Article
Chemistry, Organic
Xuemei Wang, Liang Zhou, Hongkui Zhang, Xiaoyu Ren, Guowei Gao, Tianli Wang
Summary: A highly enantioselective cascade reaction of beta,gamma-unsaturated carbonyl compounds using bifunctional ion-pair catalysis has been developed, resulting in functionalized chiral 1,3-dioxolochroman derivatives with high yields and excellent stereoselectivities. The utility of this method was demonstrated through one-pot synthesis, scaled-up preparation, and facile transformation. Mechanistic investigations provided insights into the reaction pathway and chiral induction.
Review
Chemistry, Physical
Mercedes Zurro, Aitor Maestro
Summary: This paper reviews the recent literature on the catalytic methodologies for the derivatization of aza-QM, including organocatalytic and organometallic approaches. The review analyzes various catalytic systems, involving chiral NHC carbenes, phosphoric acids, phosphoramidites, phosphine, copper, and palladium catalysis, showcasing their applicability for the synthesis of a diverse array of N-containing compounds, many of which exhibit biological activity.
Article
Chemistry, Multidisciplinary
Hongmei Qin, Qimei Xie, Long He
Summary: An efficient diastereoselective cyclization reaction was developed to synthesize spiroindolenine-bearing chroman scaffolds, which incorporated two pharmacophores, namely chroman and spiroindoline.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Fangzhi Hu, Liang Wang, Peng Wang, Zhanshuai Ding, Yuzhuo Chen, Lubin Xu, Xiong-Li Liu, Shuai-Shuai Li
Summary: The controllable synthesis of spirooxindole-fused dibenzo[b,f]oxocines and chromans from oxindole-embedded four-atom synthons and dibrominated compounds has been achieved through [4 + 4] and [4 + 2] cyclization reactions respectively. Additionally, the indole-fused nine-membered oxa-heterocycles can be selectively accessed by the ring expansion of spirooxindole-fused dibenzo[b,f]oxocines through carbocation rearrangement.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemistry & Molecular Biology
Dae Young Kim
Summary: A one-pot strategy has been developed for the synthesis of multisubstituted 3,4-dihydrocoumarins with high yields and excellent diastereoselectivity. This approach involves C-H oxidation and cyclization cascade reactions of 2-alkyl phenols and oxazolones in the presence of silver oxide and p-toluenesulfonic acid as catalysts.
Article
Chemistry, Multidisciplinary
Junwei Wang, Lei Zhao, Chen Zhu, Ben Ma, Xiaolong Xie, Jian Liu, Shiyun He, Magnus Rueping, Kun Zhao, Lihong Hu
Summary: This study developed a divergent synthesis method for medium-sized rings with controllable ring sizes, successfully synthesizing seven- to ten-membered nitrogen-containing heterocycles. The method features operational simplicity, broad substrate scope, and excellent regioselectivity.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Organic
Kavyashree Kuppayya Gond, Mahagundappa Rachappa Maddani
Summary: In this study, isochroman-1,4-diones and addition products were selectively synthesized through KOBu-Catalyzed addition of sulfonylphthalides to p-quinone methides. It is noteworthy that isochroman-1,4-diones were obtained via an unprecedented oxidative annulation pathway. The research highlights the broad substrate scope, high yields, shorter reaction time, and mild reaction conditions. Furthermore, some addition products can be transformed into functionalized heterocyclic molecules. Additionally, the scalability experiment demonstrates the practical feasibility of preparing isochroman-1,4-diones in larger scale reactions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Kyeong Seop Kim, Dae Young Kim
Summary: Chiral 3,4-dihydrocoumarin derivatives were synthesized in moderate to high yields with excellent enantioselectivity (up to 96% ee) via a one-pot cascade reaction using a binaphthyl-modified squaramide bifunctional organocatalyst. The reaction involved C-H oxidation and cyclization of 2-benzyl phenols and oxazolones under mild conditions.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Zefeng Song, Yuping Jia, Daizhou Zhang, De Wang
Summary: A novel DMAP-mediated Rauhut-Currier/oxa-Michael addition cascade reaction was reported for the first time, resulting in a series of functionalized chromenes from the reaction of hydroxylphenyl-substituted para-quinone methide with allenoate. The chromene products obtained in moderate to good yields under this one-pot cascade reaction could be easily transformed into different derivatives, and a plausible mechanism was proposed to elucidate this novel reaction.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kai Li, Shengli Huang, Tianyu Liu, Shiqi Jia, Hailong Yan
Summary: We demonstrated an organocatalytic asymmetric dearomatizing hetero-Diels-Alder reaction of benzene derivatives, which allows the synthesis of diverse stereochemically complex compounds and oxahelicenes. The high complexity and three-dimensionality of the products are crucial for their potential applications in materials science and drug discovery.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Xiaochen Tian, Xiaoli Zhang, Xiaohan Hou, Weiwu Ren, Xiaoyang Li, Fei Zhao, Houchao Tao, Yang Wang
Summary: A base-promoted formal [4+1] cycloaddition of ortho- and para-quinone methides with 3-chlorooxindoles has been reported to provide various functionalized 3,2'-tetrahydrofuryl spirooxindoles in high yields under mild conditions. Unexpected reversal in diastereoselectivity was observed in these reactions. Computational studies have revealed the origin of the diastereoselectivity, showing that different configurations of 1,4-addition and 1,6-addition at the oxindole carbanionic center result in different diastereomers. The anti-tumor activity of these structurally unique spirooxindole derivatives has been reported.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Suo-Suo Qi, Hao Yin, Yi-Feng Wang, Chao-Jie Wang, Hong-Te Han, Tong-Tong Man, Dan-Qian Xu
Summary: A new method has been developed for the selective construction of enantioenriched eight-membered cyclic ethers by combining squaramide and DBU catalysis. The reaction yields a variety of eight-membered cyclic ethers with high stereoselectivity, showcasing the practicality of ynones as C4-syntons for synthesizing chiral medium-membered rings.
