Article
Medicine, General & Internal
Nguyen Thanh Tung, Shu-Chuan Ho, Yueh-Hsun Lu, Tzu-Tao Chen, Kang-Yun Lee, Kuan-Yuan Chen, Chih-Da Wu, Kian Fan Chung, Han-Pin Kuo, Huynh Nguyen Xuan Thao, Hoang Ba Dung, Tran Phan Chung Thuy, Sheng-Ming Wu, Hsiao-Yun Kou, Yueh-Lun Lee, Hsiao-Chi Chuang
Summary: Exposure to PM2.5, NO2, and O3 has been found to be associated with lung function, BODE index, and emphysema in patients with chronic obstructive pulmonary disease (COPD). Increased levels of air pollution may lead to a higher risk of panlobular emphysema in COPD patients, especially in the upper lobes.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Chin-Ling Li, Hui-Chuan Chang, Ching-Wan Tseng, Yuh-Chyn Tsai, Jui-Fang Liu, Meng-Lin Tsai, Meng-Chih Lin, Shih-Feng Liu
Summary: The BODE and ADO indices were found to be correlated with hospitalization frequency and hospitalization days in COPD patients. However, the BODE index showed slightly better predictive accuracy than the ADO index in these aspects.
MEDICINA-LITHUANIA
(2023)
Article
Respiratory System
Sara C. Buttery, Winston Banya, Rocco Bilancia, Elizabeth Boyd, Julie Buckley, Neil J. Greening, Kay Housley, Simon Jordan, Samuel Kemp, Alan J. B. Kirk, Lorna Latimer, Kelvin Lau, Rod Lawson, Adam Lewis, John Moxham, Sridhar Rathinam, Michael C. Steiner, Sara Tenconi, David Waller, Pallav L. Shah, Nicholas S. Hopkinson, CELEB Investigators
Summary: This study found that there is no significant difference in health outcomes between lung volume reduction surgery (LVRS) and bronchoscopic lung volume reduction (BLVR) at 12 months for emphysema patients who are suitable for both procedures.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ju Gang Nam, Hye-Rin Kang, Sang Min Lee, Hyungjin Kim, Chanyoung Rhee, Jin Mo Goo, Yeon-Mok Oh, Chang-Hoon Lee, Chang Min Park
Summary: This study developed a deep learning-based survival prediction model for patients with chronic obstructive pulmonary disease (COPD) using chest radiographs and other clinical factors. The model showed superior performance in predicting 5-year survival compared to the traditional FEV1 index and demonstrated good calibration in multiple independent test cohorts. Additionally, the model achieved higher predictive accuracy compared to other clinical indexes.
Review
Biochemistry & Molecular Biology
Cristina Russo, Valeria Colaianni, Giuseppe Ielo, Maria Stella Valle, Lucia Spicuzza, Lucia Malaguarnera
Summary: This review highlights the relationship between lung microbiota and chronic obstructive pulmonary disease (COPD). Inflammation, dysbiosis, and imbalance in the immune system may contribute to the development of lung diseases. Interventions targeting lung microbiota could potentially improve these conditions.
Review
Health Care Sciences & Services
Efstathios Karakasidis, Ourania S. S. Kotsiou, Konstantinos I. I. Gourgoulianis
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. Recent research has revealed the association between lung and gut microbiomes in the development of COPD. This study aimed to discuss the role of the lung and gut microbiomes in COPD pathophysiology. The findings indicate that the lung and gut microbiomes influence each other and are crucial in the pathogenesis of COPD. However, further research is needed to determine the exact associations between microbiome diversity and COPD pathophysiology and exacerbation genesis. Additionally, investigating the impact of treatment interventions targeting the human microbiome on preventing COPD genesis and progression should be a focus of future research.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Davida Mirra, Renata Esposito, Giuseppe Spaziano, Chiara La Torre, Cristina Vocca, Martina Tallarico, Erika Cione, Luca Gallelli, Bruno D'Agostino
Summary: Non-small cell lung cancer (NSCLC) is a highly deadly disease that poses a significant burden on the healthcare system. This study compared the expression of miRNAs in the lungs of NSCLC patients, COPD patients, and healthy controls, and identified potential biomarkers that could improve early diagnosis of lung cancer by analyzing shared pathways.
Review
Biochemistry & Molecular Biology
Holly R. Keir, Marco Contoli, James D. Chalmers
Summary: The overprescription of inhaled corticosteroids (ICS) in COPD patients may increase the risk of respiratory infections, and changes in the lung microbiome have been associated with disease progression and exacerbation frequency, with the immunosuppressive effects of ICS potentially contributing to detrimental airway microbiota changes.
