Review
Cardiac & Cardiovascular Systems
Bruno Prata Martinez, Layana Lisboa Lobo, Rodrigo Santos de Queiroz, Micheli Bernardone Saquetto, Luiz Alberto Forgiarini Junior, Helena Franca Correia, Cassio Magalhaes da Silva e Silva, Iura Gonzalez Nogueira Alves, Mansueto Gomes Neto
Summary: This study analyzed the effects of ventilator hyperinflation (VHI) on pulmonary function and secretion clearance in adults receiving mechanical ventilation (MV). The results showed that VHI did not have a significant impact on the amount of secretions removed, dynamic compliance (Cdyn), and oxygenation. However, there was a slight improvement in static compliance (Cstat) compared to isolated aspiration.
Article
Critical Care Medicine
Yukie Ito, Matias G. Herrera, Justin C. Hotz, Miyako Kyogoku, Christopher J. L. Newth, Anoopindar K. Bhalla, Muneyuki Takeuchi, Robinder G. Khemani
Summary: The study found that airway pressure measured during occlusion maneuvers can be used to estimate respiratory effort in children, and expiratory occlusion pressure has the strongest correlation with esophageal pressure change.
Article
Critical Care Medicine
Clancy J. Dennis, Collette Menadue, Tessa Schneeberger, Daniela Leitl, Ursula Schoenheit-Kenn, Camilla M. Hoyos, Alison R. Harmer, David J. Barnes, Andreas R. Koczulla, Klaus Kenn, Jennifer A. Alison
Summary: The study demonstrates that NIV can reduce dynamic hyperinflation and increase cycling endurance time in COPD patients experiencing DH during exercise. The use of a standardized EPAP of 5 cm H2O is sufficient to achieve these benefits.
Article
Cardiac & Cardiovascular Systems
John K. Peel, Duane J. Funk, Peter Slinger, Sadeesh Srinathan, Biniam Kidane
Summary: Low tidal volumes during 1-lung ventilation do not worsen oxygenation or compliance. A low tidal volume ventilation strategy during 1-lung ventilation was associated with a significant reduction in postoperative pulmonary complications.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Review
Medicine, General & Internal
Keisuke Miki
Summary: Exertional dyspnea is a common symptom in COPD patients, significantly impacting prognosis. Understanding the mechanisms of dyspnea and utilizing CPET to evaluate the condition can guide targeted treatment, improving patients' quality of life.
Article
Critical Care Medicine
Francesco Mojoli, Marco Pozzi, Anita Orlando, Isabella M. Bianchi, Eric Arisi, Giorgio A. Iotti, Antonio Braschi, Laurent Brochard
Summary: This study suggests that respiratory efforts and their timing can be reliably detected during pressure support ventilation using standard ventilator waveforms, providing an opportunity to assess and improve patient-ventilator interaction without the need for special equipment.
Article
Critical Care Medicine
Benjamin Coiffard, Stephen Riegler, Michael C. Sklar, Martin Dres, Stefannie Vorona, W. Darlene Reid, Laurent J. Brochard, Niall D. Ferguson, Ewan C. Goligher
Summary: The study found that diaphragm echodensity increased in mechanically ventilated patients at the outset, and this increase in echodensity during the early course of mechanical ventilation was associated with prolonged mechanical ventilation. Moreover, both decreases and increases in diaphragm thickness were also associated with increased echodensity.
Article
Respiratory System
Michele Vitacca, Piero Ceriana, Irene Prediletto, Annalisa Carlucci, Mara Paneroni, Nicolino Ambrosino, Stefano Nava
Summary: The study found that in stable COPD patients, hypercapnic patients had significantly higher intrinsic dynamic positive end-expiratory pressure (PEEPi,dyn) compared to normocapnic patients. There were weak correlations between PEEPi,dyn and various noninvasive measurements of lung and respiratory muscle function. Transdiaphragmatic pressure was identified as the strongest variable associated with PEEPi,dyn.
