4.7 Article

Selenium deficiency sensitizes the skin for UVB-induced oxidative damage and inflammation which involved the activation of p38 MAPK signaling

Journal

FOOD AND CHEMICAL TOXICOLOGY
Volume 75, Issue -, Pages 139-145

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2014.11.017

Keywords

Selenium deficiency; UV radiation; Skin; Oxidative damage; Inflammation; p38

Funding

  1. Fundamental Research Funds for the Central Universities [XDJK2014A020, XDJK2013B009]
  2. Finance from State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University [2012009]

Ask authors/readers for more resources

Ultraviolet B (UVB) radiation causes oxidative damage and inflammation, and ultimately increases the risk of skin carcinogenesis. Selenium is an essential trace element, previous studies indicated selenium deficiency impairs tissue antioxidant capacity in different experimental models. However, the synergistic effect of selenium deficiency and UVB radiation on skin damage is not clear. In the current study, our data revealed selenium deficiency resulted in further increases of reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS) and phosphorylated H2AX levels, decreases of GSH level and antioxidant enzyme activities in UVB-irradiated mice. Selenium deficiency also exacerbated UVB-induced cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1 beta) and IL-6 mRNA expressions. Mechanism studies indicated that UVB-induced p38 signaling was further elevated in the skin of mice maintained with selenium deficiency diet, compared with those maintained with selenium adequate diet. Our investigation suggested that selenium deficiency diet weakens the antioxidant capacity of UVB-irradiated mice skin, which sensitizes to UV radiation-induced oxidative damage and inflammation. (C) 2014 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Cardiac & Cardiovascular Systems

Myocardial protective effect of sacubitril-valsartan on rats with acute myocardial infarction

Jian An, Ye Du, Xiaohong Li, Qingbo Bao, Yanqing Guo, Yang Song, Yongping Jia

Summary: The study demonstrates that early application of sacubitril-valsartan has a protective effect on rats with acute myocardial infarction. The sacubitril-valsartan group showed a reduction in left ventricular volume and collagen fiber range, as well as an increase in ejection fraction compared to the valsartan group.

PERFUSION-UK (2022)

Article Cardiac & Cardiovascular Systems

Effect of intensive versus limited monitoring on clinical trial conduct and outcomes: A randomized trial

Neel M. Butala, Yang Song, Changyu Shen, David J. Cohen, Robert W. Yeh

Summary: Intensive monitoring in TAVR trials resulted in more monitoring action items, but did not significantly affect trial outcomes. Tailored limited monitoring strategies can be implemented without influencing the integrity of TAVR trial outcomes.

AMERICAN HEART JOURNAL (2022)

Article Peripheral Vascular Disease

Predictors of blood pressure response to ultrasound renal denervation in the RADIANCE-HTN SOLO study

Manish Saxena, Roland E. Schmieder, Ajay J. Kirtane, Felix Mahfoud, Joost Daemen, Jan Basile, Philipp Lurz, Philippe Gosse, Kintur Sanghvi, Naomi D. L. Fisher, Lars C. Rump, Atul Pathak, Peter J. Blankestijn, Anthony Mathur, Yale Wang, Michael A. Weber, Andrew S. P. Sharp, Michael J. Bloch, Neil C. Barman, Lisa Claude, Yang Song, Michel Azizi, Melvin D. Lobo

Summary: This post-hoc analysis of the RADIANCE-HTN SOLO study found that predictors of response to renal denervation (RDN) included higher baseline daytime ambulatory diastolic blood pressure and use of antihypertensive medications, with orthostatic hypertension potentially predicting response. Obese females also appeared to have a better response to RDN in an interaction model.

JOURNAL OF HUMAN HYPERTENSION (2022)

Letter Cardiac & Cardiovascular Systems

Days at Home After Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients

Mabel Chung, Kamil F. Faridi, Dhruv S. Kazi, Zaid I. Almarzooq, Yang Song, Suzanne J. Baron, Robert W. Yeh

JAMA CARDIOLOGY (2022)

Article Biochemistry & Molecular Biology

Immunopharmacological Properties of VitD3: 1, 25VitD3 Modulates Regulatory T Cells and Th17 Cells and the Cytokine Balance in PBMCs from Women with Unexplained Recurrent Spontaneous Abortion (URSA)

Jiefan Gao, Li Wang, Lei Bu, Yangyang Song, Xiao Huang, Jing Zhao

Summary: This research investigates the impact of 1,25VitD3 on the regulatory T cells/Th17 axis and the expressions and concentrations of related cytokines in women with URSA. The results suggest that 1,25VitD3 plays a role in modulating immune responses by strengthening Tregs function and inhibiting inflammatory responses of Th17 cells, which may be beneficial for successful pregnancy outcomes.

CURRENT MOLECULAR PHARMACOLOGY (2022)

Article Cardiac & Cardiovascular Systems

Individualizing Dual Antiplatelet Therapy (DAPT) Duration Based on Bleeding Risk, Ischemic Risk, or Both: An Analysis From the DAPT Study

Nino Mihatov, Eric A. Secemsky, Dean J. Kereiakes, P. Gabriel Steg, Donald E. Cutlip, Ajay J. Kirtane, Roxana Mehran, Bokai Zhao, Yang Song, C. Michael Gibson, Robert W. Yeh

Summary: In a low-bleeding risk population, stratifying patients based on predicted ischemic risk and the DAPT score best discerned benefit versus harm of extended DAPT duration on ischemic events, bleeding events, and NACE.