Article
Chemistry, Organic
Henning J. Loui, Arun Suneja, Christoph Schneider
Summary: A synthetic method has been developed for the stereoselective (3 + 3)-cycloannulation of in situ generated carbonyl ylides with indolyl-2-methides, resulting in oxa-bridged azepino[1,2-a]indoles in one step. The products, with three stereogenic centers, were obtained with good stereoselectivity and yields, showcasing valuable heterocyclic complexity.
Article
Chemistry, Multidisciplinary
Eva M. Gulotty, Kevin X. Rodriguez, Erin E. Parker, Brandon L. Ashfeld
Summary: An efficient strategy for constructing spirooxindole benzofurans through a (4+1)-cycloaddition was presented, involving an isatin-derived oxyphosphonium enolate. Mechanistic investigations showed a correlation between phosphonium enolate structure and product distribution, which was heavily influenced by solvent and reaction temperature.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Alemayehu Gashaw Woldegiorgis, Haorui Gu, Xufeng Lin
Summary: The organocatalytic asymmetric reactions of C2-unsubstituted racemic naphthyl-indoles with orthoalkynylnaphthols were used to synthesize axially chiral styrenes connected to an axially chiral naphthyl-indole unit. By employing chiral phosphoric acid as the catalyst, these axially chiral styrenes were obtained in good yields (up to 96%) and excellent stereoselectivity (up to >99.9% ee, >20:1 dr, and >99:1 E/Z) under mild conditions. Furthermore, further synthetic transformations were achieved with high yields and excellent stereocontrol.
Article
Chemistry, Multidisciplinary
Qian Wu, Yubo Cui, Guifeng Xia, Jinlong Yang, Shuming Du, Xinhong Xiong, Li Yang, Dong Xu, Xu Deng, Jiaxi Cui
Summary: Passive daytime radiative cooling (PDRC) technology, while promising for global spacing cooling, faces limitations in practical application due to reduced cooling effectiveness caused by wear and dirt contamination. Researchers have developed a renewable armor structure using fluorinated hollow glass microspheres to enhance the anti-fouling and cooling properties of PDRC coatings. The coatings exhibit high solar reflectance and thermal emittance, leading to significant temperature reduction below ambient temperature.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Qiang Bei, Bei Zhang, Kaifeng Wang, Shiming Zhang, Guichuan Xing, Clement Cabanetos
Summary: The power conversion efficiency (PCE) of organic solar cells (OSCs) has reached 20% in recent years, thanks to the advantages of organic photoactive materials. Benzothiadiazole (BT) has attracted significant research attention as a building block of OSCs. OSCs based on BT structure have shown diversity, and the increasing PCE values indicate a promising future for OSCs. This review analyzes the progress made in the last decades, focusing on effective BT small-molecules and BT polymers for OSCs. The structure-property relationships, donor-acceptor matching criteria, and morphology control approaches are discussed. The remaining challenges and a personal perspective on the future advancement of OSCs are summarized.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Rong He, Dandan Tang, Ningge Xu, Heng Liu, Kun Dou, Xuejun Zhou, Fabiao Yu
Summary: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, with a high incidence in China and Southeast Asian countries. In this study, a novel near-infrared fluorescent probe, SNAFL-GSH, was designed and synthesized for the detection of glutathione (GSH). The probe showed selective detection of GSH and the ability to distinguish normal and cancer cells. It has great potential for application in the diagnosis and evaluation of NPC.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhukang Guo, Baijiang Jin, Yile Fang, Lian Jin, Song Li, Yan Deng, Zhu Chen, Hui Chen, Yuanying Zhang, Rabia Usman, Nongyue He
Summary: This study isolated primary cells that can be stably passaged from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice and used an autonomously developed automated screening instrument for efficient nucleic acid aptamer screening. The obtained aptamers were affinity verified at the cellular level. The study also investigated the impact of cell growth environment difference on the recognition ability of aptamers and confirmed the targeting ability and drug loading ability of the aptamer.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhongshan Yang, Qiqi Zhang, Hui Song, Xin Chen, Jiwei Cui, Yanhui Sun, Lequan Liu, Jinhua Ye
Summary: Methane chemistry is a significant area of research in catalysis. Converting methane into value-added chemicals is desirable but challenging due to its high C-H bonding energy and lack of pi bonding or unpaired electrons. Photocatalytic partial oxidation of methane to liquid oxygenates is a promising technology for achieving high efficiency and selectivity under mild conditions. The choice and activation of oxidants are crucial for its performance.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin
Summary: This study reports an oral radioprotectant Gel@GYY that combines a gelatin-based hydrogel and a pH-responsive hydrogen sulfide donor. Gel@GYY has excellent adhesion and sustained release properties, allowing it to release H2S in the gastrointestinal tract and effectively scavenge free radicals induced by radiation. It also reduces inflammation and has biodegradable properties.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lu Liu, Ziyi Liu, Jingnan Cui, Guiling Ning, Weitao Gong
Summary: The development of new metal-free heterogeneous catalysts has been the subject of extensive research. In this study, a new Troger's base (TB)-derived porous organic polymer (POPs) was designed and prepared by integrating multifunctional monomers. The resulting polymer, which combines the advantages of pillar[5]arene macrocycle and TB moiety, exhibited enhanced catalytic performance in Knoevenagel condensation and CO2 conversion, serving as an effective metal-free catalyst. This work provides a new strategy for fabricating metal-free heterogeneous catalysts based on macrocyclic POPs.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leyong Zhou, Changyin Yang, Weitao Dou, Tongxia Jin, Haibo Yang, Lin Xu
Summary: This review summarizes the application of micro/nanofluidic techniques in constructing supramolecular assemblies of different scales, and highlights the advantages of these techniques over conventional synthesis methods. Furthermore, it emphasizes the potential of micro/nanofluidic systems in improving our understanding of supramolecular self-assembly processes.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Yanchao Jin, Suixiaochen Chen, Peiwen Huang, Xiongjian Chen, Chun-Yan Lin, Li-Ping Li, Xiao Chen, Rui Ding, Jianxi Liu, Riyao Chen
Summary: In this study, magnesium and coconut shell carbon were used to disinfect water by adsorbing copper(II) and converting dissolved oxygen to hydrogen peroxide through Mg corrosion. The copper was enriched on the carbon surface and efficiently catalyzed the hydrogen peroxide to inactivate E.coli. The process showed promising disinfection performance both in laboratory experiments and real wastewater treatment.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Haihong Lai, Zehong Chen, Hao Zhuo, Yijie Hu, Xuan Zhao, Jiwang Yi, Hongzhi Zheng, Ge Shi, Yifan Tong, Ling Meng, Xinwen Peng, Linxin Zhong
Summary: By altering the pyrolysis route of cellulose nanofiber, the structural defects of carbon aerogels can be reduced, leading to improved compressibility and stress retention, as well as higher stress sensor sensitivity and temperature coefficient.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lina Guo, Jinsong Ding, Wenhu Zhou
Summary: Bacteria-based tumor therapy has resurfaced due to the revolution of tumor immunotherapy, offering unique solutions for traditional tumor treatments. Bacteria with active tropism can selectively colonize tumor sites and suppress tumor growth through various mechanisms, making them attractive tools for tumor treatment. This critical review introduces recent advances in bacteria-based tumor therapy, including bacterial properties, their benefits for tumor therapy, anti-tumor mechanisms, challenges, and future perspectives.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lan Liang, Chuanbin Wang, Xukai Lu, Yunan Sun, Beibei Yan, Ning Li, Guanyi Chen, Li'an Hou
Summary: This study investigates the interactions between phenol and benzaldehyde in the ECH process through experiments and theoretical calculations. The results show that phenol can accelerate the conversion of benzaldehyde, while benzaldehyde inhibits the conversion of phenol. The research provides a theoretical basis for the application of ECH in practical bio-oil upgrading.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Pengcheng Fan, Yuhao He, Junan Pan, Ning Sun, Qiyu Zhang, Chen Gu, Kang Chen, Weinan Yin, Longlu Wang
Summary: This study focuses on the recent progress in hydrogen evolution reaction (HER) based on photothermal effect. It introduces the main pathways of photothermal conversions applied in H2 evolution, summarizes the functions of the photothermal effect, and presents a method to improve the catalytic system through thermal means. The study also discusses the challenges and outlook in this promising area.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leiduo Lai, Hongyu Zhou, Yichen Hong, Mengfan Luo, Yang Shi, Heng Zhang, Zhaokun Xiong, Gang Yao, Bo Lai
Summary: In this study, a facile ammonia reduction strategy was proposed and a novel FeVO3-x catalyst was synthesized for the activation of peroxymonosulfate (PMS) to degrade the pharmaceutical carbamazepine (CBZ). The results showed that the system could rapidly degrade CBZ and generate various active species involved in the degradation process.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Tangxin Xiao, Xiuxiu Li, Liangliang Zhang, Kai Diao, Zheng-Yi Li, Xiao-Qiang Sun, Leyong Wang
Summary: This study presents the construction of a supramolecular light harvesting system based on sequential energy transfer. The system demonstrates tunable fluorescence emission through self-assembly of polymers into nanoparticles, achieving efficient two-step light harvesting.
CHINESE CHEMICAL LETTERS
(2024)