Journal
CLINICAL & TRANSLATIONAL ONCOLOGY
Volume 20, Issue 9, Pages 1109-1116Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1007/s12094-018-1839-y
Keywords
Circular RNAs; CircRNAs; Exosomes; Extracellular vesicles; Non-coding RNAs; Cancer
Categories
Funding
- National Program on Key Research Project [2016YFC0905900]
- Medical Training Programme Foundation for the Talents by Jiangsu Provincial Department of health [17 [2016]]
- 333 Talent Project of Jiangsu Province [4 [2016]]
- National key clinical specialist construction Programs of China [544 [2013]]
- Natural Science Foundation of Jiangsu Province [BK20151579]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) [JX10231802]
- Key Research Program for the Social Development of Jiangsu Province, China [BE2015718]
- National Natural Science Foundation of China [81602551]
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Circular RNAs (CircRNAs) are a type of non-coding RNAs (NcRNAs) with a closed annular structure. Until next-generation sequencing (NGS) is developed, the misunderstanding of circRNAs 'splicing error' has changed, and the mysterious veil of circRNAs has been revealed. NGS provides an approach to investigate circRNAs. Many scholars point out that circRNAs may play an important role in many diseases, especially cancer. At the same time, exosomes, as a kind of extracellular vesicles loaded with many contents, are a hotspot in recent years. They can act as 'messengers' between cells, especially in cancer. Lately, it is interesting circRNAs are enriched and stable in exosomes, also called exo-circRNAs, and there have been several articles on circRNAs associated with exosomes. In this review, we summarize the characteristics of circRNAs, especially its main functions. Then, we briefly introduce exosomes and their function in cancer. Finally, the known relation between circRNAs and exosomes is discussed. With further researches, exo-circRNAs may be a novel pathway for cancer diagnosis and targeted therapy.
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