Article
Biochemistry & Molecular Biology
Huda H. Shaaban, Walaa G. Hozayen, Amal K. Khaliefa, Ayman E. El-Kenawy, Tarek M. Ali, Osama M. Ahmed
Summary: This study demonstrated that diosmin, trolox, and their combination exert significant anti-arthritic, anti-inflammatory, and antioxidant effects in male Wistar rats by suppressing NF-kappa B signaling, inhibiting matrix metalloproteinases, and activating Nrf2.
Article
Medicine, Research & Experimental
Hossein Amiri, Fatemeh Shabkhiz, Parisa Pournemati, Amir Hossein Saffar Kohneh Quchan, Reza Zeighami Fard
Summary: This study investigated the effects of swimming exercise on oxidative stress and liver cell damage caused by electromagnetic radiation in rats. The results showed that swimming exercise attenuated the liver damage caused by electromagnetic radiation. In the electromagnetic radiation group, the activity of superoxide dismutase and catalase decreased significantly, and the concentration of malondialdehyde and liver enzymes increased significantly; while in the swimming exercise and electromagnetic radiation + swimming exercise groups, the activity of superoxide dismutase and catalase increased significantly, and the concentration of malondialdehyde and liver enzymes decreased significantly.
Article
Biochemistry & Molecular Biology
Tianhui Niu, Yan Zhi, Lizhao Wei, Wenjun Liu, Xiaoxiao Ju, Weiping Pi, Zhaojun Fu, Hao Tong, Haixiang Hu, Jing Dong
Summary: Electromagnetic radiation can cause injuries to the heart, and there is currently no therapy available to prevent these effects. This study investigated the role of Sirtuin 3 (SIRT3) in electromagnetic radiation-induced cardiomyopathy (eRIC). The study found that Sirt3 expression was down-regulated in eRIC mice, and its overexpression protected the heart from the detrimental effects of radiation. It was also found that Sirt3 maintained the AMP-activated protein kinase (AMPK) signaling pathway in stressed hearts. These findings suggest that SIRT3 could be a potential therapeutic target for treating eRIC.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yue-Mei Sun, Xin-Yue Wang, Xin-Ru Zhou, Chong Zhang, Ke-Jian Liu, Fu-Yin Zhang, Bin Xiang
Summary: This study demonstrates that salidroside has potential in protecting radiation-damaged salivary glands by improving secretion function, enhancing antioxidant defense, preserving mitochondrial ultrastructure, and inhibiting cell apoptosis.
Article
Medicine, General & Internal
Jasmina Brboric, Aleksandra Klisic, Jelena Kotur-Stevuljevic, Giovanna Delogu, Darinka Gjorgieva Ackova, Kristina Kostic, Maria Antonietta Dettori, Davide Fabbri, Paola Carta, Luciano Saso
Summary: The aim of this study was to identify representatives of natural and natural-like phenol monomers and their C2-symmetric dimers with the strongest antioxidant activity and the lowest prooxidant activity. The results showed that dehydrozingerone derivatives (compounds 6 and 12) exhibited the highest antioxidant activity and could be potential precursors for the synthesis of novel polyphenolic molecules with therapeutic applications.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Junqi Men, Li Zhang, Ruiyun Peng, Yanyang Li, Meng Li, Hui Wang, Li Zhao, Jing Zhang, Haoyu Wang, Xinping Xu, Ji Dong, Juan Wang, Binwei Yao, Jiabin Guo
Summary: The present study demonstrated that exposure to 2.856 GHz microwave radiation caused significant structural and functional impairments of the male reproductive system, including hormone disorder, decreased sperm motility, depleted sperm energy, and abnormalities of testicular structure as well as mitochondrial impairment. However, metformin was found to effectively protect the reproductive system against these damages by inhibiting oxidative stress and apoptosis, indicating its potential as a promising antioxidant to mitigate the harmful effects of microwave radiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Betul Yalcin, Arzu Hanim Yay, Fazile Canturk Tan, Saim Ozdamar, Oguz Galip Yildiz
Summary: Radiotherapy is commonly used for cancer treatment, and this study aimed to investigate the effects of melatonin on liver tissues exposed to radiation. Rats were divided into different groups and received radiation with or without melatonin treatment. Histological and biochemical analyses were performed on the liver tissues. The results showed that melatonin treatment attenuated the structural and immunoreactive changes caused by radiation, and it also decreased biochemical markers of liver damage. Administration of melatonin before radiation showed more beneficial effects. In conclusion, daily use of melatonin could mitigate radiation-induced damage in the liver.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Chemistry, Physical
Linghong Guo, Tianyou Wang, Zhixuan Li, Shuwei Wu, Yuanyuan Xu, Zhen Yang, Yiwen Li, Zhipeng Gu, Xian Jiang
Summary: Inspired by the natural photoprotective mechanism, melanin-like materials were used to enhance the efficiency and stability of sanshool, resulting in melanin-sanshool nanoparticles with uniform sizes, improved stability, effective UV absorption, and antioxidative capacities. The skin permeation, photoprotective activity, and potential mechanism of melanin-sanshool nanoparticles were investigated using cellular and animal models, providing a platform for improving the properties of naturally occurring functional molecules.