CARDIOVASCULAR REVASCULARIZATION MEDICINE (2022)

Letter Critical Care Medicine

Decline in Prolonged Acute Mechanical Ventilation, 2011-2019

Anica C. Law, Wei Tian, Yang Song, Jennifer P. Stevens, Allan J. Walkey

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

Article Psychology, Social

Family-of-origin triangulation and marital stability: A multiple mediation model

Yang Song, Sitong Liu, Yongfang Liu

Summary: This study explored the effects of family-of-origin triangulation on marital stability in China and the mediating roles of parenting sense of competence and coparenting. The results showed a negative association between family-of-origin triangulation and marital stability, with coparenting playing a mediating role, while parenting sense of competence did not have a significant mediating effect.

SOCIAL BEHAVIOR AND PERSONALITY (2022)

Article Environmental Sciences

Iron oxide nanoparticles oxidize transformed RAW 264.7 macrophages into foam cells: Impact of pulmonary surfactant component dipalmitoylphosphatidylcholine

Haidong Li, Xiaoqi Tao, Erqun Song, Yang Song

Summary: Iron oxide nanoparticles (IONPs) are an important component of airborne particulate matter and may have adverse effects on respiratory health. This study found that IONPs interact with pulmonary surfactant, leading to reduced cellular uptake and increased cytotoxicity. Mechanistic studies showed that IONPs react with intracellular hydrogen peroxide, generating hydroxyl radicals and causing oxidative stress, lipid accumulation, and inflammation.

CHEMOSPHERE (2022)

Article Cardiac & Cardiovascular Systems

Differences in Comorbidities Explain Black-White Disparities in Outcomes After Femoropopliteal Endovascular Intervention

Anna K. Krawisz, Sahana Natesan, Rishi K. Wadhera, Siyan Chen, Yang Song, Robert W. Yeh, Michael R. Jaff, Jay Giri, Howard Julien, Eric A. Secemsky

Summary: Black adults in the United States have a higher incidence of peripheral artery disease and limb amputations compared to White adults. Racial differences exist in the incidence and outcomes of peripheral endovascular intervention (PVI). Black adults who undergo PVI are younger, more likely to be female, and have a higher burden of comorbidities. They are also more likely to undergo PVI for chronic limb-threatening ischemia. The association between Black race and adverse outcomes is driven by a higher burden of comorbidities. Early identification and aggressive management of risk factors and comorbidities are important in reducing racial disparities in peripheral artery disease and adverse events after PVI.

CIRCULATION (2022)

Article Cardiac & Cardiovascular Systems

Disparities in Cardiovascular Mortality Between Black and White Adults in the United States, 1999 to 2019

Ashley N. Kyalwazi, Emefah C. Loccoh, LaPrincess C. Brewer, Elizabeth O. Ofili, Jiaman Xu, Yang Song, Karen E. Joynt Maddoxe, Robert W. Yeh, Rishi K. Wadhera

Summary: Over the past 20 years, cardiovascular mortality rates have declined significantly for Black and White adults in the United States, but disparities still exist, especially in terms of geographic determinants of health and residential racial segregation.

CIRCULATION (2022)

Review Physiology

The optimal exercise modality and intensity for hemodialysis patients incorporating Bayesian network meta-analysis and systematic review

Yangyang Song, Lei Chen, Meng Wang, Quan He, Jinhong Xue, Hongli Jiang

Summary: This network meta-analysis study found that combined training and moderate-vigorous intensity exercise may be the most effective interventions for improving physical function and blood pressure control in hemodialysis patients.

FRONTIERS IN PHYSIOLOGY (2022)

Article Environmental Sciences

Ultraviolet dechlorination of tetrachloro-p-benzoquinone by hydrogen sulfide: Theoretical confirmation of the significance of hydrosulfide radical

Jia Gu, Wei Zhang, Sai Xu, Yang Song, Jun Ma

Summary: This study systematically investigates the role of hydrogen sulfide (H2S) in the transformation of tetrachloro-p-benzoquinone (TCBQ) under UV irradiation. The findings show that the first triplet state of TCBQ can react with bisulfide anion (HS-) to form primary dechlorination product (HS-TriCBQ). The addition of nucleophiles (OH- or HS-) to the hydroxyl or thiol group is the most efficient pathway for dechlorination, and electron transfer from HS- can generate hydrosulfide radical for the dechlorination of TCBQ.

CHEMOSPHERE (2022)

Article Chemistry, Physical

Copper loaded nitrogen-rich mesoporous carbon nitride as a highly efficient photocatalyst for selective oxidative cleavage of C(sp3)-C(sp3) bonds at room temperature under visible light

Jiabao Guo, Yizhuo Zhao, Peng Wang, Yang Song, Yifei Shao, Li Zhu, Xiaoquan Yao

Summary: In this study, a novel copper loaded nitrogen-rich mesoporous carbon nitride material was designed and synthesized as a highly efficient photocatalyst for the selective cleavage of inert C-C bonds of amines under blue light irradiation. With the use of benign oxidant oxygen, good to excellent yields were achieved for various functionalized amines at room temperature, including sluggish aliphatic amines. This method offers a cost-effective and environmentally friendly alternative for the direct oxidative cleavage of amines.

JOURNAL OF MATERIALS CHEMISTRY A (2022)

Article Spectroscopy

Fluorescence Spectra Analysis of N-n-Octyl Oyridine Acetate Ionic Liquid in Different Solvents

Tian Peng, Xiao Xue-song, Su Gui-tian, Duan Han-feng, Jin Yao-dong, Song Yang-yang, Huang Tao, Zhang Hang

Summary: Ionic liquids have unique properties that make them attractive in the chemical industry and related fields. However, their classification as green solvents requires further study on their toxicity, degradation, and environmental impact. Therefore, the development of detection methods for ionic liquids in different solvents is of great importance.

SPECTROSCOPY AND SPECTRAL ANALYSIS (2022)

No Data Available