Article
Environmental Sciences
Melike Karaman, Emine Toraman, Ekrem Sulukan, Alper Baran, Smail Bolat, Serkan Yildirim, Meryem Kankaynar, Atena Ghosigharehagaji, Harun Budak, Saltuk Bugrahan Ceyhun
Summary: This study investigated the effects of fluoride exposure on anxiety and circadian clock changes in zebrafish at the molecular level. The results showed that fluoride exposure through various sources causes genotoxic effects, oxidative damage, and impaired cognitive abilities. Parental fluoride exposure disrupted the circadian rhythm, causing anxiety-like behaviors and decreased levels of brain antioxidant enzymes and melatonin. The offspring also showed negative effects, including delay in hatching, increased death and body malformations, and decreased blood flow velocity and locomotor activity. Furthermore, increased apoptosis rate, ROS level, and lipid accumulation were observed in the offspring.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Hongli Liu, Ruiqiang Fu, Yanning Zhang, Liangang Mao, Lizhen Zhu, Lan Zhang, Xingang Liu, Hongyun Jiang
Summary: In this study, the behavioral effects of imidacloprid on zebrafish were investigated at environmental concentrations. Integrated transcriptomic and metabolomic analysis revealed that disruption of circadian rhythm, metabolic imbalance, and neurotransmitter disorder were the underlying molecular mechanisms of behavioral impairment induced by imidacloprid. The identified genes and metabolites could serve as biomarkers to assess the ecological risk of imidacloprid to aquatic organisms and even human beings.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yi-Hong Wang, Ya-Qian Wang, Xiao-Gang Yu, Yin Lin, Jun-Xia Liu, Wei-Ye Wang, Chong-Huai Yan
Summary: Juvenile zebrafish exposed to environmental arsenic showed behavioral abnormalities, including anxiety and social deficits, along with increased oxidative stress in the brain, decreased dopamine content, and altered gene transcription related to dopamine metabolism. However, treatment with N-acetylcysteine helped reduce oxidative stress and improve social behavior, dopamine levels, monoamine oxidase activity, and gene transcription in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biology
Viacheslav V. Krylov, Evgeny I. Izvekov, Vera V. Pavlova, Natalia A. Pankova, Elena A. Osipova
Summary: This review discusses the circadian behavior rhythms of zebrafish, focusing on factors influencing these rhythms including ontogeny, environmental factors, and the modulation of physiological state. The complex interactions among different influences are highlighted, emphasizing the importance of considering them in behavioral studies.
BIOLOGICAL REVIEWS
(2021)
Article
Environmental Sciences
Weichao Zhao, Liang Mao, Chuqi He, Dexin Ding, Nan Hu, Xiaohua Song, Dingxin Long
Summary: Biological rhythm refers to the internal regulation of an organism's various life activities, determined by the specific time structure sequences of each individual. Behavior rhythm is the most intuitive reflection of biological rhythm. This study used zebrafish as a model organism to investigate the effects of low dose radiation on behavioral rhythm. The results showed that 1 Gy radiation could alter the circadian rhythm of zebrafish, as well as decrease the distance, amplitude, and phase of movement.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Immunology
Michal Stosik, Beata Tokarz-Deptula, Wieslaw Deptula
Summary: This review presents Danio rerio as a model organism for studying hematopoiesis in vertebrates and discusses the development of this process in fish and mammals, as well as the impact of microenvironmental factors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Marine & Freshwater Biology
Annalaura Mancia, Luigi Abelli, Giorgia Palladino, Marco Candela, Tyrone Lucon-Xiccato, Cristiano Bertolucci, Maria Cristina Fossi, Matteo Baini, Cristina Panti
Summary: This study aimed to assess the combined effects of microplastics and environmental contaminants on zebrafish health and behavior. The results showed that exposure to microplastics and pollutants can have negative effects on zebrafish, with greater impacts observed from environmentally exposed microplastics.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Jialu Luan, Shuhui Zhang, Yixin Xu, Liang Wen, Xizeng Feng
Summary: Polyglycolic acid (PGA) is an emerging biodegradable plastic material that, together with polylactic acid (PLA), is considered a suitable alternative to conventional plastics. However, PGA and PLA exposure in zebrafish larvae induces developmental toxicity, reduces voluntary locomotion, induces anxiety-like behaviors, and impairs sleep/wake behaviors. These potentially toxic effects of degradable plastics highlight the need for further research on the biological effects of PGA.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Davide Di Paola, Fabiano Capparucci, Jessica Maria Abbate, Marika Cordaro, Rosalia Crupi, Rosalba Siracusa, Ramona D'Amico, Roberta Fusco, Tiziana Genovese, Daniela Impellizzeri, Salvatore Cuzzocrea, Nunziacarla Spano, Enrico Gugliandolo, Alessio Filippo Peritore
Summary: This study evaluated the developmental toxicity of oxaliplatin (OXA) on zebrafish embryos. The results showed that OXA exposure caused developmental abnormalities, reduced hatching rate, and induced oxidative stress and apoptosis.
Article
Environmental Sciences
Ines Joao Ferreira, Liane Meneses, Alexandre Paiva, Mario Diniz, Ana Rita C. Duarte
Summary: Deep eutectic systems (DES) are considered as green alternatives to organic solvents due to their biocompatibility and biodegradability. This study evaluated the toxicity of a specific DES using zebrafish as a model and found that the DES exhibited low toxicity and did not have negative impacts on antioxidant pathways. These promising results suggest that DES could be used as a new class of green solvents in various industries without harming living organisms.
