-Hsien Chang, Kuen-Jer Tsai
Summary: Human parechovirus type 3 (PeV-A3) infection is identified as a cause of severe nerve disease or sepsis in infants and young children, with neuropathogenic mechanisms involving interferon and inflammatory cytokine expression, activation of death signaling pathways, and establishment of an experimental disease model of parechovirus encephalitis. In vivo studies in neonatal mice showed weight loss, paralysis, and mortality, with evidence of PeV-A3 infection, inflammatory cytokine expression, and death signaling transduction in the brain tissues. These findings suggest that PeV-A3-mediated neurological disorders involve activation of death signaling and inflammation responses, which may contribute to clinical manifestations associated with PeV-A3 infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Bing Yan, Yimin Ren, Chang Liu, Linping Shu, Chengshuo Wang, Luo Zhang
Summary: Cystatin SN, a member of the cystatin protein superfamily, is associated with inflammatory airway diseases. It plays a protective role against destructive proteolysis and also initiates T2 immunity, leading to disease. Understanding the role of cystatin SN can assist in the management of airway diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Daniela Siel, Caroll J. Beltran, Eduard Martinez, Macarena Pino, Nazla Vargas, Alexandra Salinas, Oliver Perez, Ismael Pereira, Galia Ramirez-Toloza
Summary: Canine chronic inflammatory enteropathy (CIE) is a common chronic gastrointestinal disease in dogs, with genetic, environmental, intestinal microbiota, and dysregulated immune responses playing a role in its development. Although there have been advances in understanding the immunological and molecular mechanisms of CIE, the exact pathogenesis remains unknown. Future research should focus on characterizing the immunopathogenesis of canine CIE in order to establish biomarkers and molecular targets for diagnosis, prognosis, or treatment.
Review
Biochemistry & Molecular Biology
Santina Venuto, Anna Rita Daniela Coda, Ruperto Gonzalez-Perez, Onofrio Laselva, Doron Tolomeo, Clelia Tiziana Storlazzi, Arcangelo Liso, Massimo Conese
Summary: The lung is an important organ for gas exchange and immune response. The insulin-like growth factor (IGF) system and its binding proteins (IGFBPs) play a role in the development of the lung as well as the pathogenesis of respiratory diseases and lung tumors. Among the IGFBPs, IGFBP-6 has emerged as a mediator of airway inflammation and tumor suppression in lung tumors. This review focuses on the multiple roles of IGFBP-6 in respiratory diseases, including its function in inflammation, fibrosis, and different types of lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Shumpei Yokota, Takako Miyamae, Yoshiyuki Kuroiwa, Kusuki Nishioka
Summary: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, is believed to have originated from bats. The virus acts on human ACE2, leading to infections in cells and triggering an inflammatory response, which can result in a range of symptoms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Libo Liu, Jiaxiang Li, Yueshuang Ke, Xianlu Zeng, Jinmin Gao, Xueqing Ba, Ruoxi Wang
Summary: Parthanatos is a form of regulated cell death that plays a role in the pathogenesis of many diseases, particularly neurodegenerative disorders. Understanding the key factors and biochemical mechanisms of the Parthanatos pathway is essential for developing drugs and therapeutic strategies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Immunology
Chongshan Yuan, Yuhong He, Kunyu Xie, Lianjun Feng, Shouyang Gao, Lifu Cai
Summary: This article reviews the important role of the microbiota gut brain axis in inflammatory and infectious diseases. It discusses the composition, communication mechanism, regulatory methods, and signaling pathways of the MGB axis. The article also explores the efficacy of interventions such as fecal microbiota transplantation, antibiotics, and probiotics in the management of these diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biology
Xinxin Chi, Miaozhen Huang, Hailin Tu, Bin Zhang, Xin Lin, Huji Xu, Chen Dong, Xiaoyu Hu
Summary: Except for a few cases caused by single gene mutations, the majority of autoimmune diseases are influenced by both environmental and genetic factors. Despite progress in understanding certain effector cells and molecules associated with inflammation and tissue damage, the exact cause of common autoimmune disorders remains unknown. Population genetics approaches have contributed greatly to our knowledge of genetic susceptibility to autoimmunity, allowing for a comprehensive re-examination of genes and pathways. This review aims to discuss the etiology and pathogenesis of common autoimmune disorders from a human genetics perspective, covering innate immunity, adaptive immunity, and inflammatory cell death processes. By exploring new molecules and pathways, we hope to broaden our understanding of autoimmunity beyond the current limited therapeutic targets.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Cell Biology
Jack L. McMurray, Anouk von Borstel, Taher E. Taher, Eleni Syrimi, Graham S. Taylor, Maria Sharif, Jamie Rossjohn, Ester B. M. Remmerswaal, Frederike J. Bemelman, Felipe A. Vieira Braga, Xi Chen, Sarah A. Teichmann, Fiyaz Mohammed, Andrea A. Berry, Kirsten E. Lyke, Kim C. Williamson, Michael J. T. Stubbington, Martin S. Davey, Carrie R. Willcox, Benjamin E. Willcox
Summary: Gamma delta T cells are traditionally considered innate-like lymphocytes, but a new adaptive-like compartment has now been identified. This adaptive subset undergoes pathogen-driven differentiation, similar to conventional CD8(+) T cells. Expansions of specific TCRs are detected exclusively in the effector cells, indicating a specialized response to antigens.