Article
Anesthesiology
Francesco Mojoli, Anita Orlando, Isabella Maria Bianchi, Roberta Puce, Eric Arisi, Giulia Salve, Giuseppe Maggio, Silvia Mongodi, Marco Pozzi
Summary: The study found that automated real-time waveform analysis-guided cycling-off appears to be a reliable solution to improve synchronization in difficult-to-wean patients under pressure support ventilation.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Article
Medicine, General & Internal
Yoav Weber, Danny Epstein, Asaf Miller, Gad Segal, Gidon Berger
Summary: This study found that low ALT levels in patients with sarcopenia are associated with an increased risk of extubation failure, with ALT levels ≤21 IU/L associated with increased risk of failure within 48 hours, and ALT levels ≤16 IU/L associated with increased risk of failure after 7 days.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Kay Choong See, Juliet Sahagun, Matthew Cove, Chew Lai Sum, Bimbo Garcia, David Chanco, Sherill Misanes, Emily Abastillas, Juvel Taculod
Summary: The implementation of bedside PVA screening and management protocol for mechanically ventilated patients was found to be associated with decreased hospital mortality, with no correlation to sedation-free days or mechanical ventilation-free days.
AUSTRALIAN CRITICAL CARE
(2021)
Article
Cardiac & Cardiovascular Systems
Joseph B. Shrager, Yoyo Wang, Myung Lee, Shannon Nesbit, Winston Trope, Harrison Konsker, Emmanuel Fatodu, Mark S. Berry, George Poulstides, Jeffrey Norton, Thomas Burdon, Leah Backhus, Roger Cooke, Huibin Tang
Summary: The clinical trial is the first-in-human mechanistic trial for preventing ventilator-induced diaphragm dysfunction (VIDD) by testing whether JAK inhibition can prevent clinical VIDD, potentially impacting ICU outcomes significantly if successful.
RESPIRATORY MEDICINE
(2021)
Article
Critical Care Medicine
Filippo Albani, Luigi Pisani, Gianni Ciabatti, Federica Fusina, Barbara Buizza, Anna Granato, Valeria Lippolis, Eros Aniballi, Francesco Murgolo, Antonio Rosano, Nicola Latronico, Massimo Antonelli, Salvatore Grasso, Giuseppe Natalini
Summary: This study aimed to assess the association between the shape of inspiratory flow quantified by Flow Index and patient's inspiratory effort during pressure support ventilation. Results showed that Flow Index was independently associated with patient effort and may provide useful information for setting inspiratory support and monitoring patient-ventilator interactions.
Article
Engineering, Biomedical
Christopher M. Bobba, Kevin Nelson, Curtis Dumond, Emre Eren, Sylvester M. Black, Joshua A. Englert, Samir N. Ghadiali, Bryan A. Whitson
Summary: Through quantifying pressure-flow waveforms during normothermic EVLP, this study confirmed that negative pressure ventilation (NPV) may have a better effect in reducing VILI compared to positive pressure ventilation (PPV). The improved lung function during NPV EVLP may be attributed to favorable airflow patterns and/or pressure dynamics, which better mimic human respiratory patterns.
Article
Critical Care Medicine
Filippo Albani, Federica Fusina, Gianni Ciabatti, Luigi Pisani, Valeria Lippolis, Maria Elena Franceschetti, Alessia Giovannini, Rossella di Mussi, Francesco Murgolo, Antonio Rosano, Salvatore Grasso, Giuseppe Natalini
Summary: The study aimed to evaluate the accuracy of Flow Index in detecting high and low inspiratory effort during pressure support ventilation and establish cutoff values. Results showed that Flow Index accurately detects high and low spontaneous inspiratory effort.
Article
Critical Care Medicine
Domenico Luca Grieco, Samir Jaber
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Critical Care Medicine
Luca S. Menga, Cecilia Berardi, Ersilia Ruggiero, Domenico Luca Grieco, Massimo Antonelli
Summary: This narrative review discusses the benefits and possible harms of noninvasive respiratory support for COVID-19 respiratory failure. Maintaining spontaneous breathing in hypoxemic patients with vigorous effort carries the risk of patient self-induced lung injury. The risk of noninvasive treatment failure is higher in patients with severe oxygenation impairment. High-flow nasal oxygen (HFNO) is the most widely applied intervention, but noninvasive ventilation (NIV) and continuous positive airway pressure (CPAP) with different interfaces have also been used with varying success rates. Prone positioning and awake prone position have shown potential in avoiding endotracheal intubation, but careful monitoring is necessary, especially in patients with severe hypoxemia.