Article
Environmental Sciences
Michelle Huang, Emma Ivantsova, Isaac Konig, Neep Patel, Cole English, Christopher L. Souders II, Christopher J. Martyniuk
Summary: This study assessed the sub-lethal toxicity potential of perfluoroheptanoic acid (PFHpA) to developing zebrafish. The results showed that PFHpA was not acutely toxic to fish up to 50 μM and exposure to 200 μM PFHpA decreased ATP-linked respiration of embryos. There was no evidence for ROS induction in larvae fish exposed to 0.1 μM or 1 μM PFHpA, but exposure to PFHpA resulted in decreased levels of certain transcripts related to mitochondrial complexes.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Zhengkang Su, Fengqing Qin, Hai Zhang, Zhengwei Huang, Kaiyu Guan, Miaomiao Zheng, Ziru Dai, Weihong Song, Xi Li
Summary: This study evaluated the developmental toxicity of Safinamide in zebrafish embryos using various concentrations of the drug. The results showed that higher concentrations (30 μM) of Safinamide caused a decrease in hatching rate and an increase in malformation and mortality in zebrafish larvae. Lower exposure (10 μM) to Safinamide resulted in increased body length and hyperactivity-like behaviors in the zebrafish larvae. The study also identified disturbances in physiological processes such as neuroactive ligand-receptor interaction signaling pathway. The findings suggest that Safinamide may cause developmental defects and toxicity during early development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Elisa Maffioli, Simona Nonnis, Francesca Grassi Scalvini, Armando Negri, Gabriella Tedeschi, Mattia Toni
Summary: This study demonstrates that temperature variations can induce neurotoxic effects in adult zebrafish. The proteomic analysis identified proteins that serve as hallmarks of neurotoxic processes and revealed protein panels associated with different temperatures and BDNF depletion, which are linked to anxiety-like or boldness behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Emma Ivantsova, Isaac Konig, Christopher L. Souders II, David McNabney, Denina D. B. Simmons, Christopher J. Martyniuk
Summary: Blood pressure medication atenolol, a beta-blocker detected in wastewater systems, has negative effects on early stages of zebrafish development. It affects survival, heart rate, mitochondrial function, lipid and amino acid profiles, and locomotor activity. Atenolol decreases heart rate and alters lipid content in zebrafish at environmentally relevant levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Xin Chen, Wenhua Li
Summary: The study found that exposure to isoflucypram may cause developmental abnormalities, hatching delay, and decreased heart rates in zebrafish embryos, affecting the expression levels of cardiac-specific genes and erythropoiesis-related genes. Furthermore, most of the differentially expressed genes were enriched in heart development or hemopoiesis processes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Zongming Ren, Shangge Li, Tingting Zhang, Luhuizi Qi, Na Xing, Huimin Yu, Jinfeng Jian, Tae-Soo Chon, Bo Tang
Article
Environmental Sciences
Hongwei Pan, Xu Zhang, Baixiang Ren, Huanhuan Yang, Zongming Ren, Weiliang Wang
WATER AIR AND SOIL POLLUTION
(2017)
Article
Environmental Sciences
Jie Song, Linlin Qiao, Lizhen Ji, Baixiang Ren, Yongyuan Hu, Ruibin Zhao, Zongming Ren
Article
Biodiversity Conservation
Zongming Ren, Baixiang Ren, Hongwei Pan, Shangge Li, Baigang Ren, Shiguo Xu, Tae-Soo Chon, Weiliang Wang, Bin Chen
ECOLOGICAL INDICATORS
(2019)
Article
Environmental Sciences
Jingchun Ma, Linlin Qiao, Lizhen Ji, Baixiang Ren, Yongyuan Hu, Ruibin Zhao, Zongming Ren
Article
Environmental Sciences
Bin Li, Jingxuan Zhang, Jingchun Ma, Linlin Qiao, Baixiang Ren, Meng Chen, Zongming Ren
Article
Environmental Sciences
Ruibin Zhao, Yongyuan Hu, Bin Li, Meng Chen, Zongming Ren
Article
Engineering, Environmental
Baixiang Ren, Yaxin Yu, Rama-Krishnan Poopal, Linlin Qiao, Baichuan Ren, Zongming Ren
Summary: We developed an infrared-based real-time online monitoring device to assess water quality by quantifying heart electrocardiogram signals in fish. The device is compact and allows long-term monitoring without causing harm or disturbance to the fish. We accurately quantified ECG indexes of carp under different experimental conditions, which showed specific responses to different chemical exposures.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Rama-Krishnan Poopal, Rajan Ashwini, Mathan Ramesh, Bin Li, Zongming Ren
Summary: The study investigated the toxicity of malachite green on carp fish, finding significant changes in blood parameters, tissue antioxidants, and biomarkers under both acute and sublethal exposure periods.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Analytical
Tamilselvan Hema, Sundaram Mohanthi, Sathisaran Umamaheswari, Mathan Ramesh, Zongming Ren, Rama-Krishnan Poopal
Summary: Cyclophosphamide (CP) is detected in the aquatic environment and has toxic effects on oxidative stress biomarkers, protein, glucose, metabolising enzymes, ion-regulatory markers, and histology in zebrafish tissues. These alterations are similar to the toxic effects reported in mammalian models.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2023)
Article
Environmental Sciences
Luhuizi Qi, Jingchun Ma, Jie Song, Shangge Li, Xiaoru Cui, Xiaojing Peng, Weiliang Wang, Zongming Ren, Mei Han, Ying Zhang