Article
Otorhinolaryngology
Ming Zeng, Heng Wang, Bo Liao, Hai Wang, Xiao-Bo Long, Jin Ma, Jin-Xin Liu, Zheng Liu
Summary: The study aimed to develop prediction models for response to postoperative glucocorticoid- and macrolide-based therapy in CRS patients. Classification trees based on clinical characteristics and biological markers were used to predict refractory CRS in patients treated with fluticasone propionate or clarithromycin, with an overall predictive accuracy of 89.3% and 87.8% respectively.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2021)
Article
Otorhinolaryngology
Kai Xu, Xin-Hao Zhang, Xiao-Bo Long, Xiang Lu, Zheng Liu
Summary: The study found that only one out of eight cases of bedside tracheostomy had positive samples in the environment, which was from a patient who underwent early tracheostomy. This suggests that delayed tracheostomy may be less contagious than early tracheostomy.
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2021)
Review
Allergy
Ming Zeng, De-Yun Wang, Joaquim Mullol, Zheng Liu
Summary: Studies from around the world have shown that chemosensory dysfunction is common in patients with COVID-19, but the prevalence of smell and/or taste disorders varies significantly among different ethnic and geographic populations. While the pathogenesis of chemosensory dysfunction remains unclear, suggestions for diagnosis and treatment of COVID-19 patients with smell and taste disorders have been summarized.
CURRENT ALLERGY AND ASTHMA REPORTS
(2021)
Article
Allergy
Zhi-Chao Wang, Yin Yao, Cai-Ling Chen, Cui-Lian Guo, Hong-Xia Ding, Jia Song, Zhe-Zheng Wang, Nan Wang, Xue-Li Li, Bo Liao, Yang Yang, Di Yu, Zheng Liu
Summary: PD-1(high) CXCR5(-)CD4(+) T cells contribute to local immunoglobulin production independent of ectopic lymphoid tissues in nasal polyps.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Allergy
Yin Yao, Ming Zeng, Zheng Liu
Summary: Chronic rhinosinusitis (CRS) is a highly heterogeneous disorder with significant epidemiological, clinical and immunopathological variations, with Asian patients presenting more neutrophilic inflammation compared to Western patients. The efficacy of T2 biologics in Asian CRS patients remains uncertain, highlighting the need for further research and the development of novel treatments targeting non-T2 inflammation.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Letter
Critical Care Medicine
Yin Yao, Ao Huang, Yi-Ke Deng, Yan Liu, Hong-Yu Zhu, Nan Wang, Zhe-Zheng Wang, Rong-Fei Zhu, Di Yu, Zheng Liu
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Allergy
Jing-Xian Li, Zhe-Zheng Wang, Guan-Ting Zhai, Cai-Ling Chen, Ke-Zhang Zhu, Ze Yu, Zheng Liu
Summary: This study identified specific metabolic signatures associated with different types of chronic rhinosinusitis (CRS), inflammatory patterns, and disease outcomes, providing novel insights into pathophysiologic mechanisms, subtype-specific biomarkers, and treatment targets of CRS.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Correction
Allergy
Li-Li Shi, Zheng Liu
Review
Immunology
Di Yu, Lucy S. K. Walker, Zheng Liu, Michelle A. Linterman, Zhanguo Li
Summary: Yu et al. review the crucial roles of follicular helper T cells in humoral immunity, including sustaining germinal center B cell responses, regulating antibody affinity maturation and memory formation, and mediating pathogenic autoimmune responses. Understanding the regulation of follicular helper T cell generation and function is important for disease prevention and treatment, as well as vaccine development and enhancement.
Review
Otorhinolaryngology
Yin Yao, Hong-Yu Zhu, Ming Zeng, Zheng Liu
Summary: This review examines the immunological mechanisms and treatable traits of chronic rhinosinusitis (CRS) in Asia. The findings suggest that Asian CRS patients display different inflammatory signatures, bacterial colonization, and comorbidities compared to patients in Western countries. Understanding the distinct immunological mechanisms between Asian and Western CRS patients may facilitate more effective treatment interventions.
CLINICAL OTOLARYNGOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Yang Liu, Zheng Liu
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Allergy
Bo Liao, Yi-Ke Deng, Ming Zeng, Zheng Liu
Summary: Olfactory dysfunction (OD) and gustatory dysfunction (GD) are common symptoms complained by COVID-19 patients, which may last for months to years. Female gender, initial severity of dysfunction, nasal congestion, emotional distress and depression, and SARS-CoV-2 variants have been identified as risk factors for persistent OD and GD in long COVID-19. The pathogenesis of OD and GD in long COVID-19 remains unknown, but may be similar to the persistent OD and GD after common respiratory viral infection. Corticosteroids and olfactory training might be potential treatment options, but more studies are needed to prove their efficacy.
CURRENT ALLERGY AND ASTHMA REPORTS
(2023)
Article
Immunology
Li Fu, Zheng Liu, Yang Liu
Summary: FGL2 is a membrane-bound protein with immune-associated coagulation activity and immunosuppressive functions. It plays an immunomodulatory role in inflammatory diseases and cancer, and could serve as a disease biomarker and therapeutic target.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Yang Liu, Li Fu, Zheng Liu
Summary: The airway epithelium is exposed to external irritants that release cytokines initiating allergic airway diseases. Biological agents targeting downstream cytokines may not be sufficient, and targeting upstream epithelial cytokines, including osteopontin (OPN), has been proposed. OPN plays a role in Th2-skewed airway diseases and has potential clinical relevance. Understanding the role of OPN in different airway diseases can provide directions for further investigation and clinical management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Allergy
Cui-Lian Guo, Ruo-Yu Lu, Chong-Shu Wang, Jie-Fang Zhao, Li Pan, Hui-Cheng Liu, Bo Liao, Zheng Liu
Summary: This study aimed to determine the optimal anchor for T2 inflammation and identify clinical characteristics and nasal secretion biomarkers predicting different endotypes in chronic rhinosinusitis with nasal polyps (CRSwNP). IL-13 was found to be the best marker for the T2 endotype, and clinical characteristics and nasal secretion biomarkers were useful for predicting different endotypes.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
