Article
Multidisciplinary Sciences
Tetsuo Sasano, Kensuke Ihara, Toshihiro Tanaka, Tetsushi Furukawa
Summary: This study aimed to assess the risk of paroxysmal atrial fibrillation (PAF) and stroke using genetic analysis and circulating biomarkers, and found that a genetic risk score using 4 SNPs associated with AF could evaluate the risk of AF. Additionally, plasma cfDNA level could be used to assess the risk of stroke, with diagnostic value for patients with a history of stroke.
Review
Biochemistry & Molecular Biology
Vanessa Desantis, Maria Assunta Potenza, Luca Sgarra, Carmela Nacci, Antonietta Scaringella, Sebastiano Cicco, Antonio Giovanni Solimando, Angelo Vacca, Monica Montagnani
Summary: The pathophysiology of atrial fibrillation (AF) may involve atrial fibrosis/remodeling and dysfunctional endothelial activities. miRNAs regulate gene expression at the post-transcriptional level and may represent novel and attractive biomarker candidates in AF due to their ease of accessibility in biofluids and prognostic and diagnostic properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Nicoline W. E. van den Berg, Makiri Kawasaki, Fransisca A. Nariswari, Benedetta Fabrizi, Jolien Neefs, Ingeborg van der Made, Robin Wesselink, Wim Jan P. van Boven, Antoine H. G. Driessen, Aldo Jongejan, Joris R. de Groot
Summary: This study aims to elucidate the regulatory role of miRNAs in the mRNA signature of atrial fibrillation (AF) and identify potential targets for future therapies. Through combined miRNA-mRNA sequencing, differentially expressed miRNAs and their target genes were discovered in atrial tissues of patients with and without AF. Downregulated miRNAs were associated with upregulated gene expression involved in cell migration and glycosaminoglycan biosynthesis. In vitro inhibition experiments confirmed the effects of miRNAs on predicted target genes. These identified miRNAs can be explored as potential targets for anti-fibrotic therapies in AF.
CELL AND TISSUE RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Lilla Szuromi, Orsolya Hajas, Edina Nagy-Balo, Ildiko N. Forgacs, Laszlo T. Nagy, Miklos Fagyas, Attila Toth, Bela Nagy Jr, Janos Kappelmayer, Zoltan Csanadi
Summary: This study aimed to evaluate the association between the concentrations of different biomarkers and the long-term success of pulmonary vein isolation (PVI) in patients with a structurally normal heart. The levels of CA-125, Caspase-3, Cathepsin L, and Galectin-3 were found to be unrelated to AF recurrence after PVI in patients with a structurally normal heart and primarily paroxysmal AF. Except for CA-125, all the other biomarkers demonstrated a significant decrease during a 3-year follow-up post-ablation. Furthermore, there was a positive correlation between Caspase-3 levels and LA dimensions in patients with AF recurrence.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Genetics & Heredity
Sven Geurts, Michelle M. J. Mens, Maxime M. Bos, M. Arfan Ikram, Mohsen Ghanbari, Maryam Kavousi
Summary: The study revealed a significant association between miR-4798-3p and prevalent AF in men, suggesting its potential role in regulating target genes related to AF pathophysiology. Further experimental studies are warranted to investigate the mechanisms underlying this association.
Review
Medicine, Research & Experimental
Chang Yi Li, Jing Rui Zhang, Wan Ning Hu, Song Nan Li
Summary: Atrial fibrillation (AF) is closely linked with fibrosis, which is a key factor in structural changes that impact the occurrence and persistence of AF. Despite the complexity of this process, advancements in technology now allow for non-invasive evaluation of fibrosis, facilitating the selection of personalized treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Andreas Metzner, Karl-Heinz Kuck, Julian K. R. Chun
Summary: Atrial fibrillation ablation is an important treatment option for symptomatic patients, with electrical isolation of the pulmonary veins as the cornerstone. The lack of persistent isolation limits the understanding of the impact on AF suppression, necessitating the development of novel ablation systems to improve success rates.
Article
Multidisciplinary Sciences
Maarten Hulsmans, Maximilian J. Schloss, I-Hsiu Lee, Aneesh Bapat, Yoshiko Iwamoto, Claudio Vinegoni, Alexandre Paccalet, Masahiro Yamazoe, Jana Grune, Steffen Pabel, Noor Momin, Hana Seung, Nina Kumowski, Fadi E. Pulous, Daniel Keller, Constanze Bening, Ursula Green, Jochen K. Lennerz, Richard N. Mitchell, Andrew Lewis, Barbara Casadei, Oriol Iborra-Egea, Antoni Bayes-Genis, Samuel Sossalla, Chin Siang Ong, Richard N. Pierson, Jon C. Aster, David Rohde, Gregory R. Wojtkiewicz, Ralph Weissleder, Filip K. Swirski, George Tellides, George Tolis, Serguei Melnitchouk, David J. Milan, Patrick T. Ellinor, Kamila Naxerova, Matthias Nahrendorf
Summary: This study deciphered the role of immune and stromal cells in atrial fibrillation and identified SPP1(+) macrophages as potential targets for immunotherapy in atrial fibrillation.