CURRENT OPINION IN CRITICAL CARE
(2022)
Letter
Medicine, General & Internal
Maurizio Gabrielli, Giulia Pignataro, Marcello Candelli, Marta Sacco Fernandez, Martina Bizzarri, Alessandra Esperide, Francesco Franceschi
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Physiology
Emanuele Rezoagli, Aurora Magliocca, Domenico Luca Grieco, Giacomo Bellani, Giuseppe Ristagno
Summary: In this study, animals undergoing mechanical chest compressions had lower levels of exhaled CO2 signal compared to animals receiving manual chest compressions. The Airway opening index (AOI) was negatively correlated with intrathoracic pressure swings, lung density, and respiratory system compliance. Animals with CPR-associated lung edema had lower levels of AOI.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2022)
Article
Critical Care Medicine
Lu Chen, Domenico L. Grieco, Francois Beloncle, Guang-Qiang Chen, Norberto Tiribelli, Fabiana Madotto, Sebastian Fredes, Cong Lu, Massimo Antonelli, Alain Mercat, Arthur S. Slutsky, Jian-Xin Zhou, Laurent Brochard
Summary: This study aimed to investigate the association between physiological parameters and 60-day outcome in patients with ARDS. The results showed that transpulmonary pressures and airway driving pressures were associated with 60-day mortality, while elastance-derived plateau P-L was not. A positive end-expiratory P-L was associated with better outcome in obese patients.
INTENSIVE CARE MEDICINE
(2022)
Letter
Anesthesiology
Daniele G. Biasucci, Danilo Buonsenso, Domenico L. Grieco
MINERVA ANESTESIOLOGICA
(2022)
Article
Multidisciplinary Sciences
Esteban Garcia-Gallo, Laura Merson, Kalynn Kennon, Sadie Kelly, Barbara Wanjiru Citarella, Daniel Vidali Fryer, Sally Shrapnel, James Lee, Sara Duque, Yuli V. Fuentes, Valeria Balan, Sue Smith, Jia Wei, Bronner P. Goncalves, Clark D. Russell, Louise Sigfrid, Andrew Dagens, Piero L. Olliaro, Joaquin Baruch, Christiana Kartsonaki, Jake Dunning, Amanda Rojek, Aasiyah Rashan, Abi Beane, Srinivas Murthy, Luis Felipe Reyes
Summary: The ISARIC COVID-19 dataset is one of the largest international databases of clinical data on hospitalized COVID-19 patients. It includes data from hospitals worldwide and provides comprehensive information on patient characteristics and treatments.
