Rapid determination of illegal additives chrysoidin and malachite green by surface-enhanced Raman scattering with silanized support based substrate

This paper reports accurate use of silanized support based substrate for surface-enhanced Raman spectroscopy (SERS) determination of illegal additives chrysoidin and malachite green. Detection of these illegal additives is very meaningful and the developed method meets this objective in a simple, rapid and cost effective way. Detection limits for chrysoidin and malachite green in aqueous solutions reached 0.001 mg/L and 0.0001 mg/L respectively. Linear relationship between the Raman intensities and chrysoidin concentrations in range of 0.001-0.05 mg/L was found with regression coefficient (R) of 0.994. To investigate the practical application performance of the method, the substrate was applied to detect chrysoidin in Sprite at 0.01 mg/L and malachite green in fish pond water at 0.0001 mg/L. The SERS method could be an alternative approach for monitoring illegal additives and toxic harmful substances. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.