Article
Cardiac & Cardiovascular Systems
Zainu Nezami, Hannes Holm, Marcus Ohlsson, John Molvin, Johan Korduner, Erasmus Bachus, Amir Zaghi, Anna Dieden, Pyotr G. G. Platonov, Amra Jujic, Martin Magnusson
Summary: This study found that elevated levels of three plasma proteins associated with myocardial fibrosis were associated with the presence of AF in HF patients, while elevated levels of five plasma proteins were associated with an increased risk of mortality in HF patients with or without AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Timothy R. Betts, Wilson W. Good, Lea Melki, Andreas Metzner, Andrew Grace, Atul Verma, Stephen Murray, Simon James, Tom Wong, Lucas V. A. Boersma, Daniel Steven, Arian Sultan, Sonia Busch, Petr Neuzil, Carlo de Asmundis, Justin Lee, Tamas Szili-Torok
Summary: The RECOVER AF study evaluated the performance of non-contact charge-density mapping to guide the ablation of non-PV targets in persistent AF patients. The study showed that 76% of patients were AF-free at 12 months. For patients who had only received PVI, the AF-free rate was 91%.
Article
Medicine, Research & Experimental
Hongting Hao, Sen Yan, Xinbo Zhao, Xuejie Han, Ning Fang, Yun Zhang, Chenguang Dai, Wenpeng Li, Hui Yu, Yunlong Gao, Dingyu Wang, Qiang Gao, Yu Duan, Yue Yuan, Yue Li
Summary: Atrial fibrosis plays a critical role in the development of atrial fibrillation. The promotion of atrial fibrosis through inhibition of GPD1L by miR-210-3p in extracellular vesicles is identified. Preventing pathological crosstalk between atrial myocytes and fibroblasts may offer a novel approach to ameliorate atrial fibrosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Genetics & Heredity
Junjie Liu, Ximao Liu, Yucheng Luo, Fangze Huang, Yu Xie, Shaoyi Zheng, Bo Jia, Zezhou Xiao
Summary: Sphingolipids play a crucial role in tissue fibrosis, including cardiac fibrosis, and are important for the development of atrial fibrillation. Understanding the impact of sphingolipid levels on cardiac fibrosis can lead to innovative therapeutic strategies for addressing fibrosis and atrial fibrillation.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Cardiac & Cardiovascular Systems
Domenico G. Della Rocca, Luigi Di Biase, Sanghamitra Mohanty, Chintan Trivedi, Carola Gianni, Jorge Romero, Nicola Tarantino, Michele Magnocavallo, Mohamed Bassiouny, Veronica N. Natale, Angel Quintero Mayedo, Bryan Macdonald, Carlo Lavalle, Ghulam Murtaza, Krishna Akella, Giovanni B. Forleo, Amin Al-Ahmad, John David Burkhardt, Gerald Joseph Gallinghouse, Javier E. Sanchez, Rodney P. Horton, Juan F. Viles-Gonzalez, Dhanunjaya Lakkireddy, Andrea Natale
Summary: Extending ablation strategy to the entire posterior wall may provide acceptable long-term arrhythmia-free survival for PerAF patients without inducible non-PV triggers, as approximately 70% of patients in this cohort had non-PV triggers, and eliminating these triggers significantly improved outcomes.
Article
Biochemistry & Molecular Biology
Leon Bloebaum, Marco Witkowski, Max Wegner, Stella Lammel, Philipp-Alexander Schencke, Kai Jakobs, Marianna Puccini, Daniela Reissner, Daniel Steffens, Ulf Landmesser, Ursula Rauch, Julian Friebel
Summary: According to the leaky gut concept, microbial products can enter the circulation and cause inflammation in various cardiovascular diseases. This study specifically looked at the levels of these products in patients with early atrial fibrillation.
Article
Health Care Sciences & Services
Aikaterini Vraka, Vicente Bertomeu-Gonzalez, Lorenzo Facila, Jose Moreno-Arribas, Raul Alcaraz, Jose J. Rieta
Summary: This study analyzes the crucial steps of coronary sinus catheterization and left and right pulmonary veins isolation in pulmonary veins catheter ablation for atrial fibrillation. The results show that P-waves are more affected than local activation waves by the ablation process, and LPVI has the most significant impact on P-wave duration.
JOURNAL OF PERSONALIZED MEDICINE
(2022)