Article
Geriatrics & Gerontology
Ziad S. Mahmassani, Alec McKenzie, Jonathan J. Petrocelli, Naomi M. de Hart, Dennis K. Fix, Joshua J. Kelly, Lisa M. Baird, Michael T. Howard, Micah J. Drummond
Summary: Periods of inactivity in older adults lead to resistance to nutrient metabolism, causing abnormalities in skeletal muscle transcription and translation, which contributes to muscle dysfunction. Leucine can alter the translation of genes related to inactivity, as well as increase the translational efficiency of certain transcripts independent of mRNA abundance.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Priscilla Ming Yi Lee, Bixia Huang, Gengze Liao, Chi Kuen Chan, Lai-bun Tai, Chun Yuk Jason Tsang, Chi Chiu Leung, Mei-Po Kwan, Lap Ah. Tse
Summary: This study found that the impact of COVID-19 on physical activity and rest-activity circadian rhythm for the community people may be short-term, indicating strong resilience of the community population.
Review
Immunology
Poppy Nathan, Julie Elizabeth Gibbs, G. Ed Rainger, Myriam Chimen
Summary: As individuals age, there is dysregulation of leukocyte trafficking and decreased circadian outputs. The relationship between age-related circadian changes and the development of immune-mediated inflammatory disorders (IMIDs) requires further investigation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Psychology, Clinical
Jennifer L. Burgess, Andrew J. Bradley, Kirstie N. Anderson, P. Gallagher, R. Hamish McAllister-Williams
Summary: This study suggests an association between sleep abnormalities and cognition in patients with bipolar disorder, with little or no relationship with physical activity, BMI, and circadian rhythm.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Jiaren Chen, Ting-Fu Lai, Li-Jung Lin, Jong-Hwan Park, Yung Liao
Summary: This study aimed to investigate the association between overall and timing-specific physical activity and depressive symptoms in older Taiwanese adults. The results showed that overall moderate-to-vigorous physical activity (MVPA) engagement was associated with lower depressive symptom scores in older adults. However, no significant associations were observed between overall light physical activity (LPA), timing-specific MVPA and LPA, and depression in older adults.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Jingen Li, Soumya Vungarala, Virend K. Somers, Junrui Di, Francisco Lopez-Jimenez, Naima Covassin
Summary: This study found an association between rest-activity rhythm and obesity. Low amplitude, low mesor, low stability, and high fragmentation of the rhythm were associated with general and abdominal obesity. These results highlight the importance of regulating circadian rhythm in obesity management.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Yanyan Xu, Shaoyong Su, William McCall, Xiaoling Wang
Summary: Disruption of circadian rhythm is associated with immune system disturbance and chronic inflammation. This study examined the association between rest-activity circadian rhythm and chronic inflammation using white blood-cell-based inflammatory indices. The results showed that a stronger circadian rhythm was associated with decreased white blood cell count, neutrophil count, and systemic immune-inflammation index.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Yiting He, Haobin Cen, Lianxia Guo, Tianpeng Zhang, Yi Yang, Dong Dong, Baojian Wu
Summary: This study aimed to investigate the potential role of NPAS2 in controlling the diurnal expression and activity of hepatic CYP1A2 and to determine the underlying mechanisms. The results showed that NPAS2 plays a key transcriptional regulatory role in mice, and its loss leads to decreased expression and activity of CYP1A2, which affects its rhythmicity. This study contributes to a better understanding of circadian metabolism and chronopharmacokinetics.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marta Budkowska, Elzbieta Cecerska-Heryc, Zuzanna Marcinowska, Aldona Siennicka, Barbara Dolegowska
Summary: This study aimed to investigate the activity of several enzymes related to oxidative stress and the concentration of glutathione in the circadian rhythm. The results showed that the activity of these enzymes and the concentration of glutathione peaked at 2 a.m. during sleep. This suggests that the processes maintaining the redox balance are intensified during sleep, thus reducing oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Ya Niu, Shuang Tang
Summary: The circadian system plays a crucial role in regulating physiological functions and has been found to influence cancer risk and progression. Recent studies have shown that certain nuclear receptors, which regulate the circadian clock, also play important roles in multiple cancer processes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Immunology
Krisztina Ella, Agnes R. Sudy, Zsofia Bur, Bence Koos, Armin S. Kisiczki, Attila Mocsai, Krisztina Kaldi
Summary: Time restricted eating can reduce the symptoms of autoinflammatory joint arthritis and modulate the rhythm and inflammatory potential of leukocytes, leading to a milder reactivity of the immune system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Enakshi Saha, Rahul Ghosal
Summary: The study investigates the impact of chronic diseases on physical activity (PA) patterns in older adults, with a specific focus on gender differences. The findings highlight that certain diseases affect PA differently in males and females, suggesting the need for gender-specific interventions in promoting PA and improving health outcomes.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Physiology
Nour Barazi, Nazari Polidovitch, Ryan Debi, Simona Yakobov, Robert Lakin, Peter H. Backx
Summary: The study found that heart rate and blood pressure in mice show clear circadian patterns, which are mainly influenced by physical activity and cardiac autonomic nerve system activity. The research revealed that, compared to physical activity, the cardiac autonomic nerve system plays a dominant role in circadian heart rate fluctuations, and the effects of physical activity on daily heart rate variations are remarkably small unless mice have access to running wheels.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Sabrina Klemz, Thomas Wallach, Sandra Korge, Mechthild Rosing, Roman Klemz, Bert Maier, Nicholas C. Fiorenza, Irem Kaymak, Anna K. Fritzsche, Erik D. Herzog, Ralf Stanewsky, Achim Kramer
Summary: In organisms with circadian clocks, the post-translational modifications of clock proteins, particularly phosphorylation, play a crucial role in controlling circadian rhythms. Protein phosphatase 4 (PPP4) and its regulatory subunit PPP4R2 have been identified as critical components in mammals and Drosophila, affecting the circadian system by regulating phosphorylation and transactivation activity of CLOCK/BMAL1.
