Journal
CHINESE JOURNAL OF ORGANIC CHEMISTRY
Volume 38, Issue 6, Pages 1364-1376Publisher
SCIENCE PRESS
DOI: 10.6023/cjoc201712031
Keywords
1,8-naphthalimide; fluorescent probe; D-pi-A; fluorescent mechanism; two-photon imaging
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Funding
- National Natural Science Foundation of China [21472172, 21272212]
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Fluorescent imaging technology has received great attention owing to their advantageous features in high sensitivity, relatively simple operations and real-time living cells, tissue and in vivo imaging. Compared with one-photon confocal imaging, two-photon confocal imaging offers considerable advantages such as high resolution, deep-tissue depth, lower tissue auto-fluorescence and so on. As typical D-pi-A two-photon dyes, 1,8-naphthalimide dyes have wide application in two-photon imaging for enzyme, reactive carbon species, reactive oxygen species, reactive nitrogen species, biothiols and ions due to their advantages such as high photostability, large Stokes/anti-Stokes shifts. According to the mechanisms of intramolecular charge transfer, photoinduced electron transfer and fluorescence resonance energy transfer, etc., the application in two-photon imaging of 1,8-naphthalimide dyes is summarized and emphasized.
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