Article
Clinical Neurology
Shama D. Karanth, Yuriko Katsumata, Peter T. Nelson, David W. Fardo, Jaclyn K. McDowell, Frederick A. Schmitt, Richard J. Kryscio, Steven R. Browning, Dejana Braithwaite, Susanne M. Arnold, Erin L. Abner
Summary: This study investigated the association between cancer diagnosis and neuropathological and cognitive features of dementia. The findings showed that cancer diagnosis was associated with a lower burden of Alzheimer's disease pathology and less cognitive impairment.
Review
Medicine, Research & Experimental
Mehdi Sanati, Samaneh Aminyavari, Amir R. Afshari, Amirhossein Sahebkar
Summary: Alzheimer's disease (AD) is a type of dementia characterized by memory decline and cognition impairment. There are similarities between AD and noninsulin-dependent diabetes mellitus (NIDDM), which suggests that metformin, a hypoglycemic agent, could be used as an alternative therapy for AD. Preclinical studies have shown that metformin can improve cognition and memory impairment in AD models through various mechanisms.
Article
Clinical Neurology
Yalun Zhang, Yi Zhang, Yahyah Aman, Cheung Toa Ng, Wing-Hin Chau, Zhigang Zhang, Ming Yue, Christopher Bohm, Yizhen Jia, Siwen Li, Qiuju Yuan, Jennifer Griffin, Kin Chiu, Dana S. M. Wong, Binbin Wang, Dongyan Jin, Ekaterina Rogaeva, Paul E. Fraser, Evandro F. Fang, Peter St George-Hyslop, You-Qiang Song
Summary: Research has shown that the transcription factor PAX6 is increased in Alzheimer's disease, playing a key role in the hyperphosphorylation of tau protein induced by amyloid-beta. Downregulation of PAX6 can protect against amyloid-beta-induced neuronal death. This study provides novel potential targets for pharmaceutical intervention by modulating signaling pathways involving CDK/pRB/E2F1.
Review
Biochemistry & Molecular Biology
Pasquale Picone, Tiziana Sanfilippo, Sonya Vasto, Sara Baldassano, Rossella Guggino, Domenico Nuzzo, Donatella Bulone, Pier Luigi San Biagio, Emanuela Muscolino, Roberto Monastero, Clelia Dispenza, Daniela Giacomazza
Summary: Alzheimer's disease is the most common neurodegenerative disorder in the elderly, characterized by senile plaques and neurofibrillary tangles. There is currently a lack of treatment options aside from symptomatic medications. This review presents research results on the use of peptides of different sizes for the treatment of Alzheimer's disease.
Review
Clinical Neurology
Jorge A. Trejo-Lopez, Anthony T. Yachnis, Stefan Prokop
Summary: Postmortem diagnosis remains central to Alzheimer's disease research, but advances in pathophysiology understanding and clinical diagnosis have shifted the perspective. In addition to the key pathological hallmarks, the diversity of accompanying pathological changes is gaining attention.
Review
Cell Biology
Kunie Ando, Siranjeevi Nagaraj, Fahri Kucukali, Marie-Ange De Fisenne, Andreea-Claudia Kosa, Emilie Doeraene, Lidia Lopez Gutierrez, Jean-Pierre Brion, Karelle Leroy
Summary: This article provides an overview of the current knowledge about the PICALM gene, including its physiological functions, genetic variants, post-translational modifications, and relevance to Alzheimer's disease pathogenesis.
Review
Biotechnology & Applied Microbiology
Sai Sreenivasamurthy, Mahek Laul, Nan Zhao, Tiffany Kim, Donghui Zhu
Summary: Alzheimer's disease is a progressive neurodegenerative disease associated with aging. Two-dimensional cell culture and animal models have contributed to our understanding of the disease mechanism, but they cannot fully capture the complexity of human brain tissue. The emergence of three-dimensional cerebral organoid models offers a more accurate representation of human brain tissue.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shuchi Goyal, Manjinder Singh, Divya Thirumal, Pratibha Sharma, Somdutt Mujwar, Krishna Kumar Mishra, Thakur Gurjeet Singh, Ravinder Singh, Varinder Singh, Tanveer Singh, Sheikh F. Ahmad
Summary: Alzheimer's disease is caused by plaque agglomeration and entanglement in neural cells, leading to apoptosis. Current research is focused on GSK-3 inhibitor analogues for potential treatment advancements.
Article
Clinical Neurology
Sudeshna Das, Zhaozhi Li, Astrid Wachter, Srinija Alla, Ayush Noori, Aicha Abdourahman, Joseph A. Tamm, Maya E. Woodbury, Robert V. Talanian, Knut Biber, Eric H. Karran, Bradley T. Hyman, Alberto Serrano-Pozo
Summary: Through RNA sequencing of brain tissues from Alzheimer's disease patients and controls using laser capture microdissection, it was found that there are molecular changes in different brain cell types associated with neuroinflammation and neuronal dysfunction, especially around Aβ plaques, and these changes are more severe in individuals with APOE ε4 genotype.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Jessica E. Owen, Bryndis Benediktsdottir, Elizabeth Cook, Isleifur Olafsson, Thorarinn Gislason, Stephen R. Robinson
Summary: The study found a link between obstructive sleep apnea and Alzheimer's disease, with OSA severity potentially negatively affecting the hippocampus, but the presence of NFTs and A beta plaques may not necessarily be related to OSA severity.
Review
Biochemistry & Molecular Biology
Hossein Ashrafian, Elaheh Hadi Zadeh, Rizwan Hasan Khan
Summary: Approximately 40 million people globally suffer from dementia, with Alzheimer's disease being the most common cause. Aggregation of Aβ outside of neuron cells and tau protein tangle formation inside cells are believed to play crucial roles. This paper reviews studies targeting the inhibition of these protein aggregations to suppress or postpone AD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Neurosciences
Devargya Ganguly, Joshua Abby Thomas, Abid Ali, Rahul Kumar
Summary: EphA-4 plays a significant role in the onset and progression of Alzheimer's disease. Inhibition of EphA-4 can alleviate symptoms and affect the development of the disease. Further research on the regulation pathways of EphA-4 and the development of therapeutic methods targeting its enzymatic activity are important.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Jasvinder Singh Bhatti, Naina Khullar, Jayapriya Mishra, Satinder Kaur, Abhishek Sehrawat, Eva Sharma, Gurjit Kaur Bhatti, Ashley Selman, P. Hemachand Reddy
Summary: Alzheimer's disease is a neurodegenerative disorder that results in memory loss and cognitive decline. The causes of AD are complex and involve factors such as protein build-up, synaptic damage, abnormal gene expression, and hormonal imbalance. Current medications only alleviate symptoms and there is a need for therapies, such as stem cell therapy, that can prevent or reverse cognitive decline. This article provides an overview of the pathophysiology of AD, existing treatments, and the future potential of stem cell-based therapies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Immunology
Clara Munoz-Castro, Ayush Noori, Colin G. Magdamo, Zhaozhi Li, Jordan D. Marks, Matthew P. Frosch, Sudeshna Das, Bradley T. Hyman, Alberto Serrano-Pozo
Summary: This study developed a method of fluorescent immunohistochemistry and image analysis that enables a comprehensive quantitative characterization of astrocytes and microglia in Alzheimer's disease. The results revealed three distinct phenotypes of glial cells and their association with AD pathology. The study also demonstrated the potential of machine learning models in accurately discriminating control vs. AD diagnoses at the single-cell level.
JOURNAL OF NEUROINFLAMMATION
(2022)