GENES & DEVELOPMENT
(2021)
Review
Neurosciences
Nicolas Jacquelot, Gabrielle T. Belz, Cyril Seillet
Summary: The Earth's rotation creates biological clocks that regulate physiological processes and immune system. Neuroimmune interactions play a role in rhythmic activity of immune cells, and disruption of these rhythms can lead to chronic inflammation in murine models.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Endocrinology & Metabolism
Giovanni Lombardi, Edgard Delvin
Summary: Osteoporosis is a prevalent bone disease and circulating microRNAs have shown potential as diagnostic and prognostic markers. However, the lack of standardization and harmonization of methods limits their application.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Neurosciences
Ramin Mahdipour, Alireza Ebrahimzadeh-Bideskan, Mahmoud Hosseini, Sara Shahba, Giovanni Lombardi, Amir Mohammad Malvandi, Abbas Mohammadipour
Summary: Neurological disorders have a significant impact on global health, and grape seed extract shows potential as a valuable therapeutic agent due to its antioxidant, anti-inflammatory, and protein homeostasis maintenance properties.
NUTRITIONAL NEUROSCIENCE
(2023)
Review
Endocrinology & Metabolism
Paola Maroni, Marta Gomarasca, Giovanni Lombardi
Summary: Long non-coding RNAs (lncRNAs) have potential as biomarkers for early cancer diagnosis, prognosis, and therapeutic targets. Bone metastasis is a common progression of advanced cancers, particularly breast, prostate, and lung cancers. Understanding the pathophysiology of bone metastasis and improving clinical management are challenging but important areas of research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Chiara Verdelli, Giulia Stefania Tavanti, Irene Forno, Valentina Vaira, Riccardo Maggiore, Leonardo Vicentini, Paolo Dalino Ciaramella, Francesca Perticone, Giovanni Lombardi, Sabrina Corbetta
Summary: This study found that osteocalcin (OC), a bone matrix protein, can modulate the function of parathyroid tumor cells by activating the calcium sensing receptor (CASR). OC reduces the activity of pERK/ERK and increases the levels of active beta-catenin through CASR activation. It also affects the expression of related genes to influence the physiological functions of parathyroid tumor cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Carlotta Mondadori, Amit Chandrakar, Silvia Lopa, Paul Wieringa, Giuseppe Talo, Silvia Perego, Giovanni Lombardi, Alessandra Colombini, Matteo Moretti, Lorenzo Moroni
Summary: The study investigated the ability of scaffold architecture to modulate macrophage polarization. The rhombus architecture was found to promote the release of certain cytokines by M2a macrophages, which may have a positive impact on the healing process.
BIOACTIVE MATERIALS
(2023)
Review
Cell Biology
Laura Gerosa, Amir Mohammad Malvandi, Marco Malavolta, Mauro Provinciali, Giovanni Lombardi
Summary: The locomotor system, consisting of skeletal muscles and bones, plays a vital role in maintaining function and preventing frailty. As individuals age, chronic disorders of the locomotor system may arise, negatively impacting bone and muscle function. Senescent cells, which accumulate in muscle tissue with advancing age or under pathological conditions, impair muscle regeneration and contribute to muscle weakness. Additionally, senescence in the bone microenvironment affects bone turnover, increasing the risk of osteoporosis. Understanding the mechanisms underlying cellular senescence in musculoskeletal tissues may aid in developing effective biomarkers for early detection of tissue flaws.