Letter
Anesthesiology
Andrea Russo, Laura Cascarano, Antonio M. Dell'Anna, Domenico L. Grieco, Luca S. Menga, Bruno Romano, Domenico Papanice, Andrea Cataldo, Nazario Foschi, Pierluigi Russo, Pierfrancesco Bassi, Liliana Sollazzi
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Letter
Critical Care Medicine
Nicolas Colaianni-Alfonso, Guillermo Cesar Montiel, Maria Laura Vega, Guido Mazzinari, Jose Miguel Alonso-Inigo, Domenico Luca Grieco
Correction
Critical Care Medicine
Lu Chen, Domenico L. Grieco, Francois Beloncle, Guang-Qiang Chen, Norberto Tiribelli, Fabiana Madotto, Sebastian Fredes, Cong Lu, Massimo Antonelli, Alain Mercat, Arthur S. Slutsky, Jian-Xin Zhou, Laurent Brochard
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Roberto Lorusso, Maria Elena De Piero, Silvia Mariani, Michele Di Mauro, Thierry Folliguet, Fabio Silvio Taccone, Luigi Camporota, Justyna Swol, Dominik Wiedemann, Mirko Belliato, Lars Mikael Broman, Alain Vuylsteke, Yigal Kassif, Anna Mara Scandroglio, Vito Fanelli, Philippe Gaudard, Stephane Ledot, Julian Barker, Udo Boeken, Sven Maier, Alexander Kersten, Bart Meyns, Matteo Pozzi, Finn M. Pedersen, Peter Schellongowski, Kaan Kirali, Nicholas Barrett, Jordi Riera, Thomas Mueller, Jan Belohlavek, EuroECMO COVID Study Grp
Summary: This study aimed to investigate in-hospital outcomes in patients who received ECMO during the first wave of COVID-19 and found that factors such as patient's age, timing of cannulation, and use of medication were associated with higher in-hospital mortality. Despite favorable post-discharge survival, some patients still require long-term rehabilitation.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Cristian Deana, Luigi Vetrugno, Andrea Cortegiani, Silvia Mongodi, Giulia Salve, Matteo Mangiagalli, Annalisa Boscolo, Tommaso Pettenuzzo, Sara Miori, Andrea Sanna, Sergio Lassola, Sandra Magnoni, Elena Ferrari, Emanuela Biagioni, Flavio Bassi, Nadia Castaldo, Alberto Fantin, Federico Longhini, Francesco Corradi, Francesco Forfori, Gianmaria Cammarota, Edoardo De Robertis, Danilo Buonsenso, Savino Spadaro, Domenico Luca Grieco, Maria De Martino, Miriam Isola, Francesco Mojoli, Massimo Girardis, Antonino Giarratano, Elena Giovanna Bignami, Paolo Navalesi, Maurizio Cecconi, Salvatore Maurizio Maggiore, Italian Odissea Grp
Summary: The study aimed to investigate the health-related quality of life (HRQoL) in COVID-19 critically ill patients one year after ICU discharge. The findings showed that these patients had lower HRQoL in terms of physical functioning, social functioning, and mental health, with 31.8% of them experiencing post-traumatic stress disorder (PTSD) which was closely associated with reduced HRQoL. Female gender, history of cardiovascular disease, liver disease, and length of hospital stay were identified as risk factors for lower HRQoL, while weight gain at follow-up was a risk factor for PTSD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Salvatore Lucio Cutuli, Domenico Luca Grieco, Teresa Michi, Melania Cesarano, Tommaso Rosa, Gabriele Pintaudi, Luca Salvatore Menga, Ersilia Ruggiero, Valentina Giammatteo, Giuseppe Bello, Gennaro De Pascale, Massimo Antonelli
Summary: Acute respiratory distress syndrome (ARDS) is a leading cause of disability and mortality worldwide. Noninvasive and invasive respiratory support strategies are life-saving interventions, but their inappropriate management may lead to disease progression. A physiology-based approach and tools for identifying ARDS sub-phenotypes can help deliver personalized respiratory support and improve patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Eloisa Sofia Tanzarella, Joel Vargas, Marco Menghini, Stefania Postorino, Francesca Pozzana, Maria Sole Vallecoccia, Francesco Lorenzo De Matteis, Federico Franchi, Amato Infante, Luigi Larosa, Maria Antonietta Mazzei, Salvatore Lucio Cutuli, Domenico Luca Grieco, Alessandra Bisanti, Simone Carelli, Gianmarco Lombardi, Edoardo Piervincenzi, Gabriele Pintaudi, Tommaso Pirronti, Mario Tumbarello, Massimo Antonelli, Gennaro De Pascale
Summary: Antibiotics overuse in COVID-19 patients remains a problem. A predictive scoring model was developed to diagnose bacterial pneumonia in ICU-admitted COVID-19 patients. The study identified seven variables as predictors of bacterial pneumonia and a composite risk score was established. This predictive score, known as C19-PNEUMOSCORE, may be an effective tool for early identification of severe COVID-19 patients with pulmonary bacterial co-infection at ICU admission.
JOURNAL OF CLINICAL MEDICINE
(2023)