Review
Medicine, General & Internal
G. E. Mandoli, G. De Carli, M. C. Pastore, P. Cameli, F. Contorni, M. D'Alessandro, E. Bargagli, S. Mondillo, M. Cameli
Summary: Lung diseases are a major healthcare concern with high morbidity and mortality rates, and the cardiovascular system, specifically the right ventricle, plays a crucial role in mitigating impaired lung function. Echocardiography is a valuable tool for assessing right ventricular function, especially in chronic obstructive and restrictive lung disease. Understanding the cardiac involvement in lung diseases and utilizing multimodality imaging techniques are essential for diagnosis and prognosis.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Oncology
Hiroki Ozawa, Yosuke Matsuura, Kohei Hashimoto, Junji Ichinose, Masayuki Nakao, Sakae Okumura, Mingyon Mun
Summary: Various calculation models have been developed worldwide to estimate prognosis and predict surgical risk. In this study, we assessed the prognostication of 1054 lung cancer patients using a Japanese model. The results showed that the model's predictions were associated with significantly poorer prognosis and could be a useful tool for multidisciplinary thoracic oncology teams to discuss treatment strategies for high-risk patients.
CLINICAL LUNG CANCER
(2023)
Article
Critical Care Medicine
Suhail Raoof, Manav Shah, Sidney Braman, Abhinav Agrawal, Hassan Allaqaband, Russell Bowler, Peter Castaldi, Dawn DeMeo, Shannon Fernando, Charles Scott Hall, MeiLan K. Han, James Hogg, Stephen Humphries, Ho Yun Lee, Kyung Soo Lee, David Lynch, Stephen Machnicki, Atul Mehta, Sanjeev Mehta, Bushra Mina, David Naidich, Jason Naidich, Yoshiharu Ohno, Elizabeth Regan, Edwin J. R. van Beek, George Washko, Barry Make
Summary: Chest CT scan imaging plays an important role in the diagnosis, prognostication, and differentiation of phenotypes of COPD, and is a prerequisite for lung volume reduction surgery and lung transplantation. Emerging imaging techniques such as micro-CT scan, ultra-high-resolution and photon-counting CT scan imaging, and MRI have potential advantages including improved resolution, prediction of reversibility, and reduced radiation exposure.
Article
Critical Care Medicine
Suhail Raoof, Manav Shah, Barry Make, Hassan Allaqaband, Russell Bowler, Shannon Fernando, Harly Greenberg, MeiLan K. Han, James Hogg, Stephen Humphries, Kyung Soo Lee, David Lynch, Stephen Machnicki, Atul Mehta, Bushra Mina, David Naidich, Jason Naidich, Zarnab Naqvi, Yoshiharu Ohno, Elizabeth Regan, William D. Travis, George Washko, Sidney Braman
Summary: COPD is a chronic respiratory condition characterized by airflow obstruction. Recent advancements in imaging techniques have allowed for quantitative and qualitative analysis of lung parenchyma and related manifestations of COPD. These imaging methods can provide valuable information for diagnosis and treatment decisions.
Article
Medicine, General & Internal
Meng-Lin Tsai, Chin-Ling Li, Hui-Chuan Chang, Yuh-Chyn Tsai, Ching-Wan Tseng, Shih-Feng Liu
Summary: This study aimed to investigate the relationship between age, dyspnea, airflow obstruction (ADO) and body mass index, airflow obstruction, dyspnea, and exercise (BODE) indexes, pulmonary function, medical costs, and exertional desaturation (ED) in chronic obstructive pulmonary disease (COPD) patients. The results showed that SpO(2) during the 6MWT was an independent factor for ED, and ED was related to BODE and ADO indices, but not related to medical expenses.
MEDICINA-LITHUANIA
(2023)
Article
Oncology
Eros Azzalini, Renzo Barbazza, Giorgio Stanta, Giorgio Giorda, Lucia Bortot, Michele Bartoletti, Fabio Puglisi, Vincenzo Canzonieri, Serena Bonin
Summary: This study identified the association between histologic and clinical features in HGSOC patients, showing that SET features were correlated with better overall and progression free survival, while intratumor heterogeneity was a negative independent prognostic factor for patients undergoing neoadjuvant chemotherapy.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Denis E. Naumov, Olesya O. Kotova, Dina A. Gassan, Ivana Y. Sugaylo, Evgeniya Y. Afanas'eva, Elizaveta G. Sheludko, Juliy M. Perelman
Summary: The study found that TRPM8 and TRPA1 gene polymorphisms do not significantly influence susceptibility to COPD, but the TRPA1 rs7819749 and TRPM8 rs11562975 genotypes are significantly associated with airway obstruction and lung function in COPD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Servet Boeluekbas, Natalie Baldes, Mir Alireza Hoda, Michael Eberlein
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Masashi Furukawa, Ernest G. Chan, Pablo G. Sanchez
Summary: This case report describes the use of an extracorporeal carbon dioxide removal system as a bridge to redo lung transplant in a patient with complete situs inversus. This approach helps optimize the patient's physical condition before the second transplant.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Immunology