CHEMISTRY OF MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Ketren Carvalho Gomes, Francisco Wanderson Bizerra Lima, Helen Quezia da Silva Aguiar, Suiane Silva de Araujo, Clarissa Amorim Silva de Cordova, Fabiano Mendes de Cordova
Summary: The study found that the use of thiamine in conjunction with Trolox or DMSO for TD treatment can enhance recovery in mice and possibly minimize late neurological sequelae.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Divya Gupta, Sajida Archoo, Shahid Hussain Naikoo, Sheikh Tasduq Abdullah
Summary: UVB radiation causes mitochondrial fragmentation, leading to ROS imbalance and activation of mitochondrial apoptotic signals.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Jessica Franco Dalenogare, Marina de Souza Vencato, Greice Franciele Feyh Dos Santos Montagner, Thiago Duarte, Marta Maria Medeiros Frescura Duarte, Camila Camponogara, Sara Marchesan Oliveira, Marcelo Leite da Veiga, Maria Izabel de Ugalde Marques da Rocha, Maria Amalia Pavanato, Liliane de Freitas Bauermann
Summary: Cubiu, an Amazonian fruit, has been widely used for food and treating inflammatory conditions like skin wound healing. This study evaluated the safety and therapeutic effects of cubiu extract in Wistar rats. The results showed that cubiu is safe and non-toxic, and has antioxidant and anti-inflammatory properties. When combined with magnetic field treatment, cubiu enhances the healing process and reduces inflammation and oxidative stress.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maria Cristina Polidori, Patrizia Mecocci
Summary: This review explores the role of oxidative stress in aging and frailty, highlighting the need for effective management strategies to prevent and address frailty.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Plant Sciences
Xiaomeng Zhang, Xiaoying Chen, Lei Wang, An Wang, Changhao He, Zhongyu Shi, Shujing Zhang, Qian Fu, Wenhui Xu, Sumin Hu
Summary: This study confirmed the protective effects of YQJD decoction on ionizing radiation-induced spermatogenic cell injury. The findings may provide a new strategy for the application of Chinese herbs in radioprotection.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Cell Biology
Qin-Qi Wang, Gang Yin, Jiang-Rong Huang, Shi-Jun Xi, Feng Qian, Rui-Xue Lee, Xiao-Chun Peng, Feng-Ru Tang
Summary: Population aging poses challenges to the global economy and healthcare services. Brain aging, influenced by external factors like ionizing radiation, can lead to various neurological disorders. Treatment targeting radiation-induced oxidative stress and neuroinflammation may prevent radiation-induced brain aging and related neurological disorders.
Review
Biochemistry & Molecular Biology
Tsutomu Shimura
Summary: Under physiological and stress conditions, mitochondria function as a signaling platform for biological events, transmitting information from the mitochondria to the rest of the cell. Mitochondrial molecules such as ATP, reactive oxygen species, cytochrome C, and damage-associated molecular patterns act as messengers in metabolism, stress response, apoptosis, senescence, and inflammation. This review paper summarizes the mitochondrial signaling in response to DNA damage, as well as the regulation of mitochondrial quality control and the role of mitochondrial dysfunction in radiation-induced carcinogenesis. The analysis of the mitochondrial radiation effect is crucial in assessing radiation risks to human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)