AGEING RESEARCH REVIEWS
(2023)
Article
Endocrinology & Metabolism
Ewa Rodziewicz-Flis, Ulana Juhas, Jakub Antoni Kortas, Joanna Jaworska, Ilona Bidzan-Bluma, Anna Babinska, Katarzyna Micielska, Malgorzata Zychowska, Giovanni Lombardi, Jedrzej Antosiewicz, Ewa Ziemann
Summary: The study showed that regular Nordic Walking training with additional resistance improved cognitive functions and physical performance in older adults. These positive effects were associated with a reduced BDNF concentration and kynurenine-to-tryptophan ratio as well as changes in the amino acid profile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Federico Pennestri, Giuseppe Banfi
Summary: The Italian Government plans to invest euro15 billion of European funds to digitalize the National Health Service and enhance primary care. Telemedicine is considered a key innovation to achieve these goals, but no details are given on how digitalization and remote care technologies should be implemented. This paper focuses on the contribution of digitalization and telemedicine to primary care innovations, drawing from implemented technology-driven policies. These policies can significantly benefit from digitalization and remote care technology, provided that risks and limitations are considered.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jacopo Antonino Vitale, Stefano Borghi, Tito Bassani, Carmelo Messina, Luca Maria Sconfienza, Fabio Galbusera
Summary: The study aimed to assess the changes of lumbar angles when lying on a mattress versus a rigid surface. The results showed that the lumbar angles were greater when lying on a mattress. The choice of mattress is important for quality of life.
EUROPEAN RADIOLOGY EXPERIMENTAL
(2023)
Article
Sport Sciences
Aleksandra Zagrodna, Anna Ksiazek, Malgorzata Slowinska-Lisowska, Jan Chmura, Piotr Ponikowski, Giovanni Lombardi
Summary: The aim of this study was to investigate the impact of running a marathon on sclerostin and intact PTH concentration in middle-aged males. The results showed that the levels of serum sclerostin and iPTH increased immediately after the marathon race but returned to baseline after 7 days. It was suggested that running a marathon affected skeletal metabolism by inhibiting bone formation through sclerostin expression and inducing long-lasting PTH elevation to maintain adequate calcium levels for neuromuscular activity and muscle contraction.
JOURNAL OF SPORTS SCIENCES
(2023)
Article
Geriatrics & Gerontology
Francesca Marchegiani, Rina Recchioni, Mirko Di Rosa, Francesco Piacenza, Fiorella Marcheselli, Anna Rita Bonfigli, Roberta Galeazzi, Giulia Matacchione, Maurizio Cardelli, Antonio Domenico Procopio, Andrea Corsonello, Antonio Cherubini, Roberto Antonicelli, Giovanni Lombardi, Fabrizia Lattanzio, Fabiola Olivieri
Summary: This study analyzed the association between circulating miRNA and routine laboratory biomarkers with mortality risk in geriatric patients affected by cardiovascular multimorbidity. The results suggest that lower levels of circulating miR-17 and miR-126-3p are associated with higher short- and medium-term mortality risk in hospitalized elderly patients with cardiovascular multimorbidity.
Article
Nutrition & Dietetics
Matteo Briguglio, Thomas W. Wainwright, Giovanni Lombardi
Summary: Accurately identifying malnourished patients in surgical research can enhance the prediction of postoperative recovery potential, utilizing literature-based equations built on historical data to classify patients is essential for efficient studies.
FRONTIERS IN NUTRITION
(2023)
Review
Medicine, Research & Experimental
Fabien D. Legrand, Benoit Dugue, Joe Costello, Chris Bleakley, Elzbieta Miller, James R. Broatch, Guillaume Polidori, Anna Lubkowska, Julien Louis, Giovanni Lombardi, Francois Bieuzen, Paolo Capodaglio
Summary: Whole-body cryotherapy is a non-pharmacological treatment that influences inflammatory events and has various benefits, such as improved sleep quality, faster neuromuscular recovery, and chronic pain relief. It may also have positive effects on mental health and cognitive functions. There have been concerns about its safety, but these concerns are often based on misunderstandings regarding the differences between whole-body cryotherapy and partial-body cryotherapy. This article reviews the literature and concludes that the safety risks associated with whole-body cryotherapy are within acceptable limits and can be prevented by following existing recommendations and guidelines.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Physiology
Jacopo A. Vitale, Stefano Borghi, Maria Francesca Piacentini, Giuseppe Banfi, Antonio La Torre
Summary: This study investigated the sleep characteristics of elite track-and-field athletes and found significant differences in sleep patterns between sexes and among different disciplines. Female athletes had better sleep quality, while sleep-hygiene strategies had a positive impact on athletes' sleep parameters.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)