Mark E. Snyder, Kaveh Moghbeli, Anna Bondonese, Andrew Craig, Iulia Popescu, Li Fan, Tracy Tabib, Robert Lafyatis, Kong Chen, Humberto E. Trejo Bittar, Elizabeth Lendermon, Joseph Pilewski, Bruce Johnson, Silpa Kilaru, Yingze Zhang, Pablo G. Sanchez, Jonathan K. Alder, Peter A. Sims, John F. McDyer
Summary: During acute cellular rejection after lung transplantation, there is an intra-allograft oligoclonal expansion of cytotoxic CD8(+) T cells. Despite treatment with systemic glucocorticoids, expanded T cell clones persist as transcriptionally reprogrammed, airway-centric tissue resident memory T cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Respiratory System
Takashi Harano, Ernest G. Chan, Masashi Furukawa, Pedro Reck dos Santos, Matthew R. Morrell, Penny L. Sappington, Pablo G. Sanchez
Summary: Peripherally cannulated oxyRVAD with percutaneous dual-lumen venous cannula may serve as an ambulatory bridge for lung transplantation. It is unknown whether oxyRVAD is feasible as a long-term bridge to lung transplantation.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Immunology
Masashi Furukawa, Ernest G. Chan, John P. Ryan, Eric J. Hyzny, Lauren M. Sacha, Jenalee N. Coster, Joseph M. Pilewski, Elizabeth A. Lendermon, Silpa D. Kilaru, John F. McDyer, Pablo G. Sanchez
Summary: This single center retrospective study found that the induction therapy strategy in lung transplantation has a significant impact on survival rates. The Alemtuzumab group had fewer episodes of acute cellular rejection in the first year and significantly higher overall survival rate compared to the Basiliximab group.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Daniel M. Neto, Ernest G. Chan, Pablo G. Sanchez
Summary: Mediastinal shift and chest wall retraction impose limitations on the indication of double lung transplant in patients with complete lung parenchymal destruction. This report presents the outcomes, as well as the preoperative and operative management, in two patients with significant lung volume reduction and mediastinal shift caused by bronchiectasis of the right lung.
CLINICAL CASE REPORTS
(2022)
Letter
Surgery
Julie M. Riggs, V. Ananth Charya, Michael H. Eberlein, Robert M. Reed, Kapil K. Saharia
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Kentaro Noda, Ernest G. Chan, Masashi Furukawa, John P. Ryan, Sarah Clifford, James D. Luketich, Pablo G. Sanchez, Pete Arlia, Christian A. Bermudez, Jonathan D'Cunha, Stephanie Dwinga, Ryan Dzadney, J. W. Awori Hayanga, Takashi Harano, John F. McDyer, Matthew R. Morrell, Sarah Rodney, Dan Ross, Christen Trosky, Norihisa Shigemura, Diana Zaldonis
Summary: This study retrospectively analyzed data from lung transplantation with ex vivo lung perfusion (EVLP) from 2014 to 2020, and found that EVLP is associated with increased early posttransplant adverse events, but does not affect transplantation outcomes and patient survival.
CLINICAL TRANSPLANTATION
(2023)
Article
Respiratory System
Matthew G. Hartwig, Jacob A. Klapper, Nagaraju Poola, Amit Banga, Pablo G. Sanchez, John S. Murala, Jim L. Potenziano
Summary: This study suggests that the administration of exogenous nitric oxide during normothermic ex vivo lung perfusion (EVLP) may improve lung health and potentially prolong the duration of organ stability.
Article
Physiology
Rachael Stadlen, Arun K. Singhal, Robert M. Reed, Jeffrey D. Hasday, Melissa L. Bates, Gregory A. Schmidt, Michael Eberlein
Summary: In this case study, a COVID-19 patient with compromised pulmonary gas exchange and oxygen delivery requiring ECMO support is described. The study aims to outline the use of basic physiology to address life-threatening consequences of COVID-19 infection and describes strategies such as whole-body cooling, utilization of the shunt equation, and transfusion to improve oxygenation when ECMO alone is insufficient.
PHYSIOLOGICAL REPORTS
(2023)
Meeting Abstract
Surgery
K. Noda, E. G. Chan, J. Ryan, M. Furukawa, J. D. Luketich, P. G. Sanchez
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Surgery
M. Furukawa, E. Chan, P. G. Sanchez
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Critical Care Medicine
J. K. Alder, R. Sutton, C. Iasella, S. Nouraie, R. Koshy, S. Hannan, E. Chan, X. Chen, Y. Zhang, M. Brown, I. Popescu, M. Veatch, S. Saul, A. Berndt, B. Methe, A. Morris, J. M. Pilewski, P. Sanchez, M. R. Morrell, S. D. Shapiro, K. O. Lindell, K. Gibson, D. Kass, J. F. McDyer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
M. E. Snyder, M. R. Anderson, L. J. Benvenuto, R. Koshy, C. J. Iasella, R. Sutton, A. Bondonese, A. Craig, Y. Zhang, P. G. Sanchez, J. K. Alder, J. F. McDyer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. M. Mallea, A. W. Brown, D. Johnson, C. Keller, M. Roberts, P. Sanchez, J. D'Cunha, D. Erasmus, M. Hartwig
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)