Journal
CHINESE CHEMICAL LETTERS
Volume 29, Issue 6, Pages 977-980Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2017.10.015
Keywords
5-HT; Barettin; Nature product; Nematicidal activity; Piperazinedione derivatives
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Funding
- National Natural Science Foundation of China [21572060]
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Nematodes are serious constraints of crop production worldwide. However, the traditional nematicides suffer from the side-effects, including environmental and human toxicity. Herein, more than 70 novel piperazinedione derivatives based on the natural product Barettin were synthesized and evaluated against the root-knot nematode Meloidogyne incognita (M. incognita). While most of synthesized compounds exhibited certain nematicidal activity at high concentration, the best one showed a nematicidal activity of 75% at 2.4 mu mol/L. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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